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The map label for this gene is gltA [H]

Identifier: 66767276

GI number: 66767276

Start: 1133762

End: 1135051

Strand: Reverse

Name: gltA [H]

Synonym: XC_0944

Alternate gene names: 66767276

Gene position: 1135051-1133762 (Counterclockwise)

Preceding gene: 66767277

Following gene: 66767273

Centisome position: 22.05

GC content: 61.32

Gene sequence:

>1290_bases
GTGTCCGATCTTGATCAGGTCACGCTCAACGCCGGCGACACGTCGGTCGTTCTGCCGGTTCTCAAGCCCACGTTGGGCAA
TGATTGCGTCGATATTTCCAAGCTGACCAAAGAAACCGGTCTGTTCACCTACGACTCGGGCTTCACCGCCACCGCCAGTT
GCAAGTCGGCCATCACCTACATCGATGGCGACAATGGCGTGCTGCTGTACCGCGGCTACCCGATCGAACAGTTGGCCGAG
AAGTCCAGCTTCCTGGAAGTTTCGTATCTGCTGATGAACGGCGAATTGCCGACGGCGGACGAATTCAAGAAGTTCGACCA
CGAAGTGACGCATCACACGATGATGCACGAGTCGCTGAAGAACTTCCTCGGCGGTTTCCGCCACGATGCGCACCCGATGG
CCATGCTGGCCGGTTCGGTGGCCTCGCTGTCGGCGTTCTACCACGACACCCTGGACCTCAACGATCCGGAGCAGCGCCGT
CAGGCCGCCATCCGTCTGATCGCCAAGGTGCCGACCCTGGCTGCTGCGGCGTACCGTTACTCGATCGGCTGGCCGATCCG
CTATCCGCGCAACAACCTGAACTACGTCGACCGCTTCCTGCACATGATGTTCGAAGTGCCGAGCGAGCCGCTGGAGATCA
ACCCGGTCGTTGCCAAGGCACTGGATCTGCTGTTCATCCTGCACGCCGATCACGAGCAGAACGCCTCCACCTCGACCGTG
CGTCTGGTCGGTTCGACCGGTGCCAACCCGTACGCGTCCGTGGCAGCCGGTATCACCGCGCTGTGGGGCCCGGCACACGG
TGGCGCCAACGAAGCCGTGCTGAAGATGCTGGAAGAGATCGGTACCGCTGACAACGTCGAGTCCGCCGTGGCCAAGGCCA
AGGACAAGAACTCCTCGTTCCGTCTGATGGGCTTCGGTCACCGCGTCTACAAGAACTTCGACCCGCGCGCCAAGATCATC
CGCGAGATGACCCACAAGGTGCTGGGCGAGCTGGGTGTCAACGACCCGCTGCTGGAAGTTGCCCTGAAGCTGGAAGAAGC
CGCGTTGAAGGACGACTACTTCGTGCAGCGCAAGCTGTACCCGAACGTGGACTTCTACTCGGGCCTCATCTACAAGGCGC
TCAATATCCCGGTGGAAATGTTCACCGTGATGTTCGCCATTGCCCGCACCGCCGGCTGGGTGTCGCATTGGCTGGAGCAG
CAGGTCGACCCGGAAATGAAGATCGGCCGTCCGCGCCAGATCTACACCGGCTACGACAAGCGCGACTACACCGACGCCGG
CAAGCGCTAA

Upstream 100 bases:

>100_bases
CTGCTGTGCGATAATGACGTGATCCGAGGCGATGCCTTGGACTTCCATCACGTGCCTGCCCATGTGGGATCAGGCGCCTT
CCACTGAAGGAGCGTACACA

Downstream 100 bases:

>100_bases
GCGCCCCGGAGTTGGTTGTTTGACCAAACGCCCCGCATTGCGGGGCGTTTTGCGTTGCGGCCTGGAGTGCTGTGGGCAGT
GCCGGGCCGGTCCTGGCGCG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSDLDQVTLNAGDTSVVLPVLKPTLGNDCVDISKLTKETGLFTYDSGFTATASCKSAITYIDGDNGVLLYRGYPIEQLAE
KSSFLEVSYLLMNGELPTADEFKKFDHEVTHHTMMHESLKNFLGGFRHDAHPMAMLAGSVASLSAFYHDTLDLNDPEQRR
QAAIRLIAKVPTLAAAAYRYSIGWPIRYPRNNLNYVDRFLHMMFEVPSEPLEINPVVAKALDLLFILHADHEQNASTSTV
RLVGSTGANPYASVAAGITALWGPAHGGANEAVLKMLEEIGTADNVESAVAKAKDKNSSFRLMGFGHRVYKNFDPRAKII
REMTHKVLGELGVNDPLLEVALKLEEAALKDDYFVQRKLYPNVDFYSGLIYKALNIPVEMFTVMFAIARTAGWVSHWLEQ
QVDPEMKIGRPRQIYTGYDKRDYTDAGKR

Sequences:

>Translated_429_residues
MSDLDQVTLNAGDTSVVLPVLKPTLGNDCVDISKLTKETGLFTYDSGFTATASCKSAITYIDGDNGVLLYRGYPIEQLAE
KSSFLEVSYLLMNGELPTADEFKKFDHEVTHHTMMHESLKNFLGGFRHDAHPMAMLAGSVASLSAFYHDTLDLNDPEQRR
QAAIRLIAKVPTLAAAAYRYSIGWPIRYPRNNLNYVDRFLHMMFEVPSEPLEINPVVAKALDLLFILHADHEQNASTSTV
RLVGSTGANPYASVAAGITALWGPAHGGANEAVLKMLEEIGTADNVESAVAKAKDKNSSFRLMGFGHRVYKNFDPRAKII
REMTHKVLGELGVNDPLLEVALKLEEAALKDDYFVQRKLYPNVDFYSGLIYKALNIPVEMFTVMFAIARTAGWVSHWLEQ
QVDPEMKIGRPRQIYTGYDKRDYTDAGKR
>Mature_428_residues
SDLDQVTLNAGDTSVVLPVLKPTLGNDCVDISKLTKETGLFTYDSGFTATASCKSAITYIDGDNGVLLYRGYPIEQLAEK
SSFLEVSYLLMNGELPTADEFKKFDHEVTHHTMMHESLKNFLGGFRHDAHPMAMLAGSVASLSAFYHDTLDLNDPEQRRQ
AAIRLIAKVPTLAAAAYRYSIGWPIRYPRNNLNYVDRFLHMMFEVPSEPLEINPVVAKALDLLFILHADHEQNASTSTVR
LVGSTGANPYASVAAGITALWGPAHGGANEAVLKMLEEIGTADNVESAVAKAKDKNSSFRLMGFGHRVYKNFDPRAKIIR
EMTHKVLGELGVNDPLLEVALKLEEAALKDDYFVQRKLYPNVDFYSGLIYKALNIPVEMFTVMFAIARTAGWVSHWLEQQ
VDPEMKIGRPRQIYTGYDKRDYTDAGKR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=363, Percent_Identity=28.3746556473829, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1786939, Length=424, Percent_Identity=60.377358490566, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1786527, Length=389, Percent_Identity=30.8483290488432, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17555174, Length=387, Percent_Identity=26.3565891472868, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=406, Percent_Identity=26.3546798029557, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324328, Length=323, Percent_Identity=26.9349845201238, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319850, Length=325, Percent_Identity=27.0769230769231, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24640126, Length=384, Percent_Identity=27.34375, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640124, Length=383, Percent_Identity=27.4151436031332, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356863, Length=404, Percent_Identity=24.2574257425743, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47776; Mature: 47645

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLDQVTLNAGDTSVVLPVLKPTLGNDCVDISKLTKETGLFTYDSGFTATASCKSAITY
CCCCCCEEECCCCCEEEEEHHCCCCCCCHHHHHHHHHHCCCEEECCCCEEEHHHCCEEEE
IDGDNGVLLYRGYPIEQLAEKSSFLEVSYLLMNGELPTADEFKKFDHEVTHHTMMHESLK
EECCCCEEEEECCCHHHHHHHCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
NFLGGFRHDAHPMAMLAGSVASLSAFYHDTLDLNDPEQRRQAAIRLIAKVPTLAAAAYRY
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
SIGWPIRYPRNNLNYVDRFLHMMFEVPSEPLEINPVVAKALDLLFILHADHEQNASTSTV
ECCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCEE
RLVGSTGANPYASVAAGITALWGPAHGGANEAVLKMLEEIGTADNVESAVAKAKDKNSSF
EEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCE
RLMGFGHRVYKNFDPRAKIIREMTHKVLGELGVNDPLLEVALKLEEAALKDDYFVQRKLY
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCC
PNVDFYSGLIYKALNIPVEMFTVMFAIARTAGWVSHWLEQQVDPEMKIGRPRQIYTGYDK
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCC
RDYTDAGKR
CCCCCCCCC
>Mature Secondary Structure 
SDLDQVTLNAGDTSVVLPVLKPTLGNDCVDISKLTKETGLFTYDSGFTATASCKSAITY
CCCCCEEECCCCCEEEEEHHCCCCCCCHHHHHHHHHHCCCEEECCCCEEEHHHCCEEEE
IDGDNGVLLYRGYPIEQLAEKSSFLEVSYLLMNGELPTADEFKKFDHEVTHHTMMHESLK
EECCCCEEEEECCCHHHHHHHCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
NFLGGFRHDAHPMAMLAGSVASLSAFYHDTLDLNDPEQRRQAAIRLIAKVPTLAAAAYRY
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
SIGWPIRYPRNNLNYVDRFLHMMFEVPSEPLEINPVVAKALDLLFILHADHEQNASTSTV
ECCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCEE
RLVGSTGANPYASVAAGITALWGPAHGGANEAVLKMLEEIGTADNVESAVAKAKDKNSSF
EEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCE
RLMGFGHRVYKNFDPRAKIIREMTHKVLGELGVNDPLLEVALKLEEAALKDDYFVQRKLY
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCC
PNVDFYSGLIYKALNIPVEMFTVMFAIARTAGWVSHWLEQQVDPEMKIGRPRQIYTGYDK
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCC
RDYTDAGKR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2507528; 10984043 [H]