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The map label for this gene is cysJ [H]

Identifier: 66767324

GI number: 66767324

Start: 1190704

End: 1192551

Strand: Reverse

Name: cysJ [H]

Synonym: XC_0992

Alternate gene names: 66767324

Gene position: 1192551-1190704 (Counterclockwise)

Preceding gene: 66767334

Following gene: 66767323

Centisome position: 23.16

GC content: 69.26

Gene sequence:

>1848_bases
ATGACCGCCGCCAGCCCCGCCGTGCCGCCCAGCCCCTTGCCCGACGAGCGCAAGGCGCTGCTGGAGCGTCTGGTCGACGG
TCTGGATGCCCCGTCCCTGTGGTGGCTGTCCGGGTATACCGCCGGCTTGGCGCAGGGTCACCCGCCGCGCTCGCTGGCGG
TACTGCCGGGTGGCCAGGTGCATGCGGTAGCGCACGAGAGCCAGCGCCTGACCGTGTTGTACGGCAGCCAGACCGGCAAT
GCCCGGCGGCAGGCCGAGCAACTGGCCGCCGAGGCCGAGGCCGCCGGAGTGAGCGTGCGCCTGCTGCGTGCCGATGCCTA
CCCCACCCGCGAGCTGGCCAGCGAACGCCTGTTGTACGTGGTGATCAGCACCCAGGGCGAAGGCGATCCGCCGGATGATG
CGATTGGCCTGGTCGAGTTCCTGAGCGGGCGCCGCGCGCCCAAGCTGCCGGAGCTCAAGTACGCGGTGCTGGGCCTGGGC
GATTCCAGCTACGCCGATTTCTGCGGCATTGCGCGGCGGATCGACGAACGCCTGGCCGAACTCGGCGGCAGCCGCGTGCA
ACCGCGCGGCGAAGCCGACCTGGACATCGACAGCGTCGCCACTCCCTGGCGCACGCATGCGCTGCGGCATGCGCGCGAGC
AGCTCAAGAGTGCCCAGCCATCGGCCACGGTCACGCCGCTGCGCAGCCAGCCGGCCGCGCCGGTGTGGTCGCAGCAGCAC
CCGTTCGCCGCCGAGTTGCTGGCCAACCAGATCATCAGCGGGCGCGATTTCAAGGGCCCGGGCTTCCGTGTCTATGGCCC
GGCGATCAAGCGGGTGCGCCACCTGGAGTTCTCGTTGGACGGCAGCGGGCTCAGCTACGAGCCCGGCGATGCGCTCGGCA
TCCGTCACCGCAACCCGCCTGCCTTGGTCGATGCGGTGCTGGAAAGCCTGCGCCTGGATGGTCATGCGTCGGTCACCATC
GGCGAGGACACTCTGGCCTTGAACGAGTGGCTTGCCACGCGGCGCGAGCTGACCAAGCTCTCGCGGCCCTTCCTGGCTGC
GCACGCCGAACGTGCCCATGCAGACGATCTGCAGGCGCTGCTCACCCAGACCCAGACTGCCGGCCTGGCGTCGCTGCTCT
CCGATCACCAGTTGATCGACGTGTTGCGACGCTGGCCGGCGGATTGGGACCACGGCGGCCTGCTGGCCGCCCTGCGTCCG
CTCACCCCACGCCTGTATTCCATCGCCTCCAGCCGCAAGCGCGTGGGCGAGGAAGTACACCTGGTGGTGGATGAACTGCA
TTACCAGGCGCACGGCCATGGGCACGTGGGTTCGGCCAGCGGATTTCTGGCGGCACTGGCCGAAGGCGACACCGCGCCGG
TGTATATCGAACCGAACGAGCGCTTCCGCGTGCCGGCAGATCCGGATCGCGACATCCTGATGATCGGCCCGGGCACCGGC
GTGGCACCGTTCCGCGCATTCGTGCAGGAACGTGCCGAAACCGGCGCCAAGGGACGCAACTGGCTGTTCTTCGGCGCGCA
GCATTTCAACACCGACTTCCTGTATCAGGCCGAATGGCAGCAGGCGCTGCAGCGCGGCGAGCTGCATGCACTGGAACTGG
CGTTCTCGCGCGACGCGGCAGAGAAGATGTACGTGCAACACCGCCTGCGCGCCCGCGGCGCCGAGGTCTATGCCTGGCTG
CAAGGCGGCGCGCACGTGTATGTGTGCGGCGCGATCGGCATGGGCAAGGACGTGCACGCCGCGCTGCTGGACATCGTCGC
CACCCACGGCGCACTCGATGCCGAAGCGGCCGCGGCGTATCTCACCCGCCTGCAGGTGGAGGGACGCTATGCGCGCGATG
TCTACTAG

Upstream 100 bases:

>100_bases
GCCGAAATAAGCACCCGGCATAACGCGATAACGGCTGATCCTTTCTGGCGGAGCGAACGCTTCCCTAACATCGTTCATCC
ATTGCCCTCCCTGGAACCGA

Downstream 100 bases:

>100_bases
TGCCGGGAATCGGGAGTGGGGAATCGGGAATGGGTACGGCCTGCACCCGAATTGTCGCGAGCGACCACGCCGCTTTTCAC
GATTCCCCTTTCCCGATTCC

Product: NADPH-sulfite reductase flavoprotein subunit

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MTAASPAVPPSPLPDERKALLERLVDGLDAPSLWWLSGYTAGLAQGHPPRSLAVLPGGQVHAVAHESQRLTVLYGSQTGN
ARRQAEQLAAEAEAAGVSVRLLRADAYPTRELASERLLYVVISTQGEGDPPDDAIGLVEFLSGRRAPKLPELKYAVLGLG
DSSYADFCGIARRIDERLAELGGSRVQPRGEADLDIDSVATPWRTHALRHAREQLKSAQPSATVTPLRSQPAAPVWSQQH
PFAAELLANQIISGRDFKGPGFRVYGPAIKRVRHLEFSLDGSGLSYEPGDALGIRHRNPPALVDAVLESLRLDGHASVTI
GEDTLALNEWLATRRELTKLSRPFLAAHAERAHADDLQALLTQTQTAGLASLLSDHQLIDVLRRWPADWDHGGLLAALRP
LTPRLYSIASSRKRVGEEVHLVVDELHYQAHGHGHVGSASGFLAALAEGDTAPVYIEPNERFRVPADPDRDILMIGPGTG
VAPFRAFVQERAETGAKGRNWLFFGAQHFNTDFLYQAEWQQALQRGELHALELAFSRDAAEKMYVQHRLRARGAEVYAWL
QGGAHVYVCGAIGMGKDVHAALLDIVATHGALDAEAAAAYLTRLQVEGRYARDVY

Sequences:

>Translated_615_residues
MTAASPAVPPSPLPDERKALLERLVDGLDAPSLWWLSGYTAGLAQGHPPRSLAVLPGGQVHAVAHESQRLTVLYGSQTGN
ARRQAEQLAAEAEAAGVSVRLLRADAYPTRELASERLLYVVISTQGEGDPPDDAIGLVEFLSGRRAPKLPELKYAVLGLG
DSSYADFCGIARRIDERLAELGGSRVQPRGEADLDIDSVATPWRTHALRHAREQLKSAQPSATVTPLRSQPAAPVWSQQH
PFAAELLANQIISGRDFKGPGFRVYGPAIKRVRHLEFSLDGSGLSYEPGDALGIRHRNPPALVDAVLESLRLDGHASVTI
GEDTLALNEWLATRRELTKLSRPFLAAHAERAHADDLQALLTQTQTAGLASLLSDHQLIDVLRRWPADWDHGGLLAALRP
LTPRLYSIASSRKRVGEEVHLVVDELHYQAHGHGHVGSASGFLAALAEGDTAPVYIEPNERFRVPADPDRDILMIGPGTG
VAPFRAFVQERAETGAKGRNWLFFGAQHFNTDFLYQAEWQQALQRGELHALELAFSRDAAEKMYVQHRLRARGAEVYAWL
QGGAHVYVCGAIGMGKDVHAALLDIVATHGALDAEAAAAYLTRLQVEGRYARDVY
>Mature_614_residues
TAASPAVPPSPLPDERKALLERLVDGLDAPSLWWLSGYTAGLAQGHPPRSLAVLPGGQVHAVAHESQRLTVLYGSQTGNA
RRQAEQLAAEAEAAGVSVRLLRADAYPTRELASERLLYVVISTQGEGDPPDDAIGLVEFLSGRRAPKLPELKYAVLGLGD
SSYADFCGIARRIDERLAELGGSRVQPRGEADLDIDSVATPWRTHALRHAREQLKSAQPSATVTPLRSQPAAPVWSQQHP
FAAELLANQIISGRDFKGPGFRVYGPAIKRVRHLEFSLDGSGLSYEPGDALGIRHRNPPALVDAVLESLRLDGHASVTIG
EDTLALNEWLATRRELTKLSRPFLAAHAERAHADDLQALLTQTQTAGLASLLSDHQLIDVLRRWPADWDHGGLLAALRPL
TPRLYSIASSRKRVGEEVHLVVDELHYQAHGHGHVGSASGFLAALAEGDTAPVYIEPNERFRVPADPDRDILMIGPGTGV
APFRAFVQERAETGAKGRNWLFFGAQHFNTDFLYQAEWQQALQRGELHALELAFSRDAAEKMYVQHRLRARGAEVYAWLQ
GGAHVYVCGAIGMGKDVHAALLDIVATHGALDAEAAAAYLTRLQVEGRYARDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI7657393, Length=611, Percent_Identity=31.7512274959083, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI221316709, Length=611, Percent_Identity=31.7512274959083, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI221316705, Length=620, Percent_Identity=31.2903225806452, Blast_Score=216, Evalue=6e-56,
Organism=Homo sapiens, GI24041029, Length=602, Percent_Identity=31.063122923588, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI221316707, Length=532, Percent_Identity=31.390977443609, Blast_Score=200, Evalue=4e-51,
Organism=Homo sapiens, GI127139033, Length=624, Percent_Identity=27.8846153846154, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI40254422, Length=657, Percent_Identity=28.7671232876712, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI10835173, Length=653, Percent_Identity=26.1868300153139, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI169790958, Length=409, Percent_Identity=29.0953545232274, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI169790956, Length=409, Percent_Identity=29.0953545232274, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1789123, Length=614, Percent_Identity=43.3224755700326, Blast_Score=454, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17554134, Length=609, Percent_Identity=28.0788177339901, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17566446, Length=589, Percent_Identity=27.1646859083192, Blast_Score=138, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17531441, Length=392, Percent_Identity=26.2755102040816, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32563863, Length=125, Percent_Identity=37.6, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321832, Length=651, Percent_Identity=27.9569892473118, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321143, Length=381, Percent_Identity=28.0839895013123, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17137192, Length=657, Percent_Identity=28.6149162861492, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24582192, Length=533, Percent_Identity=27.9549718574109, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24583543, Length=674, Percent_Identity=26.4094955489614, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI78706876, Length=674, Percent_Identity=26.4094955489614, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI78706872, Length=674, Percent_Identity=26.4094955489614, Blast_Score=162, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24660907, Length=617, Percent_Identity=28.2009724473258, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24660903, Length=617, Percent_Identity=28.2009724473258, Blast_Score=158, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 66899; Mature: 66768

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAASPAVPPSPLPDERKALLERLVDGLDAPSLWWLSGYTAGLAQGHPPRSLAVLPGGQV
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCHHHHCCCCCCCEEEECCCCCE
HAVAHESQRLTVLYGSQTGNARRQAEQLAAEAEAAGVSVRLLRADAYPTRELASERLLYV
EEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCEEEE
VISTQGEGDPPDDAIGLVEFLSGRRAPKLPELKYAVLGLGDSSYADFCGIARRIDERLAE
EEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
LGGSRVQPRGEADLDIDSVATPWRTHALRHAREQLKSAQPSATVTPLRSQPAAPVWSQQH
HCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCC
PFAAELLANQIISGRDFKGPGFRVYGPAIKRVRHLEFSLDGSGLSYEPGDALGIRHRNPP
CHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCH
ALVDAVLESLRLDGHASVTIGEDTLALNEWLATRRELTKLSRPFLAAHAERAHADDLQAL
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHH
LTQTQTAGLASLLSDHQLIDVLRRWPADWDHGGLLAALRPLTPRLYSIASSRKRVGEEVH
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCHHHH
LVVDELHYQAHGHGHVGSASGFLAALAEGDTAPVYIEPNERFRVPADPDRDILMIGPGTG
HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCEECCCCCCCCEEEECCCCC
VAPFRAFVQERAETGAKGRNWLFFGAQHFNTDFLYQAEWQQALQRGELHALELAFSRDAA
HHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCEEEHHHHHHHHHCCCCEEEEEHHHHHHH
EKMYVQHRLRARGAEVYAWLQGGAHVYVCGAIGMGKDVHAALLDIVATHGALDAEAAAAY
HHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
LTRLQVEGRYARDVY
HHHHHCCCCHHCCCC
>Mature Secondary Structure 
TAASPAVPPSPLPDERKALLERLVDGLDAPSLWWLSGYTAGLAQGHPPRSLAVLPGGQV
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCHHHHCCCCCCCEEEECCCCCE
HAVAHESQRLTVLYGSQTGNARRQAEQLAAEAEAAGVSVRLLRADAYPTRELASERLLYV
EEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCEEEE
VISTQGEGDPPDDAIGLVEFLSGRRAPKLPELKYAVLGLGDSSYADFCGIARRIDERLAE
EEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
LGGSRVQPRGEADLDIDSVATPWRTHALRHAREQLKSAQPSATVTPLRSQPAAPVWSQQH
HCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCC
PFAAELLANQIISGRDFKGPGFRVYGPAIKRVRHLEFSLDGSGLSYEPGDALGIRHRNPP
CHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCH
ALVDAVLESLRLDGHASVTIGEDTLALNEWLATRRELTKLSRPFLAAHAERAHADDLQAL
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHH
LTQTQTAGLASLLSDHQLIDVLRRWPADWDHGGLLAALRPLTPRLYSIASSRKRVGEEVH
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCHHHH
LVVDELHYQAHGHGHVGSASGFLAALAEGDTAPVYIEPNERFRVPADPDRDILMIGPGTG
HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCEECCCCCCCCEEEECCCCC
VAPFRAFVQERAETGAKGRNWLFFGAQHFNTDFLYQAEWQQALQRGELHALELAFSRDAA
HHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCEEEHHHHHHHHHCCCCEEEEEHHHHHHH
EKMYVQHRLRARGAEVYAWLQGGAHVYVCGAIGMGKDVHAALLDIVATHGALDAEAAAAY
HHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
LTRLQVEGRYARDVY
HHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA