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The map label for this gene is uvrD [H]

Identifier: 66048289

GI number: 66048289

Start: 6008585

End: 6010768

Strand: Direct

Name: uvrD [H]

Synonym: Psyr_5065

Alternate gene names: 66048289

Gene position: 6008585-6010768 (Clockwise)

Preceding gene: 66048287

Following gene: 66048290

Centisome position: 98.6

GC content: 61.49

Gene sequence:

>2184_bases
ATGCGCGATGATCTCTCTCTTCTTCTGAATTCCCTCAACGATGCCCAACGTCAGGCCGTAGCTGCCTCTCTGGGTCGTCA
GTTGGTCCTGGCTGGTGCTGGCTCCGGCAAAACCCGTGTGCTGGTGCATCGCATCGCCTGGCTGATGCAGGTCGAGCAAG
CCTCCCCGCATTCGGTCCTGTCGGTGACGTTCACCAACAAGGCCGCCGCCGAGATGCGCCACCGTATCGAGCAGCTGATG
GGCATCAGCCCGGCTGGCATGTGGGTGGGCACCTTCCACGGTCTGGCCCACCGCCTGTTGCGTGCGCACTGGCAGGAAGC
CGGGCTGGTACAGACCTTCCAGATTCTCGACAGCGACGACCAGCAGCGTCTGGTAAAGCGCGTGATGCGCGAGCTGGGCC
TGGACGAACAACGCTGGCCTGCACGTCAGGCCCAGTGGTTCATCAATGGTCAGAAAGACGAAGGCCTGCGCCCGAAACAT
ATTCAGGCCAGCGGCGACCTGTTCCTGACCACCATGAAAAGCGTTTACGAAGCCTACGAGATCGCCTGCCAACGGGCCGG
CGTCATCGACTTCTCCGAACTGCTGCTACGCGCACTCGACCTGTGGCGCGATAACCCGGGCTTGCTGGCGCATTATCAGC
GCCGCTTCCGTCACGTTCTGGTGGACGAGTTCCAGGACACCAACGCCGTGCAGTACGCCTGGCTGCGCCTGCTCGCCCAG
GGGGGCGACAGCCTGATGGTGGTCGGCGACGACGATCAGTCCATTTACGGCTGGCGTGGCGCGAAGATCGAGAACATCCA
CCAGTATTCCTCGGACTTCCCGGATACCGAAGTCATCCGCCTGGAGCAGAACTACCGCTCCACGGCGAGCATCCTCAAGG
CCGCCAATGGCTTGATCATCAATAACAGTGGTCGCCTGGGCAAGGAATTGTGGACCGACGTCGGCGATGGCGAGCTGATC
AATCTGTACGCCGCGTTCAACGAGCACGATGAAGCGCGTTACGTGGTCGAGACCATCGAGAGCGCGCTGAAAACCGGTAT
TTCGCGCAACGATATCGCCATTCTGTACCGCTCCAACGCCCAGTCGCGGGTGCTTGAAGAAGCCCTGCTGCGTGAGCGTA
TTCCGTACCGCATCTACGGCGGACAGCGCTTCTTCGAGCGTGCCGAAATCAAGAACGCCATGGCCTACATGCGCTTGCTG
GAAGGCCGTGGCAACGATGCGGCACTGGAGCGGGTGATCAATGTTCCGGCGCGCGGCATCGGTGAAAAGACCGTCGAAGC
GATTCGCGAGCATGCGCGTCATGCCGACGTCTCCATGTGGGAAGCCATGCGCCTGCTGGTGGCCAACAAGGGCCTGACCG
GACGCGCCGCCACTGCCCTGGGCGGTTTCATCGAGCTGATCGAGAACCTCGCGGCCAAGGTCATGGAGATGCCGCTGCAC
CTGATGACCCAGACGGTGATCGAACAGTCCGGACTGATTACCTATCACGAGCAGGAAAAAGGCGAGAAAGGTCAGGCGCG
GGTAGAAAACCTTGAGGAACTGGTCAGCGCTGCGCGTGCCTTCGAGAATCACGAAAGCGAAGAAGACCTGACGCCACTGG
CAGCGTTCCTGGGGCATGCCTCGCTGGAAGCGGGCGACACCCAGGCGCAGGAGCATGAAGACAGCATTCAGCTGATGACC
CTGCACAGCGCCAAGGGCCTGGAATTCCCGCATGTGTTCCTGGTGGGCATGGAGGAAGGGCTGTTCCCGCACAAGATGAG
CCTGGAAGAACCAGGCCGTCTTGAAGAGGAACGGCGTCTGGCCTATGTCGGCATCACCCGGGCCATGAAACAGCTGGTGA
TGACCTACGCCGAGACGCGTCGTCTGTACGGCAGCGAAACCTACAACAAGGTCTCGCGTTTCGTACGGGAGATCCCGCCG
GCGCTGATTCAGGAAGTCCGGCTGTCCAACAGCGTCAACCGTCCGTTCGGCGGCACGCCGAAATTCAACAGCAGCAGCCT
GTTCAACGGCACCGGCATTCCGGAAACCGAGTTCACCATGGGCCAGCGCGTCCAGCATGCGGTGTTCGGCGAAGGCGTGA
TCCTCAACTTCGAAGGCGCTGGCGCCCAGGCGCGGGTGCAGGTCAACTTCTCCGAGGGCAGCAAGTGGCTGATGATGGGC
TACGCGAAGCTGGTGCCGTTGTAG

Upstream 100 bases:

>100_bases
CGGCGACAGGCGACGACCGGTCGTCAGCGCCTCCGCCATTTTTATTGCCTGACGCAAAGCATGGTTTGCCCGTCATCGCG
CGGCACCCTAGAATGCGCTG

Downstream 100 bases:

>100_bases
GCCGGTCAATCATCGTCCATACGCCCCTGACTGCCCCTGACTATCGTTCCCGCGCTGAGCGTGAGGAACGATAATCCTCG
TACACATCTTACGAAGCGCG

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
MRDDLSLLLNSLNDAQRQAVAASLGRQLVLAGAGSGKTRVLVHRIAWLMQVEQASPHSVLSVTFTNKAAAEMRHRIEQLM
GISPAGMWVGTFHGLAHRLLRAHWQEAGLVQTFQILDSDDQQRLVKRVMRELGLDEQRWPARQAQWFINGQKDEGLRPKH
IQASGDLFLTTMKSVYEAYEIACQRAGVIDFSELLLRALDLWRDNPGLLAHYQRRFRHVLVDEFQDTNAVQYAWLRLLAQ
GGDSLMVVGDDDQSIYGWRGAKIENIHQYSSDFPDTEVIRLEQNYRSTASILKAANGLIINNSGRLGKELWTDVGDGELI
NLYAAFNEHDEARYVVETIESALKTGISRNDIAILYRSNAQSRVLEEALLRERIPYRIYGGQRFFERAEIKNAMAYMRLL
EGRGNDAALERVINVPARGIGEKTVEAIREHARHADVSMWEAMRLLVANKGLTGRAATALGGFIELIENLAAKVMEMPLH
LMTQTVIEQSGLITYHEQEKGEKGQARVENLEELVSAARAFENHESEEDLTPLAAFLGHASLEAGDTQAQEHEDSIQLMT
LHSAKGLEFPHVFLVGMEEGLFPHKMSLEEPGRLEEERRLAYVGITRAMKQLVMTYAETRRLYGSETYNKVSRFVREIPP
ALIQEVRLSNSVNRPFGGTPKFNSSSLFNGTGIPETEFTMGQRVQHAVFGEGVILNFEGAGAQARVQVNFSEGSKWLMMG
YAKLVPL

Sequences:

>Translated_727_residues
MRDDLSLLLNSLNDAQRQAVAASLGRQLVLAGAGSGKTRVLVHRIAWLMQVEQASPHSVLSVTFTNKAAAEMRHRIEQLM
GISPAGMWVGTFHGLAHRLLRAHWQEAGLVQTFQILDSDDQQRLVKRVMRELGLDEQRWPARQAQWFINGQKDEGLRPKH
IQASGDLFLTTMKSVYEAYEIACQRAGVIDFSELLLRALDLWRDNPGLLAHYQRRFRHVLVDEFQDTNAVQYAWLRLLAQ
GGDSLMVVGDDDQSIYGWRGAKIENIHQYSSDFPDTEVIRLEQNYRSTASILKAANGLIINNSGRLGKELWTDVGDGELI
NLYAAFNEHDEARYVVETIESALKTGISRNDIAILYRSNAQSRVLEEALLRERIPYRIYGGQRFFERAEIKNAMAYMRLL
EGRGNDAALERVINVPARGIGEKTVEAIREHARHADVSMWEAMRLLVANKGLTGRAATALGGFIELIENLAAKVMEMPLH
LMTQTVIEQSGLITYHEQEKGEKGQARVENLEELVSAARAFENHESEEDLTPLAAFLGHASLEAGDTQAQEHEDSIQLMT
LHSAKGLEFPHVFLVGMEEGLFPHKMSLEEPGRLEEERRLAYVGITRAMKQLVMTYAETRRLYGSETYNKVSRFVREIPP
ALIQEVRLSNSVNRPFGGTPKFNSSSLFNGTGIPETEFTMGQRVQHAVFGEGVILNFEGAGAQARVQVNFSEGSKWLMMG
YAKLVPL
>Mature_727_residues
MRDDLSLLLNSLNDAQRQAVAASLGRQLVLAGAGSGKTRVLVHRIAWLMQVEQASPHSVLSVTFTNKAAAEMRHRIEQLM
GISPAGMWVGTFHGLAHRLLRAHWQEAGLVQTFQILDSDDQQRLVKRVMRELGLDEQRWPARQAQWFINGQKDEGLRPKH
IQASGDLFLTTMKSVYEAYEIACQRAGVIDFSELLLRALDLWRDNPGLLAHYQRRFRHVLVDEFQDTNAVQYAWLRLLAQ
GGDSLMVVGDDDQSIYGWRGAKIENIHQYSSDFPDTEVIRLEQNYRSTASILKAANGLIINNSGRLGKELWTDVGDGELI
NLYAAFNEHDEARYVVETIESALKTGISRNDIAILYRSNAQSRVLEEALLRERIPYRIYGGQRFFERAEIKNAMAYMRLL
EGRGNDAALERVINVPARGIGEKTVEAIREHARHADVSMWEAMRLLVANKGLTGRAATALGGFIELIENLAAKVMEMPLH
LMTQTVIEQSGLITYHEQEKGEKGQARVENLEELVSAARAFENHESEEDLTPLAAFLGHASLEAGDTQAQEHEDSIQLMT
LHSAKGLEFPHVFLVGMEEGLFPHKMSLEEPGRLEEERRLAYVGITRAMKQLVMTYAETRRLYGSETYNKVSRFVREIPP
ALIQEVRLSNSVNRPFGGTPKFNSSSLFNGTGIPETEFTMGQRVQHAVFGEGVILNFEGAGAQARVQVNFSEGSKWLMMG
YAKLVPL

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=726, Percent_Identity=61.7079889807163, Blast_Score=924, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=641, Percent_Identity=38.8455538221529, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1787196, Length=343, Percent_Identity=27.9883381924198, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322369, Length=669, Percent_Identity=27.0553064275037, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324477, Length=682, Percent_Identity=23.3137829912023, Blast_Score=117, Evalue=5e-27,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81720; Mature: 81720

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDDLSLLLNSLNDAQRQAVAASLGRQLVLAGAGSGKTRVLVHRIAWLMQVEQASPHSVL
CCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEE
SVTFTNKAAAEMRHRIEQLMGISPAGMWVGTFHGLAHRLLRAHWQEAGLVQTFQILDSDD
EEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
QQRLVKRVMRELGLDEQRWPARQAQWFINGQKDEGLRPKHIQASGDLFLTTMKSVYEAYE
HHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
IACQRAGVIDFSELLLRALDLWRDNPGLLAHYQRRFRHVLVDEFQDTNAVQYAWLRLLAQ
HHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GGDSLMVVGDDDQSIYGWRGAKIENIHQYSSDFPDTEVIRLEQNYRSTASILKAANGLII
CCCEEEEEECCCCCEECCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCEEE
NNSGRLGKELWTDVGDGELINLYAAFNEHDEARYVVETIESALKTGISRNDIAILYRSNA
ECCCCCHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
QSRVLEEALLRERIPYRIYGGQRFFERAEIKNAMAYMRLLEGRGNDAALERVINVPARGI
HHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
GEKTVEAIREHARHADVSMWEAMRLLVANKGLTGRAATALGGFIELIENLAAKVMEMPLH
CHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTQTVIEQSGLITYHEQEKGEKGQARVENLEELVSAARAFENHESEEDLTPLAAFLGHA
HHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
SLEAGDTQAQEHEDSIQLMTLHSAKGLEFPHVFLVGMEEGLFPHKMSLEEPGRLEEERRL
CCCCCCCHHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
AYVGITRAMKQLVMTYAETRRLYGSETYNKVSRFVREIPPALIQEVRLSNSVNRPFGGTP
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
KFNSSSLFNGTGIPETEFTMGQRVQHAVFGEGVILNFEGAGAQARVQVNFSEGSKWLMMG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCEEEEH
YAKLVPL
HHHHCCC
>Mature Secondary Structure
MRDDLSLLLNSLNDAQRQAVAASLGRQLVLAGAGSGKTRVLVHRIAWLMQVEQASPHSVL
CCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEE
SVTFTNKAAAEMRHRIEQLMGISPAGMWVGTFHGLAHRLLRAHWQEAGLVQTFQILDSDD
EEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
QQRLVKRVMRELGLDEQRWPARQAQWFINGQKDEGLRPKHIQASGDLFLTTMKSVYEAYE
HHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
IACQRAGVIDFSELLLRALDLWRDNPGLLAHYQRRFRHVLVDEFQDTNAVQYAWLRLLAQ
HHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GGDSLMVVGDDDQSIYGWRGAKIENIHQYSSDFPDTEVIRLEQNYRSTASILKAANGLII
CCCEEEEEECCCCCEECCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCEEE
NNSGRLGKELWTDVGDGELINLYAAFNEHDEARYVVETIESALKTGISRNDIAILYRSNA
ECCCCCHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
QSRVLEEALLRERIPYRIYGGQRFFERAEIKNAMAYMRLLEGRGNDAALERVINVPARGI
HHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
GEKTVEAIREHARHADVSMWEAMRLLVANKGLTGRAATALGGFIELIENLAAKVMEMPLH
CHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTQTVIEQSGLITYHEQEKGEKGQARVENLEELVSAARAFENHESEEDLTPLAAFLGHA
HHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
SLEAGDTQAQEHEDSIQLMTLHSAKGLEFPHVFLVGMEEGLFPHKMSLEEPGRLEEERRL
CCCCCCCHHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
AYVGITRAMKQLVMTYAETRRLYGSETYNKVSRFVREIPPALIQEVRLSNSVNRPFGGTP
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
KFNSSSLFNGTGIPETEFTMGQRVQHAVFGEGVILNFEGAGAQARVQVNFSEGSKWLMMG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCEEEEH
YAKLVPL
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]