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The map label for this gene is virB8 [H]

Identifier: 66767956

GI number: 66767956

Start: 1958610

End: 1959653

Strand: Direct

Name: virB8 [H]

Synonym: XC_1632

Alternate gene names: 66767956

Gene position: 1958610-1959653 (Clockwise)

Preceding gene: 66767955

Following gene: 66767957

Centisome position: 38.04

GC content: 54.69

Gene sequence:

>1044_bases
GTGACGGATCTAGACATGTTGCGTAAGAAGGTCAGTGAAAAGGATGGGTCCGCCCAGGTTGGCGCGGCCGTCCAGAAGGC
GGTCAATTACGAGGTGAGCATCGCTGATCTCGCGCGGCGCAGTGAAAGGCGCGCATGGTTAGTTGCGACCGTTTCCATGT
TAATCACCGTCATAACAGCTGGTGGTTACTACTACATGTTGCCGCTGAAAGAGAAAGTGCCGTACCTTGTGATGGCTGAT
GCTTATTCTGGTACCAGTACTATCGCCAAGCTCGAAGCGAATTACGGCGGCCGCACCATCAGCACCAGTGAGGCATTGGC
GCGCAGCAACATCGCGCGTTTCATCCTGGCGCGTGAATCATTCGATGTGTCCACCATTGGTGATCGCGATTGGAACACCG
TTGCAGCGATGGCAGCGACAAATGTACTTGCCGAGTATCGCACGCTGCATGCCGGCAATAATCCACTGAGACCTTTCAAT
ACATATGGAAGGTCGCGCGCAATCCGGATCAATATTCTCAGTATCACCCTGGTTGGTGGCAAGGGTAAAGCATACACGGG
TGCGACCGTACGCTTTCAGCGCAATGTCTATGACAAGACATCTACTGTGACAACTTTGTTAGATAATAAAATTGCGACGA
TGGGGTTCGCCTACCAAGACAATCTGCAGATGAGCGATAGCCTTAGAGTGGAAAATCCTTTAGGTTTCCGTGTGACTGAT
TATCGGGTCGATAGCGACTATTCGGCCTTGCCTGCAGCGCCGGCCTCAATCAGCACGCAGGCGCAGGCTGCACCACAGGC
TTCCGTATATCAGCAGCAGATGACTCCAGGCATGGCTGAACAAAACGTAGCAGGCGCTGCGGGGCAGGCCGGCTCCCCCA
TGCAGCAGGTTATGCCTACGGGCCCAGGGAGCGCGCCGATGCAACAGCAGCAGCCTGGATATCCTGGACAGGCGCAACCT
CAGTCAGCCAGCCAACCTCAAGCTCAGCCCACGATTCAACCTCAAGGGATGCCGAACAATGTCAATGGAGCAAGCGGTCG
ATGA

Upstream 100 bases:

>100_bases
TTGATGCACTTGCGCACCTCGCAGAGTGATGAAGTAACTCAAGCCCCAAAGGTGCCCGCGCTTGCCGCGGCAATAGTTTC
AGGCCTGACAAGGCCTCACG

Downstream 100 bases:

>100_bases
ATCCCTTTAACCCTTACAGGGCAGCATTGGTCGCAGCATTGCCGCTCGTGCTATGTGCATTTCCGGTCGCCTCTCAAGTC
GTGCAAGAGTATGAGTACAC

Product: VirB8 protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTDLDMLRKKVSEKDGSAQVGAAVQKAVNYEVSIADLARRSERRAWLVATVSMLITVITAGGYYYMLPLKEKVPYLVMAD
AYSGTSTIAKLEANYGGRTISTSEALARSNIARFILARESFDVSTIGDRDWNTVAAMAATNVLAEYRTLHAGNNPLRPFN
TYGRSRAIRINILSITLVGGKGKAYTGATVRFQRNVYDKTSTVTTLLDNKIATMGFAYQDNLQMSDSLRVENPLGFRVTD
YRVDSDYSALPAAPASISTQAQAAPQASVYQQQMTPGMAEQNVAGAAGQAGSPMQQVMPTGPGSAPMQQQQPGYPGQAQP
QSASQPQAQPTIQPQGMPNNVNGASGR

Sequences:

>Translated_347_residues
MTDLDMLRKKVSEKDGSAQVGAAVQKAVNYEVSIADLARRSERRAWLVATVSMLITVITAGGYYYMLPLKEKVPYLVMAD
AYSGTSTIAKLEANYGGRTISTSEALARSNIARFILARESFDVSTIGDRDWNTVAAMAATNVLAEYRTLHAGNNPLRPFN
TYGRSRAIRINILSITLVGGKGKAYTGATVRFQRNVYDKTSTVTTLLDNKIATMGFAYQDNLQMSDSLRVENPLGFRVTD
YRVDSDYSALPAAPASISTQAQAAPQASVYQQQMTPGMAEQNVAGAAGQAGSPMQQVMPTGPGSAPMQQQQPGYPGQAQP
QSASQPQAQPTIQPQGMPNNVNGASGR
>Mature_346_residues
TDLDMLRKKVSEKDGSAQVGAAVQKAVNYEVSIADLARRSERRAWLVATVSMLITVITAGGYYYMLPLKEKVPYLVMADA
YSGTSTIAKLEANYGGRTISTSEALARSNIARFILARESFDVSTIGDRDWNTVAAMAATNVLAEYRTLHAGNNPLRPFNT
YGRSRAIRINILSITLVGGKGKAYTGATVRFQRNVYDKTSTVTTLLDNKIATMGFAYQDNLQMSDSLRVENPLGFRVTDY
RVDSDYSALPAAPASISTQAQAAPQASVYQQQMTPGMAEQNVAGAAGQAGSPMQQVMPTGPGSAPMQQQQPGYPGQAQPQ
SASQPQAQPTIQPQGMPNNVNGASGR

Specific function: The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice [H]

COG id: COG3736

COG function: function code U; Type IV secretory pathway, component VirB8

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the virB8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007430 [H]

Pfam domain/function: PF04335 VirB8 [H]

EC number: NA

Molecular weight: Translated: 37264; Mature: 37132

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLDMLRKKVSEKDGSAQVGAAVQKAVNYEVSIADLARRSERRAWLVATVSMLITVITA
CCCHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHC
GGYYYMLPLKEKVPYLVMADAYSGTSTIAKLEANYGGRTISTSEALARSNIARFILARES
CCEEEEEEHHHCCCEEEEEECCCCCCEEEEEECCCCCCEECHHHHHHHHHHHHEEEECCC
FDVSTIGDRDWNTVAAMAATNVLAEYRTLHAGNNPLRPFNTYGRSRAIRINILSITLVGG
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEEEEEEEECC
KGKAYTGATVRFQRNVYDKTSTVTTLLDNKIATMGFAYQDNLQMSDSLRVENPLGFRVTD
CCCEECCEEEEEECCCCCCHHHHHHHHCCCHHHEEEEECCCCCCCCCEEECCCCCEEEEE
YRVDSDYSALPAAPASISTQAQAAPQASVYQQQMTPGMAEQNVAGAAGQAGSPMQQVMPT
EEECCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCC
GPGSAPMQQQQPGYPGQAQPQSASQPQAQPTIQPQGMPNNVNGASGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLDMLRKKVSEKDGSAQVGAAVQKAVNYEVSIADLARRSERRAWLVATVSMLITVITA
CCHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHC
GGYYYMLPLKEKVPYLVMADAYSGTSTIAKLEANYGGRTISTSEALARSNIARFILARES
CCEEEEEEHHHCCCEEEEEECCCCCCEEEEEECCCCCCEECHHHHHHHHHHHHEEEECCC
FDVSTIGDRDWNTVAAMAATNVLAEYRTLHAGNNPLRPFNTYGRSRAIRINILSITLVGG
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEEEEEEEECC
KGKAYTGATVRFQRNVYDKTSTVTTLLDNKIATMGFAYQDNLQMSDSLRVENPLGFRVTD
CCCEECCEEEEEECCCCCCHHHHHHHHCCCHHHEEEEECCCCCCCCCEEECCCCCEEEEE
YRVDSDYSALPAAPASISTQAQAAPQASVYQQQMTPGMAEQNVAGAAGQAGSPMQQVMPT
EEECCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCC
GPGSAPMQQQQPGYPGQAQPQSASQPQAQPTIQPQGMPNNVNGASGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10940027 [H]