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The map label for this gene is xseA

Identifier: 66768133

GI number: 66768133

Start: 2203035

End: 2204375

Strand: Reverse

Name: xseA

Synonym: XC_1812

Alternate gene names: 66768133

Gene position: 2204375-2203035 (Counterclockwise)

Preceding gene: 66768134

Following gene: 66768130

Centisome position: 42.81

GC content: 69.8

Gene sequence:

>1341_bases
ATGGCCGACCGCACCGAACAGATCCTCACTCCCAGCCAGCTCAACACGCTGGCGCGCGACCTGCTCGAAGGCAGTTTCCC
CCTGGTGTGGGTGGAGGCCGAACTGGGCAATGTGACCCGCCCCGCCTCCGGCCATCTGTATTTCACGCTCAAGGATGCGC
GTGCACAGATCCGCTGCGCGATGTTCAAGCCCAAGAGCACCTGGCTGAAGTTCCAGCCGCGCGAGGGGCTGCGCGTGCTC
GCGCGCGGGCGCCTCACCTTGTACGAGGCACGTGGCGATTACCAGCTGGTGCTGGACCACATGGAAGAAGCCGGCGAAGG
CGCGTTGCGGCGCGCGTTCGAGGAACTGCGCGCGCGGCTGGCAGCCGAGGGCGTGTTCGACGCAGAGCGCAAGCAGCCGC
TGCCCGCGCATGTGCGCCGCCTGGCGGTGATCACCTCGCCCAGCGGTGCGGCCGTGCGCGACGTGCTCAGCGTGCTGGCG
CGCCGCTTCCCGCTGCTGGAGGTGGATATTTTGCCGTCGCTGGTACAAGGCGACAGCGCGGCCGCGCAGATCACTTCGCT
GCTGCAACGCGCCGATGCCTCCGGCCGCTACGACGTCATCTTGATCACTCGCGGTGGCGGTTCGCTGGAAGACCTGTGGG
CGTTCAACGACGAGCGCCTGGCGCGGGCGATCGCCGCAGCACACACGCCCGTGGTGTCGGCGGTCGGTCACGAGACCGAT
GTCAGCCTGAGCGACTTCGCCGCCGATGTGCGCGCCCCCACGCCCTCGGTCGCCGCCGAGTTGCTGGTGCCCGATCAACG
CGAACTGGTGGCACGTGTGCGGCGCGCGCAGGCCCGGCTCAGCCAGCTGCAGCAGCACACGCTTGGCCAGGCGATGCAAC
ACGCGGACCGGCTGGCGCTACGCCTGCGCGCGCGCAGCCCGCAGGCACGCCTGCAGCTGCTGCAACGCCGCCAGGAAGAC
GCCGCGCGGCATCTGCGTGCGCGCATGCAGCATATCCTGGAGCGGCTACAGGCACGTGTGCAGCGCGCGCAGGCCGGTGT
GCAGTCACACAGCCCGCAGCGCCACCTGGCACCCCTGCAGCAACGCCTGCGCGCTGCACATCCGCAAGCGGCAATGCAGC
GGCGCCTGCAACAGGATCACCTGCATCTGCGCGGCCTGGTGCGTTCGCTGGAAGCCGTCAGCCCGCTGGCCACGGTGGCA
CGCGGCTATGCCATCGTCACCCGCCAGGCCGATGGCAGCGTGGTGCGCAGTGCCGCCGAACTGACCCAGGGTGATCGCCT
GCGCGCACAACTGGCCGATGGCAGCGTGACGGTGGTGGTCGACACCAGCGAGACCGGCTGA

Upstream 100 bases:

>100_bases
TGCTGCACGTGGGCGCCGCACTTGCTTCACCGTCCACACCAGATCGTTCGCCGCATCAACCGCTCACGCATTGCGTGCCC
CGCTGCGGGATAATGCGGCG

Downstream 100 bases:

>100_bases
CGCGCTCATCCAGGCACGCTGTGCAACCTGCCTGCCGCTGCGCGGGCGTCACGCATGCCCAGGCAGTTGCGCTGCGCGCT
GCCAGCCCTGCAGCAGGATG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MADRTEQILTPSQLNTLARDLLEGSFPLVWVEAELGNVTRPASGHLYFTLKDARAQIRCAMFKPKSTWLKFQPREGLRVL
ARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFEELRARLAAEGVFDAERKQPLPAHVRRLAVITSPSGAAVRDVLSVLA
RRFPLLEVDILPSLVQGDSAAAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAHTPVVSAVGHETD
VSLSDFAADVRAPTPSVAAELLVPDQRELVARVRRAQARLSQLQQHTLGQAMQHADRLALRLRARSPQARLQLLQRRQED
AARHLRARMQHILERLQARVQRAQAGVQSHSPQRHLAPLQQRLRAAHPQAAMQRRLQQDHLHLRGLVRSLEAVSPLATVA
RGYAIVTRQADGSVVRSAAELTQGDRLRAQLADGSVTVVVDTSETG

Sequences:

>Translated_446_residues
MADRTEQILTPSQLNTLARDLLEGSFPLVWVEAELGNVTRPASGHLYFTLKDARAQIRCAMFKPKSTWLKFQPREGLRVL
ARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFEELRARLAAEGVFDAERKQPLPAHVRRLAVITSPSGAAVRDVLSVLA
RRFPLLEVDILPSLVQGDSAAAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAHTPVVSAVGHETD
VSLSDFAADVRAPTPSVAAELLVPDQRELVARVRRAQARLSQLQQHTLGQAMQHADRLALRLRARSPQARLQLLQRRQED
AARHLRARMQHILERLQARVQRAQAGVQSHSPQRHLAPLQQRLRAAHPQAAMQRRLQQDHLHLRGLVRSLEAVSPLATVA
RGYAIVTRQADGSVVRSAAELTQGDRLRAQLADGSVTVVVDTSETG
>Mature_445_residues
ADRTEQILTPSQLNTLARDLLEGSFPLVWVEAELGNVTRPASGHLYFTLKDARAQIRCAMFKPKSTWLKFQPREGLRVLA
RGRLTLYEARGDYQLVLDHMEEAGEGALRRAFEELRARLAAEGVFDAERKQPLPAHVRRLAVITSPSGAAVRDVLSVLAR
RFPLLEVDILPSLVQGDSAAAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAHTPVVSAVGHETDV
SLSDFAADVRAPTPSVAAELLVPDQRELVARVRRAQARLSQLQQHTLGQAMQHADRLALRLRARSPQARLQLLQRRQEDA
ARHLRARMQHILERLQARVQRAQAGVQSHSPQRHLAPLQQRLRAAHPQAAMQRRLQQDHLHLRGLVRSLEAVSPLATVAR
GYAIVTRQADGSVVRSAAELTQGDRLRAQLADGSVTVVVDTSETG

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=431, Percent_Identity=43.3874709976798, Blast_Score=341, Evalue=6e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_XANC8 (Q4UVP8)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242895.1
- STRING:   Q4UVP8
- GeneID:   3380359
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1812
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- PhylomeDB:   Q4UVP8
- ProtClustDB:   PRK00286
- BioCyc:   XCAM314565:XC_1812-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 49299; Mature: 49168

Theoretical pI: Translated: 11.21; Mature: 11.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRTEQILTPSQLNTLARDLLEGSFPLVWVEAELGNVTRPASGHLYFTLKDARAQIRCA
CCCCHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEE
MFKPKSTWLKFQPREGLRVLARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFEELRARL
EECCCCCCEEECCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
AAEGVFDAERKQPLPAHVRRLAVITSPSGAAVRDVLSVLARRFPLLEVDILPSLVQGDSA
HHCCCCCHHHCCCCHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHH
AAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAHTPVVSAVGHETD
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHCHHHHHCCCCCC
VSLSDFAADVRAPTPSVAAELLVPDQRELVARVRRAQARLSQLQQHTLGQAMQHADRLAL
CCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRARSPQARLQLLQRRQEDAARHLRARMQHILERLQARVQRAQAGVQSHSPQRHLAPLQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QRLRAAHPQAAMQRRLQQDHLHLRGLVRSLEAVSPLATVARGYAIVTRQADGSVVRSAAE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHH
LTQGDRLRAQLADGSVTVVVDTSETG
HCCCCHHHEEECCCCEEEEEECCCCC
>Mature Secondary Structure 
ADRTEQILTPSQLNTLARDLLEGSFPLVWVEAELGNVTRPASGHLYFTLKDARAQIRCA
CCCHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEE
MFKPKSTWLKFQPREGLRVLARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFEELRARL
EECCCCCCEEECCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
AAEGVFDAERKQPLPAHVRRLAVITSPSGAAVRDVLSVLARRFPLLEVDILPSLVQGDSA
HHCCCCCHHHCCCCHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHH
AAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAHTPVVSAVGHETD
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHCHHHHHCCCCCC
VSLSDFAADVRAPTPSVAAELLVPDQRELVARVRRAQARLSQLQQHTLGQAMQHADRLAL
CCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRARSPQARLQLLQRRQEDAARHLRARMQHILERLQARVQRAQAGVQSHSPQRHLAPLQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QRLRAAHPQAAMQRRLQQDHLHLRGLVRSLEAVSPLATVARGYAIVTRQADGSVVRSAAE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHH
LTQGDRLRAQLADGSVTVVVDTSETG
HCCCCHHHEEECCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA