Click here to switch to the map view.

The map label for this gene is fda [H]

Identifier: 68535281

GI number: 68535281

Start: 269105

End: 270139

Strand: Direct

Name: fda [H]

Synonym: jk0216

Alternate gene names: 68535281

Gene position: 269105-270139 (Clockwise)

Preceding gene: 68535280

Following gene: 68535282

Centisome position: 10.93

GC content: 61.45

Gene sequence:

>1035_bases
ATGCCAATTGCAACCCCTGACGTCTACCGCGACATGCTGGATAATGCGAAGGAGAACGGCTTCGCATACCCCGCCATTAA
CTGCACCTCTTCCGAGACCATCAACGCTGCTCTGAAGGGCTTTGCGGATGCGGAGTCCGACGGCATTATCCAGTTCTCCA
CCGGTGGCGCCCAGTTCGGTTCCGGCCTGGCTGTGAAGAACATGGTTGCAGGTGCGGAGGCCCTGGCTGCGTTTGCTCAC
CAGGCTGCTAAGCACTACGGCGTGAATGTTGCTCTGCACACTGACCACTGCCAGAAGGAAGTTCTGGACGAGTACGTCCG
CCCGCTGATGGAGATCTCCCGCAAGCGCGTGGAGGCCGGCGAGAATCCGCTGTTCCAGTCCCACATGTGGGACGGCTCCG
CTATCCCGATCGACGAGAACCTGGAGATCGCCAAGGGGCTGCTGGCTGACGCGCAGAAGGCCAACATCATCCTCGAGGTG
GAGATCGGCGTTGTCGGTGGCGAGGAAGACGGCGTGGAGGCTAAGGCTGGCGCTAACCTGTACACCACCGAAGAGGATTT
CGCTAAGACTGTCGATGCTCTGGGCACCGGCGAGCACGGTCGCTACCTGCTGGCCGCTACCTTCGGCAACGTCCACGGCG
TGTACAAGCCGGGCAACGTGAAGCTGCGCCCGGAGGTTCTGGACATGGGCCAGAAGGTTGCGGAGAAGAAGCTGGGCCTG
GCTGCCGGCTCCAACCCGTTCGACTTCGTCTTCCACGGTGGCTCCGGCTCCGAGAAGGAGAAGATCGAGGAGGCTCTGCG
TTACGGCGTGATCAAGATGAACGTGGACACGGACACCCAGTACGCCTTCACCAACCCGGTTGCCCGCCACATGTTCACCA
ACTTCGACGGCGTGCTGAAGATCGACGGCGAGGTCGGCAACAAGAAGGTTTACGACCCGCGCTCCTACCTGAAGAAGGCT
GAGGAGGCCATGTCCGTCCGCGTGGTGGAGGCCTGCAACGACCTGCACTCCGCTGGCACTTCCGTCGCTAAGTAG

Upstream 100 bases:

>100_bases
GGGAGTGCTCGGCGGAGTGACTGCACGGCGTTGAATTTGTGGGCATAATTGTGGGCGGAGACTTACCTGCCCTATTTCAA
GGAATTGAAGGAGCATCGAA

Downstream 100 bases:

>100_bases
GTTCCGCTAGCAAGATGGCAGAACAGATTCGTCACAGTCGAGACCTCTTCGGCGCGGAGCACCCGGAGGTGCGCCTGCCG
CAGGAACTGGCAAGTTCCAT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPIATPDVYRDMLDNAKENGFAYPAINCTSSETINAALKGFADAESDGIIQFSTGGAQFGSGLAVKNMVAGAEALAAFAH
QAAKHYGVNVALHTDHCQKEVLDEYVRPLMEISRKRVEAGENPLFQSHMWDGSAIPIDENLEIAKGLLADAQKANIILEV
EIGVVGGEEDGVEAKAGANLYTTEEDFAKTVDALGTGEHGRYLLAATFGNVHGVYKPGNVKLRPEVLDMGQKVAEKKLGL
AAGSNPFDFVFHGGSGSEKEKIEEALRYGVIKMNVDTDTQYAFTNPVARHMFTNFDGVLKIDGEVGNKKVYDPRSYLKKA
EEAMSVRVVEACNDLHSAGTSVAK

Sequences:

>Translated_344_residues
MPIATPDVYRDMLDNAKENGFAYPAINCTSSETINAALKGFADAESDGIIQFSTGGAQFGSGLAVKNMVAGAEALAAFAH
QAAKHYGVNVALHTDHCQKEVLDEYVRPLMEISRKRVEAGENPLFQSHMWDGSAIPIDENLEIAKGLLADAQKANIILEV
EIGVVGGEEDGVEAKAGANLYTTEEDFAKTVDALGTGEHGRYLLAATFGNVHGVYKPGNVKLRPEVLDMGQKVAEKKLGL
AAGSNPFDFVFHGGSGSEKEKIEEALRYGVIKMNVDTDTQYAFTNPVARHMFTNFDGVLKIDGEVGNKKVYDPRSYLKKA
EEAMSVRVVEACNDLHSAGTSVAK
>Mature_343_residues
PIATPDVYRDMLDNAKENGFAYPAINCTSSETINAALKGFADAESDGIIQFSTGGAQFGSGLAVKNMVAGAEALAAFAHQ
AAKHYGVNVALHTDHCQKEVLDEYVRPLMEISRKRVEAGENPLFQSHMWDGSAIPIDENLEIAKGLLADAQKANIILEVE
IGVVGGEEDGVEAKAGANLYTTEEDFAKTVDALGTGEHGRYLLAATFGNVHGVYKPGNVKLRPEVLDMGQKVAEKKLGLA
AGSNPFDFVFHGGSGSEKEKIEEALRYGVIKMNVDTDTQYAFTNPVARHMFTNFDGVLKIDGEVGNKKVYDPRSYLKKAE
EAMSVRVVEACNDLHSAGTSVAK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=351, Percent_Identity=41.3105413105413, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87082041, Length=315, Percent_Identity=25.3968253968254, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789526, Length=313, Percent_Identity=26.517571884984, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322790, Length=350, Percent_Identity=34.8571428571429, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 36975; Mature: 36844

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPDVYRDMLDNAKENGFAYPAINCTSSETINAALKGFADAESDGIIQFSTGGAQFG
CCCCCHHHHHHHHHCHHHCCEECCEECCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCC
SGLAVKNMVAGAEALAAFAHQAAKHYGVNVALHTDHCQKEVLDEYVRPLMEISRKRVEAG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCC
ENPLFQSHMWDGSAIPIDENLEIAKGLLADAQKANIILEVEIGVVGGEEDGVEAKAGANL
CCCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHCCCCC
YTTEEDFAKTVDALGTGEHGRYLLAATFGNVHGVYKPGNVKLRPEVLDMGQKVAEKKLGL
EECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHHHHHHHHHHHCC
AAGSNPFDFVFHGGSGSEKEKIEEALRYGVIKMNVDTDTQYAFTNPVARHMFTNFDGVLK
CCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCEEECCHHHHHHHCCCCCEEE
IDGEVGNKKVYDPRSYLKKAEEAMSVRVVEACNDLHSAGTSVAK
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PIATPDVYRDMLDNAKENGFAYPAINCTSSETINAALKGFADAESDGIIQFSTGGAQFG
CCCCHHHHHHHHHCHHHCCEECCEECCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCC
SGLAVKNMVAGAEALAAFAHQAAKHYGVNVALHTDHCQKEVLDEYVRPLMEISRKRVEAG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCC
ENPLFQSHMWDGSAIPIDENLEIAKGLLADAQKANIILEVEIGVVGGEEDGVEAKAGANL
CCCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHCCCCC
YTTEEDFAKTVDALGTGEHGRYLLAATFGNVHGVYKPGNVKLRPEVLDMGQKVAEKKLGL
EECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHHHHHHHHHHHCC
AAGSNPFDFVFHGGSGSEKEKIEEALRYGVIKMNVDTDTQYAFTNPVARHMFTNFDGVLK
CCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCEEECCHHHHHHHCCCCCEEE
IDGEVGNKKVYDPRSYLKKAEEAMSVRVVEACNDLHSAGTSVAK
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2615658; 12948626 [H]