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The map label for this gene is rnd [H]

Identifier: 66768130

GI number: 66768130

Start: 2198569

End: 2199657

Strand: Reverse

Name: rnd [H]

Synonym: XC_1809

Alternate gene names: 66768130

Gene position: 2199657-2198569 (Counterclockwise)

Preceding gene: 66768133

Following gene: 66768127

Centisome position: 42.72

GC content: 66.67

Gene sequence:

>1089_bases
GTGCCCCATTGGATCACCCACCCCTCCGAATTGACCGAACGCCTGCAATTGCGTCCGTCCCGCATTGGCCTGGATACCGA
ATTCATTCGCGAGCGCACCTATTGGCCGCAACTGGCGCTGGTGCAGATGGCGATCGGTGAGGAGATCCTGCTGATCGACC
CGTTGATTCCGGGCATGACCGATGCACTGAAGGACTGGCTGATCGCGCCGGACATCGTCAAGGTGATGCACAGCGCCAGC
GAAGATCTGGTCACCTTCAAGTGTGCCTGCGGCGTGCTGCCGCGGCCGTTGTTCGACACCCAGATCGCGGCCGCACTGGC
CGGCGTCGGTGGCGGCATGGGCTATCAGAAACTGGTGCAGGAAGTCACCGGCACCCTGCTCACCAAGGGCGAGACCCGCT
CGGACTGGATGCGCCGCCCGCTCTCGCCCGCACAGCTGGAATACGCTGCCGACGACGTGCGCTACCTGTTTGCCATCCAC
GACGCGCTCACCGCCAAGCTGACCGCGCAAGACCGCCTGGGCTGGCTGGCCGAAGATGGCGAGCGCTTGCTCGGCACGGT
GGAGCACGACGATGGCGACCGTTGGCCGCACGTGAGCCTGCGCACCGCACAGTTTCTGGAACCGGCCGCACAGCGCCGCC
TGCTGCGCCTGTTGCGCTGGCGCGACCTGCAGGCACGGCAGAGCGATCGTCCACGCAGCTGGATCCTGGACAACGAACTG
GCCAGCCAGCTGGCGCGCTTCCCGCCAGCGGATCTGGACGCACTGATGCGCCAGTTCGACAAATTTCCCAAGGCACCGCG
CAAGCTCGCCAACGCGGTCTGGGAGGCGCTCAACACGCCCTTGCCCGACGAAGACCACGCTCCGCTGGCGCAGGCCTCCA
CCGATGGCAACAAGGCCACGCTCAAGCGCCTGCAGGATGCAGTGGCGCAGCGCAGCCGCGAGCTCGAACTGCCGGACGGC
ATCCTTGCCTCGCGCCGCCATCTGGAAACCCTGATCGAGCAGCGCAGCTGGCCGGCCGCGCTCGGGCAGTGGCGACGCGA
CGCATTGGAAGCAGATCTGCTGCCGCTGCTGGATGCGGCAACGCCCTGA

Upstream 100 bases:

>100_bases
CACACCCACTCCTTGCCCGGCACTGCCCCTTCGGCAGGCGATCGCGACGTTAGGCTATTCTGCGCGCTCTACGCAAACCC
TTGCTGTCGACGGAAATCAC

Downstream 100 bases:

>100_bases
GCGGCGTGTTGCGCACGTTTGCCGCGTGACTGCGGCGGCGTGCGGCAACAACGCATCCGGCGTGCTTGTGTGAGAGGCAG
TACGTGCCTCAGCCCTGGTC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MPHWITHPSELTERLQLRPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMTDALKDWLIAPDIVKVMHSAS
EDLVTFKCACGVLPRPLFDTQIAAALAGVGGGMGYQKLVQEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIH
DALTAKLTAQDRLGWLAEDGERLLGTVEHDDGDRWPHVSLRTAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILDNEL
ASQLARFPPADLDALMRQFDKFPKAPRKLANAVWEALNTPLPDEDHAPLAQASTDGNKATLKRLQDAVAQRSRELELPDG
ILASRRHLETLIEQRSWPAALGQWRRDALEADLLPLLDAATP

Sequences:

>Translated_362_residues
MPHWITHPSELTERLQLRPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMTDALKDWLIAPDIVKVMHSAS
EDLVTFKCACGVLPRPLFDTQIAAALAGVGGGMGYQKLVQEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIH
DALTAKLTAQDRLGWLAEDGERLLGTVEHDDGDRWPHVSLRTAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILDNEL
ASQLARFPPADLDALMRQFDKFPKAPRKLANAVWEALNTPLPDEDHAPLAQASTDGNKATLKRLQDAVAQRSRELELPDG
ILASRRHLETLIEQRSWPAALGQWRRDALEADLLPLLDAATP
>Mature_361_residues
PHWITHPSELTERLQLRPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMTDALKDWLIAPDIVKVMHSASE
DLVTFKCACGVLPRPLFDTQIAAALAGVGGGMGYQKLVQEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIHD
ALTAKLTAQDRLGWLAEDGERLLGTVEHDDGDRWPHVSLRTAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILDNELA
SQLARFPPADLDALMRQFDKFPKAPRKLANAVWEALNTPLPDEDHAPLAQASTDGNKATLKRLQDAVAQRSRELELPDGI
LASRRHLETLIEQRSWPAALGQWRRDALEADLLPLLDAATP

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Escherichia coli, GI1788105, Length=375, Percent_Identity=34.9333333333333, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17531757, Length=241, Percent_Identity=27.3858921161826, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=328, Percent_Identity=25.609756097561, Blast_Score=83, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 40829; Mature: 40698

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHWITHPSELTERLQLRPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMT
CCCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCHH
DALKDWLIAPDIVKVMHSASEDLVTFKCACGVLPRPLFDTQIAAALAGVGGGMGYQKLVQ
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
EVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIHDALTAKLTAQDRLGWLAEDG
HHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCH
ERLLGTVEHDDGDRWPHVSLRTAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILDNEL
HHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
ASQLARFPPADLDALMRQFDKFPKAPRKLANAVWEALNTPLPDEDHAPLAQASTDGNKAT
HHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCHHHH
LKRLQDAVAQRSRELELPDGILASRRHLETLIEQRSWPAALGQWRRDALEADLLPLLDAA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
TP
CC
>Mature Secondary Structure 
PHWITHPSELTERLQLRPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMT
CCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCHH
DALKDWLIAPDIVKVMHSASEDLVTFKCACGVLPRPLFDTQIAAALAGVGGGMGYQKLVQ
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
EVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIHDALTAKLTAQDRLGWLAEDG
HHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCH
ERLLGTVEHDDGDRWPHVSLRTAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILDNEL
HHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
ASQLARFPPADLDALMRQFDKFPKAPRKLANAVWEALNTPLPDEDHAPLAQASTDGNKAT
HHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCHHHH
LKRLQDAVAQRSRELELPDGILASRRHLETLIEQRSWPAALGQWRRDALEADLLPLLDAA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
TP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]