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The map label for this gene is uvrB [H]

Identifier: 66767952

GI number: 66767952

Start: 1953215

End: 1955236

Strand: Direct

Name: uvrB [H]

Synonym: XC_1628

Alternate gene names: 66767952

Gene position: 1953215-1955236 (Clockwise)

Preceding gene: 66767950

Following gene: 66767953

Centisome position: 37.94

GC content: 62.81

Gene sequence:

>2022_bases
ATGACCGACCGCTTTGAGCTTGTATCCCCGTATTCCCCAGCCGGCGACCAACCTGCGGCCATCGACAAGTTGGTGGCCAA
CTTCGAGGCGGGGCTGGCCAAGCAGACGCTGCTGGGGGTGACGGGTTCGGGTAAGACCTACACCATCGCCAACGTCGTGC
AGCAGGTGCAGAAGCCGACGCTAGTGATGGCGCCGAACAAGACGTTGGCGGCGCAGCTGTACGGCGAGTTCAAGTCGTTT
TTCCCGAACAACGCGGTGGAGTACTTCGTCAGCTATTACGACTATTACCAGCCTGAAGCATACGTGCCGTCGTCGGACAC
CTTCATCGAGAAGGACAGCTCGATCAACGAGCACATCGAGCAGATGCGTCTGTCGGCGACCAAGACGCTGCTGTCGCGGC
GCGACTCGCTGGTGGTGGCCACGGTTTCGGCGATCTACGGCCTCGGCGCGCCAGAAGACTATCTGTCGCTGCGCCTGATT
CTCTCGATCGGCGAGCACATCGATCAGCGCCAGCTGATCCGCCATCTCACCGATCTGCAGTACACGCGCAACGAGTTCGA
GCTCACGCGCGGCGCGTTCCGTGTGCGCGGCGAGGTGCTTGACGTTTTTCCCGCCGAGTCGGATACCGAGGCGTTGCGCA
TCGAACTGTTCGATGGCGACATCGAGCAACTGACGCTGTTCGATCCGCTGACCGGCGAGACGCTGCGCAAGCTGCAGCGT
TACACCGTGTATCCCAAGACCCATTACGCCACCACGCGCGAGCGCACCTTGAGCGCGGTCGACACCATCAAAGAAGAGTT
GAAGGAGCGCTTGGAGCAGTTGTATTCGCAGAACAAGCTGGTGGAGGCGCAGCGCCTGGCGCAACGCACCCAGTTCGATC
TGGAGATGATGGCCGAGGTGGGCTTCTGTAACGGCATCGAGAACTACTCGCGGCACTTGACCGGCAAGGCGCCTGGCGAG
CCGCCGCCGACCTTGTTCGACTACTTGCCGCCGGATGCGCTGCTGGTGATCGACGAGTCGCACGTGACCATTCCGCAGAT
CGGCGCAATGTACAAGGGCGACCGCTCGCGCAAGGAAACGCTGGTGGAATTCGGCTTCCGCCTGCCGTCGGCGCTGGACA
ATCGCCCGTTGCGCTTTGAGGAATGGGAAGCGCGTTCGCCGCGTAGCATCTATGTGTCGGCAACACCGGGGCCGTACGAG
CTGCGCGAATCTGCTGGCGAGATCACCGAGCTGGTGGTGCGGCCTACCGGCTTGATCGACCCGGTGGTCGAGATCCGCCC
GGTAGGCACACAGGTCGACGATCTGATGTCCGAGGTGCACGAGCGCATCAAGCTGGGCGACCGCGTGCTGGTCACCACTT
TGACCAAGCGTATGGCCGAAAACCTCACCGAATACCTCGGTGAGCACGGCATCCGCGTGCGCTATCTGCACTCGGACATC
GACACCGTAGAGCGCGTAGAGATCATCCGCGACCTGCGCCTTGGCAAGTTCGACGTACTGGTCGGCATCAATCTATTGCG
CGAAGGCCTGGACATGCCGGAGGTGTCGCTGGTTGCGATCCTGGACGCAGACAAGGAAGGCTTCCTGCGCTCCACCGGCT
CGCTGATCCAGACCATCGGGCGCGCGGCGCGCAACCTGCGCGGCAAGGCGATCCTCTATGCCGACAAGATGACGCGTTCG
ATGCAGGCGGCCATCGACGAGACTGACCGCCGGCGCGAGAAGCAGGTTGAGTACAACCTTGAGCACGGCATCACCCCGAA
GTCGGTCGCGCGGCCGATCTCCGACATCATGGAAGGCGCGCGCGAAGACGCGGCCGAGAAGAAGGCTGGCAAGGGGCGCT
CGAAGTCGCGCCAGGTGGCCGAGGAGCCCGCCGACTATCGCGCGATGGGGCCTGCCGAAATTGCCGGCAAGCTCAAGGCA
CTCGAGCAGAAGATGTACCAGCACGCCAAGGATCTGGAATTCGAAGCGGCGGCGCAGATCCGCGACCAGATCCTGAAGCT
CAAGGCGGCCAGCCTCGCGTGA

Upstream 100 bases:

>100_bases
ATTGCGTGGTGCAGCAGGGGGCTTTGGCCTGGCGTGCTGTCAGGTTTCTACCTTCAAAGACCTCCGTTGTTTCGTACTGT
CCTCCCCCGAGAGTTGCTCC

Downstream 100 bases:

>100_bases
GGTGCCAGCACCGCGATCGCGCACAGGGAGGGCTTGTGGCAGCCAAATCCCTGCGCTAGAATGCGCGCCCTGCACAGCGC
AATGCTGACGCAGGAAACGG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MTDRFELVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQKPTLVMAPNKTLAAQLYGEFKSF
FPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLI
LSIGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQR
YTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEVGFCNGIENYSRHLTGKAPGE
PPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYE
LRESAGEITELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIGRAARNLRGKAILYADKMTRS
MQAAIDETDRRREKQVEYNLEHGITPKSVARPISDIMEGAREDAAEKKAGKGRSKSRQVAEEPADYRAMGPAEIAGKLKA
LEQKMYQHAKDLEFEAAAQIRDQILKLKAASLA

Sequences:

>Translated_673_residues
MTDRFELVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQKPTLVMAPNKTLAAQLYGEFKSF
FPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLI
LSIGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQR
YTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEVGFCNGIENYSRHLTGKAPGE
PPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYE
LRESAGEITELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIGRAARNLRGKAILYADKMTRS
MQAAIDETDRRREKQVEYNLEHGITPKSVARPISDIMEGAREDAAEKKAGKGRSKSRQVAEEPADYRAMGPAEIAGKLKA
LEQKMYQHAKDLEFEAAAQIRDQILKLKAASLA
>Mature_672_residues
TDRFELVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQKPTLVMAPNKTLAAQLYGEFKSFF
PNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLIL
SIGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQRY
TVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEVGFCNGIENYSRHLTGKAPGEP
PPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYEL
RESAGEITELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDID
TVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIGRAARNLRGKAILYADKMTRSM
QAAIDETDRRREKQVEYNLEHGITPKSVARPISDIMEGAREDAAEKKAGKGRSKSRQVAEEPADYRAMGPAEIAGKLKAL
EQKMYQHAKDLEFEAAAQIRDQILKLKAASLA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=673, Percent_Identity=67.9049034175334, Blast_Score=925, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=309, Percent_Identity=21.3592233009709, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75827; Mature: 75696

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRFELVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQKPT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHHHCCCE
LVMAPNKTLAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLILSIGEHIDQRQLIRHLTDLQ
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQR
HHHHHHHHHHHHHHHCCHHHEECCCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHH
YTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEV
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKET
HHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHH
LVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYELRESAGEITELVVRPTGLID
HHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
PVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDI
CCHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCH
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLRGKAILYADKMTRSMQAAIDETDRRREKQVEYNLEHGITPKSVARPISDIMEGA
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
REDAAEKKAGKGRSKSRQVAEEPADYRAMGPAEIAGKLKALEQKMYQHAKDLEFEAAAQI
HHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RDQILKLKAASLA
HHHHHHHHHHHCC
>Mature Secondary Structure 
TDRFELVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQKPT
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHHHCCCE
LVMAPNKTLAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLILSIGEHIDQRQLIRHLTDLQ
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQR
HHHHHHHHHHHHHHHCCHHHEECCCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHH
YTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEV
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKET
HHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHH
LVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYELRESAGEITELVVRPTGLID
HHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
PVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDI
CCHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCH
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLRGKAILYADKMTRSMQAAIDETDRRREKQVEYNLEHGITPKSVARPISDIMEGA
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
REDAAEKKAGKGRSKSRQVAEEPADYRAMGPAEIAGKLKALEQKMYQHAKDLEFEAAAQI
HHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RDQILKLKAASLA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA