Click here to switch to the map view.

The map label for this gene is ldc [H]

Identifier: 66047474

GI number: 66047474

Start: 5061734

End: 5062897

Strand: Reverse

Name: ldc [H]

Synonym: Psyr_4247

Alternate gene names: 66047474

Gene position: 5062897-5061734 (Counterclockwise)

Preceding gene: 66047476

Following gene: 66047470

Centisome position: 83.08

GC content: 56.19

Gene sequence:

>1164_bases
ATGCCGATCAATGTCGAAGACTACTACTCAGCCGAAACCTTCAAGAAAATGAAGGCGTTCGCTGACAAGCAAGAAACCCC
GTTCGTGGTCATTGATACTGACATCATCAGCAAGGCATATGACGACCTGCGTGCGGGCTTCGAATTCGCCAAGGTTTACT
ACGCGGTCAAGGCCAACCCTGCCGTTGAAGTCATCAATCTGCTCAAGGAAAAGGGTTCGAGCTTCGACATCGCCTCGATC
TACGAGCTGGACAAGGTCCTGAGCTGCGGCGTTGGTCCGGAGCGCATGAGCTACGGCAACACCATCAAGAAATCCAAGGA
CATTCGTTACTTCTACGAGAAGGGCGTGCGTCTGTTCGCCACCGACTCCGAAGCCGACCTGCGCAACATTGCCAAGGCTG
CACCGGGCGCGAAAGTCTATGTGCGCATCCTGACCGAAGGGTCGACCACCGCCGACTGGCCTCTGTCGCGCAAATTCGGC
TGCCAGACCGACATGGCCATGGACCTGCTGATTCTTGCCCGCGATCTGGGTCTGGTGCCTTACGGCATCTCGTTCCACGT
CGGCTCGCAGCAGCGCGACATCAGCGTCTGGGATGCTGCCATCGCCAAGGTCAAAGTGATCTTCGAGCGTCTGAAAGAAG
AAGACGGCATCGTTCTCAAGCTGATCAACATGGGTGGCGGCTTCCCGGCCAACTACATCACCCGCACCAACAGCCTGGAA
ACCTACGCTGAAGAGATCATCCGCTTCCTGAAGGAAGACTTCGGTGATGACCTGCCGGAAATCATTCTCGAGCCAGGCCG
TTCGTTGATCTCCAACGCCGGTATTCTGGTCAGCGAAGTGGTACTGGTTGCCCGCAAGTCGCGTACCGCGGTCGAGCGTT
GGGTATACACCGATGTGGGCAAGTTCTCCGGCCTGATCGAAACCATGGACGAAGCCATCAAGTTTCCGATCTGGACCGAA
AAGAAAGGCGAAATGGAAGAAGTGGTCATCGCCGGTCCTACCTGCGACAGCGCCGACATCATGTACGAAAACTACAAGTA
CGGTCTGCCCCTCAACCTGGCCATCGGTGACCGCATGTACTGGTTGTCCACCGGTGCCTACACCACCAGTTACAGCGCAG
TGGAATTCAATGGCTTCCCGCCGCTGAAGTCGTTCTACCTGTAA

Upstream 100 bases:

>100_bases
GCGACATGCCTTGGGAAGTAGGCGAACCAAAGTGGGGATACGGAGGGCGTTCATTTGTACCCATTGACCAATACCGTTTG
CCAATAGGAGTTCCAGCAGC

Downstream 100 bases:

>100_bases
GCGCTGTCCTGATATAAAAACCCGCGAGTGATCGCGGGTTTTTTTTGCGTTTCATCCGGGGTCAGGCAGTCAGCTCCTGC
CCAGTGTCGAACCCTTTGGA

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MPINVEDYYSAETFKKMKAFADKQETPFVVIDTDIISKAYDDLRAGFEFAKVYYAVKANPAVEVINLLKEKGSSFDIASI
YELDKVLSCGVGPERMSYGNTIKKSKDIRYFYEKGVRLFATDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFG
CQTDMAMDLLILARDLGLVPYGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIVLKLINMGGGFPANYITRTNSLE
TYAEEIIRFLKEDFGDDLPEIILEPGRSLISNAGILVSEVVLVARKSRTAVERWVYTDVGKFSGLIETMDEAIKFPIWTE
KKGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRMYWLSTGAYTTSYSAVEFNGFPPLKSFYL

Sequences:

>Translated_387_residues
MPINVEDYYSAETFKKMKAFADKQETPFVVIDTDIISKAYDDLRAGFEFAKVYYAVKANPAVEVINLLKEKGSSFDIASI
YELDKVLSCGVGPERMSYGNTIKKSKDIRYFYEKGVRLFATDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFG
CQTDMAMDLLILARDLGLVPYGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIVLKLINMGGGFPANYITRTNSLE
TYAEEIIRFLKEDFGDDLPEIILEPGRSLISNAGILVSEVVLVARKSRTAVERWVYTDVGKFSGLIETMDEAIKFPIWTE
KKGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRMYWLSTGAYTTSYSAVEFNGFPPLKSFYL
>Mature_386_residues
PINVEDYYSAETFKKMKAFADKQETPFVVIDTDIISKAYDDLRAGFEFAKVYYAVKANPAVEVINLLKEKGSSFDIASIY
ELDKVLSCGVGPERMSYGNTIKKSKDIRYFYEKGVRLFATDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFGC
QTDMAMDLLILARDLGLVPYGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIVLKLINMGGGFPANYITRTNSLET
YAEEIIRFLKEDFGDDLPEIILEPGRSLISNAGILVSEVVLVARKSRTAVERWVYTDVGKFSGLIETMDEAIKFPIWTEK
KGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRMYWLSTGAYTTSYSAVEFNGFPPLKSFYL

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=389, Percent_Identity=31.1053984575836, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI22538418, Length=381, Percent_Identity=26.509186351706, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI21361583, Length=381, Percent_Identity=26.509186351706, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI16506287, Length=393, Percent_Identity=26.4631043256997, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562780, Length=384, Percent_Identity=30.9895833333333, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322664, Length=388, Percent_Identity=30.6701030927835, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24586472, Length=354, Percent_Identity=29.9435028248588, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24586474, Length=336, Percent_Identity=30.0595238095238, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43384; Mature: 43253

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPINVEDYYSAETFKKMKAFADKQETPFVVIDTDIISKAYDDLRAGFEFAKVYYAVKANP
CCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHEEHEEEEEECCC
AVEVINLLKEKGSSFDIASIYELDKVLSCGVGPERMSYGNTIKKSKDIRYFYEKGVRLFA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCHHCCCCHHHHHHCCCEEEE
TDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFGCQTDMAMDLLILARDLGLVP
ECCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
YGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIVLKLINMGGGFPANYITRTNSLE
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHEECCCCHH
TYAEEIIRFLKEDFGDDLPEIILEPGRSLISNAGILVSEVVLVARKSRTAVERWVYTDVG
HHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KFSGLIETMDEAIKFPIWTEKKGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRMY
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEEECCEEE
WLSTGAYTTSYSAVEFNGFPPLKSFYL
EEECCCEEEEECEEEECCCCCHHHHCC
>Mature Secondary Structure 
PINVEDYYSAETFKKMKAFADKQETPFVVIDTDIISKAYDDLRAGFEFAKVYYAVKANP
CCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHEEHEEEEEECCC
AVEVINLLKEKGSSFDIASIYELDKVLSCGVGPERMSYGNTIKKSKDIRYFYEKGVRLFA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCHHCCCCHHHHHHCCCEEEE
TDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFGCQTDMAMDLLILARDLGLVP
ECCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
YGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIVLKLINMGGGFPANYITRTNSLE
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHEECCCCHH
TYAEEIIRFLKEDFGDDLPEIILEPGRSLISNAGILVSEVVLVARKSRTAVERWVYTDVG
HHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KFSGLIETMDEAIKFPIWTEKKGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRMY
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEEECCEEE
WLSTGAYTTSYSAVEFNGFPPLKSFYL
EEECCCEEEEECEEEECCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]