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The map label for this gene is tpiA [H]

Identifier: 66047411

GI number: 66047411

Start: 4976938

End: 4977693

Strand: Reverse

Name: tpiA [H]

Synonym: Psyr_4184

Alternate gene names: 66047411

Gene position: 4977693-4976938 (Counterclockwise)

Preceding gene: 66047412

Following gene: 66047410

Centisome position: 81.69

GC content: 58.86

Gene sequence:

>756_bases
ATGCGTCGCCCAATGGTAGCTGGTAACTGGAAAATGCACGGTACCCGCGCCAGCGTCGCTGAGCTGATCGAGGGTTTGTG
CAAGCAGTCGTTGCCAGGCAGCGTCGATATCGCCGTGATGCCTGCCAGTCTGTTTACCTGTCAGGTGGTCGATGGGCTCA
AGGCCACGTCGATCATCGTCGGTGCGCAGGACGCAGCCATTCAGGCTGAGCAGGGCGCGCTGACGGGTGAAGTTGCATCT
AGCCAGCTGGCTGATGCAGGTTGCAAGCTGGTACTTGTCGGGCACTCCGAGCGTCGTCAGTTGATTGGCGAACAGGATGA
TGTTCTGAACAAAAAGTTTGCGGCAATCCAGGCGAAAGGTCTGACACCTGTGCTTTGCGTAGGTGAAACCCTGGAAGAGC
GCAAGGCGGGGCAAACGCTTGAAGTGGTAGGGCGTCAGCTGGACAGTGTTATCGCCGAGTTTGGCGTCAATGCACTGGTC
AACGCCGTCATTGCCTACGAGCCGGTCTGGGCCATTGGCACCGGATTGACTGCTTCGCCTCAGGAAGCGCAGGAAGTGCA
CGCAGCCATCCGTGCGCAACTGGCAAAAGAGAATGCCGAAGTCGCACAAGGCGTGCGACTTCTCTATGGCGGCAGCGTGA
AGGCGGCCAATGCGGTCGAGCTCTTCAGCATGCCGGATATCGATGGGGGGCTCATTGGTGGAGCTTCCCTGAATGCAGAT
GAGTTCGGTGCGATCTGTCGCGCCGCGGGAAACTGA

Upstream 100 bases:

>100_bases
ACTCGCAAAACTGGTTACTGAAGTTTGCGCCTGATTTCGGCTTGCCAGTGTCGGAACTGTTGGGTAACATCTGCGCCCAC
TTTGACCCACGAGGTGTAGC

Downstream 100 bases:

>100_bases
AAAAATGCTGGAAACAGTCGTAATCGTTTTTCACCTGTTGGGCGCTCTGGGCGTTGTCGCTCTGGTATTGCTGCAGCAGG
GTAAAGGTGCCGACGCAGGC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MRRPMVAGNWKMHGTRASVAELIEGLCKQSLPGSVDIAVMPASLFTCQVVDGLKATSIIVGAQDAAIQAEQGALTGEVAS
SQLADAGCKLVLVGHSERRQLIGEQDDVLNKKFAAIQAKGLTPVLCVGETLEERKAGQTLEVVGRQLDSVIAEFGVNALV
NAVIAYEPVWAIGTGLTASPQEAQEVHAAIRAQLAKENAEVAQGVRLLYGGSVKAANAVELFSMPDIDGGLIGGASLNAD
EFGAICRAAGN

Sequences:

>Translated_251_residues
MRRPMVAGNWKMHGTRASVAELIEGLCKQSLPGSVDIAVMPASLFTCQVVDGLKATSIIVGAQDAAIQAEQGALTGEVAS
SQLADAGCKLVLVGHSERRQLIGEQDDVLNKKFAAIQAKGLTPVLCVGETLEERKAGQTLEVVGRQLDSVIAEFGVNALV
NAVIAYEPVWAIGTGLTASPQEAQEVHAAIRAQLAKENAEVAQGVRLLYGGSVKAANAVELFSMPDIDGGLIGGASLNAD
EFGAICRAAGN
>Mature_251_residues
MRRPMVAGNWKMHGTRASVAELIEGLCKQSLPGSVDIAVMPASLFTCQVVDGLKATSIIVGAQDAAIQAEQGALTGEVAS
SQLADAGCKLVLVGHSERRQLIGEQDDVLNKKFAAIQAKGLTPVLCVGETLEERKAGQTLEVVGRQLDSVIAEFGVNALV
NAVIAYEPVWAIGTGLTASPQEAQEVHAAIRAQLAKENAEVAQGVRLLYGGSVKAANAVELFSMPDIDGGLIGGASLNAD
EFGAICRAAGN

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=251, Percent_Identity=43.8247011952191, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI4507645, Length=251, Percent_Identity=43.8247011952191, Blast_Score=182, Evalue=2e-46,
Organism=Escherichia coli, GI1790353, Length=251, Percent_Identity=47.808764940239, Blast_Score=233, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI17536593, Length=240, Percent_Identity=46.25, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320255, Length=240, Percent_Identity=44.5833333333333, Blast_Score=205, Evalue=5e-54,
Organism=Drosophila melanogaster, GI28572004, Length=248, Percent_Identity=43.1451612903226, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28572008, Length=248, Percent_Identity=43.1451612903226, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28572006, Length=248, Percent_Identity=43.1451612903226, Blast_Score=185, Evalue=2e-47,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26002; Mature: 26002

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPMVAGNWKMHGTRASVAELIEGLCKQSLPGSVDIAVMPASLFTCQVVDGLKATSIIV
CCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCEEEEEE
GAQDAAIQAEQGALTGEVASSQLADAGCKLVLVGHSERRQLIGEQDDVLNKKFAAIQAKG
ECCCHHEEHHCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHCCCCHHHHHHHHHHHEECC
LTPVLCVGETLEERKAGQTLEVVGRQLDSVIAEFGVNALVNAVIAYEPVWAIGTGLTASP
CCEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHCCCCCCCH
QEAQEVHAAIRAQLAKENAEVAQGVRLLYGGSVKAANAVELFSMPDIDGGLIGGASLNAD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCCEECCCCCCHH
EFGAICRAAGN
HHHHHHHCCCC
>Mature Secondary Structure
MRRPMVAGNWKMHGTRASVAELIEGLCKQSLPGSVDIAVMPASLFTCQVVDGLKATSIIV
CCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCEEEEEE
GAQDAAIQAEQGALTGEVASSQLADAGCKLVLVGHSERRQLIGEQDDVLNKKFAAIQAKG
ECCCHHEEHHCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHCCCCHHHHHHHHHHHEECC
LTPVLCVGETLEERKAGQTLEVVGRQLDSVIAEFGVNALVNAVIAYEPVWAIGTGLTASP
CCEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHCCCCCCCH
QEAQEVHAAIRAQLAKENAEVAQGVRLLYGGSVKAANAVELFSMPDIDGGLIGGASLNAD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCCEECCCCCCHH
EFGAICRAAGN
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA