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The map label for this gene is gph [C]

Identifier: 66768168

GI number: 66768168

Start: 2241661

End: 2242326

Strand: Direct

Name: gph [C]

Synonym: XC_1847

Alternate gene names: 66768168

Gene position: 2241661-2242326 (Clockwise)

Preceding gene: 66768167

Following gene: 66768169

Centisome position: 43.54

GC content: 68.02

Gene sequence:

>666_bases
GTGAGGTTTCCGCGTGCGGTGTTGTTCGACCTGGATGGCACCTTGCTCGACAGTGCGCCGGACATGTTGGCCACCGTCAA
CGCGATGCTGAGCGAGCGTGGACTGCCGTGCATCACGCTGGCGCAGCTGCGGCCGGTGGTGTCGAAAGGATCGCGCGCCA
TGCTCGCTGTGGCCTTCGCGCATCTGGATGCGGCCGCGCGCGAGGCGTTGGTGCCGGAGTTTCTCAAGCGCTATGAAGCG
CTGCTCGGCACGCAGGCACAGCTGTTCGACGGAGTCGAGGTCATGCTGCAGCGCCTGGAGCAGGCCGGCTGTGTCTGGGG
CATTGTCACCAACAAGCCCGAATACCTTGCGCAACTCATTCTGCCGCAGCTGGGCTGGCAGCAGCGCTGCGCGGTGCTGA
TCGGCGGCGATACGCTGGCCGAGCGCAAGCCGCATCCGCTGCCGTTGCTGGTGGCGGCCGATCGCATCGGCGTCGCCGCC
ACGCAGTGCGTCTATGTGGGTGACGACGAGCGCGACATCCTGGCCGCACGTGCGGCCGGCATGCCGTCGGTGGCTGCGTT
ATGGGGTTACCGGCTGGGCGATGACGACCCGCTGAGCTGGCAGGCCGACGTGCTGGTGGAACAGCCGCCGCAGTTGTGGG
AGCCGGCCGCCTGGCCGCAGCCCTGA

Upstream 100 bases:

>100_bases
GGGGAATCGGGATTCGGGAATCGCAACGGCGGTTGGTTGCGGTCTTGATGTCGACCGGTTCCTGTCTGATGGCCGATCGC
GCTGGGATGGCGGTGCGTCT

Downstream 100 bases:

>100_bases
TCTTTTCTTTCGCTTTTCTGGACCCGCCATGAGCCAATCCAGCGCCCTGGACAGTTTTCTCGACAAGTGGCGCAGCCGCT
GGCCGGAATGGTCGGTGGCC

Product: phosphoglycolate phosphatase

Products: NA

Alternate protein names: PGP; PGPase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRFPRAVLFDLDGTLLDSAPDMLATVNAMLSERGLPCITLAQLRPVVSKGSRAMLAVAFAHLDAAAREALVPEFLKRYEA
LLGTQAQLFDGVEVMLQRLEQAGCVWGIVTNKPEYLAQLILPQLGWQQRCAVLIGGDTLAERKPHPLPLLVAADRIGVAA
TQCVYVGDDERDILAARAAGMPSVAALWGYRLGDDDPLSWQADVLVEQPPQLWEPAAWPQP

Sequences:

>Translated_221_residues
MRFPRAVLFDLDGTLLDSAPDMLATVNAMLSERGLPCITLAQLRPVVSKGSRAMLAVAFAHLDAAAREALVPEFLKRYEA
LLGTQAQLFDGVEVMLQRLEQAGCVWGIVTNKPEYLAQLILPQLGWQQRCAVLIGGDTLAERKPHPLPLLVAADRIGVAA
TQCVYVGDDERDILAARAAGMPSVAALWGYRLGDDDPLSWQADVLVEQPPQLWEPAAWPQP
>Mature_221_residues
MRFPRAVLFDLDGTLLDSAPDMLATVNAMLSERGLPCITLAQLRPVVSKGSRAMLAVAFAHLDAAAREALVPEFLKRYEA
LLGTQAQLFDGVEVMLQRLEQAGCVWGIVTNKPEYLAQLILPQLGWQQRCAVLIGGDTLAERKPHPLPLLVAADRIGVAA
TQCVYVGDDERDILAARAAGMPSVAALWGYRLGDDDPLSWQADVLVEQPPQLWEPAAWPQP

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family

Homologues:

Organism=Escherichia coli, GI1789787, Length=225, Percent_Identity=35.1111111111111, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789046, Length=182, Percent_Identity=30.7692307692308, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPH_XANC8 (Q4UVL3)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242930.1
- ProteinModelPortal:   Q4UVL3
- SMR:   Q4UVL3
- STRING:   Q4UVL3
- GeneID:   3380394
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1847
- eggNOG:   COG0546
- HOGENOM:   HBG742904
- OMA:   CAVHSKL
- PhylomeDB:   Q4UVL3
- ProtClustDB:   PRK13226
- BioCyc:   XCAM314565:XC_1847-MONOMER
- HAMAP:   MF_00495
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR005833
- InterPro:   IPR006346
- InterPro:   IPR023198
- Gene3D:   G3DSA:3.40.50.1000
- Gene3D:   G3DSA:1.10.150.240
- PRINTS:   PR00413
- TIGRFAMs:   TIGR01549
- TIGRFAMs:   TIGR01509
- TIGRFAMs:   TIGR01449

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: =3.1.3.18

Molecular weight: Translated: 24075; Mature: 24075

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFPRAVLFDLDGTLLDSAPDMLATVNAMLSERGLPCITLAQLRPVVSKGSRAMLAVAFA
CCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHH
HLDAAAREALVPEFLKRYEALLGTQAQLFDGVEVMLQRLEQAGCVWGIVTNKPEYLAQLI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
LPQLGWQQRCAVLIGGDTLAERKPHPLPLLVAADRIGVAATQCVYVGDDERDILAARAAG
HHHCCCCCCEEEEECCCHHHCCCCCCCEEEEECCCCCCEEEEEEEECCCCHHHHHHHHCC
MPSVAALWGYRLGDDDPLSWQADVLVEQPPQLWEPAAWPQP
CCHHHHHHCCCCCCCCCCCEEECEEECCCHHHCCCCCCCCC
>Mature Secondary Structure
MRFPRAVLFDLDGTLLDSAPDMLATVNAMLSERGLPCITLAQLRPVVSKGSRAMLAVAFA
CCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHH
HLDAAAREALVPEFLKRYEALLGTQAQLFDGVEVMLQRLEQAGCVWGIVTNKPEYLAQLI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
LPQLGWQQRCAVLIGGDTLAERKPHPLPLLVAADRIGVAATQCVYVGDDERDILAARAAG
HHHCCCCCCEEEEECCCHHHCCCCCCCEEEEECCCCCCEEEEEEEECCCCHHHHHHHHCC
MPSVAALWGYRLGDDDPLSWQADVLVEQPPQLWEPAAWPQP
CCHHHHHHCCCCCCCCCCCEEECEEECCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA