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The map label for this gene is phoR [H]

Identifier: 66048257

GI number: 66048257

Start: 5971772

End: 5973094

Strand: Direct

Name: phoR [H]

Synonym: Psyr_5033

Alternate gene names: 66048257

Gene position: 5971772-5973094 (Clockwise)

Preceding gene: 66048256

Following gene: 66048258

Centisome position: 98.0

GC content: 60.62

Gene sequence:

>1323_bases
TTGAATCAAAATTGGCACGGCACTCTGATACGCCACATGTTGTTGCTGGTCACCGCCTGCCTGTTGGTCGGCCTGATCAG
TGGGCAATATGCCTGGAGCCTGGCCGCCGGGCTGGGGCTGTATCTGGCCTGGACCCTCAAGCAACTGTTGCGCCTGCATG
AATGGCTGAGCAGCCACAAGGCCGACGAGCCGCCTCCGGACGGTTACGGTCTGTGGGGCGAGGTCTTCGATAGCATTTAT
CACCTGCAACGTCGTGATCAACGCGTCCGCGGTCGCCTTCAGGCGGTCATCGACCGCGTGCAGGAATCCACCGCCGCGCT
GCGTGATGCGGTGATCATGCTCGACAGCGACGGCAATCTGGAGTGGTGGAACCGTGCCGCTGAAACCCTGCTGGGTCTGA
AGACGCCGCAGGACAGCGGGCAGCCCGTGACCAACCTGGTGCGGCATCCACGTTTCAAGGAATACTTTGCGCTGGGCGAC
TACAGCGAGCCGCTGGAAATCCCGTCGCCGACCAACGATCGCCTGCGCATTCAGTTGCTGATCACCCGTTATGGCAACAA
TGAGCATCTGATGCTGGTGCGCGACGTAACGCGCATTCATCAGCTGGAGCAGATGCGCAAAGACTTCGTCGCTAACGTGT
CTCACGAGTTGCGGACGCCGCTCACGGTGATCTTCGGCTACCTGGAAACGCTGCTCGATAACGTGGACGAGGTCAATCCA
CGCTGGGTCCGTGCGCTGCAACAGATGCATCAGCAAGGCGGGCGCATGCAGACGCTGCTCAATGACCTGCTGTTGCTGGC
CAAGCTCGAGGCCACCGATTACCCCTCGGACAACCACCCGGTGGTCGTCAATTCCCTGCTCAAGACCATCACCGCCGATG
CCAACGCGCTGTCGGGCAGCAAGAACCAGCAGATCCACCTCAGCCTGGAAAGCGACATGCGCCTCAAGGGCAGCGAAAGC
GAACTGCGCAGCGCGTTTTCCAACCTGATTTTCAATGCCGTCAAATACACCCCGGCCGAGGGCGTGATCCGTATTCGCTG
GTGGGCCGACGAACGGGGCGCGCACCTGAGCGTGCAGGATTCAGGGATCGGCATCGAGACCAAACACCTGCCGCGCCTGA
CAGAGCGCTTCTACCGGGTCGATACCAGCCGCGCGTCCAATACCGGCGGTACAGGGCTCGGTCTGGCCATCGTCAAACAT
GTGCTGCTGCGCCATCGCGGCAACCTCGAGATCAACAGTGTTCTCGGCAAGGGCAGTGTTTTTACCTGTCACTTTGCCAG
CGCTCAGTTGTCCAAACCCGCGAGCGACGATTCAGACTACTAG

Upstream 100 bases:

>100_bases
CGTACGCGGCACTGGCTATCGTTTCTCGACCAAAAGCTGACAACCGCTGCGTCGACGCAGGGCAAGGGCCGGTGCAGACC
AGACAAGGATTTACCCCTAA

Downstream 100 bases:

>100_bases
GCAATCCCGCTTCGAGCCGCTACATTGCCGGGTTCATAGCGTCCTCTCTGGCGTGACACGACCCTCTTCCTGTTAATACG
GACCCTGCAAAACCCAATCA

Product: PAS:ATP-binding region, ATPase-like:histidine kinase A, N-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MNQNWHGTLIRHMLLLVTACLLVGLISGQYAWSLAAGLGLYLAWTLKQLLRLHEWLSSHKADEPPPDGYGLWGEVFDSIY
HLQRRDQRVRGRLQAVIDRVQESTAALRDAVIMLDSDGNLEWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFALGD
YSEPLEIPSPTNDRLRIQLLITRYGNNEHLMLVRDVTRIHQLEQMRKDFVANVSHELRTPLTVIFGYLETLLDNVDEVNP
RWVRALQQMHQQGGRMQTLLNDLLLLAKLEATDYPSDNHPVVVNSLLKTITADANALSGSKNQQIHLSLESDMRLKGSES
ELRSAFSNLIFNAVKYTPAEGVIRIRWWADERGAHLSVQDSGIGIETKHLPRLTERFYRVDTSRASNTGGTGLGLAIVKH
VLLRHRGNLEINSVLGKGSVFTCHFASAQLSKPASDDSDY

Sequences:

>Translated_440_residues
MNQNWHGTLIRHMLLLVTACLLVGLISGQYAWSLAAGLGLYLAWTLKQLLRLHEWLSSHKADEPPPDGYGLWGEVFDSIY
HLQRRDQRVRGRLQAVIDRVQESTAALRDAVIMLDSDGNLEWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFALGD
YSEPLEIPSPTNDRLRIQLLITRYGNNEHLMLVRDVTRIHQLEQMRKDFVANVSHELRTPLTVIFGYLETLLDNVDEVNP
RWVRALQQMHQQGGRMQTLLNDLLLLAKLEATDYPSDNHPVVVNSLLKTITADANALSGSKNQQIHLSLESDMRLKGSES
ELRSAFSNLIFNAVKYTPAEGVIRIRWWADERGAHLSVQDSGIGIETKHLPRLTERFYRVDTSRASNTGGTGLGLAIVKH
VLLRHRGNLEINSVLGKGSVFTCHFASAQLSKPASDDSDY
>Mature_440_residues
MNQNWHGTLIRHMLLLVTACLLVGLISGQYAWSLAAGLGLYLAWTLKQLLRLHEWLSSHKADEPPPDGYGLWGEVFDSIY
HLQRRDQRVRGRLQAVIDRVQESTAALRDAVIMLDSDGNLEWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFALGD
YSEPLEIPSPTNDRLRIQLLITRYGNNEHLMLVRDVTRIHQLEQMRKDFVANVSHELRTPLTVIFGYLETLLDNVDEVNP
RWVRALQQMHQQGGRMQTLLNDLLLLAKLEATDYPSDNHPVVVNSLLKTITADANALSGSKNQQIHLSLESDMRLKGSES
ELRSAFSNLIFNAVKYTPAEGVIRIRWWADERGAHLSVQDSGIGIETKHLPRLTERFYRVDTSRASNTGGTGLGLAIVKH
VLLRHRGNLEINSVLGKGSVFTCHFASAQLSKPASDDSDY

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=413, Percent_Identity=40.1937046004843, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI1788393, Length=207, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI48994928, Length=273, Percent_Identity=32.2344322344322, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI145693157, Length=329, Percent_Identity=28.2674772036474, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786783, Length=224, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789149, Length=234, Percent_Identity=27.7777777777778, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788549, Length=381, Percent_Identity=25.9842519685039, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=29.2035398230088, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790346, Length=217, Percent_Identity=27.1889400921659, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=31.1965811965812, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=217, Percent_Identity=29.4930875576037, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790861, Length=230, Percent_Identity=29.1304347826087, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=28.6363636363636, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=207, Percent_Identity=33.8164251207729, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788279, Length=269, Percent_Identity=25.6505576208178, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=28.448275862069, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=25.5230125523013, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49700; Mature: 49700

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNWHGTLIRHMLLLVTACLLVGLISGQYAWSLAAGLGLYLAWTLKQLLRLHEWLSSHK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADEPPPDGYGLWGEVFDSIYHLQRRDQRVRGRLQAVIDRVQESTAALRDAVIMLDSDGNL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCH
EWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFALGDYSEPLEIPSPTNDRLRIQLL
HHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
ITRYGNNEHLMLVRDVTRIHQLEQMRKDFVANVSHELRTPLTVIFGYLETLLDNVDEVNP
EEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RWVRALQQMHQQGGRMQTLLNDLLLLAKLEATDYPSDNHPVVVNSLLKTITADANALSGS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHCCCC
KNQQIHLSLESDMRLKGSESELRSAFSNLIFNAVKYTPAEGVIRIRWWADERGAHLSVQD
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEC
SGIGIETKHLPRLTERFYRVDTSRASNTGGTGLGLAIVKHVLLRHRGNLEINSVLGKGSV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHEECCCCE
FTCHFASAQLSKPASDDSDY
EEEEECCHHCCCCCCCCCCC
>Mature Secondary Structure
MNQNWHGTLIRHMLLLVTACLLVGLISGQYAWSLAAGLGLYLAWTLKQLLRLHEWLSSHK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADEPPPDGYGLWGEVFDSIYHLQRRDQRVRGRLQAVIDRVQESTAALRDAVIMLDSDGNL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCH
EWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFALGDYSEPLEIPSPTNDRLRIQLL
HHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
ITRYGNNEHLMLVRDVTRIHQLEQMRKDFVANVSHELRTPLTVIFGYLETLLDNVDEVNP
EEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RWVRALQQMHQQGGRMQTLLNDLLLLAKLEATDYPSDNHPVVVNSLLKTITADANALSGS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHCCCC
KNQQIHLSLESDMRLKGSESELRSAFSNLIFNAVKYTPAEGVIRIRWWADERGAHLSVQD
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEC
SGIGIETKHLPRLTERFYRVDTSRASNTGGTGLGLAIVKHVLLRHRGNLEINSVLGKGSV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHEECCCCE
FTCHFASAQLSKPASDDSDY
EEEEECCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]