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The map label for this gene is yuxL [H]

Identifier: 66766598

GI number: 66766598

Start: 305800

End: 307893

Strand: Reverse

Name: yuxL [H]

Synonym: XC_0253

Alternate gene names: 66766598

Gene position: 307893-305800 (Counterclockwise)

Preceding gene: 66766599

Following gene: 66766596

Centisome position: 5.98

GC content: 65.57

Gene sequence:

>2094_bases
ATGCAACGCCTGCTTCTCGCATCCAGCCTGCTCCTGGCGCTCAGCGCCTGCAGCGACAAATCCGCGCCCGCCAACACCGC
TGACGCCGCCGCCCCCGCTGCGGCACCGGCAGCGACTGCGCCGGCCACAGCGCCCGAATTGATCCCGCGCGACGCCCTGT
TCGGCAATCCCGAGCGCGCCAGCGTGCGCATCAGCCCCGATGGCAAATATCTCAGCTGGGTCGCGCCACTGGATGGCGTG
CTCAACGTGTGGGTGGCGCCGGTCGACGCGCCGGACAAGGCGCGCGCCATCACCAAGGACACCGCACGCGGCATCCGCAG
TTATTACTGGACCTATCACAGCGACACCTTGCTCTATCTGCGCGACACCGGCGGCGATGAGGACTTCCACCTCTATGCCG
TCAACCTCAGCGATGGCAGCAGCAAGGACCTCACCCCGTTCAAGAAGACCAACGCCGAGGTGTACGGCATCAGCGACCAG
CATCCGGACGCGATCATGGTCGGCATGAACGATCGGGATGCCAAATGGCACGACCTGTACAAGGTCGAACTGGCCTCGGG
CACACGCACCCTGGTGCAGAAGAACACCGACAGCCTGGACAGCTACCTGCTCGATGGCAATTACCAGCTGCGCTACGCCA
CCCGCGCCACCGATGACGCCGGCCGCGAGTTACTGGTGCCCGAGGGCAAGGGTTGGAAGAGCGTGGACCGCATCCCGTTC
GAGGATGTCACCAATACCGCGCCGGCCGGCCTCACCGATGACGGCAAGACGCTCTACATGCTGGACTCGCGTAACCGCGA
TACCGCCGCGCTGTACGCGATCGACACCGCCAGCAATGCACGCACGCTGCTGTTCGAAGACGCGCGCGCCGATGCCGGCA
GCACCTTGAACGACCCCAAGACCGGCGTGGTGCAGGCCGTGTCCACCGACTATCTGCGCGAAGAGTGGAAGACGCTGGAC
ACCAGCATCGCCGCCGACCTGCAGAAGCTCAAATCCCTCGGCCCAGGCGATGCCGGCATTGCCGCACGCACGCTCGATGA
CCGCACCTGGATCGTCGCCTATTCGGCCGCCGAAACCCCGCTGACCTACTACCGCTACGACCGTGCCGATGGCGGCAAGC
TCACCAAGCTGTTCTCCGCACGCCCGGCGCTGGAGGGCAAACCGTTGGTGCCGATGTGGCCGCAGGAGATTGCCGCACGC
GACGGCCTAAAACTGGTCAGCTACCTGTCGCTACCGGCCGAGGCCGACAGCAACCATGATGGCAAGGCCGATAAAGCAGT
GCCGTTGGTGCTGTTCGTGCACGGCGGCCCGTGGGCGCGCGACAGTTATGGCTATGGCGCGTACGAGCAATGGCTGGCCA
ACCGCGGCTACGCAGTGCTGTCGGTGAACTTCCGCGGCTCCACCGGCTTCGGCAAGGCGTTCACCAACGCCGGCAACGGC
GAGTGGGCCGGCAAGATGCACTACGACCTGCTCGACGCGGTGCAATGGGCGGTCAAGCAGGGCGTCACCACGCCGCAGGA
CGTCGCCATCATGGGCGGTAGCTACGGCGGGTACGCGACGCTGGTGGGCATGACCTTCACCCCGGACGCGTTCAAGTGCG
GCGTGGACATCGTGGGCCCGGCCAACCTCAACACCTTGCTCGGCACCGTGCCGCCCTATTGGGCCAGCTTCTACAAGCAA
CTGACCAAGCGCATGGGTGACCCGGCCACCGCCGCCGGCAAGCAGTGGCTCACCGAGCGCTCGCCGCTCAGCCACGTCGA
CAAGATCAGCAAACCGCTGCTGATTGGCCAGGGCGCCAACGACCCGCGCGTCAAACAGGCCGAAAGCGACCAGATCGTCA
ACGCGATGAAGGCCAAGAACATCCCGGTGACCTACGTGCTGTTCCCCGATGAAGGCCACGGCTTCCAGCGCCCGGAGAAC
AGCAAGGCGTTCAACGCAGTGACCGAAGGGTTCCTGAGCCAATGCCTGGGCGGCCGCGCACAACCCATCGGCGCGGACTT
CGAAGGCTCCAGCATCACCGTGCCCGAGGGCGCAGACCGCATCACTGGCCTGGCCGATGCATTGAAGACGCATACGCAGG
CGATTCGGAAGTAG

Upstream 100 bases:

>100_bases
GCATCCGCCAGCGTGACCAACGGCACGTTCCCCGGGGCGGCCGCTGCCTCTAGCGTGGCTGCTTCGGCTGGATTGGCCGA
GGTTCCCTCCGGAGGCTTTC

Downstream 100 bases:

>100_bases
GCCTGGCGATGCGGTTCGTCGCCAGTGGACGCTGGCGACGAACCGCTCTACGTGGTTATTTCTGCAGCGCGAAAATTCAG
GCCGTATCGTTGGGGCCAGC

Product: dipeptidyl anminopeptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 697; Mature: 697

Protein sequence:

>697_residues
MQRLLLASSLLLALSACSDKSAPANTADAAAPAAAPAATAPATAPELIPRDALFGNPERASVRISPDGKYLSWVAPLDGV
LNVWVAPVDAPDKARAITKDTARGIRSYYWTYHSDTLLYLRDTGGDEDFHLYAVNLSDGSSKDLTPFKKTNAEVYGISDQ
HPDAIMVGMNDRDAKWHDLYKVELASGTRTLVQKNTDSLDSYLLDGNYQLRYATRATDDAGRELLVPEGKGWKSVDRIPF
EDVTNTAPAGLTDDGKTLYMLDSRNRDTAALYAIDTASNARTLLFEDARADAGSTLNDPKTGVVQAVSTDYLREEWKTLD
TSIAADLQKLKSLGPGDAGIAARTLDDRTWIVAYSAAETPLTYYRYDRADGGKLTKLFSARPALEGKPLVPMWPQEIAAR
DGLKLVSYLSLPAEADSNHDGKADKAVPLVLFVHGGPWARDSYGYGAYEQWLANRGYAVLSVNFRGSTGFGKAFTNAGNG
EWAGKMHYDLLDAVQWAVKQGVTTPQDVAIMGGSYGGYATLVGMTFTPDAFKCGVDIVGPANLNTLLGTVPPYWASFYKQ
LTKRMGDPATAAGKQWLTERSPLSHVDKISKPLLIGQGANDPRVKQAESDQIVNAMKAKNIPVTYVLFPDEGHGFQRPEN
SKAFNAVTEGFLSQCLGGRAQPIGADFEGSSITVPEGADRITGLADALKTHTQAIRK

Sequences:

>Translated_697_residues
MQRLLLASSLLLALSACSDKSAPANTADAAAPAAAPAATAPATAPELIPRDALFGNPERASVRISPDGKYLSWVAPLDGV
LNVWVAPVDAPDKARAITKDTARGIRSYYWTYHSDTLLYLRDTGGDEDFHLYAVNLSDGSSKDLTPFKKTNAEVYGISDQ
HPDAIMVGMNDRDAKWHDLYKVELASGTRTLVQKNTDSLDSYLLDGNYQLRYATRATDDAGRELLVPEGKGWKSVDRIPF
EDVTNTAPAGLTDDGKTLYMLDSRNRDTAALYAIDTASNARTLLFEDARADAGSTLNDPKTGVVQAVSTDYLREEWKTLD
TSIAADLQKLKSLGPGDAGIAARTLDDRTWIVAYSAAETPLTYYRYDRADGGKLTKLFSARPALEGKPLVPMWPQEIAAR
DGLKLVSYLSLPAEADSNHDGKADKAVPLVLFVHGGPWARDSYGYGAYEQWLANRGYAVLSVNFRGSTGFGKAFTNAGNG
EWAGKMHYDLLDAVQWAVKQGVTTPQDVAIMGGSYGGYATLVGMTFTPDAFKCGVDIVGPANLNTLLGTVPPYWASFYKQ
LTKRMGDPATAAGKQWLTERSPLSHVDKISKPLLIGQGANDPRVKQAESDQIVNAMKAKNIPVTYVLFPDEGHGFQRPEN
SKAFNAVTEGFLSQCLGGRAQPIGADFEGSSITVPEGADRITGLADALKTHTQAIRK
>Mature_697_residues
MQRLLLASSLLLALSACSDKSAPANTADAAAPAAAPAATAPATAPELIPRDALFGNPERASVRISPDGKYLSWVAPLDGV
LNVWVAPVDAPDKARAITKDTARGIRSYYWTYHSDTLLYLRDTGGDEDFHLYAVNLSDGSSKDLTPFKKTNAEVYGISDQ
HPDAIMVGMNDRDAKWHDLYKVELASGTRTLVQKNTDSLDSYLLDGNYQLRYATRATDDAGRELLVPEGKGWKSVDRIPF
EDVTNTAPAGLTDDGKTLYMLDSRNRDTAALYAIDTASNARTLLFEDARADAGSTLNDPKTGVVQAVSTDYLREEWKTLD
TSIAADLQKLKSLGPGDAGIAARTLDDRTWIVAYSAAETPLTYYRYDRADGGKLTKLFSARPALEGKPLVPMWPQEIAAR
DGLKLVSYLSLPAEADSNHDGKADKAVPLVLFVHGGPWARDSYGYGAYEQWLANRGYAVLSVNFRGSTGFGKAFTNAGNG
EWAGKMHYDLLDAVQWAVKQGVTTPQDVAIMGGSYGGYATLVGMTFTPDAFKCGVDIVGPANLNTLLGTVPPYWASFYKQ
LTKRMGDPATAAGKQWLTERSPLSHVDKISKPLLIGQGANDPRVKQAESDQIVNAMKAKNIPVTYVLFPDEGHGFQRPEN
SKAFNAVTEGFLSQCLGGRAQPIGADFEGSSITVPEGADRITGLADALKTHTQAIRK

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=233, Percent_Identity=30.9012875536481, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI194394146, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144537, Length=654, Percent_Identity=38.3792048929664, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI25144540, Length=400, Percent_Identity=47.5, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI25144543, Length=556, Percent_Identity=35.2517985611511, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI17552908, Length=252, Percent_Identity=29.7619047619048, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25149159, Length=250, Percent_Identity=29.6, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45551969, Length=243, Percent_Identity=28.3950617283951, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550825, Length=243, Percent_Identity=28.3950617283951, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45553511, Length=243, Percent_Identity=28.3950617283951, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 75265; Mature: 75265

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00698 GLYCOSYL_HYDROL_F9_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLLLASSLLLALSACSDKSAPANTADAAAPAAAPAATAPATAPELIPRDALFGNPERA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCCC
SVRISPDGKYLSWVAPLDGVLNVWVAPVDAPDKARAITKDTARGIRSYYWTYHSDTLLYL
EEEECCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEECCEEEEE
RDTGGDEDFHLYAVNLSDGSSKDLTPFKKTNAEVYGISDQHPDAIMVGMNDRDAKWHDLY
EECCCCCCEEEEEEEECCCCCCCCCCHHHCCCEEEECCCCCCCEEEEECCCCCCCCCEEE
KVELASGTRTLVQKNTDSLDSYLLDGNYQLRYATRATDDAGRELLVPEGKGWKSVDRIPF
EEEECCCCHHHHHCCCCCHHHEEECCCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCC
EDVTNTAPAGLTDDGKTLYMLDSRNRDTAALYAIDTASNARTLLFEDARADAGSTLNDPK
HHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCC
TGVVQAVSTDYLREEWKTLDTSIAADLQKLKSLGPGDAGIAARTLDDRTWIVAYSAAETP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCCC
LTYYRYDRADGGKLTKLFSARPALEGKPLVPMWPQEIAARDGLKLVSYLSLPAEADSNHD
EEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHCCCCCCCCCCC
GKADKAVPLVLFVHGGPWARDSYGYGAYEQWLANRGYAVLSVNFRGSTGFGKAFTNAGNG
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCCCCCHHHCCCCCC
EWAGKMHYDLLDAVQWAVKQGVTTPQDVAIMGGSYGGYATLVGMTFTPDAFKCGVDIVGP
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEEEECCCHHHCCEEEECC
ANLNTLLGTVPPYWASFYKQLTKRMGDPATAAGKQWLTERSPLSHVDKISKPLLIGQGAN
CCCHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCEEEECCCC
DPRVKQAESDQIVNAMKAKNIPVTYVLFPDEGHGFQRPENSKAFNAVTEGFLSQCLGGRA
CCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
QPIGADFEGSSITVPEGADRITGLADALKTHTQAIRK
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQRLLLASSLLLALSACSDKSAPANTADAAAPAAAPAATAPATAPELIPRDALFGNPERA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCCC
SVRISPDGKYLSWVAPLDGVLNVWVAPVDAPDKARAITKDTARGIRSYYWTYHSDTLLYL
EEEECCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEECCEEEEE
RDTGGDEDFHLYAVNLSDGSSKDLTPFKKTNAEVYGISDQHPDAIMVGMNDRDAKWHDLY
EECCCCCCEEEEEEEECCCCCCCCCCHHHCCCEEEECCCCCCCEEEEECCCCCCCCCEEE
KVELASGTRTLVQKNTDSLDSYLLDGNYQLRYATRATDDAGRELLVPEGKGWKSVDRIPF
EEEECCCCHHHHHCCCCCHHHEEECCCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCC
EDVTNTAPAGLTDDGKTLYMLDSRNRDTAALYAIDTASNARTLLFEDARADAGSTLNDPK
HHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCC
TGVVQAVSTDYLREEWKTLDTSIAADLQKLKSLGPGDAGIAARTLDDRTWIVAYSAAETP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCCC
LTYYRYDRADGGKLTKLFSARPALEGKPLVPMWPQEIAARDGLKLVSYLSLPAEADSNHD
EEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHCCCCCCCCCCC
GKADKAVPLVLFVHGGPWARDSYGYGAYEQWLANRGYAVLSVNFRGSTGFGKAFTNAGNG
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCCCCCHHHCCCCCC
EWAGKMHYDLLDAVQWAVKQGVTTPQDVAIMGGSYGGYATLVGMTFTPDAFKCGVDIVGP
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEEEECCCHHHCCEEEECC
ANLNTLLGTVPPYWASFYKQLTKRMGDPATAAGKQWLTERSPLSHVDKISKPLLIGQGAN
CCCHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCEEEECCCC
DPRVKQAESDQIVNAMKAKNIPVTYVLFPDEGHGFQRPENSKAFNAVTEGFLSQCLGGRA
CCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
QPIGADFEGSSITVPEGADRITGLADALKTHTQAIRK
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]