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The map label for this gene is trpA

Identifier: 66767901

GI number: 66767901

Start: 1895655

End: 1896473

Strand: Direct

Name: trpA

Synonym: XC_1577

Alternate gene names: 66767901

Gene position: 1895655-1896473 (Clockwise)

Preceding gene: 66767900

Following gene: 66767902

Centisome position: 36.82

GC content: 71.06

Gene sequence:

>819_bases
ATGAGCCGCGCGCCCGACCGTATCGCTGCGTGCTTCGACGCGCTGCGTCACTCCGGCCGCAAGGCGCTGATTCCCTTCAT
CACCGCCGGCGACCCCTCATTGGAAGCCACCGTGCCGGTGATGCATGCCCTGGTGCGCGCTGGTGCGAACATCATCGAGC
TCGGCGTGCCGTTCTCCGACCCGATGGCCGACGGCCCCACCATCCAGCGCAGCTCCGAGCGCGCGCTGGGCCGCGGTGCC
GGGCTGGCCTATGTGATCGAAGCCGTGCAGGAATTCCGGCGCGAGGACGCCACCACCCCGGTGGTACTGATGGGCTACCT
CAACCCGATCGAAATCCACGGCACGCGGCGCTTTGCCGAAACCGCGGTGGCCGCCGGCATCGATGGCGTGCTGCTGGTCG
ACCTGCCGCCCGAGGAGGCCGACGAGACCCGCGCCATCTTCACCGAGGTCGGTCTGGCGCTGATCGCCTTGGCGTCGCCC
ACCACCGGCGAGGCCCGGCTGGACATGCTGTGCAGCACTGCGCAGGGCTATTTGTATTACGTCAGCTTCTCTGGCGTGAC
TGGCGCGGCCGACCGGCTGGACACGCACGCGGCCAGCGACCGCCTGCGCCAGCTGCGCGCCCGTGCCGGCGCACCCGTGG
TGGCCGGCTTCGGCATCAAGGACGCCGCCAGTGCTGCCGCGATGGCGGTGGATGCGGACGGCGTGGTCGTCGGCAGCGCG
CTGGTGGCGGCCCTGGCCGATGCGTCGGATGTGCGCAGCGCGCGTAAGCGGGCCGAAGACTTCCTGCAGCCGCTGCGGCA
GGCGCTGGACGCCGGCTGA

Upstream 100 bases:

>100_bases
CCGCGCGTGGGCTCGCCGTTCGCTACGAAACTGGAGAAGGCAGCGTGACATCGATGTACTGGGGAAGCTGGGACGCCGTG
CAACTGGTGGAGGGATGCGC

Downstream 100 bases:

>100_bases
GGCACCGCTGCCGGTTGCATGCAGGTGCCCAACGGCGGCGATCATGCCGGCAACACGTTCCCGCATGATCGCCTGGCGGC
TTGGCCCAAGCCTCTCGGCG

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSRAPDRIAACFDALRHSGRKALIPFITAGDPSLEATVPVMHALVRAGANIIELGVPFSDPMADGPTIQRSSERALGRGA
GLAYVIEAVQEFRREDATTPVVLMGYLNPIEIHGTRRFAETAVAAGIDGVLLVDLPPEEADETRAIFTEVGLALIALASP
TTGEARLDMLCSTAQGYLYYVSFSGVTGAADRLDTHAASDRLRQLRARAGAPVVAGFGIKDAASAAAMAVDADGVVVGSA
LVAALADASDVRSARKRAEDFLQPLRQALDAG

Sequences:

>Translated_272_residues
MSRAPDRIAACFDALRHSGRKALIPFITAGDPSLEATVPVMHALVRAGANIIELGVPFSDPMADGPTIQRSSERALGRGA
GLAYVIEAVQEFRREDATTPVVLMGYLNPIEIHGTRRFAETAVAAGIDGVLLVDLPPEEADETRAIFTEVGLALIALASP
TTGEARLDMLCSTAQGYLYYVSFSGVTGAADRLDTHAASDRLRQLRARAGAPVVAGFGIKDAASAAAMAVDADGVVVGSA
LVAALADASDVRSARKRAEDFLQPLRQALDAG
>Mature_271_residues
SRAPDRIAACFDALRHSGRKALIPFITAGDPSLEATVPVMHALVRAGANIIELGVPFSDPMADGPTIQRSSERALGRGAG
LAYVIEAVQEFRREDATTPVVLMGYLNPIEIHGTRRFAETAVAAGIDGVLLVDLPPEEADETRAIFTEVGLALIALASPT
TGEARLDMLCSTAQGYLYYVSFSGVTGAADRLDTHAASDRLRQLRARAGAPVVAGFGIKDAASAAAMAVDADGVVVGSAL
VAALADASDVRSARKRAEDFLQPLRQALDAG

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=216, Percent_Identity=35.1851851851852, Blast_Score=133, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321412, Length=250, Percent_Identity=40.4, Blast_Score=185, Evalue=7e-48,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_XANC8 (Q4UWD0)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242663.1
- HSSP:   P42390
- ProteinModelPortal:   Q4UWD0
- SMR:   Q4UWD0
- STRING:   Q4UWD0
- GeneID:   3380184
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1577
- eggNOG:   COG0159
- HOGENOM:   HBG391690
- OMA:   VILMTYY
- PhylomeDB:   Q4UWD0
- ProtClustDB:   PRK13111
- BioCyc:   XCAM314565:XC_1577-MONOMER
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28397; Mature: 28265

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 53-53 ACT_SITE 64-64

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAPDRIAACFDALRHSGRKALIPFITAGDPSLEATVPVMHALVRAGANIIELGVPFSD
CCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCC
PMADGPTIQRSSERALGRGAGLAYVIEAVQEFRREDATTPVVLMGYLNPIEIHGTRRFAE
CCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCHHHHH
TAVAAGIDGVLLVDLPPEEADETRAIFTEVGLALIALASPTTGEARLDMLCSTAQGYLYY
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEE
VSFSGVTGAADRLDTHAASDRLRQLRARAGAPVVAGFGIKDAASAAAMAVDADGVVVGSA
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHEEECCCCCHHHHH
LVAALADASDVRSARKRAEDFLQPLRQALDAG
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRAPDRIAACFDALRHSGRKALIPFITAGDPSLEATVPVMHALVRAGANIIELGVPFSD
CCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCC
PMADGPTIQRSSERALGRGAGLAYVIEAVQEFRREDATTPVVLMGYLNPIEIHGTRRFAE
CCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCHHHHH
TAVAAGIDGVLLVDLPPEEADETRAIFTEVGLALIALASPTTGEARLDMLCSTAQGYLYY
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEE
VSFSGVTGAADRLDTHAASDRLRQLRARAGAPVVAGFGIKDAASAAAMAVDADGVVVGSA
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHEEECCCCCHHHHH
LVAALADASDVRSARKRAEDFLQPLRQALDAG
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA