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The map label for this gene is argG [H]

Identifier: 66768192

GI number: 66768192

Start: 2264661

End: 2265854

Strand: Direct

Name: argG [H]

Synonym: XC_1871

Alternate gene names: 66768192

Gene position: 2264661-2265854 (Clockwise)

Preceding gene: 66768191

Following gene: 66768193

Centisome position: 43.99

GC content: 64.91

Gene sequence:

>1194_bases
ATGAGCAGCAAAGATATCGTCCTCGCTTTCTCCGGTGGCCTCGACACCAGCTTCTGCATTCCGTACCTGCAGGAGCGCGG
CTATGCCGTGCACACCGTGTTCGCCGATACCGGCGGTGTGGATGCCGAAGAACGCGATTTCATCGAGAAGCGCGCCGCCG
AGCTGGGCGCAGCCAGCCATGTCACCGTCGATGGCGGCCCGGCGATCTGGGAAGGCTTCGTCAAGCCGTTCGTGTGGGCC
GGCGAGGGCTACCAGGGCCAGTACCCGTTGCTGGTGTCCGACCGTTACCTGATCGTCGATGCTGCGCTCAAGCGCGCCGA
AGAACTGGGCACGCGGATCATCGCGCACGGCTGCACCGGCATGGGCAACGATCAGGTGCGTTTCGACCTGGCGGTAAAGG
CGCTGGGCGACTACCAGATTGTGGCGCCGATTCGCGAGATCCAGAAAGAACACACCCAGACCCGCGCCTACGAGCAAAAG
TACCTGGAAGAGCGCGGCTTCGGCGTGCGTGCCAAGCAGAAGGCCTACACCATCAACGAGAACCTGTTGGGCGTGACCAT
GTCCGGCGGCGAGATCGATCGCTGGGAAGCACCGGGCGAAGGCGCACGCGGCTGGTGTGCACCGCGTAGCGCGTGGCCGA
CCGAAGCGTTGACGGTGACGCTGAAGTTTGTCGAAGGCGAGGCCGTGGCGCTGGACGGCAAGGCCCTGCCAGGTGCGCAG
ATCCTGGCCAAGCTCAACACCTTGTTCGCGCAGTACGGCGTGGGCCGTGGCGTGTACACCGGCGACACCGTGATCGGCCT
GAAGGGCCGCATCGTGTTCGAAGCGCCGGGCCTGATCTCGCTGCTCACCGCGCACCGTGCGCTGGAAGACGCGGTGCTGA
CCAAGCAGCAGAACCGCTTCAAGCCGGACGTGGCGCGCAAGTGGGTGGAGCTGGTGTACGAGGGCTTCTACCACGACCCG
CTCAAGACCGATATCGAGGCGTTCCTGAAGTCGTCGCAGTCCAAGGTCAATGGCGAAGTCACGCTGGAAACTCGCGGTGG
CCGCGTCGATGCGGTGGCGGTGCGTTCGCCGCACCTGCTCAACGCCAAGGGCGCGACCTACGCCCAGTCGGCCGACTGGG
GCGTGGAAGAGGCCGAGGGGTTCATCAAGCTGTTCGGCATGAGCTCCACGCTGTATGCGCAGGTCAACCGCTGA

Upstream 100 bases:

>100_bases
AGCCTGTTTCATCGCCAATTCGGTCAACTTCCCGGTGCGCTGCGAACCGCGCATCGTGGTGACGGACTAACTTTTCTCCC
TTGCCCCCAGGAACTTCGTC

Downstream 100 bases:

>100_bases
GGTTTCCAGGCACGTAGGCAAAGCCCCTCTCCCCTCGGGAGAGGGGTTGGGGTGAGGGTACGGGCAAAGCTCCCGCAATG
TGCAGTGCACTAGGCTTCGC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSSKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEERDFIEKRAAELGAASHVTVDGGPAIWEGFVKPFVWA
GEGYQGQYPLLVSDRYLIVDAALKRAEELGTRIIAHGCTGMGNDQVRFDLAVKALGDYQIVAPIREIQKEHTQTRAYEQK
YLEERGFGVRAKQKAYTINENLLGVTMSGGEIDRWEAPGEGARGWCAPRSAWPTEALTVTLKFVEGEAVALDGKALPGAQ
ILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLLTAHRALEDAVLTKQQNRFKPDVARKWVELVYEGFYHDP
LKTDIEAFLKSSQSKVNGEVTLETRGGRVDAVAVRSPHLLNAKGATYAQSADWGVEEAEGFIKLFGMSSTLYAQVNR

Sequences:

>Translated_397_residues
MSSKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEERDFIEKRAAELGAASHVTVDGGPAIWEGFVKPFVWA
GEGYQGQYPLLVSDRYLIVDAALKRAEELGTRIIAHGCTGMGNDQVRFDLAVKALGDYQIVAPIREIQKEHTQTRAYEQK
YLEERGFGVRAKQKAYTINENLLGVTMSGGEIDRWEAPGEGARGWCAPRSAWPTEALTVTLKFVEGEAVALDGKALPGAQ
ILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLLTAHRALEDAVLTKQQNRFKPDVARKWVELVYEGFYHDP
LKTDIEAFLKSSQSKVNGEVTLETRGGRVDAVAVRSPHLLNAKGATYAQSADWGVEEAEGFIKLFGMSSTLYAQVNR
>Mature_396_residues
SSKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEERDFIEKRAAELGAASHVTVDGGPAIWEGFVKPFVWAG
EGYQGQYPLLVSDRYLIVDAALKRAEELGTRIIAHGCTGMGNDQVRFDLAVKALGDYQIVAPIREIQKEHTQTRAYEQKY
LEERGFGVRAKQKAYTINENLLGVTMSGGEIDRWEAPGEGARGWCAPRSAWPTEALTVTLKFVEGEAVALDGKALPGAQI
LAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLLTAHRALEDAVLTKQQNRFKPDVARKWVELVYEGFYHDPL
KTDIEAFLKSSQSKVNGEVTLETRGGRVDAVAVRSPHLLNAKGATYAQSADWGVEEAEGFIKLFGMSSTLYAQVNR

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=410, Percent_Identity=28.2926829268293, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI16950633, Length=410, Percent_Identity=28.2926829268293, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1789563, Length=366, Percent_Identity=27.3224043715847, Blast_Score=91, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324514, Length=365, Percent_Identity=29.8630136986301, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21358151, Length=403, Percent_Identity=30.272952853598, Blast_Score=151, Evalue=7e-37,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 43372; Mature: 43240

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEERDFIEKRAAELGAASH
CCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCE
VTVDGGPAIWEGFVKPFVWAGEGYQGQYPLLVSDRYLIVDAALKRAEELGTRIIAHGCTG
EEECCCHHHHHHHHCCEEECCCCCCCCCCEEECCCEEEEHHHHHHHHHHHHEEEECCCCC
MGNDQVRFDLAVKALGDYQIVAPIREIQKEHTQTRAYEQKYLEERGFGVRAKQKAYTINE
CCCCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCEEEECC
NLLGVTMSGGEIDRWEAPGEGARGWCAPRSAWPTEALTVTLKFVEGEAVALDGKALPGAQ
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCCCCHHH
ILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLLTAHRALEDAVLTKQQNRF
HHHHHHHHHHHHCCCCCEECCCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
KPDVARKWVELVYEGFYHDPLKTDIEAFLKSSQSKVNGEVTLETRGGRVDAVAVRSPHLL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCCCEE
NAKGATYAQSADWGVEEAEGFIKLFGMSSTLYAQVNR
CCCCCCCCCCCCCCHHHHCCEEEEEECCCEEEEEECC
>Mature Secondary Structure 
SSKDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEERDFIEKRAAELGAASH
CCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCE
VTVDGGPAIWEGFVKPFVWAGEGYQGQYPLLVSDRYLIVDAALKRAEELGTRIIAHGCTG
EEECCCHHHHHHHHCCEEECCCCCCCCCCEEECCCEEEEHHHHHHHHHHHHEEEECCCCC
MGNDQVRFDLAVKALGDYQIVAPIREIQKEHTQTRAYEQKYLEERGFGVRAKQKAYTINE
CCCCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCEEEECC
NLLGVTMSGGEIDRWEAPGEGARGWCAPRSAWPTEALTVTLKFVEGEAVALDGKALPGAQ
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCCCCHHH
ILAKLNTLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLISLLTAHRALEDAVLTKQQNRF
HHHHHHHHHHHHCCCCCEECCCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
KPDVARKWVELVYEGFYHDPLKTDIEAFLKSSQSKVNGEVTLETRGGRVDAVAVRSPHLL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCCCEE
NAKGATYAQSADWGVEEAEGFIKLFGMSSTLYAQVNR
CCCCCCCCCCCCCCHHHHCCEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]