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The map label for this gene is cho [H]

Identifier: 66768008

GI number: 66768008

Start: 2023229

End: 2024086

Strand: Reverse

Name: cho [H]

Synonym: XC_1684

Alternate gene names: 66768008

Gene position: 2024086-2023229 (Counterclockwise)

Preceding gene: 66768011

Following gene: 66768006

Centisome position: 39.31

GC content: 64.57

Gene sequence:

>858_bases
ATGGTGGGGCGCGCTGAGCGGGCAAAGCGCAGCTGGGGCGCTCCGGACTACACCTACCCCGAGCATCTGCGTGCAGAACT
GGACACCTTGCCGGCCACGCCCGGGGTCTATCTGTTCCATGGACAGAGCAGCACGTTGCCGTTGTACATCGGCAAGAGCA
TCCACCTGCGCAACCGCGTCATGGACCATTTCCGTAACGCGGCCGAAGCCTCGCTGCTGCGTCAGACGCGCAGCATCCAG
GTGATCGAAATGGCCGGTGACATCGGCGCACAGCTGCTGGAGTCGCAGCTGATCAAGACCCTGCGCCCGCTGTACAACCA
GAAGCTGCGGCGGATCCCGCGCCAGTTTTCGATCCGGCTGTATCGCGGCGAGGTGTCGATCGAACATTCCGGCGAGATCG
ATCCGGCGGCAGCGCCCTGGTTGTACGGGCTGTATTCCAGCCCCCGTGCGGCCAAGGAAACGTTGCGCCGCCTCGCCGAC
CAGCATCATCTTTGTTACGGCTTGTTGGGACTGGAGCGGCTGCAAGCAGGCCGGCCCTGTTTCCGCGCCATGCTGAAACG
CTGCAGCGGCGCCTGCCATGGTGCCGAGCCCTTGGACGCGCACGAAGAACGGCTACGCAGCGTGCTGCAGCATCTGGAAC
AGGCGGCGTGGCCATTTCCCGGCGCCATCGCGCTGAAGGAGCAAGGCGCGCAACGCACCCAGTTCCATGTGCTGCGCGAT
TGGCACTATCTGGGCAGCGCCACCTCGTTGGCGGGCGCACGCCGTTTGCAGGCGACACCCGGTGCATTCGACCGCGATTG
CTACCGCATCCTGCGCAAATATCTGGAGACGCAGCTGCATTGCGTGTCGCTGCTGTAG

Upstream 100 bases:

>100_bases
ACCACAACGGCTACTCGCCGCACCACATTGATTGAACGGCGGCACTGCGCGCCTGGCATCGCGCCAAGCAACGCGTTACC
ACCGAGACAGGAGGCCGGCG

Downstream 100 bases:

>100_bases
CCGCAAGCGGGCCCAACTGGCTCAGCGCTTTCTGCTTCGGCGCGATTGCACAGCACTGCGCTGCTGCGTGGCCGGCACCT
GCTGCGCGAACACTGCGTGC

Product: nucleotide excision repair endonuclease

Products: NA

Alternate protein names: Endonuclease cho; UvrC homolog protein [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MVGRAERAKRSWGAPDYTYPEHLRAELDTLPATPGVYLFHGQSSTLPLYIGKSIHLRNRVMDHFRNAAEASLLRQTRSIQ
VIEMAGDIGAQLLESQLIKTLRPLYNQKLRRIPRQFSIRLYRGEVSIEHSGEIDPAAAPWLYGLYSSPRAAKETLRRLAD
QHHLCYGLLGLERLQAGRPCFRAMLKRCSGACHGAEPLDAHEERLRSVLQHLEQAAWPFPGAIALKEQGAQRTQFHVLRD
WHYLGSATSLAGARRLQATPGAFDRDCYRILRKYLETQLHCVSLL

Sequences:

>Translated_285_residues
MVGRAERAKRSWGAPDYTYPEHLRAELDTLPATPGVYLFHGQSSTLPLYIGKSIHLRNRVMDHFRNAAEASLLRQTRSIQ
VIEMAGDIGAQLLESQLIKTLRPLYNQKLRRIPRQFSIRLYRGEVSIEHSGEIDPAAAPWLYGLYSSPRAAKETLRRLAD
QHHLCYGLLGLERLQAGRPCFRAMLKRCSGACHGAEPLDAHEERLRSVLQHLEQAAWPFPGAIALKEQGAQRTQFHVLRD
WHYLGSATSLAGARRLQATPGAFDRDCYRILRKYLETQLHCVSLL
>Mature_285_residues
MVGRAERAKRSWGAPDYTYPEHLRAELDTLPATPGVYLFHGQSSTLPLYIGKSIHLRNRVMDHFRNAAEASLLRQTRSIQ
VIEMAGDIGAQLLESQLIKTLRPLYNQKLRRIPRQFSIRLYRGEVSIEHSGEIDPAAAPWLYGLYSSPRAAKETLRRLAD
QHHLCYGLLGLERLQAGRPCFRAMLKRCSGACHGAEPLDAHEERLRSVLQHLEQAAWPFPGAIALKEQGAQRTQFHVLRD
WHYLGSATSLAGARRLQATPGAFDRDCYRILRKYLETQLHCVSLL

Specific function: Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than uvrC. Not able to incise the 5' site of a lesion. When a lesion remains because uvrC is not able to induce the 3' incision, cho

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrC C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1788037, Length=263, Percent_Identity=50.1901140684411, Blast_Score=266, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG [H]

EC number: NA

Molecular weight: Translated: 32355; Mature: 32355

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGRAERAKRSWGAPDYTYPEHLRAELDTLPATPGVYLFHGQSSTLPLYIGKSIHLRNRV
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCHHHHHHH
MDHFRNAAEASLLRQTRSIQVIEMAGDIGAQLLESQLIKTLRPLYNQKLRRIPRQFSIRL
HHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEE
YRGEVSIEHSGEIDPAAAPWLYGLYSSPRAAKETLRRLADQHHLCYGLLGLERLQAGRPC
EECEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FRAMLKRCSGACHGAEPLDAHEERLRSVLQHLEQAAWPFPGAIALKEQGAQRTQFHVLRD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHHHHHHHH
WHYLGSATSLAGARRLQATPGAFDRDCYRILRKYLETQLHCVSLL
HHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVGRAERAKRSWGAPDYTYPEHLRAELDTLPATPGVYLFHGQSSTLPLYIGKSIHLRNRV
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCHHHHHHH
MDHFRNAAEASLLRQTRSIQVIEMAGDIGAQLLESQLIKTLRPLYNQKLRRIPRQFSIRL
HHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEE
YRGEVSIEHSGEIDPAAAPWLYGLYSSPRAAKETLRRLADQHHLCYGLLGLERLQAGRPC
EECEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FRAMLKRCSGACHGAEPLDAHEERLRSVLQHLEQAAWPFPGAIALKEQGAQRTQFHVLRD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHHHHHHHH
WHYLGSATSLAGARRLQATPGAFDRDCYRILRKYLETQLHCVSLL
HHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]