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The map label for this gene is ggt [H]

Identifier: 66768049

GI number: 66768049

Start: 2084464

End: 2086245

Strand: Direct

Name: ggt [H]

Synonym: XC_1726

Alternate gene names: 66768049

Gene position: 2084464-2086245 (Clockwise)

Preceding gene: 66768048

Following gene: 66768050

Centisome position: 40.49

GC content: 67.73

Gene sequence:

>1782_bases
GTGATCACTTCCCCCCGACGCTTGTTCCCGCGTGGCCTGTTGTTGCTGGCCTTCGTGGTCGCCCCAGCCGCGTGGGCGGC
CCAGCCCGACGCCGCAGCGGCCACGCCGCCGCCCGCCGGCACCGCCACGCATCCGCCGGGTGCGGCGGTGGCCAGTGGCC
ACGCGCTGGCCACCGATGCCGGGCTGCAGATCCTGCGCGAAGGCGGCAATGCCTTCGATGCGGCGATCGCGGTGTCGTCC
ACGCTGGCGGTGGTCGAGCCAATCAGCTCGGGGCTGGGCGGCGGCGGGTTCTTCCTGTTGCACGACGCCAAGACCGGCAA
GGACGTGATGCTGGACGCGCGCGAGTACGCGCCGGAGTCCGCCACTTCCGCACAGTTTTTGGACAAGAACGGCGGGCTGG
ACCGCGACCGCTCGGTCAACGGCCCGTGGTCGGCCGGCATCCCCGGTTTGCCAGCGGCGCTTGTGGAACTGGCGGCCAAG
CACGGCCGGCTGCCGCTCACCCAATCGCTGGCACCGGCGATCCGCATCGCTACCGAGGGCTTCCCGGTGTATGCGCGCAT
GGCCAAGGGCTACGCCTCGCGGCGCGAAGTGATGGAGCGCTACCCCGGCACGCGCGAGGTTTACTTGCGCGGCGGAAAAC
CCATTGCCGAAGGCGACATCTTCAAGCAGCCCGAGCTCGCGCACACCCTGACGCTGCTGGGCGACAAGGGCTTTGACGGT
TTCTACAAGGGCGAGACCGCCAAGAAACTGCTGGCCGGCGTCAAGCAGGCCGGTGGGCGCTGGACCGCTGCCGAACTGGC
CGGGTATCAGGTCAAGGAGCGCACGCCGATCCAGTTCGATTACCGCGGCTGGAAGGTCACCACCGCGCCGCCGCCTTCTT
CCGGTGGTATTGCACTCGCGGCGATGCTGCAGATCCTGGAAGGCTGGGACTTGAACACGCTCGACGACGCGCACCGCACT
CATTTGGTGGTGGAAGCGATGCGCCGCGCCTACCGTGACCGCACCTTTTTCCTGGGCGACCCGGACTTTGTCGACGTACC
GCAGCGCGTGCTGACCAGCAAGGATTACGCGCAGGGCCTGCGTGCCACCATCAATCCGGACAAGGCCACGCCGAGCAACC
TGCTGTCGGGCAACCCGACGCCGCTGGAAGACGACGAGACCACGCACTTTTCCATCATCGATGGCGAAGGCAACCGCGTG
GGCGCCACCCAGACGGTGAACCTGCTGTACGGCTCCGGGCTGATCCCCAAGGGCACTGGCGTGCTGCTCAACGACGAGAT
GGATGACTTTGCGCTCAAGCCCGGCACCCCGAACGCGTTTGGCGTGATGGGCTATGCCGCCAACGCGCCCAAGCCGGGCA
AGCGCATGCTCAGCTCGATGACGCCCACCTTCATGGAGTCGGCCGACAAGGTCGCCGTGCTCGGCACCCCGGGCGGCAGC
CGCATCATCACCATGGTGCTGCTCGGCATCCTGGGGTACGACGCCGGACTGGACGCGCAGCAGGTCAGTGCCTTGCCGCG
GTATCACCACCAGTGGTTGCCGGACGTCATCGAGGCCGAGAGCAATGCGTTCTCGCCGCAAACCGCCAAGGCGCTGGAAG
CAATGGGCCACGCGCTCAAGTTGCCGGGCGACACCGCTGAGGGCGGCCGCGGTTCCAGCCACGTCTGGGGTAATTTCCAG
ACCGTGGAATGGGACAAGCGCCGCAATGTGCTCAGCGGTGGTAGTGACCCGCGCAATCCGGTGGGCAAGGCCGCAGTGCA
GCTGGCAACGCCGGCACGGTGA

Upstream 100 bases:

>100_bases
CGGACCCGGCGATCCCGGAAACACATGATCAATTGCTGGCCAAGCTCATCCAGCTGCAGCGCGATCATCCCGAACTGTAC
GAACAGGAGCCTCCCGCCCC

Downstream 100 bases:

>100_bases
GTCCCGCATGCCTGCGCCGTTTCCCGGAGCAGGCATGACGGAAGCGTTCGACGGAGCGCGCTTTTGCTGATACGCGATCT
TGCTCAGCGGCTCGGCTTTG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MITSPRRLFPRGLLLLAFVVAPAAWAAQPDAAAATPPPAGTATHPPGAAVASGHALATDAGLQILREGGNAFDAAIAVSS
TLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDAREYAPESATSAQFLDKNGGLDRDRSVNGPWSAGIPGLPAALVELAAK
HGRLPLTQSLAPAIRIATEGFPVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDIFKQPELAHTLTLLGDKGFDG
FYKGETAKKLLAGVKQAGGRWTAAELAGYQVKERTPIQFDYRGWKVTTAPPPSSGGIALAAMLQILEGWDLNTLDDAHRT
HLVVEAMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSNLLSGNPTPLEDDETTHFSIIDGEGNRV
GATQTVNLLYGSGLIPKGTGVLLNDEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKVAVLGTPGGS
RIITMVLLGILGYDAGLDAQQVSALPRYHHQWLPDVIEAESNAFSPQTAKALEAMGHALKLPGDTAEGGRGSSHVWGNFQ
TVEWDKRRNVLSGGSDPRNPVGKAAVQLATPAR

Sequences:

>Translated_593_residues
MITSPRRLFPRGLLLLAFVVAPAAWAAQPDAAAATPPPAGTATHPPGAAVASGHALATDAGLQILREGGNAFDAAIAVSS
TLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDAREYAPESATSAQFLDKNGGLDRDRSVNGPWSAGIPGLPAALVELAAK
HGRLPLTQSLAPAIRIATEGFPVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDIFKQPELAHTLTLLGDKGFDG
FYKGETAKKLLAGVKQAGGRWTAAELAGYQVKERTPIQFDYRGWKVTTAPPPSSGGIALAAMLQILEGWDLNTLDDAHRT
HLVVEAMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSNLLSGNPTPLEDDETTHFSIIDGEGNRV
GATQTVNLLYGSGLIPKGTGVLLNDEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKVAVLGTPGGS
RIITMVLLGILGYDAGLDAQQVSALPRYHHQWLPDVIEAESNAFSPQTAKALEAMGHALKLPGDTAEGGRGSSHVWGNFQ
TVEWDKRRNVLSGGSDPRNPVGKAAVQLATPAR
>Mature_593_residues
MITSPRRLFPRGLLLLAFVVAPAAWAAQPDAAAATPPPAGTATHPPGAAVASGHALATDAGLQILREGGNAFDAAIAVSS
TLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDAREYAPESATSAQFLDKNGGLDRDRSVNGPWSAGIPGLPAALVELAAK
HGRLPLTQSLAPAIRIATEGFPVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDIFKQPELAHTLTLLGDKGFDG
FYKGETAKKLLAGVKQAGGRWTAAELAGYQVKERTPIQFDYRGWKVTTAPPPSSGGIALAAMLQILEGWDLNTLDDAHRT
HLVVEAMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSNLLSGNPTPLEDDETTHFSIIDGEGNRV
GATQTVNLLYGSGLIPKGTGVLLNDEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKVAVLGTPGGS
RIITMVLLGILGYDAGLDAQQVSALPRYHHQWLPDVIEAESNAFSPQTAKALEAMGHALKLPGDTAEGGRGSSHVWGNFQ
TVEWDKRRNVLSGGSDPRNPVGKAAVQLATPAR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=507, Percent_Identity=34.9112426035503, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI73915090, Length=507, Percent_Identity=34.9112426035503, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI73915096, Length=507, Percent_Identity=34.9112426035503, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI73915094, Length=507, Percent_Identity=34.9112426035503, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI113429324, Length=520, Percent_Identity=32.8846153846154, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=32.3809523809524, Blast_Score=216, Evalue=7e-56,
Organism=Homo sapiens, GI109148539, Length=517, Percent_Identity=31.3346228239845, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI153266901, Length=508, Percent_Identity=27.755905511811, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI153266885, Length=507, Percent_Identity=27.4161735700197, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI153266907, Length=507, Percent_Identity=26.0355029585799, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI30581157, Length=198, Percent_Identity=36.8686868686869, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI30581155, Length=198, Percent_Identity=36.8686868686869, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI218505805, Length=191, Percent_Identity=35.6020942408377, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI310124095, Length=193, Percent_Identity=32.1243523316062, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789856, Length=500, Percent_Identity=42.8, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI72000294, Length=493, Percent_Identity=34.4827586206897, Blast_Score=218, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI212646519, Length=493, Percent_Identity=34.4827586206897, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI193208247, Length=513, Percent_Identity=32.1637426900585, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI193208245, Length=513, Percent_Identity=32.1637426900585, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17506189, Length=518, Percent_Identity=31.0810810810811, Blast_Score=199, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17542894, Length=549, Percent_Identity=29.6903460837887, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17564448, Length=391, Percent_Identity=26.5984654731458, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=547, Percent_Identity=28.5191956124314, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI45551474, Length=510, Percent_Identity=31.7647058823529, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24642670, Length=510, Percent_Identity=31.7647058823529, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24642666, Length=510, Percent_Identity=31.7647058823529, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI161077878, Length=510, Percent_Identity=31.7647058823529, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI161077880, Length=510, Percent_Identity=31.7647058823529, Blast_Score=199, Evalue=6e-51,
Organism=Drosophila melanogaster, GI18859893, Length=510, Percent_Identity=31.5686274509804, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI161077496, Length=533, Percent_Identity=30.2063789868668, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI18859741, Length=491, Percent_Identity=26.4765784114053, Blast_Score=132, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62752; Mature: 62752

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITSPRRLFPRGLLLLAFVVAPAAWAAQPDAAAATPPPAGTATHPPGAAVASGHALATDA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHH
GLQILREGGNAFDAAIAVSSTLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDAREYAPES
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEHHHHCCCC
ATSAQFLDKNGGLDRDRSVNGPWSAGIPGLPAALVELAAKHGRLPLTQSLAPAIRIATEG
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCCHHEEECCC
FPVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDIFKQPELAHTLTLLGDKGFDG
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
FYKGETAKKLLAGVKQAGGRWTAAELAGYQVKERTPIQFDYRGWKVTTAPPPSSGGIALA
CCCCHHHHHHHHHHHHCCCCEEHHHHCCCEECCCCCEEEECCCEEEECCCCCCCCCHHHH
AMLQILEGWDLNTLDDAHRTHLVVEAMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCHHHHCC
RATINPDKATPSNLLSGNPTPLEDDETTHFSIIDGEGNRVGATQTVNLLYGSGLIPKGTG
CEECCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCCCEECCCEEEEEEECCCCCCCCCC
VLLNDEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKVAVLGTPGGS
EEECCCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHCCCCEEEEECCCCH
RIITMVLLGILGYDAGLDAQQVSALPRYHHQWLPDVIEAESNAFSPQTAKALEAMGHALK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHCCEEE
LPGDTAEGGRGSSHVWGNFQTVEWDKRRNVLSGGSDPRNPVGKAAVQLATPAR
CCCCCCCCCCCCCCCCCCCEEECHHHHCCHHCCCCCCCCCHHHHHEEECCCCC
>Mature Secondary Structure
MITSPRRLFPRGLLLLAFVVAPAAWAAQPDAAAATPPPAGTATHPPGAAVASGHALATDA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHH
GLQILREGGNAFDAAIAVSSTLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDAREYAPES
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEHHHHCCCC
ATSAQFLDKNGGLDRDRSVNGPWSAGIPGLPAALVELAAKHGRLPLTQSLAPAIRIATEG
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCCHHEEECCC
FPVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDIFKQPELAHTLTLLGDKGFDG
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
FYKGETAKKLLAGVKQAGGRWTAAELAGYQVKERTPIQFDYRGWKVTTAPPPSSGGIALA
CCCCHHHHHHHHHHHHCCCCEEHHHHCCCEECCCCCEEEECCCEEEECCCCCCCCCHHHH
AMLQILEGWDLNTLDDAHRTHLVVEAMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCHHHHCC
RATINPDKATPSNLLSGNPTPLEDDETTHFSIIDGEGNRVGATQTVNLLYGSGLIPKGTG
CEECCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCCCEECCCEEEEEEECCCCCCCCCC
VLLNDEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKVAVLGTPGGS
EEECCCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHCCCCEEEEECCCCH
RIITMVLLGILGYDAGLDAQQVSALPRYHHQWLPDVIEAESNAFSPQTAKALEAMGHALK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHCCEEE
LPGDTAEGGRGSSHVWGNFQTVEWDKRRNVLSGGSDPRNPVGKAAVQLATPAR
CCCCCCCCCCCCCCCCCCCEEECHHHHCCHHCCCCCCCCCHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]