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The map label for this gene is folP [H]

Identifier: 66047413

GI number: 66047413

Start: 4979120

End: 4979971

Strand: Reverse

Name: folP [H]

Synonym: Psyr_4186

Alternate gene names: 66047413

Gene position: 4979971-4979120 (Counterclockwise)

Preceding gene: 66047414

Following gene: 66047412

Centisome position: 81.72

GC content: 62.09

Gene sequence:

>852_bases
ATGACATCTGCGCTGTATCCAACCCGGTTGCCTTGCGGCAACCGGGTTCTTGATTTGGCCCATACGCACGTGATGGGCAT
CCTCAACGCAACCCCTGACTCATTTTCCGACGGCGGCCGCTACAGCCAGCTCGATGCTGCGCTGCGCCATGCCGAGGCAA
TGGTGCAGGCAGGCGCGACGCTTATCGATATCGGTGGTGAGTCAACGCGGCCGGGTGCGCGTCCAGTTTCTGCATCGGAA
GAGGTCGAACGTGTGGCCCCGCTGGTCGAGGTCATCGCGCGCGAGCTGGATGTGATCATCTCGGTGGATACCTCCACGCC
TGAGGTCATGCTGGCGACGGCTGGGCTGGGTGCCGGGCTCATCAACGACGTTCGCTCGCTGCAGCGCCCAGGCGCGCTTG
AGGCGGCCGCAAGCACCGGTTTGCCGGTCTGTCTCATGCATATGCTGGGCGAGCCCGGAACCATGCAGAATGACCCGCAC
TACGATGACCTGGTGGGCGAGGTCTGTGCCTTCCTGGCTGAGCGCATGAAGCAGTGCATCGCTGCAGGCATCGGTCAGCA
GCAGATCATTCTTGATCCGGGCTTTGGCTTTGCCAAGACACTGGAGCACAATCTGAGCCTGTTCAAGCATATGGAAGCGC
TGCATGCGCTCGGCCGGCCTTTGCTGGTGGGTGTTTCGCGCAAGAGCATGATCGGTGCTGTGCTGGGGCGTCCCGTCGAC
CAGCGTCTGTCCGGCGGGCTCGCCCTGGCGGTTCTGGCGATGGCCAAAGGGGCAAGAATTCTACGTGTGCATGATGTCGC
CGAAACGGCTGACGTGGTGCGCATGATCGCAGCTGTCGAAGCAGCTGAATAA

Upstream 100 bases:

>100_bases
ACTGGGGTGGTGGTTCGGGTACCAACGGTACTCCGATCACGCCTGACCCTCGTCCGGAAACTCCGATTGGCGGTCCTGCT
GCCGAGCACTAAGGTCTGAC

Downstream 100 bases:

>100_bases
CAACAGTGGGGCATCCATGACTAGCAGAAAATATTTCGGAACCGACGGCATTCGCGGTCGTGTAGGGCAATTCCCGATCA
CTCCCGAGTTCATGCTGAAA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTSALYPTRLPCGNRVLDLAHTHVMGILNATPDSFSDGGRYSQLDAALRHAEAMVQAGATLIDIGGESTRPGARPVSASE
EVERVAPLVEVIARELDVIISVDTSTPEVMLATAGLGAGLINDVRSLQRPGALEAAASTGLPVCLMHMLGEPGTMQNDPH
YDDLVGEVCAFLAERMKQCIAAGIGQQQIILDPGFGFAKTLEHNLSLFKHMEALHALGRPLLVGVSRKSMIGAVLGRPVD
QRLSGGLALAVLAMAKGARILRVHDVAETADVVRMIAAVEAAE

Sequences:

>Translated_283_residues
MTSALYPTRLPCGNRVLDLAHTHVMGILNATPDSFSDGGRYSQLDAALRHAEAMVQAGATLIDIGGESTRPGARPVSASE
EVERVAPLVEVIARELDVIISVDTSTPEVMLATAGLGAGLINDVRSLQRPGALEAAASTGLPVCLMHMLGEPGTMQNDPH
YDDLVGEVCAFLAERMKQCIAAGIGQQQIILDPGFGFAKTLEHNLSLFKHMEALHALGRPLLVGVSRKSMIGAVLGRPVD
QRLSGGLALAVLAMAKGARILRVHDVAETADVVRMIAAVEAAE
>Mature_282_residues
TSALYPTRLPCGNRVLDLAHTHVMGILNATPDSFSDGGRYSQLDAALRHAEAMVQAGATLIDIGGESTRPGARPVSASEE
VERVAPLVEVIARELDVIISVDTSTPEVMLATAGLGAGLINDVRSLQRPGALEAAASTGLPVCLMHMLGEPGTMQNDPHY
DDLVGEVCAFLAERMKQCIAAGIGQQQIILDPGFGFAKTLEHNLSLFKHMEALHALGRPLLVGVSRKSMIGAVLGRPVDQ
RLSGGLALAVLAMAKGARILRVHDVAETADVVRMIAAVEAAE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=267, Percent_Identity=57.3033707865169, Blast_Score=315, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6324073, Length=325, Percent_Identity=28.9230769230769, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29765; Mature: 29634

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSALYPTRLPCGNRVLDLAHTHVMGILNATPDSFSDGGRYSQLDAALRHAEAMVQAGAT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
LIDIGGESTRPGARPVSASEEVERVAPLVEVIARELDVIISVDTSTPEVMLATAGLGAGL
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEEECCCCHHH
INDVRSLQRPGALEAAASTGLPVCLMHMLGEPGTMQNDPHYDDLVGEVCAFLAERMKQCI
HHHHHHHCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AAGIGQQQIILDPGFGFAKTLEHNLSLFKHMEALHALGRPLLVGVSRKSMIGAVLGRPVD
HHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCHH
QRLSGGLALAVLAMAKGARILRVHDVAETADVVRMIAAVEAAE
HHHCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSALYPTRLPCGNRVLDLAHTHVMGILNATPDSFSDGGRYSQLDAALRHAEAMVQAGAT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
LIDIGGESTRPGARPVSASEEVERVAPLVEVIARELDVIISVDTSTPEVMLATAGLGAGL
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEEECCCCHHH
INDVRSLQRPGALEAAASTGLPVCLMHMLGEPGTMQNDPHYDDLVGEVCAFLAERMKQCI
HHHHHHHCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AAGIGQQQIILDPGFGFAKTLEHNLSLFKHMEALHALGRPLLVGVSRKSMIGAVLGRPVD
HHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCHH
QRLSGGLALAVLAMAKGARILRVHDVAETADVVRMIAAVEAAE
HHHCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]