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The map label for this gene is holA [H]

Identifier: 66767825

GI number: 66767825

Start: 1805131

End: 1806159

Strand: Direct

Name: holA [H]

Synonym: XC_1499

Alternate gene names: 66767825

Gene position: 1805131-1806159 (Clockwise)

Preceding gene: 66767824

Following gene: 66767826

Centisome position: 35.06

GC content: 69.19

Gene sequence:

>1029_bases
ATGGAACTTCGCCCAGAGCAGCTGGCCGGCCAGTCCAGCCAGCCGTTGCAGCCGGTCTATCTGATTGCCGGCCCGGAAAC
CTTGCGTGTGCTGGAGGCCGCCGACGCGGTGCGCGCCCGCGCGCGCGCCGAAGGCATCAGTGAACGCGAAGTGTTCGACG
CCGACGGGCGTGAGTTCGACTGGAACCAGCTGGACGCCAGCTTCAATGCGCCCAGCCTGTTCAGCCCGCGCCGCCTGGTC
GAGGTACGCATGCCCAGCGGCAAGCCGGGCAAGGACGGCGCCGAGGTCATCACCCGGTTCTGCGCCAACCCGCCGCCGGA
CGTGGTGCTACTGATCACCGCCAACGACTGGAGCAAGGCGCACCAAGGCAAATGGGCCGATGCGGTCGGGCGGATCGGCA
CCATCGCCGTGGCCTGGCCGATCAAACCGCATGAGTTATCGGACTGGATTGAGCGCCGCCTACGTGCGCAGGGCTTGCGC
GCCGATGCGGCCGCGGTGCAGCGGCTGAGCGAGCGGGTGGAAGGCAACCTGCTGGCCGCTGCGCAGGAGATCGACAAGCT
CGCGTTGCTGGCCGATGGCAAGGTGCTGGATCTGGAGGCGATGGAATCGCTGGTGGCCGATGCCGCCCGTTACGACGTCT
TCCGCCTGGCCGAAACCACTTTTTCCGGGCAGCCGGCCGCGGTGGTGCGCATGCTCGCCGGCCTGCGCGCCGAAGGCGAG
GCAGTCGCGGCGCTGATGCCCATCCTGATCAAGGAATTGCTGCGCACCGCTTCCCTGGCCAAGGTGCAGGCCGGCGGCGG
CAACCTGGGCGCCGAAATGAAGGCCCAGGGCATCTGGGAATCCCGCCAGGCACCGTTCAAGCGCGCCTTGCAACGGCATC
CCGAGCCGCGCCGATGGGAGCGCTTCGTCGCCGAGGCCGGGCTGGTCGATCGCATGGCCAAGGGGCGCGCCGAGGGTGAC
CCCTGGGTGGCGCTGGAACGCCTGCTGGTCGCTGTCGCCGAAGCCCGCGCGGTGAGATTGCTGGCGTGA

Upstream 100 bases:

>100_bases
GGTGCAGCCGTCCGGCACGCCGGAGTCGAGCGTGCCGGCCTCGCTGCCGCCCGCACCGCAGCCGTCGAACAACAACTAAG
CGCTCGCGCGCTTTTCGTCC

Downstream 100 bases:

>100_bases
CAGCGGGGCAGGCCGGAACTGCTGAGCGGGGCGCCGGCGCCGCAGAGCGAGAGCCTCCAACCGCAGCGCAAGGCGCACGG
CCGGTACCTCCCACCGGCGT

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGISEREVFDADGREFDWNQLDASFNAPSLFSPRRLV
EVRMPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSKAHQGKWADAVGRIGTIAVAWPIKPHELSDWIERRLRAQGLR
ADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKVLDLEAMESLVADAARYDVFRLAETTFSGQPAAVVRMLAGLRAEGE
AVAALMPILIKELLRTASLAKVQAGGGNLGAEMKAQGIWESRQAPFKRALQRHPEPRRWERFVAEAGLVDRMAKGRAEGD
PWVALERLLVAVAEARAVRLLA

Sequences:

>Translated_342_residues
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGISEREVFDADGREFDWNQLDASFNAPSLFSPRRLV
EVRMPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSKAHQGKWADAVGRIGTIAVAWPIKPHELSDWIERRLRAQGLR
ADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKVLDLEAMESLVADAARYDVFRLAETTFSGQPAAVVRMLAGLRAEGE
AVAALMPILIKELLRTASLAKVQAGGGNLGAEMKAQGIWESRQAPFKRALQRHPEPRRWERFVAEAGLVDRMAKGRAEGD
PWVALERLLVAVAEARAVRLLA
>Mature_342_residues
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGISEREVFDADGREFDWNQLDASFNAPSLFSPRRLV
EVRMPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSKAHQGKWADAVGRIGTIAVAWPIKPHELSDWIERRLRAQGLR
ADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKVLDLEAMESLVADAARYDVFRLAETTFSGQPAAVVRMLAGLRAEGE
AVAALMPILIKELLRTASLAKVQAGGGNLGAEMKAQGIWESRQAPFKRALQRHPEPRRWERFVAEAGLVDRMAKGRAEGD
PWVALERLLVAVAEARAVRLLA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=294, Percent_Identity=31.6326530612245, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37347; Mature: 37347

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGISEREVFDADGREFD
CCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCC
WNQLDASFNAPSLFSPRRLVEVRMPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSKA
HHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHH
HQGKWADAVGRIGTIAVAWPIKPHELSDWIERRLRAQGLRADAAAVQRLSERVEGNLLAA
HCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHH
AQEIDKLALLADGKVLDLEAMESLVADAARYDVFRLAETTFSGQPAAVVRMLAGLRAEGE
HHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCH
AVAALMPILIKELLRTASLAKVQAGGGNLGAEMKAQGIWESRQAPFKRALQRHPEPRRWE
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCHHHCCCHHHHHHHCCCCHHHHH
RFVAEAGLVDRMAKGRAEGDPWVALERLLVAVAEARAVRLLA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGISEREVFDADGREFD
CCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCC
WNQLDASFNAPSLFSPRRLVEVRMPSGKPGKDGAEVITRFCANPPPDVVLLITANDWSKA
HHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHH
HQGKWADAVGRIGTIAVAWPIKPHELSDWIERRLRAQGLRADAAAVQRLSERVEGNLLAA
HCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHH
AQEIDKLALLADGKVLDLEAMESLVADAARYDVFRLAETTFSGQPAAVVRMLAGLRAEGE
HHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCH
AVAALMPILIKELLRTASLAKVQAGGGNLGAEMKAQGIWESRQAPFKRALQRHPEPRRWE
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCHHHCCCHHHHHHHCCCCHHHHH
RFVAEAGLVDRMAKGRAEGDPWVALERLLVAVAEARAVRLLA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]