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The map label for this gene is deoR [H]

Identifier: 66047717

GI number: 66047717

Start: 5352121

End: 5352885

Strand: Reverse

Name: deoR [H]

Synonym: Psyr_4490

Alternate gene names: 66047717

Gene position: 5352885-5352121 (Counterclockwise)

Preceding gene: 66047719

Following gene: 66047713

Centisome position: 87.84

GC content: 62.35

Gene sequence:

>765_bases
GTGGACGTCAAGAAAACCGACCGCATCAAACAGATTCAACAGGCCCTGCAAGATCAGAAAGCGATCCATCTGCGGGAGAT
GGCGGCGCTGCTCGATGTGTCCGAAATGACCTTGCGCCGCGACCTCAGCCGGCACCCCGAGCGGTTACGACTGCTGGGCG
GCTACATCACCCGTGCCCACGATGATCCTGAACCGGGGGATTACCGGGTCAGCGAGCAGGGCACCCGCCATGTCGAGGAG
AAGCGCCGCATCGGCAAGCTGGCCGCCACCTTCATCCAGCCCGGCGATACGGTATTTTTCGACTGTGGCACGACGATCCC
CTTCGTGGTCGACTTCATCCCCGACGAGCTGGAGTTCACCGCGGTGTGCAACTCGCTCAACGTGCTGCTCAAGCTGCAGC
AGAAACCCAACTGCAGCATCGTCCTGTGCGGCGGCATGTTCCACCGCAAGAACCAGGTGTTCGAGAGCCATGCCGAAACC
AGCATCCTCGATGGCGTGCGCCTGACCTGGGCCTTTGTCTCGGCGGCCGGGGTCAGCCTGGACTGCGGTGTCACCTGCTT
CAATCTCCACGAGGTTGAGGTCAAGCAGAAGGTCATGCGCCAGGCCCGGCAAAGCCTGCTGCTGGCCGACCACTCCAAAT
TCGACGCCGTACGCACTGCGCACTTCGGTGCCTTGAGCGATTTCCATTGCGTGGTCAGCGACAAGAAAATCCCGCGCAGC
TACCGCGAGGCCATCGAGGCCGGCGGCGCGCAGCTTGTGCTCTAG

Upstream 100 bases:

>100_bases
TCCTGTCATCGGTAAAAATACTTGGGTGGATACCCGTAAGTTATAAAATTAACACTTGGTGTTACTCTAGTGACCCCACC
AACGGATTGCCGGGATGCCC

Downstream 100 bases:

>100_bases
ATGCATCACGGTTGCAGCGCCCGGCGTTCGGGTGCGTTGAGGTAACCGGTGGTCACGCTGAATTCGGCGCGGGCACCGGG
CGCCAGGCTGCGCACGTTGC

Product: regulatory protein, DeoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MDVKKTDRIKQIQQALQDQKAIHLREMAALLDVSEMTLRRDLSRHPERLRLLGGYITRAHDDPEPGDYRVSEQGTRHVEE
KRRIGKLAATFIQPGDTVFFDCGTTIPFVVDFIPDELEFTAVCNSLNVLLKLQQKPNCSIVLCGGMFHRKNQVFESHAET
SILDGVRLTWAFVSAAGVSLDCGVTCFNLHEVEVKQKVMRQARQSLLLADHSKFDAVRTAHFGALSDFHCVVSDKKIPRS
YREAIEAGGAQLVL

Sequences:

>Translated_254_residues
MDVKKTDRIKQIQQALQDQKAIHLREMAALLDVSEMTLRRDLSRHPERLRLLGGYITRAHDDPEPGDYRVSEQGTRHVEE
KRRIGKLAATFIQPGDTVFFDCGTTIPFVVDFIPDELEFTAVCNSLNVLLKLQQKPNCSIVLCGGMFHRKNQVFESHAET
SILDGVRLTWAFVSAAGVSLDCGVTCFNLHEVEVKQKVMRQARQSLLLADHSKFDAVRTAHFGALSDFHCVVSDKKIPRS
YREAIEAGGAQLVL
>Mature_254_residues
MDVKKTDRIKQIQQALQDQKAIHLREMAALLDVSEMTLRRDLSRHPERLRLLGGYITRAHDDPEPGDYRVSEQGTRHVEE
KRRIGKLAATFIQPGDTVFFDCGTTIPFVVDFIPDELEFTAVCNSLNVLLKLQQKPNCSIVLCGGMFHRKNQVFESHAET
SILDGVRLTWAFVSAAGVSLDCGVTCFNLHEVEVKQKVMRQARQSLLLADHSKFDAVRTAHFGALSDFHCVVSDKKIPRS
YREAIEAGGAQLVL

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=235, Percent_Identity=47.6595744680851, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1790753, Length=258, Percent_Identity=27.1317829457364, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI226510968, Length=245, Percent_Identity=27.7551020408163, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789829, Length=255, Percent_Identity=28.6274509803922, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI87082344, Length=251, Percent_Identity=25.0996015936255, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1789059, Length=257, Percent_Identity=26.4591439688716, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789519, Length=254, Percent_Identity=24.4094488188976, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787540, Length=238, Percent_Identity=25.2100840336134, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788069, Length=235, Percent_Identity=24.6808510638298, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1789170, Length=238, Percent_Identity=23.9495798319328, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28560; Mature: 28560

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKKTDRIKQIQQALQDQKAIHLREMAALLDVSEMTLRRDLSRHPERLRLLGGYITRAH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
DDPEPGDYRVSEQGTRHVEEKRRIGKLAATFIQPGDTVFFDCGTTIPFVVDFIPDELEFT
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCHHHHH
AVCNSLNVLLKLQQKPNCSIVLCGGMFHRKNQVFESHAETSILDGVRLTWAFVSAAGVSL
HHHHHHHEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEE
DCGVTCFNLHEVEVKQKVMRQARQSLLLADHSKFDAVRTAHFGALSDFHCVVSDKKIPRS
ECCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCHH
YREAIEAGGAQLVL
HHHHHHCCCCEECC
>Mature Secondary Structure
MDVKKTDRIKQIQQALQDQKAIHLREMAALLDVSEMTLRRDLSRHPERLRLLGGYITRAH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
DDPEPGDYRVSEQGTRHVEEKRRIGKLAATFIQPGDTVFFDCGTTIPFVVDFIPDELEFT
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCHHHHH
AVCNSLNVLLKLQQKPNCSIVLCGGMFHRKNQVFESHAETSILDGVRLTWAFVSAAGVSL
HHHHHHHEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEE
DCGVTCFNLHEVEVKQKVMRQARQSLLLADHSKFDAVRTAHFGALSDFHCVVSDKKIPRS
ECCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCHH
YREAIEAGGAQLVL
HHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]