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The map label for this gene is ddl

Identifier: 77761078

GI number: 77761078

Start: 279629

End: 280735

Strand: Reverse

Name: ddl

Synonym: XC_0232

Alternate gene names: 77761078

Gene position: 280735-279629 (Counterclockwise)

Preceding gene: 66766581

Following gene: 66766576

Centisome position: 5.45

GC content: 66.76

Gene sequence:

>1107_bases
ATGCGCAGGATTCGGGTCGGACTCATCTTTGGCGGCAAGTCGGCCGAGCACGAGGTCTCGCTGCAATCGGCGCGCAATAT
CCTGCAGGCGCTGGACCCGCAGCGGTTCGAGCCGGTGCTGATCGGCATCGACAAACAGGGCCAGTGGCACCTCAGCGCAC
AAGAGAGTTTCCTGCTCGATGCCGACGACCCCAGCCGCATTGCGCTGCGCCACAGCGGCCGCGGGCTGGCCGTGCTGCCC
GGTGCCGCCAGTGCGCAGCTGCGCGCGGTGGATGCCGAACAGGCGTTGGCGCAGATCGATGTGGTGTTCCCGATCGTGCA
CGGCACGCTGGGCGAAGACGGCTCGCTGCAGGGGCTGCTGCGCATGGCCAACCTGCCGTTCGTCGGTTCCGGCGTGCTGG
GGTCGGCCGTGGCGATGGACAAGGACATGGCCAAGCGGGTGCTGCGCGATGCCGGCCTGGAGGTGGCGCCGTTCGCATGC
TTCACGCGCCACACCGCTGCGCAGGCCGACGTGCAGACGCTGATTGCCCAATTCGGGCTGCCGTTGTTCGTCAAGCCGGC
CAACCAGGGCTCGTCGGTCGGCGTCAGCCAGGTCCGCAGCGCTGAGGAGTTCAGCGCTGCATTGGAGCTCGCGCTGCGCT
ACGACCACAAGGTGCTGGTGGAAGCGGCGATCGCCGGGCGCGAGATCGAATGCGCGGTGCTGGGCAATGCCACGCCGCAG
GCCAGCGTGTGCGGCGAGGTGGTGGTGCACGACGCGTTCTATTCGTACCAGACCAAGTACATCCGCGACGATGGCGCAGC
GACGGTGATTCCCGCCGATATCGATGCCCACACCCAGCACCGTATCCAGCAGTGCGCACTACAGGCCTATCAGGCGCTGG
ACTGCGCCGGCATGGCGCGCGTGGATGTGTTCCTGTGCGCGGATGGGCGCATCGTCATCAACGAGGTCAACACCTTGCCC
GGCTTCACCCGCATCAGCATGTATCCCAAGTTGTGGGAGGCAAGCGGGCTGGACTATCGCAGCCTGGTTACGCGCTTGAT
CGAGCTGGCACTGGAGCGGCATGCCGACGATGGGCGCCTGTACAGCAGCGTGGTCACGCACGCGTGA

Upstream 100 bases:

>100_bases
GGTGCATGTGCCACGGCTCGGGCAGGCACCCGGCGCCTCCGTTCGGCACCGCGCCGGCGGCATCCTGTGCCGCTTCCGTG
GAGCAATGACAGGAGCAGGC

Downstream 100 bases:

>100_bases
CCGCGGCACAGTTGCGTGCAGTGCATCCGTACGATCACGCAGCACTGTTGGCACTCAACAACGCCGATGCCAGCGCCTTG
TCGTGGCTCACGCCTGATGC

Product: D-alanyl-alanine synthetase A

Products: NA

Alternate protein names: D-Ala-D-Ala ligase A; D-alanylalanine synthetase A

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MRRIRVGLIFGGKSAEHEVSLQSARNILQALDPQRFEPVLIGIDKQGQWHLSAQESFLLDADDPSRIALRHSGRGLAVLP
GAASAQLRAVDAEQALAQIDVVFPIVHGTLGEDGSLQGLLRMANLPFVGSGVLGSAVAMDKDMAKRVLRDAGLEVAPFAC
FTRHTAAQADVQTLIAQFGLPLFVKPANQGSSVGVSQVRSAEEFSAALELALRYDHKVLVEAAIAGREIECAVLGNATPQ
ASVCGEVVVHDAFYSYQTKYIRDDGAATVIPADIDAHTQHRIQQCALQAYQALDCAGMARVDVFLCADGRIVINEVNTLP
GFTRISMYPKLWEASGLDYRSLVTRLIELALERHADDGRLYSSVVTHA

Sequences:

>Translated_368_residues
MRRIRVGLIFGGKSAEHEVSLQSARNILQALDPQRFEPVLIGIDKQGQWHLSAQESFLLDADDPSRIALRHSGRGLAVLP
GAASAQLRAVDAEQALAQIDVVFPIVHGTLGEDGSLQGLLRMANLPFVGSGVLGSAVAMDKDMAKRVLRDAGLEVAPFAC
FTRHTAAQADVQTLIAQFGLPLFVKPANQGSSVGVSQVRSAEEFSAALELALRYDHKVLVEAAIAGREIECAVLGNATPQ
ASVCGEVVVHDAFYSYQTKYIRDDGAATVIPADIDAHTQHRIQQCALQAYQALDCAGMARVDVFLCADGRIVINEVNTLP
GFTRISMYPKLWEASGLDYRSLVTRLIELALERHADDGRLYSSVVTHA
>Mature_368_residues
MRRIRVGLIFGGKSAEHEVSLQSARNILQALDPQRFEPVLIGIDKQGQWHLSAQESFLLDADDPSRIALRHSGRGLAVLP
GAASAQLRAVDAEQALAQIDVVFPIVHGTLGEDGSLQGLLRMANLPFVGSGVLGSAVAMDKDMAKRVLRDAGLEVAPFAC
FTRHTAAQADVQTLIAQFGLPLFVKPANQGSSVGVSQVRSAEEFSAALELALRYDHKVLVEAAIAGREIECAVLGNATPQ
ASVCGEVVVHDAFYSYQTKYIRDDGAATVIPADIDAHTQHRIQQCALQAYQALDCAGMARVDVFLCADGRIVINEVNTLP
GFTRISMYPKLWEASGLDYRSLVTRLIELALERHADDGRLYSSVVTHA

Specific function: Cell wall formation

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Escherichia coli, GI1786579, Length=367, Percent_Identity=62.3978201634877, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1786280, Length=351, Percent_Identity=33.048433048433, Blast_Score=177, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DDLA_XANCP (Q8PDW3)

Other databases:

- EMBL:   AE008922
- RefSeq:   NP_635617.2
- ProteinModelPortal:   Q8PDW3
- SMR:   Q8PDW3
- GeneID:   999929
- GenomeReviews:   AE008922_GR
- KEGG:   xcc:XCC0222
- HOGENOM:   HBG427092
- OMA:   FTDISMY
- ProtClustDB:   PRK01966
- BioCyc:   XCAM190485:XCC0222-MONOMER
- BRENDA:   6.3.2.4
- GO:   GO:0005737
- HAMAP:   MF_00047
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- TIGRFAMs:   TIGR01205

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N; SSF52440 PreATP-grasp-like

EC number: =6.3.2.4

Molecular weight: Translated: 39693; Mature: 39693

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50975 ATP_GRASP; PS00843 DALA_DALA_LIGASE_1; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIRVGLIFGGKSAEHEVSLQSARNILQALDPQRFEPVLIGIDKQGQWHLSAQESFLLD
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCEEEE
ADDPSRIALRHSGRGLAVLPGAASAQLRAVDAEQALAQIDVVFPIVHGTLGEDGSLQGLL
CCCCCEEEEEECCCCEEEECCCCCCEEEEECHHHHHHHHHHHEEEEECCCCCCCCHHHHH
RMANLPFVGSGVLGSAVAMDKDMAKRVLRDAGLEVAPFACFTRHTAAQADVQTLIAQFGL
HHHCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHCCC
PLFVKPANQGSSVGVSQVRSAEEFSAALELALRYDHKVLVEAAIAGREIECAVLGNATPQ
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEECCCCCC
ASVCGEVVVHDAFYSYQTKYIRDDGAATVIPADIDAHTQHRIQQCALQAYQALDCAGMAR
HHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCE
VDVFLCADGRIVINEVNTLPGFTRISMYPKLWEASGLDYRSLVTRLIELALERHADDGRL
EEEEEECCCEEEEEECCCCCCCEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHH
YSSVVTHA
HHHHHHCC
>Mature Secondary Structure
MRRIRVGLIFGGKSAEHEVSLQSARNILQALDPQRFEPVLIGIDKQGQWHLSAQESFLLD
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCEEEE
ADDPSRIALRHSGRGLAVLPGAASAQLRAVDAEQALAQIDVVFPIVHGTLGEDGSLQGLL
CCCCCEEEEEECCCCEEEECCCCCCEEEEECHHHHHHHHHHHEEEEECCCCCCCCHHHHH
RMANLPFVGSGVLGSAVAMDKDMAKRVLRDAGLEVAPFACFTRHTAAQADVQTLIAQFGL
HHHCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHCCC
PLFVKPANQGSSVGVSQVRSAEEFSAALELALRYDHKVLVEAAIAGREIECAVLGNATPQ
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEECCCCCC
ASVCGEVVVHDAFYSYQTKYIRDDGAATVIPADIDAHTQHRIQQCALQAYQALDCAGMAR
HHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCE
VDVFLCADGRIVINEVNTLPGFTRISMYPKLWEASGLDYRSLVTRLIELALERHADDGRL
EEEEEECCCEEEEEECCCCCCCEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHH
YSSVVTHA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217