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The map label for this gene is mtaD [H]

Identifier: 66768166

GI number: 66768166

Start: 2239451

End: 2240800

Strand: Direct

Name: mtaD [H]

Synonym: XC_1845

Alternate gene names: 66768166

Gene position: 2239451-2240800 (Clockwise)

Preceding gene: 66768165

Following gene: 66768167

Centisome position: 43.5

GC content: 67.19

Gene sequence:

>1350_bases
ATGGATCCGCTCATGACCAACGCCCCGCCCGAACCCTGCGACCTGCTGATCGAGGCCGGCTATGTGGTGCCGATCGAACC
GCATGCGGTGGTGCTTGAAGACCACGCGGTGGCGGTCAGCAACGGTGTCATCGTTGCCGTGCTGCCAACGGCCGACGCAC
GCGTGCGTTTCGCGCCGGCACGCACCGTGTCGCGCCCCGACGCGGCGCTGATGCCCGGCCTGGTCAACGCGCACACGCAC
AACCCGATGACGCTGCTGCGCGGCGTGGCCGACGATCTGCCGCTGATGGTGTGGCTGCAGCAGCACATCTGGCCGGTGGA
AGCGGCAGTGATCGGCCCGGAATTCGTCGCCGATGGCACCACCCTGGCGATCGCCGAGATGCTGCGCGGCGGCACCACCT
GCGTCAACGAGAACTACTTCTTTGCCGACGTGCAGGCGGCCGTCTACAAGCAGCATGGCTTCCGTGCGCTGGTGGGCGCG
GTGATCATCGATTTCCCCACCGCCTGGGCCTCGTCGGACGACGAATACTTCGCACGTGCCGGCGAGCTGCACGACCAGTG
GCGCGACGACCCGCTGATCAGCACCGCGTTTGCACCGCATGCGCCGTACACGGTGAACGATGCCAACTTCGAGCGCGTAC
GCATGCTGGCCGACCAGCTGGACATGCCGGTGCATCTGCACACGCACGAAACCGCGCAGGAAGTGGCTGATTCGGTGGCG
CAGTATGGCCAGCGCCCGCTGGCACGGCTGGATCGTCTGGGCCTGGTCAACGACCGCCTGATTGCGGTGCACATGACCCA
GCTCACCGAGGCCGAAATCCACCTGTGCGCCGAGCGCGGTGTCAGCGTGGTGCACTGCCCCGAATCCAATCTCAAGCTGG
CCTCGGGCTTTTGCCCGGCGTGCGCGCTGCAACGCGCCAGCGTGAATCTGGCGATCGGCACCGACGGCTGCGCCAGCAAC
AATGACCTGGACATGTTCAGCGAGAACCGCACCGCGGCGATCCTGGCCAAGGCAGTGGCCAACGATGCCACCGCGCTGGA
TGCGGCCACCACCTTGCGCGCCGCCACCTTGGGGGGCGCACGCGCACTCGGCTTTGGCGACCGCATCGGCTCGATCGAGG
TGGGCAAGCAGGCCGACCTGGTTTGCGTGGATCTGTCCGCGCTGGAAACCCAGCCGCTGCATCACGTGTTGTCGCAGCTG
ATCTATGCCGCCGGCCGCCACCAGGTGACCGATGTGTGGATCGCCGGCAAGCCCAAGCTGGTGCAACGCGAGCTCATCGA
CATGGATACCGCTGCCCTGGTCGCCAACGCGCGCCAGTGGCGCGACCGTATCCGCACCGTCCGCGCCTGA

Upstream 100 bases:

>100_bases
AACGCACGCGCCGCCAACGCCAAGTGTTGCGCTACGACGGCATGCGCTACGTGCCTGTGTCACGCTCCACCGACTCCTGG
CCGTTCGGCAACTAACTTCA

Downstream 100 bases:

>100_bases
GCGCGGCCATCGCATCACGGAGAGCCACATGAATCCGAATCCACAATCCACATCGTCCAATTTCCACCAGACCGAGCTGG
ACAAGTTCGCTGCGCTGGCC

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVRFAPARTVSRPDAALMPGLVNAHTH
NPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGA
VIIDFPTAWASSDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETAQEVADSVA
QYGQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESNLKLASGFCPACALQRASVNLAIGTDGCASN
NDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALETQPLHHVLSQL
IYAAGRHQVTDVWIAGKPKLVQRELIDMDTAALVANARQWRDRIRTVRA

Sequences:

>Translated_449_residues
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVRFAPARTVSRPDAALMPGLVNAHTH
NPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGA
VIIDFPTAWASSDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETAQEVADSVA
QYGQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESNLKLASGFCPACALQRASVNLAIGTDGCASN
NDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALETQPLHHVLSQL
IYAAGRHQVTDVWIAGKPKLVQRELIDMDTAALVANARQWRDRIRTVRA
>Mature_449_residues
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVRFAPARTVSRPDAALMPGLVNAHTH
NPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGA
VIIDFPTAWASSDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETAQEVADSVA
QYGQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESNLKLASGFCPACALQRASVNLAIGTDGCASN
NDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALETQPLHHVLSQL
IYAAGRHQVTDVWIAGKPKLVQRELIDMDTAALVANARQWRDRIRTVRA

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=443, Percent_Identity=25.2821670428894, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1789249, Length=337, Percent_Identity=27.0029673590504, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082177, Length=451, Percent_Identity=24.390243902439, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17540282, Length=389, Percent_Identity=22.879177377892, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319963, Length=389, Percent_Identity=24.6786632390745, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24643849, Length=379, Percent_Identity=25.3298153034301, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48514; Mature: 48514

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVRFAPA
CCCCCCCCCCCCHHHHEECCEEEECCCCEEEEECCEEEEECCEEEEEECCCCCEEEECCC
RTVSRPDAALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGT
CCCCCCCHHHCCCHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHEEECCHHHCCCH
TLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGAVIIDFPTAWASSDDEYFARA
HHHHHHHHCCCCEEECCCEEEEHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
GELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETAQEVADSVA
HHHHHHHCCCCCEEECCCCCCCEEECCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHH
QYGQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESNLKLASGFCPA
HHCCCHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEECCCCCCEEECCCCHH
CALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGA
HHHHHCEEEEEEECCCCCCCCCCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RALGFGDRIGSIEVGKQADLVCVDLSALETQPLHHVLSQLIYAAGRHQVTDVWIAGKPKL
EECCCCCCCCCEECCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHH
VQRELIDMDTAALVANARQWRDRIRTVRA
HHHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVRFAPA
CCCCCCCCCCCCHHHHEECCEEEECCCCEEEEECCEEEEECCEEEEEECCCCCEEEECCC
RTVSRPDAALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGT
CCCCCCCHHHCCCHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHEEECCHHHCCCH
TLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGAVIIDFPTAWASSDDEYFARA
HHHHHHHHCCCCEEECCCEEEEHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
GELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETAQEVADSVA
HHHHHHHCCCCCEEECCCCCCCEEECCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHH
QYGQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESNLKLASGFCPA
HHCCCHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEECCCCCCEEECCCCHH
CALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGA
HHHHHCEEEEEEECCCCCCCCCCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RALGFGDRIGSIEVGKQADLVCVDLSALETQPLHHVLSQLIYAAGRHQVTDVWIAGKPKL
EECCCCCCCCCEECCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHH
VQRELIDMDTAALVANARQWRDRIRTVRA
HHHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA