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The map label for this gene is lpxC

Identifier: 66047323

GI number: 66047323

Start: 4884064

End: 4884975

Strand: Reverse

Name: lpxC

Synonym: Psyr_4096

Alternate gene names: 66047323

Gene position: 4884975-4884064 (Counterclockwise)

Preceding gene: 66047324

Following gene: 66047321

Centisome position: 80.16

GC content: 55.92

Gene sequence:

>912_bases
ATGATTAAACAACGCACCCTGAAAAATATTATCCGTGCCACAGGTGTAGGCCTGCACTCCGGGGAGAAGGTTTACCTGAC
CCTCAAGCCCGCACCTGTGAATACCGGCATTGTGTTTTGCCGAGCTGACCTTGACCCCGTCGTGCAGATCCCTGCGCGTG
CGGAAAACGTCGGTGACACCACTCTGTCGACCACTCTGGTCAATGGTGATGTCAAAGTCGACACGGTAGAACACTTGCTC
TCGGCCATGGCTGGCCTTGGCATCGATAACGCCTACGTCGAGCTCTCTGCCTCCGAAGTTCCTATCATGGACGGCAGCGC
AGGCCCTTTCGTATTCCTGATTCAATCGGCAGGCCTGGAAGAACAGGACGCGCCGAAGAAATTCATCCGTATCCTGCGTG
AAGTCACGGTGGAGGAGGGCGGTAAACGCGCTACCTTCGTGCCTTTCGAAGGGTTCAAGGTCAGTTTCGAGATCGATTTC
GATCACCCCGTCTTCCGTGACCGCACCCAGAGTGCAAGCGTGGACTTTTCCAGCACTTCCTTTGTGAAGGAAGTCAGCCG
TGCCCGGACCTTCGGGTTCATGAGTGATATCGAGTACCTGCGCAAGCACAACCTCGCACTCGGCGGCAGCGTGGAAAACG
CCATCGTGGTCGACAAGGACGGTGTACTGAACGAAGACGGCCTGCGTTACGAGGACGAATTCGTCAAACACAAAATCCTC
GACGCCATCGGTGACCTCTACCTGCTGGGCAACAGCCTGATAGGTGAGTTCCGGGGTTTCAAATCGGGGCATGCACTGAA
CAACCGTCTGCTGCGCACGTTGATCGAGCAGAAAGACGCTTGGGAAGTGGTGACTTTCGAGGATGCCAGTACGGCACCAA
TTTCTTACATGCGCCCTGTCGCGGCCGTGTAA

Upstream 100 bases:

>100_bases
GGGGTATTAGGGTGATTGGTGTTCAGCAAAGGCATGGTCTGCTATCATCGCCAGCCTTTGTTGATACCAGTTCGCAACTT
GCGCTGAAGCGGCCCATGCC

Downstream 100 bases:

>100_bases
GCAAGCTTTACTCTCTTTCCTTTTGTTCTTTAAAGGCTGCCCTCGGGTGGCCTTTTTTTATGGGTTTATTCAGGGGAAGT
CAGTGTTCGTGGAGGCCTTG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVNTGIVFCRADLDPVVQIPARAENVGDTTLSTTLVNGDVKVDTVEHLL
SAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLEEQDAPKKFIRILREVTVEEGGKRATFVPFEGFKVSFEIDF
DHPVFRDRTQSASVDFSSTSFVKEVSRARTFGFMSDIEYLRKHNLALGGSVENAIVVDKDGVLNEDGLRYEDEFVKHKIL
DAIGDLYLLGNSLIGEFRGFKSGHALNNRLLRTLIEQKDAWEVVTFEDASTAPISYMRPVAAV

Sequences:

>Translated_303_residues
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVNTGIVFCRADLDPVVQIPARAENVGDTTLSTTLVNGDVKVDTVEHLL
SAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLEEQDAPKKFIRILREVTVEEGGKRATFVPFEGFKVSFEIDF
DHPVFRDRTQSASVDFSSTSFVKEVSRARTFGFMSDIEYLRKHNLALGGSVENAIVVDKDGVLNEDGLRYEDEFVKHKIL
DAIGDLYLLGNSLIGEFRGFKSGHALNNRLLRTLIEQKDAWEVVTFEDASTAPISYMRPVAAV
>Mature_303_residues
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVNTGIVFCRADLDPVVQIPARAENVGDTTLSTTLVNGDVKVDTVEHLL
SAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLEEQDAPKKFIRILREVTVEEGGKRATFVPFEGFKVSFEIDF
DHPVFRDRTQSASVDFSSTSFVKEVSRARTFGFMSDIEYLRKHNLALGGSVENAIVVDKDGVLNEDGLRYEDEFVKHKIL
DAIGDLYLLGNSLIGEFRGFKSGHALNNRLLRTLIEQKDAWEVVTFEDASTAPISYMRPVAAV

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=56.25, Blast_Score=367, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_PSE14 (Q48EG4)

Other databases:

- EMBL:   CP000058
- RefSeq:   YP_276224.1
- ProteinModelPortal:   Q48EG4
- SMR:   Q48EG4
- STRING:   Q48EG4
- GeneID:   3555758
- GenomeReviews:   CP000058_GR
- KEGG:   psp:PSPPH_4102
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   Q48EG4
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33284; Mature: 33284

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVNTGIVFCRADLDPVVQIPARAENVGDT
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCEEECCCCCCCCCCC
TLSTTLVNGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLE
EEEEEEECCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCEEEEEECCCCC
EQDAPKKFIRILREVTVEEGGKRATFVPFEGFKVSFEIDFDHPVFRDRTQSASVDFSSTS
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCHHH
FVKEVSRARTFGFMSDIEYLRKHNLALGGSVENAIVVDKDGVLNEDGLRYEDEFVKHKIL
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
DAIGDLYLLGNSLIGEFRGFKSGHALNNRLLRTLIEQKDAWEVVTFEDASTAPISYMRPV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCHH
AAV
HCC
>Mature Secondary Structure
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVNTGIVFCRADLDPVVQIPARAENVGDT
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCEEECCCCCCCCCCC
TLSTTLVNGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLE
EEEEEEECCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCEEEEEECCCCC
EQDAPKKFIRILREVTVEEGGKRATFVPFEGFKVSFEIDFDHPVFRDRTQSASVDFSSTS
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCHHH
FVKEVSRARTFGFMSDIEYLRKHNLALGGSVENAIVVDKDGVLNEDGLRYEDEFVKHKIL
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
DAIGDLYLLGNSLIGEFRGFKSGHALNNRLLRTLIEQKDAWEVVTFEDASTAPISYMRPV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCHH
AAV
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA