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The map label for this gene is hemE [H]

Identifier: 66767592

GI number: 66767592

Start: 1554152

End: 1555216

Strand: Reverse

Name: hemE [H]

Synonym: XC_1265

Alternate gene names: 66767592

Gene position: 1555216-1554152 (Counterclockwise)

Preceding gene: 66767593

Following gene: 66767591

Centisome position: 30.21

GC content: 67.79

Gene sequence:

>1065_bases
ATGCTCAAGAACGACCGTCTGTTGCGTGCCCTGCGCCGCCAGCCCGTGGACCGCACCCCCGTCTGGCTGATGCGCCAGGC
AGGCCGCTATTTGCCGGAATACCGCGCCACCCGCGCGCGCGCCGGCAGTTTCCTGGGCATGGCCAAGAACCCGGACATCG
CCTGCGAAGTCACCCTGCAACCGCTGGAACGCTTTCCGCTGGATGCGGCGATCCTGTTCTCCGACATCCTGACCATCCCC
GATGCGATGGGGCTGGAGCTGTATTTCGTCGAAGGCGAAGGCCCCAAGTTCCGCCACCCGGTGCGCGACGCCGACGCCAT
CCATCGCCTCGGCGTGCCGGACATGGAAACCGAGCTGCGCTACGTGATGGACGCGGTGCGCTTGATCCGCCGCGAGCTGG
ATGGCGCGGTACCGCTGATCGGCTTCTCCGGCAGCCCGTGGACGCTGGCCTGCTACATGATCGAAGGCGGCGGCAGCAAG
GAATATGCGCGCATCAAGGCCATGGCCTTCAACGCGCCGCAGCTGCTGCACCACCTGCTCAGCACCGTCACCGATGCGGT
GATCGCCTACCTGTCCGCACAGCGCGCGGCCGGTGCGCAGGCGCTGCAGGTGTTCGATACCTGGGGCGGCGTGTTGTCGC
CGGCGATGTACCGCGAATTCTCGTTGCCCTACCTCACCCGCATCGCCCAGGAACTGGAGCGCGGCAGCGGCGAAGAGCGC
ACCCCGCTGGTGCTGTTCGGCAAGGGCAATGGCGCCTATGTGTCCGAGCTGGCCGCCAGCGGTGCCGAAGCGGTGGGCGT
GGACTGGACGATCTCGCTGGCCGACGCCGCTGAACGCGCCGGCGGCCGTGTCGCCCTGCAAGGCAACCTGGACCCGGCCA
CGCTGTACGGCTCGCCCGACGCAATCCGCAGCGAAGTCGGCAAGACCCTGGACAGCTACGCGTACGGCAACGGCGGCTCG
CGCGAAGGCCACGTCTTCAACCTCGGCCACGGCATGTCGCCGGACATGAATCCGGATCACGTTGGCGTGCTGGTGGAAGC
GGTGCAGACGCTGAGCAAGCGGTGA

Upstream 100 bases:

>100_bases
GGCGGACCGGGCCTTCGAAAAGGCCCGCGACACCCAACTCAAACGCGGCTTCCATGTCATCACCGGCGGCGCCGACGCGC
CGCGCTGAGGAATCACCTCC

Downstream 100 bases:

>100_bases
AGTAGCAAGCGATCGACAGCCACTGCTGTCGATCGTGCACGATGTCGGTCTGGCTCATGGTGACGACCGATGTCGTGCGA
TGGGATGCTGTCCGCGCGAT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MLKNDRLLRALRRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQPLERFPLDAAILFSDILTIP
DAMGLELYFVEGEGPKFRHPVRDADAIHRLGVPDMETELRYVMDAVRLIRRELDGAVPLIGFSGSPWTLACYMIEGGGSK
EYARIKAMAFNAPQLLHHLLSTVTDAVIAYLSAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIAQELERGSGEER
TPLVLFGKGNGAYVSELAASGAEAVGVDWTISLADAAERAGGRVALQGNLDPATLYGSPDAIRSEVGKTLDSYAYGNGGS
REGHVFNLGHGMSPDMNPDHVGVLVEAVQTLSKR

Sequences:

>Translated_354_residues
MLKNDRLLRALRRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQPLERFPLDAAILFSDILTIP
DAMGLELYFVEGEGPKFRHPVRDADAIHRLGVPDMETELRYVMDAVRLIRRELDGAVPLIGFSGSPWTLACYMIEGGGSK
EYARIKAMAFNAPQLLHHLLSTVTDAVIAYLSAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIAQELERGSGEER
TPLVLFGKGNGAYVSELAASGAEAVGVDWTISLADAAERAGGRVALQGNLDPATLYGSPDAIRSEVGKTLDSYAYGNGGS
REGHVFNLGHGMSPDMNPDHVGVLVEAVQTLSKR
>Mature_354_residues
MLKNDRLLRALRRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQPLERFPLDAAILFSDILTIP
DAMGLELYFVEGEGPKFRHPVRDADAIHRLGVPDMETELRYVMDAVRLIRRELDGAVPLIGFSGSPWTLACYMIEGGGSK
EYARIKAMAFNAPQLLHHLLSTVTDAVIAYLSAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIAQELERGSGEER
TPLVLFGKGNGAYVSELAASGAEAVGVDWTISLADAAERAGGRVALQGNLDPATLYGSPDAIRSEVGKTLDSYAYGNGGS
REGHVFNLGHGMSPDMNPDHVGVLVEAVQTLSKR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=356, Percent_Identity=47.752808988764, Blast_Score=330, Evalue=1e-90,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=58.6402266288952, Blast_Score=421, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6320252, Length=360, Percent_Identity=41.3888888888889, Blast_Score=289, Evalue=4e-79,
Organism=Drosophila melanogaster, GI221330099, Length=352, Percent_Identity=43.75, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI19921920, Length=352, Percent_Identity=43.75, Blast_Score=285, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38590; Mature: 38590

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNDRLLRALRRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQ
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCCCEEEEEEEC
PLERFPLDAAILFSDILTIPDAMGLELYFVEGEGPKFRHPVRDADAIHRLGVPDMETELR
HHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHH
YVMDAVRLIRRELDGAVPLIGFSGSPWTLACYMIEGGGSKEYARIKAMAFNAPQLLHHLL
HHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCCCCCHHEEEEEECCCHHHHHHHH
STVTDAVIAYLSAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIAQELERGSGEER
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHCCCCCC
TPLVLFGKGNGAYVSELAASGAEAVGVDWTISLADAAERAGGRVALQGNLDPATLYGSPD
CCEEEEECCCCHHHHHHHHCCCCEECCEEEEEHHHHHHHCCCEEEEECCCCCEEECCCHH
AIRSEVGKTLDSYAYGNGGSREGHVFNLGHGMSPDMNPDHVGVLVEAVQTLSKR
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKNDRLLRALRRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQ
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCCCEEEEEEEC
PLERFPLDAAILFSDILTIPDAMGLELYFVEGEGPKFRHPVRDADAIHRLGVPDMETELR
HHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHH
YVMDAVRLIRRELDGAVPLIGFSGSPWTLACYMIEGGGSKEYARIKAMAFNAPQLLHHLL
HHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCCCCCHHEEEEEECCCHHHHHHHH
STVTDAVIAYLSAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIAQELERGSGEER
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHCCCCCC
TPLVLFGKGNGAYVSELAASGAEAVGVDWTISLADAAERAGGRVALQGNLDPATLYGSPD
CCEEEEECCCCHHHHHHHHCCCCEECCEEEEEHHHHHHHCCCEEEEECCCCCEEECCCHH
AIRSEVGKTLDSYAYGNGGSREGHVFNLGHGMSPDMNPDHVGVLVEAVQTLSKR
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]