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The map label for this gene is mutL

Identifier: 66768138

GI number: 66768138

Start: 2209466

End: 2211340

Strand: Direct

Name: mutL

Synonym: XC_1817

Alternate gene names: 66768138

Gene position: 2209466-2211340 (Clockwise)

Preceding gene: 66768137

Following gene: 66768139

Centisome position: 42.91

GC content: 68.64

Gene sequence:

>1875_bases
ATGGCGATCCGGCAATTGCCCGAGATCCTGATCAACCAGATCGCTGCCGGCGAGGTGGTCGAGCGCCCGGCATCGGTCGT
CAAGGAACTGGTCGAAAACGCCCTCGATGCCGGCGCCACCCGCGTGGATATCGATCTGGAAGAGGGCGGCGTGCGGCTGA
TCCGCATCCGCGACAATGGCGGCGGCATTGCGCCGGAAGAGCTGCCGCTGGCGGTGTCGCGTCATGCCACCAGCAAGATC
GCCTCGCTGGATGATCTGGAAACCGTCGCCACGCTGGGCTTCCGCGGCGAAGCGTTGCCGTCCATCGCCTCGGTCAGCCG
CTTTACGCTGGCCTCGCGTCGCCCGGATGCCGAGCACGGCTCCGCGCTGCAGATCGAAGGCGGGCGCCTGGGCGAGGTGA
TGCCGCGTGCGCATGCGCCGGGCACCACCGTTGAGGTGCGCGAGCTGTTCTTCAACGTGCCGGCACGGCGCAAGTTCCTG
CGCGCCGAGCGCACCGAGTTGGGCCATATCGAAGAGTGGCTGCGTTCGCTGGCACTGGCGCGCCCGGACGTGGAATTGCG
CGTCTCGCATAACGGCAAACCGTCGCGGCGCTACAAGCCGGGCGATCTGTATTCGGACGCGCGGCTGGGCGAGACCTTGG
GCGAGGATTTCGCGCGCCAGGCGCTGCGCGTGGACCACAGCGGTGCCGGCCTGCGCCTGCACGGCTGGGTGGCGCAGCCG
CATTACTCGCGCGCCAGTACCGATCAGCAGTATCTCTACGTCAACGGCCGCTCGGTGCGGGATCGCAGCGTGGCGCATGC
GGTGAAGATGGCCTACGGCGATGTGCTGTTCCACGGGCGCCAGCCGGCATATGTGCTGTTTCTCGAGCTGGACCCTGCGC
GCGTGGACGTCAACGTGCACCCGGCCAAACACGAGGTGCGCTTCCGCGAGGCGCGGCTGATCCACGACTTCGTCTATCGC
ACTCTGCAGGACGCACTAGCGCAGACCCGTGCCGGCGCGCTGCCCGCTGATGTTGGGGTCGGGGGGGCGGCAGCCCTCGG
TATCGGCGCCGTTGCCGCGCAGGGCGGCGGAAGCTACGTTGCTGACGCCGGTGCAGGGCATCCGGGCGCTGGCAGTGGCT
CCGGCTATGCAAGCTGGGCGCCGTCGCAGGCACCGCTGGGTTTGCGCGTAGACGAGGCGCGCGCCGCCTACGCCGCGTTG
TATGCCCCTGCGGCCGGCAGCGCGTTGCGCGACGACGGGCAACCGGTGCTGTCCGGCACCGGCTTGCCGGCGACCGCGCA
CGACAGCGGAGTCCCGCCATTGGGCTACGCGGTGGCGCAGTTGCACGGCATCTATATCCTCGCGGAAAACGCCGAAGGCC
TGATCGTGGTCGACATGCATGCCGCGCATGAGCGTATCGGCTACGAACGCCTCAAGCAGGCGCACGACAGCATTGGCCTG
CATGCGCAGCCGCTGCTGGTACCGATGACGCTGGCAGTGGGCGAGCGCGAGGCCGACACCGCCGAGCGCGAGGCCGATAC
GCTTGCCAGCCTGGGCTTCGAAATCACCCGCAGCGGTCCGCAATCGCTGCACGTGCGCAGCATTCCGGCGCTGCTCGCCA
ATGCCGACCCGGAGGCGTTGTTACGCGATGTGCTCGGCGATCTGCGTGAGCACGGCCAGAGCCGGCGCATCGCCACCGCG
CGCGACGAGTTGCTGTCCACCATGGCCTGCCACGGCGCGGTGCGTGCAAACCGCCGGCTCACCGTGCCGGAAATGAACGC
CTTGCTGCGCGACATGGAAGCCACCGAGCGCTCGGGCCAATGCAACCATGGCCGGCCAACCTGGGCCCGGTTTACGCTGG
GCGAAATCGATCGCTGGTTCCTGAGGGGACGTTGA

Upstream 100 bases:

>100_bases
GCCGGATGGCCGTGCCGACGTTTTTCCCCTTGATGTCATCATTCGCCCATGCGGGCGGCCACTGCGTGCGCGCAGCGCAT
CTGCCAGGGAGCTCCCGCTG

Downstream 100 bases:

>100_bases
TGACAGTGCTGCACAGGGGGAGGGGCTGGCTGCTCGGCATGTTGGTAGCGGTAGGTGTGCTCGGCTGTGGCCGCGAGGCA
CCACCCGCACCGGCGCCAGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIDLEEGGVRLIRIRDNGGGIAPEELPLAVSRHATSKI
ASLDDLETVATLGFRGEALPSIASVSRFTLASRRPDAEHGSALQIEGGRLGEVMPRAHAPGTTVEVRELFFNVPARRKFL
RAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGEDFARQALRVDHSGAGLRLHGWVAQP
HYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYR
TLQDALAQTRAGALPADVGVGGAAALGIGAVAAQGGGSYVADAGAGHPGAGSGSGYASWAPSQAPLGLRVDEARAAYAAL
YAPAAGSALRDDGQPVLSGTGLPATAHDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKQAHDSIGL
HAQPLLVPMTLAVGEREADTAEREADTLASLGFEITRSGPQSLHVRSIPALLANADPEALLRDVLGDLREHGQSRRIATA
RDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLGEIDRWFLRGR

Sequences:

>Translated_624_residues
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIDLEEGGVRLIRIRDNGGGIAPEELPLAVSRHATSKI
ASLDDLETVATLGFRGEALPSIASVSRFTLASRRPDAEHGSALQIEGGRLGEVMPRAHAPGTTVEVRELFFNVPARRKFL
RAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGEDFARQALRVDHSGAGLRLHGWVAQP
HYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYR
TLQDALAQTRAGALPADVGVGGAAALGIGAVAAQGGGSYVADAGAGHPGAGSGSGYASWAPSQAPLGLRVDEARAAYAAL
YAPAAGSALRDDGQPVLSGTGLPATAHDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKQAHDSIGL
HAQPLLVPMTLAVGEREADTAEREADTLASLGFEITRSGPQSLHVRSIPALLANADPEALLRDVLGDLREHGQSRRIATA
RDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLGEIDRWFLRGR
>Mature_623_residues
AIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIDLEEGGVRLIRIRDNGGGIAPEELPLAVSRHATSKIA
SLDDLETVATLGFRGEALPSIASVSRFTLASRRPDAEHGSALQIEGGRLGEVMPRAHAPGTTVEVRELFFNVPARRKFLR
AERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGEDFARQALRVDHSGAGLRLHGWVAQPH
YSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYRT
LQDALAQTRAGALPADVGVGGAAALGIGAVAAQGGGSYVADAGAGHPGAGSGSGYASWAPSQAPLGLRVDEARAAYAALY
APAAGSALRDDGQPVLSGTGLPATAHDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKQAHDSIGLH
AQPLLVPMTLAVGEREADTAEREADTLASLGFEITRSGPQSLHVRSIPALLANADPEALLRDVLGDLREHGQSRRIATAR
DELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLGEIDRWFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=33.6363636363636, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=29.5321637426901, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=29.5321637426901, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=29.6296296296296, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4505911, Length=351, Percent_Identity=29.6296296296296, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI189458896, Length=344, Percent_Identity=30.5232558139535, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI310128480, Length=298, Percent_Identity=26.8456375838926, Blast_Score=112, Evalue=2e-24,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=27.2340425531915, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI91992162, Length=330, Percent_Identity=25.7575757575758, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI91992160, Length=330, Percent_Identity=25.7575757575758, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1790612, Length=564, Percent_Identity=43.9716312056738, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=34.5911949685535, Blast_Score=185, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17562796, Length=336, Percent_Identity=28.8690476190476, Blast_Score=141, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=315, Percent_Identity=33.968253968254, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=365, Percent_Identity=27.9452054794521, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6325093, Length=720, Percent_Identity=21.8055555555556, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323063, Length=367, Percent_Identity=24.2506811989101, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136968, Length=312, Percent_Identity=34.9358974358974, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136970, Length=369, Percent_Identity=28.4552845528455, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_XANC8 (Q4UVP3)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242900.1
- HSSP:   P23367
- ProteinModelPortal:   Q4UVP3
- STRING:   Q4UVP3
- GeneID:   3380364
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1817
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   Q4UVP3
- ProtClustDB:   PRK00095
- BioCyc:   XCAM314565:XC_1817-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 67195; Mature: 67063

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIDLEEGGVRLIRIRDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCC
GGIAPEELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLASRRPDAEHG
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
SALQIEGGRLGEVMPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALA
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGEDFARQALRVDHSGAGLRLHGWVAQP
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECC
HYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVH
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEC
PAKHEVRFREARLIHDFVYRTLQDALAQTRAGALPADVGVGGAAALGIGAVAAQGGGSYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCEE
ADAGAGHPGAGSGSGYASWAPSQAPLGLRVDEARAAYAALYAPAAGSALRDDGQPVLSGT
ECCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCEEECC
GLPATAHDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKQAHDSIGL
CCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCC
HAQPLLVPMTLAVGEREADTAEREADTLASLGFEITRSGPQSLHVRSIPALLANADPEAL
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEHHHHHHHHHCCCHHHH
LRDVLGDLREHGQSRRIATARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
CNHGRPTWARFTLGEIDRWFLRGR
CCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
AIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIDLEEGGVRLIRIRDNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCC
GGIAPEELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLASRRPDAEHG
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
SALQIEGGRLGEVMPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALA
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGEDFARQALRVDHSGAGLRLHGWVAQP
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECC
HYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVH
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEC
PAKHEVRFREARLIHDFVYRTLQDALAQTRAGALPADVGVGGAAALGIGAVAAQGGGSYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCEE
ADAGAGHPGAGSGSGYASWAPSQAPLGLRVDEARAAYAALYAPAAGSALRDDGQPVLSGT
ECCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCEEECC
GLPATAHDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKQAHDSIGL
CCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCC
HAQPLLVPMTLAVGEREADTAEREADTLASLGFEITRSGPQSLHVRSIPALLANADPEAL
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEHHHHHHHHHCCCHHHH
LRDVLGDLREHGQSRRIATARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
CNHGRPTWARFTLGEIDRWFLRGR
CCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA