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The map label for this gene is creC [H]

Identifier: 66767747

GI number: 66767747

Start: 1715865

End: 1717298

Strand: Direct

Name: creC [H]

Synonym: XC_1421

Alternate gene names: 66767747

Gene position: 1715865-1717298 (Clockwise)

Preceding gene: 66767746

Following gene: 66767749

Centisome position: 33.33

GC content: 67.85

Gene sequence:

>1434_bases
ATGCGGCTCGGACTCAAGCTGTTTCTCGGGTTCTTTCTGATCGTCGGGCTGGCCGCGTTCTTCGTGATGCGGGTGTTCGT
CAACGAGGTCAAGCCGGGCGTGCGCCAGGCGATGGAATCCACGTTGGTGGACGCGGCCAACGTGCTGGCCGAGATGGCCA
GCCCCGAGCTTGCGGCCGGGCAGATTGCCACCGGCCGCTTTGCGCGCCACCTGGCACAGGCCCAGCAGCGCGACCCCAAG
GCCTGGGTGTGGCGCTTCCGCAAGAACAACGTGGATTACCGCGTCACCGTGACCGATGCGCGTGGTGTGGTGGTGTTCGA
TTCGCTGGGCCGCGACGTCGGCCGCGACAACTCGCGCTGGAACGATGTCTACCGCACCTTGCGCGGCGAATACGGCGCGC
GCTCCAGTCCGGAGCTGGATGGCACCCCCGGCGCCACGGTGATGCATGTGGCCGCACCGATCTATGCGCCTGACGCACCG
GGCACACTGATCGGCGTGCTCACGCTGGCGCAGCCCAATCGCAGCATCGACCCCTTCATCGAAGCCAGCCAGCGCAACAT
CCTGCAACGTGGCGCCTGGTTGATCGGCATTTCCGCATTGATCGGCATCGGCATGACCTGGTGGCTGATGCGCGGCATCG
GCCGGTTGAATCGCTATGCGCAGGCGGTGAGCGCGGGCATCCCGGTGCCGCCGCCCAAGCCGCGCGGCGATGAAATCGGC
GACCTGGGCCAGGCGCTGGAAACCATGCGCCGCAAGCTGGAGGGCAAGGCCTACGTCGAGCACTACGTGCAATCGCTGAC
GCACGAGATGAAAAGCCCGCTGGCGGCCATTCGTGGCGCCTCGGAGCTGTTGACCGAGCCATTGCCGGAGTGCGACCGCC
AGCATTTTGTGGCCAGCATCCGCGCCCAGGAGCAGCGCCTGACCGAAACCATCGACAAGCTGCTCGCCCTGGCCGAGGTT
GAACAACACGGCTGGCTGCAGACCCGTGTGCGCGTGGCCGTGCCTGGCGTGTTGCAGGCTGCGGTGGACGCGGTATTGCT
GCGCGCCGCTGGCGCCGGCGTGCTGGTGGAGCTCGATGCGGCAAGCATGGCCGCCAGCGACCAGGCCGTGCTCGGCGATG
CCTTCCTGCTGCGGCAGGCCGTGATCAACCTGCTGGAAAACGCCATCGCCTTCTCGCCGGACGGCGGCACCGTGCAGCTG
CGCACGCAGCGGGAGGACGGGCAGGTGCAGCTGTTGGTCGAAGACCGCGGCAGTGGCGTGCCCGATTACGCGATCGAACG
CGTGTTCGAGCGGTTCTATTCGCTGGCGCGCCCGCAGACCGGGCAACGCAGTTCCGGCCTGGGCTTGCCGTTCGTGCGTG
AGGTGGCCCGCCTGCACGGCGGCGACGTGCGCCTGCGCAATCGCGACGGCGGCGGTGCGATCGCCACCTTGTGA

Upstream 100 bases:

>100_bases
CCAAATGCGTCGGCTGTTGACGGCTACTTGACCACGCGGTGTTCGACTCACGACCACGTGCACACAGCTGCGTGCGCAGC
CAACGGGATTCGGTGCTGAC

Downstream 100 bases:

>100_bases
TTGCCCATCGCGTAAATCCCGCTGCAGGCCAGGTGCGACCTGCTGGCAACTTGCGGCGGCTGGCTGCCGCGTGGATGCGG
CAGGTGCCGGAGCACATGCC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASPELAAGQIATGRFARHLAQAQQRDPK
AWVWRFRKNNVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPELDGTPGATVMHVAAPIYAPDAP
GTLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISALIGIGMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
DLGQALETMRRKLEGKAYVEHYVQSLTHEMKSPLAAIRGASELLTEPLPECDRQHFVASIRAQEQRLTETIDKLLALAEV
EQHGWLQTRVRVAVPGVLQAAVDAVLLRAAGAGVLVELDAASMAASDQAVLGDAFLLRQAVINLLENAIAFSPDGGTVQL
RTQREDGQVQLLVEDRGSGVPDYAIERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVRLRNRDGGGAIATL

Sequences:

>Translated_477_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASPELAAGQIATGRFARHLAQAQQRDPK
AWVWRFRKNNVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPELDGTPGATVMHVAAPIYAPDAP
GTLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISALIGIGMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
DLGQALETMRRKLEGKAYVEHYVQSLTHEMKSPLAAIRGASELLTEPLPECDRQHFVASIRAQEQRLTETIDKLLALAEV
EQHGWLQTRVRVAVPGVLQAAVDAVLLRAAGAGVLVELDAASMAASDQAVLGDAFLLRQAVINLLENAIAFSPDGGTVQL
RTQREDGQVQLLVEDRGSGVPDYAIERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVRLRNRDGGGAIATL
>Mature_477_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASPELAAGQIATGRFARHLAQAQQRDPK
AWVWRFRKNNVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPELDGTPGATVMHVAAPIYAPDAP
GTLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISALIGIGMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
DLGQALETMRRKLEGKAYVEHYVQSLTHEMKSPLAAIRGASELLTEPLPECDRQHFVASIRAQEQRLTETIDKLLALAEV
EQHGWLQTRVRVAVPGVLQAAVDAVLLRAAGAGVLVELDAASMAASDQAVLGDAFLLRQAVINLLENAIAFSPDGGTVQL
RTQREDGQVQLLVEDRGSGVPDYAIERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVRLRNRDGGGAIATL

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=481, Percent_Identity=46.3617463617464, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=28.3842794759825, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=28.4, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=26.4462809917355, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789403, Length=290, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI48994928, Length=222, Percent_Identity=24.7747747747748, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=26.5060240963855, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=206, Percent_Identity=24.7572815533981, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082128, Length=303, Percent_Identity=25.4125412541254, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=287, Percent_Identity=26.4808362369338, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=26.3392857142857, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=25.4310344827586, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788279, Length=260, Percent_Identity=23.4615384615385, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786912, Length=212, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=256, Percent_Identity=25.390625, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790300, Length=214, Percent_Identity=27.1028037383178, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52019; Mature: 52019

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASPELAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QIATGRFARHLAQAQQRDPKAWVWRFRKNNVDYRVTVTDARGVVVFDSLGRDVGRDNSRW
CHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCEEEEHHHCCCCCCCCCHH
NDVYRTLRGEYGARSSPELDGTPGATVMHVAAPIYAPDAPGTLIGVLTLAQPNRSIDPFI
HHHHHHHHCCCCCCCCCCCCCCCCCEEHEEECCCCCCCCCCCEEEEEEECCCCCCCCHHH
EASQRNILQRGAWLIGISALIGIGMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DLGQALETMRRKLEGKAYVEHYVQSLTHEMKSPLAAIRGASELLTEPLPECDRQHFVASI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
RAQEQRLTETIDKLLALAEVEQHGWLQTRVRVAVPGVLQAAVDAVLLRAAGAGVLVELDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEECH
ASMAASDQAVLGDAFLLRQAVINLLENAIAFSPDGGTVQLRTQREDGQVQLLVEDRGSGV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEECCCCCC
PDYAIERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVRLRNRDGGGAIATL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEMASPELAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QIATGRFARHLAQAQQRDPKAWVWRFRKNNVDYRVTVTDARGVVVFDSLGRDVGRDNSRW
CHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCEEEEHHHCCCCCCCCCHH
NDVYRTLRGEYGARSSPELDGTPGATVMHVAAPIYAPDAPGTLIGVLTLAQPNRSIDPFI
HHHHHHHHCCCCCCCCCCCCCCCCCEEHEEECCCCCCCCCCCEEEEEEECCCCCCCCHHH
EASQRNILQRGAWLIGISALIGIGMTWWLMRGIGRLNRYAQAVSAGIPVPPPKPRGDEIG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DLGQALETMRRKLEGKAYVEHYVQSLTHEMKSPLAAIRGASELLTEPLPECDRQHFVASI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
RAQEQRLTETIDKLLALAEVEQHGWLQTRVRVAVPGVLQAAVDAVLLRAAGAGVLVELDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEECH
ASMAASDQAVLGDAFLLRQAVINLLENAIAFSPDGGTVQLRTQREDGQVQLLVEDRGSGV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEECCCCCC
PDYAIERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVRLRNRDGGGAIATL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]