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The map label for this gene is gyrA [H]

Identifier: 68535073

GI number: 68535073

Start: 14296

End: 16809

Strand: Direct

Name: gyrA [H]

Synonym: jk0011

Alternate gene names: 68535073

Gene position: 14296-16809 (Clockwise)

Preceding gene: 68535068

Following gene: 68535074

Centisome position: 0.58

GC content: 64.12

Gene sequence:

>2514_bases
GTGAGCGACGACAACAACGGTAGCGACAACCTCTTCGATCGAGTCACACCGATCGATCTGCAGGAGGAAATGAAGTCCAG
CTACATCGATTACGCCATGAGCGTGATCGTCGGACGCGCCCTGCCCGAAGTCCGTGACGGTCTGAAGCCCGTGCACCGAC
GCATCCTCTACGCGATGTTCGACAACGGTTACCGCCCCGAGCGCAGCTATGTGAAGTCCGCAAAGCCTGTCGCCGACACG
ATGGGTAACTACCACCCGCACGGCGATAGCGCGATCTACGACACCCTCGTGCGCTTGGCTCAACCGTGGTCCATGCGTTA
TCCACTGGTCGACGGCCAGGGCAACTTCGGTTCCCGCGGTAATGACGGCGCGGCCGCCATGCGTTACACCGAGTGCCGCA
TGACGCCCCTGGCGATGGAGATGGTGCGCGATATCCGCGAGAACACCGTCGAGTTCCAGCCCAACTACGACGGCAAGACT
ACCGAGCCGACCGTGCTGCCGTCCCGCGTGCCGAACCTGCTGATGAACGGCTCCGGCGGCATTGCCGTGGGCATGGCCAC
CAACATCCCGCCGCACAACCTGAACGAGCTGGCGGAAGCCATCTACTGGCTGCTCGACAACCCGGATGCAGAGGAAGCCG
ACGCGCTGGAAGCCTGCATGGAGCGGGTGAAGGGACCGGACTTCCCGACTGCTGGCCTGATCGTCGGCGACAAGGGCATC
CAGGACACCTACCGCACAGGCCGTGGCTCCATCCGCATGCGTGGCGTGACCAGCATTGAGGAAGAGGGCAACCGCCAGGT
CATCATCATCACCGAGCTGCCCTACCAGGTGAACCCGGACAACCTGGTGGCCTCGATCGCGGAGCAGATCCGCGACGGCA
AGATCGCCGGCATCTCCAAGATCGACGATGAGTCCTCCGACCGCGTGGGCATGCGCATCGTCATCACTCTGAAGCGCGAC
GCTGTGCCGCGCGTGGTGCTGAACAACCTGTACAAGCACTCCCAGCTGCAGACCAGCTTCGGCTCCAACATGCTGTCTAT
CGTGGACGGCGTGCCGCGCACTTTGCGCCTGGACCAGATGTTGCGCCACTACGTGGACCACCAGATCGACGTGATTGTGC
GCCGCACCCAGTTCCGCCTGGACGAGGCCGAGAAGCGCGCTCACATTTTGCGCGGCCTGGTGAAGGCTCTGGACATGCTG
GACGAGGTCATCGCCCTAATCCGCCGCTCCCCGACGGTGGATGAGGCCCGCACCGGCCTGATCGACCTGCTGGACGTCGA
CGAGGTACAGGCCGACCACATCCTTGCTATGCAGCTGCGCCGCCTGGCCGCGATGGAGCGCCAGAAGATCATCGACGAGT
TGGCGGAGTTGGAGGAGACCATCGCCGACCTGAAGGCGATCCTGGAATCCCCGCAGCGCCAGCGCGACATCGTCCGTACC
GAGCTGGCCGAGATCGTAGATAAGTACGGCGACGAGCGCCGCACGCAGATCATCGCCGCTTCCGGCGACGTGTCGGAGGA
AGACCTGATCGCCCGCGAGAACGTGGTCGTGACCATCACTTCCACCGGCTACGCGAAGCGCACGAAGGTGGATAGCTACC
GTAGCCAGCGCCGCGGCGGCAAGGGCGTGCGCGGTGCCGAGTTGAAGCAGGACGACGTGGTACGCCACTTCTTCGTCTGC
TCGACGCACGACACGATCCTGTTCTTCACCAACTTCGGCCGCGTGTACCGCCTGCGCGCCTTCGAGCTGCCGGAGGCCAC
CCGCACGGCCCGTGGCCAGCACGTAGCTAACCTGCTGGAGTTCCAGCCGGGCGAACAGATCGCCCAGGTTATCCAGATCC
AGTCCTACGAGGACGCCCCGTACCTGGTGCTGGCTACCGCACATGGTCGGGTGAAGAAGTCCCGCCTGACGGATTACGAC
ACTGCCCGTTCCGGCGGCCTGATCGCCATCAACTTGAACGAGGGCGATCGCCTGGTCGGCGCGCAACTGTGCACCGCCGA
GGACGACCTGCTGCTGGTCTCCGAAGAGGGCCAGGCTATGCGCTTCACCGCTGATGATGAGACGCTGCGCCCGATGGGTC
GCGCCACCGCCGGTGTTAAGGGCATGCGCTTCCGCGAGGAGGACCAGCTGTTGGCCCTGACGGTCGTGGCGGAGGATTCT
TCCCTGTTCGTGGCTACCTCCGGTGGATATGGCAAGCGCACGCCGATGGAGGAATACCCGACGAAGGGCCGTGGCGGCCT
GGGCGTGGTTGCGTTTAAGTACGACAAGAAGCGTGGCAAGCTGATCGGCGCGCTGACGGTCAACGACGATGACGAGATTC
TGGCCATGACCTCCAACGGTGGCGTGATCCGCACCGAGGTCAGCCAGATCCGCCACAGCGGTCGCGCGACGATGGGCGTG
CGCCTGGTGGACCTGGCTAAGGGCAACGAGTTGGTTGCCGTGGATCGCAACGTGGAGGAAGAGGCAGAGGAGTCTGCCGA
GGCCACTGCGAAGGCGGAGACGGAATCCGAGTAG

Upstream 100 bases:

>100_bases
GGGAAAGGTGGCGTCACAAAGCCTCCAAAGCGCAGGAAACCCACAACAAGGGGGTAGAATGGATAGGTCTGAAGGCTAAA
CAGAAAGGCTTCTCAAAACA

Downstream 100 bases:

>100_bases
TCCGATTAGCCCGGGCAGGCCGAGTAGGCCTGCAGGGTAAGCCGTGAACCGAAGTAGCCTGGCGGTCGATACCGCTAGGC
TACTGTCGTATAAGGCACAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 837; Mature: 836

Protein sequence:

>837_residues
MSDDNNGSDNLFDRVTPIDLQEEMKSSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMFDNGYRPERSYVKSAKPVADT
MGNYHPHGDSAIYDTLVRLAQPWSMRYPLVDGQGNFGSRGNDGAAAMRYTECRMTPLAMEMVRDIRENTVEFQPNYDGKT
TEPTVLPSRVPNLLMNGSGGIAVGMATNIPPHNLNELAEAIYWLLDNPDAEEADALEACMERVKGPDFPTAGLIVGDKGI
QDTYRTGRGSIRMRGVTSIEEEGNRQVIIITELPYQVNPDNLVASIAEQIRDGKIAGISKIDDESSDRVGMRIVITLKRD
AVPRVVLNNLYKHSQLQTSFGSNMLSIVDGVPRTLRLDQMLRHYVDHQIDVIVRRTQFRLDEAEKRAHILRGLVKALDML
DEVIALIRRSPTVDEARTGLIDLLDVDEVQADHILAMQLRRLAAMERQKIIDELAELEETIADLKAILESPQRQRDIVRT
ELAEIVDKYGDERRTQIIAASGDVSEEDLIARENVVVTITSTGYAKRTKVDSYRSQRRGGKGVRGAELKQDDVVRHFFVC
STHDTILFFTNFGRVYRLRAFELPEATRTARGQHVANLLEFQPGEQIAQVIQIQSYEDAPYLVLATAHGRVKKSRLTDYD
TARSGGLIAINLNEGDRLVGAQLCTAEDDLLLVSEEGQAMRFTADDETLRPMGRATAGVKGMRFREEDQLLALTVVAEDS
SLFVATSGGYGKRTPMEEYPTKGRGGLGVVAFKYDKKRGKLIGALTVNDDDEILAMTSNGGVIRTEVSQIRHSGRATMGV
RLVDLAKGNELVAVDRNVEEEAEESAEATAKAETESE

Sequences:

>Translated_837_residues
MSDDNNGSDNLFDRVTPIDLQEEMKSSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMFDNGYRPERSYVKSAKPVADT
MGNYHPHGDSAIYDTLVRLAQPWSMRYPLVDGQGNFGSRGNDGAAAMRYTECRMTPLAMEMVRDIRENTVEFQPNYDGKT
TEPTVLPSRVPNLLMNGSGGIAVGMATNIPPHNLNELAEAIYWLLDNPDAEEADALEACMERVKGPDFPTAGLIVGDKGI
QDTYRTGRGSIRMRGVTSIEEEGNRQVIIITELPYQVNPDNLVASIAEQIRDGKIAGISKIDDESSDRVGMRIVITLKRD
AVPRVVLNNLYKHSQLQTSFGSNMLSIVDGVPRTLRLDQMLRHYVDHQIDVIVRRTQFRLDEAEKRAHILRGLVKALDML
DEVIALIRRSPTVDEARTGLIDLLDVDEVQADHILAMQLRRLAAMERQKIIDELAELEETIADLKAILESPQRQRDIVRT
ELAEIVDKYGDERRTQIIAASGDVSEEDLIARENVVVTITSTGYAKRTKVDSYRSQRRGGKGVRGAELKQDDVVRHFFVC
STHDTILFFTNFGRVYRLRAFELPEATRTARGQHVANLLEFQPGEQIAQVIQIQSYEDAPYLVLATAHGRVKKSRLTDYD
TARSGGLIAINLNEGDRLVGAQLCTAEDDLLLVSEEGQAMRFTADDETLRPMGRATAGVKGMRFREEDQLLALTVVAEDS
SLFVATSGGYGKRTPMEEYPTKGRGGLGVVAFKYDKKRGKLIGALTVNDDDEILAMTSNGGVIRTEVSQIRHSGRATMGV
RLVDLAKGNELVAVDRNVEEEAEESAEATAKAETESE
>Mature_836_residues
SDDNNGSDNLFDRVTPIDLQEEMKSSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMFDNGYRPERSYVKSAKPVADTM
GNYHPHGDSAIYDTLVRLAQPWSMRYPLVDGQGNFGSRGNDGAAAMRYTECRMTPLAMEMVRDIRENTVEFQPNYDGKTT
EPTVLPSRVPNLLMNGSGGIAVGMATNIPPHNLNELAEAIYWLLDNPDAEEADALEACMERVKGPDFPTAGLIVGDKGIQ
DTYRTGRGSIRMRGVTSIEEEGNRQVIIITELPYQVNPDNLVASIAEQIRDGKIAGISKIDDESSDRVGMRIVITLKRDA
VPRVVLNNLYKHSQLQTSFGSNMLSIVDGVPRTLRLDQMLRHYVDHQIDVIVRRTQFRLDEAEKRAHILRGLVKALDMLD
EVIALIRRSPTVDEARTGLIDLLDVDEVQADHILAMQLRRLAAMERQKIIDELAELEETIADLKAILESPQRQRDIVRTE
LAEIVDKYGDERRTQIIAASGDVSEEDLIARENVVVTITSTGYAKRTKVDSYRSQRRGGKGVRGAELKQDDVVRHFFVCS
THDTILFFTNFGRVYRLRAFELPEATRTARGQHVANLLEFQPGEQIAQVIQIQSYEDAPYLVLATAHGRVKKSRLTDYDT
ARSGGLIAINLNEGDRLVGAQLCTAEDDLLLVSEEGQAMRFTADDETLRPMGRATAGVKGMRFREEDQLLALTVVAEDSS
LFVATSGGYGKRTPMEEYPTKGRGGLGVVAFKYDKKRGKLIGALTVNDDDEILAMTSNGGVIRTEVSQIRHSGRATMGVR
LVDLAKGNELVAVDRNVEEEAEESAEATAKAETESE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=322, Percent_Identity=25.1552795031056, Blast_Score=87, Evalue=9e-17,
Organism=Homo sapiens, GI19913406, Length=367, Percent_Identity=25.3405994550409, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=851, Percent_Identity=45.475910693302, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=764, Percent_Identity=33.7696335078534, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=190, Percent_Identity=32.1052631578947, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=171, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=167, Percent_Identity=31.1377245508982, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=178, Percent_Identity=31.4606741573034, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136538, Length=367, Percent_Identity=24.2506811989101, Blast_Score=83, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93090; Mature: 92958

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDNNGSDNLFDRVTPIDLQEEMKSSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMF
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
DNGYRPERSYVKSAKPVADTMGNYHPHGDSAIYDTLVRLAQPWSMRYPLVDGQGNFGSRG
CCCCCCCHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCC
NDGAAAMRYTECRMTPLAMEMVRDIRENTVEFQPNYDGKTTEPTVLPSRVPNLLMNGSGG
CCCCHHEEEHHHCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCHHHCCHHEECCCCC
IAVGMATNIPPHNLNELAEAIYWLLDNPDAEEADALEACMERVKGPDFPTAGLIVGDKGI
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCC
QDTYRTGRGSIRMRGVTSIEEEGNRQVIIITELPYQVNPDNLVASIAEQIRDGKIAGISK
HHHHHCCCCCEEEECCCCHHHCCCEEEEEEEECCCEECHHHHHHHHHHHHCCCCEECCCC
IDDESSDRVGMRIVITLKRDAVPRVVLNNLYKHSQLQTSFGSNMLSIVDGVPRTLRLDQM
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
LRHYVDHQIDVIVRRTQFRLDEAEKRAHILRGLVKALDMLDEVIALIRRSPTVDEARTGL
HHHHHCCHHHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCE
IDLLDVDEVQADHILAMQLRRLAAMERQKIIDELAELEETIADLKAILESPQRQRDIVRT
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELAEIVDKYGDERRTQIIAASGDVSEEDLIARENVVVTITSTGYAKRTKVDSYRSQRRGG
HHHHHHHHHCCCHHEEEEEECCCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
KGVRGAELKQDDVVRHFFVCSTHDTILFFTNFGRVYRLRAFELPEATRTARGQHVANLLE
CCCCCCCCCHHHHHHEEEEEECCCEEEEEECCCCEEEEEEECCCCHHHHHCHHHHHHHHH
FQPGEQIAQVIQIQSYEDAPYLVLATAHGRVKKSRLTDYDTARSGGLIAINLNEGDRLVG
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCEEEEECCCCCEEEC
AQLCTAEDDLLLVSEEGQAMRFTADDETLRPMGRATAGVKGMRFREEDQLLALTVVAEDS
CEEECCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCC
SLFVATSGGYGKRTPMEEYPTKGRGGLGVVAFKYDKKRGKLIGALTVNDDDEILAMTSNG
EEEEEECCCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCCEEEEECCC
GVIRTEVSQIRHSGRATMGVRLVDLAKGNELVAVDRNVEEEAEESAEATAKAETESE
CEEEHHHHHHHHCCCCEECEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDDNNGSDNLFDRVTPIDLQEEMKSSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMF
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
DNGYRPERSYVKSAKPVADTMGNYHPHGDSAIYDTLVRLAQPWSMRYPLVDGQGNFGSRG
CCCCCCCHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCC
NDGAAAMRYTECRMTPLAMEMVRDIRENTVEFQPNYDGKTTEPTVLPSRVPNLLMNGSGG
CCCCHHEEEHHHCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCHHHCCHHEECCCCC
IAVGMATNIPPHNLNELAEAIYWLLDNPDAEEADALEACMERVKGPDFPTAGLIVGDKGI
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCC
QDTYRTGRGSIRMRGVTSIEEEGNRQVIIITELPYQVNPDNLVASIAEQIRDGKIAGISK
HHHHHCCCCCEEEECCCCHHHCCCEEEEEEEECCCEECHHHHHHHHHHHHCCCCEECCCC
IDDESSDRVGMRIVITLKRDAVPRVVLNNLYKHSQLQTSFGSNMLSIVDGVPRTLRLDQM
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
LRHYVDHQIDVIVRRTQFRLDEAEKRAHILRGLVKALDMLDEVIALIRRSPTVDEARTGL
HHHHHCCHHHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCE
IDLLDVDEVQADHILAMQLRRLAAMERQKIIDELAELEETIADLKAILESPQRQRDIVRT
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELAEIVDKYGDERRTQIIAASGDVSEEDLIARENVVVTITSTGYAKRTKVDSYRSQRRGG
HHHHHHHHHCCCHHEEEEEECCCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
KGVRGAELKQDDVVRHFFVCSTHDTILFFTNFGRVYRLRAFELPEATRTARGQHVANLLE
CCCCCCCCCHHHHHHEEEEEECCCEEEEEECCCCEEEEEEECCCCHHHHHCHHHHHHHHH
FQPGEQIAQVIQIQSYEDAPYLVLATAHGRVKKSRLTDYDTARSGGLIAINLNEGDRLVG
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCEEEEECCCCCEEEC
AQLCTAEDDLLLVSEEGQAMRFTADDETLRPMGRATAGVKGMRFREEDQLLALTVVAEDS
CEEECCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCC
SLFVATSGGYGKRTPMEEYPTKGRGGLGVVAFKYDKKRGKLIGALTVNDDDEILAMTSNG
EEEEEECCCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCCEEEEECCC
GVIRTEVSQIRHSGRATMGVRLVDLAKGNELVAVDRNVEEEAEESAEATAKAETESE
CEEEHHHHHHHHCCCCEECEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8878580 [H]