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The map label for this gene is edd [H]

Identifier: 66768295

GI number: 66768295

Start: 2385912

End: 2387828

Strand: Reverse

Name: edd [H]

Synonym: XC_1974

Alternate gene names: 66768295

Gene position: 2387828-2385912 (Counterclockwise)

Preceding gene: 66768296

Following gene: 66768294

Centisome position: 46.38

GC content: 67.61

Gene sequence:

>1917_bases
ATGAGCCTGCATCCGAACATCCAAGCTGTCACCGACCGTATCCGCAAGCGCAGCGCGCCCTCGCGCGCGGCGTACCTGGC
CGGCCTTGATGCCGCCCTGCGTGAAGGCCCGTTCCGTAGCCGCCTGAGTTGCGGCAATCTCGCGCACGGTTTTGCGGCCT
CCGAGGCGACCGACAAGTCGCGCCTGCGCGGCGCGGCCACGCCGAACCTGGGCATCATCACCGCCTACAACGACATGCTC
TCGGCGCATCAGCCGTTCGAGCATTACCCGCAGATGATCCGCGACACCGCGCGTGCGCTCGGCGCCACCGCGCAGGTCGC
CGGCGGCGTGCCGGCAATGTGCGACGGCGTGACCCAGGGCCGTGCTGGCATGGAGCTGTCGCTGTTTTCGCGCGACAACA
TCGCCCAGGCCGCGGCCATCGGCCTCAGCCACGACATGTTCGATGCGGTGGTCTATCTGGGCGTGTGCGACAAGATCGTG
CCTGGCCTGTTGATCGGCGCATTGGCCTTCGGCCACCTGCCGGCGTTGTTCATGCCGGCCGGCCCGATGAGCCCGGGCAT
TCCCAACAAGCAGAAGGCCGAAGTGCGTGAGCGCTATGCCGCGGGCGAAGCCACCCGTGCCGAGTTGCTGGAAGCCGAAT
CCGCCTCCTACCACTCGCCCGGCACCTGCACCTTTTACGGGACCGCCAACTCCAATCAGGTGTTGCTGGAAGCGATGGGC
GTGCAACTGCCCGGCGCCTCGTTCGTCAATCCCGAACAGCCGTTGCGTGATGCGCTGACCCGTGAGGGCACCGAGCGGGC
GCTGGCGATCTCCGCGCTAGGCCAGGACTTCCGCCCGTTCGGTCGTTTGATCGACGAACGCGCGATCGTCAACGCCGTGG
TCGCCCTGATGGCCACTGGCGGCTCCACCAACCACACCATCCACTGGATCGCTGTGGCACGTGCGGCGGGCATCGTGCTG
ACCTGGGACGACATGGATCTGATCTCGCAGACCGTGCCGCTGCTGACCCGTGTCTACCCGAACGGCGAAGCCGACGTGAA
CCGCTTCCAGGCTGCTGGCGGCACGGCATTCGTGTTCCGCGAACTGATGGACGCCGGCTACATGCACGACGACCTGCCCA
CCGTGGTCGAAGGCGGCATGCGTGCCTATGCCAACGAGCCGCGTTTGCAGGACGGCAAGGTCATCTATGTGCCCGGCACA
GCGACCAGCGCCGATGACAGCGTGGCACGCCCGGTCAGCGATGCATTCGAATCGCAAGGTGGCCTGCGCCTGCTGCGCGG
CAACCTGGGCCGCTCGCTGATCAAGCTGTCGGCGGTCAAGCCCCAGCACCGCAAGATCGAAGCGCCTGCGGTGGTGATCG
ACACCCCGCAGGTGCTCAACAAGCTGCATGCGGCCGGCGTGTTGCCGCATGACTTCGTGGTGGTGCTGCGTTACCAGGGC
CCGCGTGCCAACGGTATGCCGGAGCTGCATTCAATGGCCCCGTTGCTCGGCCTGTTGCAGAACCAGGGCCGTCGCGTGGC
GCTGGTCACCGACGGCCGTTTGTCCGGTGCCTCGGGCAAGTTCCCCGCCGCGATCCACATGACGCCGGAAGCCGCGCGTG
GCGGCCCGATCGGGCGTGTCCGCGAAGGCGACATGGTGCGCCTGGACGGCGAAGCCGGCACGCTGGAAGTGCTGGTTTCG
GCCGAAGAATGGGCATCGCGCGAGGTTGCACCCAACACCGCCGTGGCCGGCAACGACCTGGGCCGTAACCTGTTTGCGAT
CAACCGCCAGGTCGTCGGCCCGGCCGACCAGGGCGCGATTTCGATTTCGTGCGGCCCGACCCATCCGGACGGTGCGCTGT
GGAGCTACGACGCCGAGTACGAACTGGGCGCCGATGCGGCCGCTGCCGCGGCGCCGCACGAGTCCAAGGACGCCTGA

Upstream 100 bases:

>100_bases
TGCAAGCACTTGCCCACGTTGTGATACCGCGGCAGCCCGCATCGCCTGATGCCGGGCTGCCATTGAACACCTTCCCCCTG
TTTCTCATAGCCGGTAGCCA

Downstream 100 bases:

>100_bases
TCCCCTTCCCTCTCTGCGATCGCCCAGGCGGTCGCCGTCTCCAGGAGTTGCAATGACGATTGCCCAGACCCAAAACACCG
CTGAACAGCTGCTGCGCGAC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEATDKSRLRGAATPNLGIITAYNDML
SAHQPFEHYPQMIRDTARALGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQAAAIGLSHDMFDAVVYLGVCDKIV
PGLLIGALAFGHLPALFMPAGPMSPGIPNKQKAEVRERYAAGEATRAELLEAESASYHSPGTCTFYGTANSNQVLLEAMG
VQLPGASFVNPEQPLRDALTREGTERALAISALGQDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVL
TWDDMDLISQTVPLLTRVYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLPTVVEGGMRAYANEPRLQDGKVIYVPGT
ATSADDSVARPVSDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRKIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHMTPEAARGGPIGRVREGDMVRLDGEAGTLEVLVS
AEEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA

Sequences:

>Translated_638_residues
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEATDKSRLRGAATPNLGIITAYNDML
SAHQPFEHYPQMIRDTARALGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQAAAIGLSHDMFDAVVYLGVCDKIV
PGLLIGALAFGHLPALFMPAGPMSPGIPNKQKAEVRERYAAGEATRAELLEAESASYHSPGTCTFYGTANSNQVLLEAMG
VQLPGASFVNPEQPLRDALTREGTERALAISALGQDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVL
TWDDMDLISQTVPLLTRVYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLPTVVEGGMRAYANEPRLQDGKVIYVPGT
ATSADDSVARPVSDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRKIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHMTPEAARGGPIGRVREGDMVRLDGEAGTLEVLVS
AEEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
>Mature_637_residues
SLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEATDKSRLRGAATPNLGIITAYNDMLS
AHQPFEHYPQMIRDTARALGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQAAAIGLSHDMFDAVVYLGVCDKIVP
GLLIGALAFGHLPALFMPAGPMSPGIPNKQKAEVRERYAAGEATRAELLEAESASYHSPGTCTFYGTANSNQVLLEAMGV
QLPGASFVNPEQPLRDALTREGTERALAISALGQDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVLT
WDDMDLISQTVPLLTRVYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLPTVVEGGMRAYANEPRLQDGKVIYVPGTA
TSADDSVARPVSDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRKIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQGP
RANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHMTPEAARGGPIGRVREGDMVRLDGEAGTLEVLVSA
EEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=52.8239202657807, Blast_Score=658, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=547, Percent_Identity=27.6051188299817, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI2367371, Length=462, Percent_Identity=30.3030303030303, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786464, Length=458, Percent_Identity=29.2576419213974, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322476, Length=481, Percent_Identity=30.1455301455301, Blast_Score=177, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 67452; Mature: 67321

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEATDKS
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHH
RLRGAATPNLGIITAYNDMLSAHQPFEHYPQMIRDTARALGATAQVAGGVPAMCDGVTQG
HHCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCC
RAGMELSLFSRDNIAQAAAIGLSHDMFDAVVYLGVCDKIVPGLLIGALAFGHLPALFMPA
CCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
GPMSPGIPNKQKAEVRERYAAGEATRAELLEAESASYHSPGTCTFYGTANSNQVLLEAMG
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEECC
VQLPGASFVNPEQPLRDALTREGTERALAISALGQDFRPFGRLIDERAIVNAVVALMATG
CCCCCCCCCCCHHHHHHHHHHCCCHHEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GSTNHTIHWIAVARAAGIVLTWDDMDLISQTVPLLTRVYPNGEADVNRFQAAGGTAFVFR
CCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHH
ELMDAGYMHDDLPTVVEGGMRAYANEPRLQDGKVIYVPGTATSADDSVARPVSDAFESQG
HHHHCCCCCCCCHHHHHCCHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCC
GLRLLRGNLGRSLIKLSAVKPQHRKIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
CEEEEHHHHCHHHHHHHCCCCHHHCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEECC
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHMTPEAARGGPIGRV
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCHHCCCCCCCCC
REGDMVRLDGEAGTLEVLVSAEEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAI
CCCCEEEECCCCCEEEEEEEHHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCEE
SISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
EEEECCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEATDKS
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHH
RLRGAATPNLGIITAYNDMLSAHQPFEHYPQMIRDTARALGATAQVAGGVPAMCDGVTQG
HHCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCC
RAGMELSLFSRDNIAQAAAIGLSHDMFDAVVYLGVCDKIVPGLLIGALAFGHLPALFMPA
CCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
GPMSPGIPNKQKAEVRERYAAGEATRAELLEAESASYHSPGTCTFYGTANSNQVLLEAMG
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEECC
VQLPGASFVNPEQPLRDALTREGTERALAISALGQDFRPFGRLIDERAIVNAVVALMATG
CCCCCCCCCCCHHHHHHHHHHCCCHHEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GSTNHTIHWIAVARAAGIVLTWDDMDLISQTVPLLTRVYPNGEADVNRFQAAGGTAFVFR
CCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHH
ELMDAGYMHDDLPTVVEGGMRAYANEPRLQDGKVIYVPGTATSADDSVARPVSDAFESQG
HHHHCCCCCCCCHHHHHCCHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCC
GLRLLRGNLGRSLIKLSAVKPQHRKIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
CEEEEHHHHCHHHHHHHCCCCHHHCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEECC
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHMTPEAARGGPIGRV
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCHHCCCCCCCCC
REGDMVRLDGEAGTLEVLVSAEEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAI
CCCCEEEECCCCCEEEEEEEHHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCEE
SISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
EEEECCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]