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The map label for this gene is flp [H]

Identifier: 66767562

GI number: 66767562

Start: 1509985

End: 1511364

Strand: Reverse

Name: flp [H]

Synonym: XC_1235

Alternate gene names: 66767562

Gene position: 1511364-1509985 (Counterclockwise)

Preceding gene: 66767565

Following gene: 66767552

Centisome position: 29.35

GC content: 67.39

Gene sequence:

>1380_bases
ATGACAGAAATACGCAGGCGCCGACGGTTCCGTCCGTTGGCCGTTGGGCTGTTCGGGGCATTGCTGCCTCTGGCGCTTTC
TTCCACCGCGCAGACCCCTGCCCTGACTGCCAATAGCTTGCAGCCGGCGACCGCCGCGCAGTCGCCCACTGCTCCGTTGC
CTTACCGCACGTCGCTGCCTGCCAGCAGCGTGCTGGCGCCTGCCGCTGGCTTCGATGTGCCTTCGTTCGAGTCGATGGCC
GACCAGCTCACCTACGGCAACCGCGTACCTGGCATGGCGATGGCCATCGTGCAGGGCGGCAAGGTGCTCAGCGCGCGCGG
CTATGGCGTCACCGACGTCAATCATCCGCAGCCTGTCGACGGCCACACCGTGTTCCGGCTGGCGTCGTTGTCCAAGGCAT
TTGCCGGCACCATGGCCGGGCTGCTGGTCAACGACGGCGTGCTGCGCTGGGACAGCAAGGTGGTGGACTACGTCCCCGGC
TTCCAGCTCAGCGACTCCACTGCCACCCGTCAGCTCACCGTAGCCGAAGTCCTCAGCCACCGCGTCGGCCTGACCCGCAA
CGCCTACGACCGCGACATCGAATCCAACGCCGACTACTACTCGCTCAGCCACAAGCTGGCAGCCGCGCCACTGCGCTGCG
CGCCTGGCGATTGCTATGCCTACCAGAACGTCGCCTTCAGCCTGGTCGGTGATGTGGTGTTCGCGGCATCGGGCAGCTTC
TATGAGCAATCAGTGGAGCGCCGCATCTTCAAGCCGCTGGGCATGAACGATGCCAGCATGGGCCTGGCCGGTATCCAGGC
CAGCCCGCATTGGGCACGCCCGCATGTGCGCAGCCGCAATGGCTGGGTGTCGCTGACGCCCAAGCCGACCTACTACCGCC
TGGCACCGGCCGCCGGCGTCAATGCCAGCGCCAGCGACATGGCGCAGTGGCTGCTCGCCCACACCGGGCATCGCACCGAC
GTCCTGCCTGCGCCGCTGCTGGCGACATTGCACGCACCGCTGATCTCCACACCGGGCGAAATGCGCTCGGGCTGGCGCCA
CGAGCGCGTGGACGCAGCCAGCTATGCACTGGGCTGGCGCGTGTTCGACTACGCCGGGCATCAGGTGATCTTCCACGCCG
GCGCCGTGCAGGGCTATCGCGGCCTGGTGGCGTTGCTGCCCGAACGCGACCTCGGCATTGCCATCATGTGGAACGGCGAA
AGCGGCCTGCCCTCGGGCATGCTGCCGACCATCCTGGATCGCGCGCTTGGCCTGCCGGCCAAGCGTTGGCTGGATATCGA
TGTGGACGGCGACTTCGGCAGCGAGAACATGCTGGCCGAGCGTCCGGATCCTGCCGGTAAGGGCGCCTCGTCCGGCAAGT
CGGTGGCATCGCCGCGCTGA

Upstream 100 bases:

>100_bases
CAATAGGATCAATACGATGCCCATTCATCTTCCGGCAGTTTGTGCTATTGCAAAGCGCGGCGCTAGAATCGCCGGAGGCA
GTGGAACAGGCGGGAACACC

Downstream 100 bases:

>100_bases
CCTGGTGGCTGGATAACGCATAGATCGAAAGGCGGCTTCGGCCGCCTTTTTTGTTGCCTTGTTGGGAGGCGGTGCGATGG
ATTTCGTGGCAGCCGATCGC

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTEIRRRRRFRPLAVGLFGALLPLALSSTAQTPALTANSLQPATAAQSPTAPLPYRTSLPASSVLAPAAGFDVPSFESMA
DQLTYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVDGHTVFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPG
FQLSDSTATRQLTVAEVLSHRVGLTRNAYDRDIESNADYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSF
YEQSVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGVNASASDMAQWLLAHTGHRTD
VLPAPLLATLHAPLISTPGEMRSGWRHERVDAASYALGWRVFDYAGHQVIFHAGAVQGYRGLVALLPERDLGIAIMWNGE
SGLPSGMLPTILDRALGLPAKRWLDIDVDGDFGSENMLAERPDPAGKGASSGKSVASPR

Sequences:

>Translated_459_residues
MTEIRRRRRFRPLAVGLFGALLPLALSSTAQTPALTANSLQPATAAQSPTAPLPYRTSLPASSVLAPAAGFDVPSFESMA
DQLTYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVDGHTVFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPG
FQLSDSTATRQLTVAEVLSHRVGLTRNAYDRDIESNADYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSF
YEQSVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGVNASASDMAQWLLAHTGHRTD
VLPAPLLATLHAPLISTPGEMRSGWRHERVDAASYALGWRVFDYAGHQVIFHAGAVQGYRGLVALLPERDLGIAIMWNGE
SGLPSGMLPTILDRALGLPAKRWLDIDVDGDFGSENMLAERPDPAGKGASSGKSVASPR
>Mature_458_residues
TEIRRRRRFRPLAVGLFGALLPLALSSTAQTPALTANSLQPATAAQSPTAPLPYRTSLPASSVLAPAAGFDVPSFESMAD
QLTYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVDGHTVFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPGF
QLSDSTATRQLTVAEVLSHRVGLTRNAYDRDIESNADYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSFY
EQSVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGVNASASDMAQWLLAHTGHRTDV
LPAPLLATLHAPLISTPGEMRSGWRHERVDAASYALGWRVFDYAGHQVIFHAGAVQGYRGLVALLPERDLGIAIMWNGES
GLPSGMLPTILDRALGLPAKRWLDIDVDGDFGSENMLAERPDPAGKGASSGKSVASPR

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=382, Percent_Identity=21.7277486910995, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786574, Length=256, Percent_Identity=26.953125, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082101, Length=328, Percent_Identity=22.2560975609756, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=279, Percent_Identity=25.4480286738351, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533026, Length=349, Percent_Identity=22.3495702005731, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 49071; Mature: 48940

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIRRRRRFRPLAVGLFGALLPLALSSTAQTPALTANSLQPATAAQSPTAPLPYRTSLP
CCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCC
ASSVLAPAAGFDVPSFESMADQLTYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVD
HHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCC
GHTVFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPGFQLSDSTATRQLTVAEVLSH
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCEECCCCHHHHHHHHHHHHH
RVGLTRNAYDRDIESNADYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSF
HCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
YEQSVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGV
HHHHHHHHHHHCCCCCCHHCCEECCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCC
NASASDMAQWLLAHTGHRTDVLPAPLLATLHAPLISTPGEMRSGWRHERVDAASYALGWR
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHE
VFDYAGHQVIFHAGAVQGYRGLVALLPERDLGIAIMWNGESGLPSGMLPTILDRALGLPA
EEECCCCEEEEECCCHHCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCH
KRWLDIDVDGDFGSENMLAERPDPAGKGASSGKSVASPR
HHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEIRRRRRFRPLAVGLFGALLPLALSSTAQTPALTANSLQPATAAQSPTAPLPYRTSLP
CHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCC
ASSVLAPAAGFDVPSFESMADQLTYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVD
HHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCC
GHTVFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPGFQLSDSTATRQLTVAEVLSH
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCEECCCCHHHHHHHHHHHHH
RVGLTRNAYDRDIESNADYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSF
HCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
YEQSVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGV
HHHHHHHHHHHCCCCCCHHCCEECCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCC
NASASDMAQWLLAHTGHRTDVLPAPLLATLHAPLISTPGEMRSGWRHERVDAASYALGWR
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHE
VFDYAGHQVIFHAGAVQGYRGLVALLPERDLGIAIMWNGESGLPSGMLPTILDRALGLPA
EEECCCCEEEEECCCHHCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCH
KRWLDIDVDGDFGSENMLAERPDPAGKGASSGKSVASPR
HHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA