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The map label for this gene is 66766553

Identifier: 66766553

GI number: 66766553

Start: 257314

End: 258114

Strand: Reverse

Name: 66766553

Synonym: XC_0208

Alternate gene names: NA

Gene position: 258114-257314 (Counterclockwise)

Preceding gene: 66766560

Following gene: 66766552

Centisome position: 5.01

GC content: 71.66

Gene sequence:

>801_bases
GTGCTGCTCTCGCATAATCCCGAGATGACCCACACGCGCACAACTGCCACGTCCTGGACCCTGCTGTCGCTGCGTCCCAG
CGGCGAGCACGCGCCACTGCGGCGTGCGGTGGCCCGGCATGGCGGCCAGTTGCTGGCGGTGTCGCCATGGCGCCTGCAGA
TCAACGACACGCTGCAGGCACGCGATGCGCTGCGGCAGGCACTGGGCGCGCCGATTGTCGTGTTCACCAGCCCGGCCGCC
GTGCACGCGGCGCACCGGCTGCTGCCCTTGCAGCGGCCTGGACCGGCCCAGTGGGCAAGCGTGGGCGAAGGCACGGCGCG
GGCGCTGCAGGCCTGCGGGATCGACGCGGTGGTGCGCCCGGCGCGCATGGACAGCGAAGGCCTGCTGGCACTGCCGGTGT
TCGATGCCCCGCTACACGCCGTGGGCCTGATCACCGCGCCCGGCGGCCGCGGCACGCTGTCGCCGGCGCTGGAGCAGCGC
GGTGCGCAGATCCTGCGCGCAGATGTGTATCAGCGTGTTGCGCTCCGGCTGCGTGCGTCGACGCTGCATGCGCTGGAGAG
CGCGCTGCCACGCAGCGTGATGGCCTTGAGCAGCAGTGAAGCGCTGACGTTGATCGTGCAGCAGCTGCCGCCGTCATTGG
CCACTGCATTGAAGACCCGCCCGGTGGTCGCCTCCAGCGACCGCATGCTGGAGGCTGCGCGCGCTGCGGGCTTCGTGCAG
GTCCATCGCTCCGAAGGCCCACTGCCTGCGCAGTTGGCGGCCGCCGCCGCTGCGATCATGACGCCGCCGCCACCTTGCTG
A

Upstream 100 bases:

>100_bases
ACTTGGGAGTGCGCGGCGGACTCGCACTGCATCGGCGGAAGGCCCGCTGGTTCCATACGCAAAGGACGACATCGACAGCA
GCCGACCCGACCCGGTCTAC

Downstream 100 bases:

>100_bases
ACTGCGGACTCAAGCACAGCTTGCAGGTGTCTGTGGCCACACGCCATGCTGTGGCGGATGACTGCGGCGCCTGCGCCTGT
CGTGACCGCCCGAGGATGCC

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen-III Synthase Protein

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MLLSHNPEMTHTRTTATSWTLLSLRPSGEHAPLRRAVARHGGQLLAVSPWRLQINDTLQARDALRQALGAPIVVFTSPAA
VHAAHRLLPLQRPGPAQWASVGEGTARALQACGIDAVVRPARMDSEGLLALPVFDAPLHAVGLITAPGGRGTLSPALEQR
GAQILRADVYQRVALRLRASTLHALESALPRSVMALSSSEALTLIVQQLPPSLATALKTRPVVASSDRMLEAARAAGFVQ
VHRSEGPLPAQLAAAAAAIMTPPPPC

Sequences:

>Translated_266_residues
MLLSHNPEMTHTRTTATSWTLLSLRPSGEHAPLRRAVARHGGQLLAVSPWRLQINDTLQARDALRQALGAPIVVFTSPAA
VHAAHRLLPLQRPGPAQWASVGEGTARALQACGIDAVVRPARMDSEGLLALPVFDAPLHAVGLITAPGGRGTLSPALEQR
GAQILRADVYQRVALRLRASTLHALESALPRSVMALSSSEALTLIVQQLPPSLATALKTRPVVASSDRMLEAARAAGFVQ
VHRSEGPLPAQLAAAAAAIMTPPPPC
>Mature_266_residues
MLLSHNPEMTHTRTTATSWTLLSLRPSGEHAPLRRAVARHGGQLLAVSPWRLQINDTLQARDALRQALGAPIVVFTSPAA
VHAAHRLLPLQRPGPAQWASVGEGTARALQACGIDAVVRPARMDSEGLLALPVFDAPLHAVGLITAPGGRGTLSPALEQR
GAQILRADVYQRVALRLRASTLHALESALPRSVMALSSSEALTLIVQQLPPSLATALKTRPVVASSDRMLEAARAAGFVQ
VHRSEGPLPAQLAAAAAAIMTPPPPC

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 28009; Mature: 28009

Theoretical pI: Translated: 11.81; Mature: 11.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSHNPEMTHTRTTATSWTLLSLRPSGEHAPLRRAVARHGGQLLAVSPWRLQINDTLQA
CCCCCCCCCCEEEECCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCEEEEECCHHHH
RDALRQALGAPIVVFTSPAAVHAAHRLLPLQRPGPAQWASVGEGTARALQACGIDAVVRP
HHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHCCHHHHHCC
ARMDSEGLLALPVFDAPLHAVGLITAPGGRGTLSPALEQRGAQILRADVYQRVALRLRAS
CCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TLHALESALPRSVMALSSSEALTLIVQQLPPSLATALKTRPVVASSDRMLEAARAAGFVQ
HHHHHHHHCCHHHHHHCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHCCEEE
VHRSEGPLPAQLAAAAAAIMTPPPPC
EECCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLLSHNPEMTHTRTTATSWTLLSLRPSGEHAPLRRAVARHGGQLLAVSPWRLQINDTLQA
CCCCCCCCCCEEEECCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCEEEEECCHHHH
RDALRQALGAPIVVFTSPAAVHAAHRLLPLQRPGPAQWASVGEGTARALQACGIDAVVRP
HHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHCCHHHHHCC
ARMDSEGLLALPVFDAPLHAVGLITAPGGRGTLSPALEQRGAQILRADVYQRVALRLRAS
CCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TLHALESALPRSVMALSSSEALTLIVQQLPPSLATALKTRPVVASSDRMLEAARAAGFVQ
HHHHHHHHCCHHHHHHCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHCCEEE
VHRSEGPLPAQLAAAAAAIMTPPPPC
EECCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA