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The map label for this gene is modE [H]

Identifier: 66047913

GI number: 66047913

Start: 5556864

End: 5557628

Strand: Direct

Name: modE [H]

Synonym: Psyr_4689

Alternate gene names: 66047913

Gene position: 5556864-5557628 (Clockwise)

Preceding gene: 66047912

Following gene: 66047914

Centisome position: 91.19

GC content: 61.96

Gene sequence:

>765_bases
ATGTCCCTGCCTCCCTTACTCACGCAACACATGGTCCGCCGCCCGCAACGCATTGCGCTGCTGCAGCATATTGCCGAACA
GGGCTCGATCACCCGTGCGGCGAAAAGCGCAGGGCTGAGTTACAAGGCGGCCTGGGACGCGATCGACGAGCTGAACAATC
TGGCGCAAAAACCGCTGGTAGAGCGCAGTGTCGGCGGGCGCGGCGGTGGCGGCGCTAAGTTGTCGGTCGAGGGCGAGCGA
GTGCTGCGTCTCTATCAGCGCGTCCAGGCATTGCAAGCCCAGGTGCTGGAAGCCGCCGAAGACAGCAGCGATCTGGACTT
GCTCAATCGCCTGACCCTGCGCACCAGCGCACGCAACCAGTTGCTGGGGCGGATCGTCAGTATCACGCGTCAGGGGCACA
ACGATCAGGTTCGCCTGCAACTGGCCGACGAGGTATTTATCGAAGCACAGGTCACCCATGACAGCACGCTGCGTCTGCAG
CTGGAGAACGGCACGGAAGTGGTTGCACTGATCAAGGCCGGCTGGCTGGAGCTGCACGCAGACAGCAGCGAAGAAACAAA
TGGAAACAATTGCCTGACCGGCCGAATCGACAGCGTGACCGACGCTGAAGATGGCCCAAGCGAAGTACGCATCACACTCC
CCGGCGGCCAGACGCTGTGCGCCCTGGCGACACCTGAGCACCTGCGTGCACAGCAGTTGAAAACCGGTGCCACGGTGCAG
GCAAGATTCGCAGCTTCACTGGTGTTGCTGGGCATACCGCTGTAA

Upstream 100 bases:

>100_bases
TCCGCGTGGTAGCGCAGCCCTGGACGCTCCGCGTCCGGTTTCGACGTCATGCACCAGAGCGATCATACTGCCCTCTCCTA
CTCGACCACCCCGGATCACC

Downstream 100 bases:

>100_bases
GCGCCGGCAGGTCATCACCACGACACAATTTCGTCATATGCGCGCACTAAGGTGGCTGCCATATTCGAGGGAGCCGTGAT
GATGAAACTATTAGAAGAAA

Product: helix-turn-helix, Fis-type:molybdenum-binding protein, N-terminal:molybdenum-pterin binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSLPPLLTQHMVRRPQRIALLQHIAEQGSITRAAKSAGLSYKAAWDAIDELNNLAQKPLVERSVGGRGGGGAKLSVEGER
VLRLYQRVQALQAQVLEAAEDSSDLDLLNRLTLRTSARNQLLGRIVSITRQGHNDQVRLQLADEVFIEAQVTHDSTLRLQ
LENGTEVVALIKAGWLELHADSSEETNGNNCLTGRIDSVTDAEDGPSEVRITLPGGQTLCALATPEHLRAQQLKTGATVQ
ARFAASLVLLGIPL

Sequences:

>Translated_254_residues
MSLPPLLTQHMVRRPQRIALLQHIAEQGSITRAAKSAGLSYKAAWDAIDELNNLAQKPLVERSVGGRGGGGAKLSVEGER
VLRLYQRVQALQAQVLEAAEDSSDLDLLNRLTLRTSARNQLLGRIVSITRQGHNDQVRLQLADEVFIEAQVTHDSTLRLQ
LENGTEVVALIKAGWLELHADSSEETNGNNCLTGRIDSVTDAEDGPSEVRITLPGGQTLCALATPEHLRAQQLKTGATVQ
ARFAASLVLLGIPL
>Mature_253_residues
SLPPLLTQHMVRRPQRIALLQHIAEQGSITRAAKSAGLSYKAAWDAIDELNNLAQKPLVERSVGGRGGGGAKLSVEGERV
LRLYQRVQALQAQVLEAAEDSSDLDLLNRLTLRTSARNQLLGRIVSITRQGHNDQVRLQLADEVFIEAQVTHDSTLRLQL
ENGTEVVALIKAGWLELHADSSEETNGNNCLTGRIDSVTDAEDGPSEVRITLPGGQTLCALATPEHLRAQQLKTGATVQA
RFAASLVLLGIPL

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=247, Percent_Identity=40.4858299595142, Blast_Score=141, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 27496; Mature: 27364

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPPLLTQHMVRRPQRIALLQHIAEQGSITRAAKSAGLSYKAAWDAIDELNNLAQKPLV
CCCCHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
ERSVGGRGGGGAKLSVEGERVLRLYQRVQALQAQVLEAAEDSSDLDLLNRLTLRTSARNQ
HHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLGRIVSITRQGHNDQVRLQLADEVFIEAQVTHDSTLRLQLENGTEVVALIKAGWLELHA
HHHHHHHHHHCCCCCEEEEEEECEEEEEEEECCCCEEEEEECCCCEEEEEEECCCEEEEC
DSSEETNGNNCLTGRIDSVTDAEDGPSEVRITLPGGQTLCALATPEHLRAQQLKTGATVQ
CCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCH
ARFAASLVLLGIPL
HHHHHHHHEEECCC
>Mature Secondary Structure 
SLPPLLTQHMVRRPQRIALLQHIAEQGSITRAAKSAGLSYKAAWDAIDELNNLAQKPLV
CCCHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
ERSVGGRGGGGAKLSVEGERVLRLYQRVQALQAQVLEAAEDSSDLDLLNRLTLRTSARNQ
HHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLGRIVSITRQGHNDQVRLQLADEVFIEAQVTHDSTLRLQLENGTEVVALIKAGWLELHA
HHHHHHHHHHCCCCCEEEEEEECEEEEEEEECCCCEEEEEECCCCEEEEEEECCCEEEEC
DSSEETNGNNCLTGRIDSVTDAEDGPSEVRITLPGGQTLCALATPEHLRAQQLKTGATVQ
CCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCH
ARFAASLVLLGIPL
HHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]