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The map label for this gene is ilvC [H]

Identifier: 66767174

GI number: 66767174

Start: 1012001

End: 1013002

Strand: Reverse

Name: ilvC [H]

Synonym: XC_0841

Alternate gene names: 66767174

Gene position: 1013002-1012001 (Counterclockwise)

Preceding gene: 66767177

Following gene: 66767173

Centisome position: 19.67

GC content: 62.67

Gene sequence:

>1002_bases
ATGAGCAACGACACCCAACCGACCATCGCGATCATCGGCTACGGCAGCCAGGGCCGCGCGCATGCGCTGAACCTGCGCGA
TTCCGGCTTCGACGTCACCGTTGGCCTGCGCCCCGGTGGCCCGACCGAAGCCAAGGCCCAGGCCGATGGCTTCACCGTCG
TTGCGCCGGCCGAAGCGGTAAAGACCGCTGATCTGGTCGCGGTGCTGACCCCGGACATGGTGCAGAAGAAGCTCTACGAA
GAGGTCATTGCGCCGAACATGAAGCAGGGCGCCTGCCTGCTGTTCGCGCACGGGTTGAACGTGCATTTCGACATGATCAA
GCCGCGCGCGGATCTGGACGTGGTGTTGGTCGCGCCGAAGGGCCCGGGCGCACTGGTGCGTCGCGAATATGAAATCGGCC
GCGGCGTGCCGTGCATCTATGCGGTCTACCAGGACACCAGTGGCAAGGCCGAGCAGTTCGCGCTCACATACGCCGGCGGC
CTGGGCGGCGCGCGCGCCAACATCATCAAGACCACCTTCAAGGAAGAGACCGAAACCGATCTGTTCGGCGAGCAGGCGGT
GCTGTGCGGTGGTGCGTCCTCGCTGGTGCAGGCCGGTTTCGAAGTGCTGGTGGAAGCTGGTTATCAGCCGGAAATCGCCT
ATTACGAAGTGCTGCACGAACTGAAGCTGATCGTGGACCTGTTCTACGAAGGCGGCATCACCCGCATGCTGGAGTTCGTC
TCCGAAACCGCGCAGTACGGCGACTACGTCAGCGGCCCGCGCGTCATCGATGCCAGCACCAAGGCACGCATGAAAGATGT
GCTGACCGACATCCAGAACGGCACCTTCACCAAGAACTGGGTGGCCGAATACGAAGCCGGCCTGCCGAACTACACCAAGT
TCAAGCAGGCCGATCTGGAGCACCCGATCGAAGAAGTGGGCAAGAAATTGCGCGCCAAGATGGTATGGCTCAATGGTGAG
CAGCAGGCCGCCGCTACACCTGCCAAGCAACAGGCGGCGTAA

Upstream 100 bases:

>100_bases
GCATGGACGACGCCGTTGTGATTCCCCGCTTTGTTCGGCCAGTACGTATCTCCACTGCCGGCTGATTCCTTTCCCACTGC
CCACACCGCAAGGATTTTCA

Downstream 100 bases:

>100_bases
CGCCGCCGCCTCCCCCACCGTTTAACCGAAAGGTCCGCACAACGCATGAACACCTCCGCACACAGCAAGCCCCGCAATGG
CGCGCGCTGGCTGACGCAGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSNDTQPTIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPAEAVKTADLVAVLTPDMVQKKLYE
EVIAPNMKQGACLLFAHGLNVHFDMIKPRADLDVVLVAPKGPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGG
LGGARANIIKTTFKEETETDLFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFV
SETAQYGDYVSGPRVIDASTKARMKDVLTDIQNGTFTKNWVAEYEAGLPNYTKFKQADLEHPIEEVGKKLRAKMVWLNGE
QQAAATPAKQQAA

Sequences:

>Translated_333_residues
MSNDTQPTIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPAEAVKTADLVAVLTPDMVQKKLYE
EVIAPNMKQGACLLFAHGLNVHFDMIKPRADLDVVLVAPKGPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGG
LGGARANIIKTTFKEETETDLFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFV
SETAQYGDYVSGPRVIDASTKARMKDVLTDIQNGTFTKNWVAEYEAGLPNYTKFKQADLEHPIEEVGKKLRAKMVWLNGE
QQAAATPAKQQAA
>Mature_332_residues
SNDTQPTIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPAEAVKTADLVAVLTPDMVQKKLYEE
VIAPNMKQGACLLFAHGLNVHFDMIKPRADLDVVLVAPKGPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGGL
GGARANIIKTTFKEETETDLFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFVS
ETAQYGDYVSGPRVIDASTKARMKDVLTDIQNGTFTKNWVAEYEAGLPNYTKFKQADLEHPIEEVGKKLRAKMVWLNGEQ
QAAATPAKQQAA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=287, Percent_Identity=35.191637630662, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=331, Percent_Identity=32.3262839879154, Blast_Score=139, Evalue=5e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36026; Mature: 35895

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDTQPTIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPAEAV
CCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEECHHHH
KTADLVAVLTPDMVQKKLYEEVIAPNMKQGACLLFAHGLNVHFDMIKPRADLDVVLVAPK
HHHHEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCCCCCEEEEECCC
GPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGGLGGARANIIKTTFKEETETD
CCCHHHEEEHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHH
LFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFV
HCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SETAQYGDYVSGPRVIDASTKARMKDVLTDIQNGTFTKNWVAEYEAGLPNYTKFKQADLE
HHHHHHCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHC
HPIEEVGKKLRAKMVWLNGEQQAAATPAKQQAA
CHHHHHHHHHHEEEEEECCCCHHHCCCCHHCCC
>Mature Secondary Structure 
SNDTQPTIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPAEAV
CCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEECHHHH
KTADLVAVLTPDMVQKKLYEEVIAPNMKQGACLLFAHGLNVHFDMIKPRADLDVVLVAPK
HHHHEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCCCCCEEEEECCC
GPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGGLGGARANIIKTTFKEETETD
CCCHHHEEEHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHH
LFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFV
HCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SETAQYGDYVSGPRVIDASTKARMKDVLTDIQNGTFTKNWVAEYEAGLPNYTKFKQADLE
HHHHHHCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHC
HPIEEVGKKLRAKMVWLNGEQQAAATPAKQQAA
CHHHHHHHHHHEEEEEECCCCHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]