BacMap

Definition	Corynebacterium jeikeium K411, complete genome.
Accession	NC_007164
Length	2,462,499

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The map label for this gene is yqhE [C]

Identifier: 68535500

GI number: 68535500

Start: 515204

End: 516061

Strand: Direct

Name: yqhE [C]

Synonym: jk0430

Alternate gene names: 68535500

Gene position: 515204-516061 (Clockwise)

Preceding gene: 68535497

Following gene: 68535501

Centisome position: 20.92

GC content: 64.34

Gene sequence:

>858_bases
ATGAACGAAAAGAACAATGCAGTACCGACTCTTGAGATGAATGACGGTAAGACCACTCCGCAGCTGGGGCTGGGCGTGTG
GCAGTTGAGCGACGAGGACACATACACCTCGGTGCGTGCGGCGATCGAGACCGGCTATCGCCACATCGATACCGCCGCGA
TCTACGGCAACGAAGAGGCCGTGGGGCGCGCTGTGGCCGACGCGGTGAAGGCCGGGGATGTGCAGCGCGAGGAGCTGTTC
ATCACCACCAAGCTGTGGAACGCCGACCAGGCGTGCGGTAAGGAAGCATTCGCGGAATCCCAGAAGAAGCTGGGGATGGA
TTATGTGGATCTGTACCTGCTGCACTGGCCGTGCCCGCAGGCCGATTCGTTCGTGCAGGCCTACGACTCTATGGCGGAGA
TCCAGCAGTCCGGCGGCGCGACCAGCATCGGCGTGTGCAACTTCTACCCCGAGGCGCTGGATGCCCTGAAGCAGGCCGGC
CACACCCCAGCCGTGAACCAGATCGAGATTCACCCGGGCTTTAGCCAGGCCGAGCAGCGCTCGGACAACCGCGACCGCGG
GATCGTCACCGAGGCGTGGTCGCCGCTGGGGCAGGGGCAAAACCTGACCGACCCGACCATCGCGAAGATCGCCGCCGAGC
ACGGAGTGAGCGTGGCGCAGGCCATCATCCGCTGGCACATCCAGCGTGGCGACGTCGTTATCCCGCGTTCCTCCAAGGTG
GAGCGCGTGCGCCAGAACTTCGACGTCTTCGGTTTTGAGCTTTCCGCTGACGAGGTCTCCGCCATCGAGGCTCTGGACGT
GGAGGACGGTCGCATCGGCGGCGACCCGCTGACTTTCCACGCCGGCCTAGAGGGCTAG

Upstream 100 bases:

>100_bases
AATGCTTTCTGGCTTTCTGGGACTTCGCAGTACGTTCGTGGTTGCGATTCCTCTGCCAGCGCCGTCGCGAGAATGAAGTC
GGTGGCGTACAAAGGAGGCC

Downstream 100 bases:

>100_bases
CGCAACTCCGCGCGGGTTACCGCGAAACACCCGCGTATGGCACCGTCCCTGCGGTACATTGCTAGCCATGAGCGCAGGGC
ACGTCATCACTCATCTAGAG

Product: putative oxidoreductase

Products: 2-keto-L-gulonate; NADP [C]

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNEKNNAVPTLEMNDGKTTPQLGLGVWQLSDEDTYTSVRAAIETGYRHIDTAAIYGNEEAVGRAVADAVKAGDVQREELF
ITTKLWNADQACGKEAFAESQKKLGMDYVDLYLLHWPCPQADSFVQAYDSMAEIQQSGGATSIGVCNFYPEALDALKQAG
HTPAVNQIEIHPGFSQAEQRSDNRDRGIVTEAWSPLGQGQNLTDPTIAKIAAEHGVSVAQAIIRWHIQRGDVVIPRSSKV
ERVRQNFDVFGFELSADEVSAIEALDVEDGRIGGDPLTFHAGLEG

Sequences:

>Translated_285_residues
MNEKNNAVPTLEMNDGKTTPQLGLGVWQLSDEDTYTSVRAAIETGYRHIDTAAIYGNEEAVGRAVADAVKAGDVQREELF
ITTKLWNADQACGKEAFAESQKKLGMDYVDLYLLHWPCPQADSFVQAYDSMAEIQQSGGATSIGVCNFYPEALDALKQAG
HTPAVNQIEIHPGFSQAEQRSDNRDRGIVTEAWSPLGQGQNLTDPTIAKIAAEHGVSVAQAIIRWHIQRGDVVIPRSSKV
ERVRQNFDVFGFELSADEVSAIEALDVEDGRIGGDPLTFHAGLEG
>Mature_285_residues
MNEKNNAVPTLEMNDGKTTPQLGLGVWQLSDEDTYTSVRAAIETGYRHIDTAAIYGNEEAVGRAVADAVKAGDVQREELF
ITTKLWNADQACGKEAFAESQKKLGMDYVDLYLLHWPCPQADSFVQAYDSMAEIQQSGGATSIGVCNFYPEALDALKQAG
HTPAVNQIEIHPGFSQAEQRSDNRDRGIVTEAWSPLGQGQNLTDPTIAKIAAEHGVSVAQAIIRWHIQRGDVVIPRSSKV
ERVRQNFDVFGFELSADEVSAIEALDVEDGRIGGDPLTFHAGLEG

Specific function: Reduction [C]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=33.5640138408304, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI310109922, Length=276, Percent_Identity=34.7826086956522, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI24497577, Length=286, Percent_Identity=32.8671328671329, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI5174391, Length=286, Percent_Identity=32.8671328671329, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI310109920, Length=294, Percent_Identity=32.9931972789116, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI45446745, Length=294, Percent_Identity=32.9931972789116, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI4503285, Length=294, Percent_Identity=32.9931972789116, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI93277124, Length=308, Percent_Identity=34.4155844155844, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI24497583, Length=317, Percent_Identity=32.1766561514196, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI5453543, Length=294, Percent_Identity=32.9931972789116, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI5174695, Length=294, Percent_Identity=32.312925170068, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI4502049, Length=285, Percent_Identity=36.8421052631579, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI24497585, Length=307, Percent_Identity=32.2475570032573, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI291291012, Length=263, Percent_Identity=33.0798479087452, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=31.7689530685921, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI300116271, Length=275, Percent_Identity=32.3636363636364, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI310109926, Length=113, Percent_Identity=39.8230088495575, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI207028673, Length=113, Percent_Identity=39.8230088495575, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI310109924, Length=150, Percent_Identity=34, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI87082198, Length=277, Percent_Identity=48.014440433213, Blast_Score=254, Evalue=3e-69,
Organism=Escherichia coli, GI1786400, Length=263, Percent_Identity=37.2623574144487, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788081, Length=266, Percent_Identity=29.6992481203008, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI48994888, Length=249, Percent_Identity=26.5060240963855, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787674, Length=281, Percent_Identity=26.6903914590747, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081735, Length=218, Percent_Identity=26.1467889908257, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17537077, Length=291, Percent_Identity=33.3333333333333, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17537075, Length=291, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71998625, Length=275, Percent_Identity=34.9090909090909, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17550248, Length=289, Percent_Identity=32.5259515570934, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17537079, Length=300, Percent_Identity=30.6666666666667, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17564128, Length=296, Percent_Identity=31.0810810810811, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17566692, Length=289, Percent_Identity=31.8339100346021, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17561298, Length=271, Percent_Identity=29.1512915129151, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17552492, Length=265, Percent_Identity=32.4528301886792, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17538386, Length=279, Percent_Identity=29.3906810035842, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=28.3088235294118, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=26.4492753623188, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17550246, Length=77, Percent_Identity=45.4545454545455, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320576, Length=291, Percent_Identity=40.2061855670103, Blast_Score=208, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6324694, Length=291, Percent_Identity=39.1752577319588, Blast_Score=203, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6322556, Length=269, Percent_Identity=33.457249070632, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319625, Length=287, Percent_Identity=33.7979094076655, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6321896, Length=303, Percent_Identity=30.03300330033, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320079, Length=286, Percent_Identity=32.8671328671329, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI20129731, Length=283, Percent_Identity=37.4558303886926, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24644950, Length=295, Percent_Identity=36.9491525423729, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24662789, Length=300, Percent_Identity=35.3333333333333, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24663317, Length=308, Percent_Identity=32.4675324675325, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221378297, Length=315, Percent_Identity=34.6031746031746, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=34.9480968858132, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI45553081, Length=287, Percent_Identity=32.0557491289199, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI21356425, Length=301, Percent_Identity=30.2325581395349, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24662781, Length=297, Percent_Identity=35.016835016835, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24662785, Length=305, Percent_Identity=34.0983606557377, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI281366140, Length=251, Percent_Identity=31.4741035856574, Blast_Score=128, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31047; Mature: 31047

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKNNAVPTLEMNDGKTTPQLGLGVWQLSDEDTYTSVRAAIETGYRHIDTAAIYGNEEA
CCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHCCEEEECCHHH
VGRAVADAVKAGDVQREELFITTKLWNADQACGKEAFAESQKKLGMDYVDLYLLHWPCPQ
HHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
ADSFVQAYDSMAEIQQSGGATSIGVCNFYPEALDALKQAGHTPAVNQIEIHPGFSQAEQR
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHC
SDNRDRGIVTEAWSPLGQGQNLTDPTIAKIAAEHGVSVAQAIIRWHIQRGDVVIPRSSKV
CCCCCCCEEHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCEEECCCHHH
ERVRQNFDVFGFELSADEVSAIEALDVEDGRIGGDPLTFHAGLEG
HHHHHCCCEEEEEECCCHHHHHHEECCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
MNEKNNAVPTLEMNDGKTTPQLGLGVWQLSDEDTYTSVRAAIETGYRHIDTAAIYGNEEA
CCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHCCEEEECCHHH
VGRAVADAVKAGDVQREELFITTKLWNADQACGKEAFAESQKKLGMDYVDLYLLHWPCPQ
HHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
ADSFVQAYDSMAEIQQSGGATSIGVCNFYPEALDALKQAGHTPAVNQIEIHPGFSQAEQR
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHC
SDNRDRGIVTEAWSPLGQGQNLTDPTIAKIAAEHGVSVAQAIIRWHIQRGDVVIPRSSKV
CCCCCCCEEHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCEEECCCHHH
ERVRQNFDVFGFELSADEVSAIEALDVEDGRIGGDPLTFHAGLEG
HHHHHCCCEEEEEECCCHHHHHHEECCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2,5-diketo-D-gluconate; NADPH [C]

Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA