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The map label for this gene is pheS

Identifier: 66767978

GI number: 66767978

Start: 1988939

End: 1989949

Strand: Direct

Name: pheS

Synonym: XC_1654

Alternate gene names: 66767978

Gene position: 1988939-1989949 (Clockwise)

Preceding gene: 66767977

Following gene: 66767979

Centisome position: 38.63

GC content: 64.09

Gene sequence:

>1011_bases
ATGAGTGAGATTCAATCCCTGACCGCGCAGGCGTTGGCCGATGTTGCTGCCGCGCACACGCCGGACCAGCTGGAAACGCT
GCGCGTCGCGCTGCTGGGCAAGAACGGCAGCATCACCGCCCAGCTCAAGCAGCTCGGCACGTTGCCGGCCGACCAGCGCA
AGGCGGCTGGTGAGGCGATCAATCTGGCGCGCGATGCGCTGACCACGGCGCTTTCCGAGCGCAAACAGGTGCTCGAAACC
GCAGCGCTGGACGCCCGTCTGGAAGGTGAGCGCATCGATGTGACGCTGCCCGGCCGACGCGGTGAGCGCGGCGGTCTGCA
TCCGGTGACGCGGACCCTGGAGCGCATCGTCGAGATCTTTGCGCGGCTGGGTTACGAGTTGTCTGACGGCCCGGAGATCG
AGGACGACTGGCACAACTTCGAAGCGTTGAACTTCCCGCCGCATCATCCGGCGCGTGCCATGCACGACACGTTCTACTTC
GGCGATGGCCGCCTGCTGCGCACGCATACCTCCGGCGTGCAGGTGCGTTACATGGATACCGCAGTGGCCACCAAGAGTGG
CCCGCCGCTGCGCATGATTGCGGCCGGCAAGGTGTATCGCTCCGATTCGGATCAGACCCACTCGCCGATGTTCCATCAGG
TCGAAGGTCTGCTGGTGGACGAGCATTCCAACTTCGCCGATCTCAAGGGCACCTTGTCCGAGTTCGTGCGTGCGTTCTTC
GAGCGCGATTTCGAAATGCGCTTCCGGCCCAGCTATTTCCCGTTCGTTGAGCCTGGTGCGGAAGTGGATATCGCCTGGCA
GCAGCCCGATGGCAGCACCCGGTGGCTGGAAGTGCTTGGCTGCGGCATGGTGCACCCGAACGTGCTGCGCAGCGTCGGCA
TCGATCCGGAGCGCTACACCGGCTTCGCCTTCGGTCTGGGCGTCGAGCGCTTTGCGATGCTGCGCTATGGCGTCAACGAC
CTGCGTGCCTTCTTCGAAAACGACGTGCGGTTTCTCAGGCAGTTTGCTTGA

Upstream 100 bases:

>100_bases
AGCGGCCACCGCAGCAACGCGCGGTACGGCTTCCAGGTGTGCAAGGCGGCCCGGTGCAGTCCGGGAGTTCGTTCGGCTGA
GCAGGTGAGGCACGAGTGCA

Downstream 100 bases:

>100_bases
GGGCAGGAAATCGGGAATAGGGAATAGAGAATCGGAGCAGCCAAGCGCGCTCCTGGCTCACCTTCCAGATCCCCGAAGAC
CTCCCGCTGCTGCGATTCCC

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSEIQSLTAQALADVAAAHTPDQLETLRVALLGKNGSITAQLKQLGTLPADQRKAAGEAINLARDALTTALSERKQVLET
AALDARLEGERIDVTLPGRRGERGGLHPVTRTLERIVEIFARLGYELSDGPEIEDDWHNFEALNFPPHHPARAMHDTFYF
GDGRLLRTHTSGVQVRYMDTAVATKSGPPLRMIAAGKVYRSDSDQTHSPMFHQVEGLLVDEHSNFADLKGTLSEFVRAFF
ERDFEMRFRPSYFPFVEPGAEVDIAWQQPDGSTRWLEVLGCGMVHPNVLRSVGIDPERYTGFAFGLGVERFAMLRYGVND
LRAFFENDVRFLRQFA

Sequences:

>Translated_336_residues
MSEIQSLTAQALADVAAAHTPDQLETLRVALLGKNGSITAQLKQLGTLPADQRKAAGEAINLARDALTTALSERKQVLET
AALDARLEGERIDVTLPGRRGERGGLHPVTRTLERIVEIFARLGYELSDGPEIEDDWHNFEALNFPPHHPARAMHDTFYF
GDGRLLRTHTSGVQVRYMDTAVATKSGPPLRMIAAGKVYRSDSDQTHSPMFHQVEGLLVDEHSNFADLKGTLSEFVRAFF
ERDFEMRFRPSYFPFVEPGAEVDIAWQQPDGSTRWLEVLGCGMVHPNVLRSVGIDPERYTGFAFGLGVERFAMLRYGVND
LRAFFENDVRFLRQFA
>Mature_335_residues
SEIQSLTAQALADVAAAHTPDQLETLRVALLGKNGSITAQLKQLGTLPADQRKAAGEAINLARDALTTALSERKQVLETA
ALDARLEGERIDVTLPGRRGERGGLHPVTRTLERIVEIFARLGYELSDGPEIEDDWHNFEALNFPPHHPARAMHDTFYFG
DGRLLRTHTSGVQVRYMDTAVATKSGPPLRMIAAGKVYRSDSDQTHSPMFHQVEGLLVDEHSNFADLKGTLSEFVRAFFE
RDFEMRFRPSYFPFVEPGAEVDIAWQQPDGSTRWLEVLGCGMVHPNVLRSVGIDPERYTGFAFGLGVERFAMLRYGVNDL
RAFFENDVRFLRQFA

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI5729820, Length=288, Percent_Identity=30.9027777777778, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4758340, Length=269, Percent_Identity=29.7397769516729, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1788007, Length=335, Percent_Identity=59.7014925373134, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17508957, Length=267, Percent_Identity=29.2134831460674, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32563657, Length=267, Percent_Identity=29.2134831460674, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32566635, Length=248, Percent_Identity=31.8548387096774, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321087, Length=277, Percent_Identity=30.6859205776173, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6325304, Length=277, Percent_Identity=27.4368231046931, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18858079, Length=262, Percent_Identity=31.6793893129771, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17137424, Length=247, Percent_Identity=29.1497975708502, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_XANC8 (Q4UW53)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242740.1
- ProteinModelPortal:   Q4UW53
- SMR:   Q4UW53
- STRING:   Q4UW53
- GeneID:   3380203
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1654
- eggNOG:   COG0016
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- PhylomeDB:   Q4UW53
- ProtClustDB:   PRK00488
- BioCyc:   XCAM314565:XC_1654-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 37602; Mature: 37471

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIQSLTAQALADVAAAHTPDQLETLRVALLGKNGSITAQLKQLGTLPADQRKAAGEAI
CCHHHHHHHHHHHHHHHCCCCHHHHHEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHH
NLARDALTTALSERKQVLETAALDARLEGERIDVTLPGRRGERGGLHPVTRTLERIVEIF
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
ARLGYELSDGPEIEDDWHNFEALNFPPHHPARAMHDTFYFGDGRLLRTHTSGVQVRYMDT
HHCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHCEEEECCCEEEEEECCCEEEEEECH
AVATKSGPPLRMIAAGKVYRSDSDQTHSPMFHQVEGLLVDEHSNFADLKGTLSEFVRAFF
HHCCCCCCCEEEEECCEEECCCCCCCCCCHHHHHCCEEEECCCCHHHHHHHHHHHHHHHH
ERDFEMRFRPSYFPFVEPGAEVDIAWQQPDGSTRWLEVLGCGMVHPNVLRSVGIDPERYT
HCCCCEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHCCCCHHHHC
GFAFGLGVERFAMLRYGVNDLRAFFENDVRFLRQFA
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEIQSLTAQALADVAAAHTPDQLETLRVALLGKNGSITAQLKQLGTLPADQRKAAGEAI
CHHHHHHHHHHHHHHHCCCCHHHHHEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHH
NLARDALTTALSERKQVLETAALDARLEGERIDVTLPGRRGERGGLHPVTRTLERIVEIF
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
ARLGYELSDGPEIEDDWHNFEALNFPPHHPARAMHDTFYFGDGRLLRTHTSGVQVRYMDT
HHCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHCEEEECCCEEEEEECCCEEEEEECH
AVATKSGPPLRMIAAGKVYRSDSDQTHSPMFHQVEGLLVDEHSNFADLKGTLSEFVRAFF
HHCCCCCCCEEEEECCEEECCCCCCCCCCHHHHHCCEEEECCCCHHHHHHHHHHHHHHHH
ERDFEMRFRPSYFPFVEPGAEVDIAWQQPDGSTRWLEVLGCGMVHPNVLRSVGIDPERYT
HCCCCEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHCCCCHHHHC
GFAFGLGVERFAMLRYGVNDLRAFFENDVRFLRQFA
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA