Click here to switch to the map view.

The map label for this gene is pcaR [H]

Identifier: 66047241

GI number: 66047241

Start: 4781407

End: 4782249

Strand: Reverse

Name: pcaR [H]

Synonym: Psyr_4014

Alternate gene names: 66047241

Gene position: 4782249-4781407 (Counterclockwise)

Preceding gene: 66047244

Following gene: 66047240

Centisome position: 78.48

GC content: 60.62

Gene sequence:

>843_bases
ATGAACGACGAACTGCGTAAATCTTTTGCCTCATTGGCACCGCCCATCGTGGCGTCGCCCGCAAAGCGCATTCAGGCGCT
GACCGGTGATCCGGATTTCATGACCTCGCTGGCGCGTGGGCTGGCCGTGATTCATGCCTTTCAGGAGCGCAAGCGGCACC
TGACCATTGCGCAGATCAGCCATCGCACGGAGATCCCCCGTGCGGCAGTGCGTCGTTGTCTGCACACCCTGATCAAGCTC
GGTTATGCGACCACTGACGGCCGTACCTACTCGCTACTGCCCAAGGTGCTGACGCTGGGCCACGCCTATTTGTCATCGAC
GCCACTGGCAACCTCGTCGCAGCCTTATCTGGACCGTATGAGCGACCAGCTGCACGAGGCGTGCAACATGGCCACGCTGG
AAGGCGACGACATTCTTTATATCGCGCGCTCTGCCACCACGCAGCGGCTGATCTCGGTCGACCTTTCCGTGGGCGGTCGT
CTTCCCGCGTACTGCACGTCCATGGGCCGCATTCTGCTGGCCGCACTGGATGACGTGTCGTTGCATGAATACCTTGACCA
TGTCGATCTGCAGCCCAAGACCAGCCGCACCATTCGCACCCCGGAAGCCTTGCTCGAATGTCTGCAACTGGTTCGGCAAC
AGGGCTGGTGCATTGTCGATCAGGAACTGGAACAGGGGCTGCGTTCAATTGCGGTACCGGTCTATGATGCGTCGGGCCAG
GTGCTGGCGGCGCTGAATGTCAGCACCAGCGCCGGACGTGTGGCACGCAGCGAGCTGGAACAGCGCTTTCTGCCCATCAT
GCTTGATGCCAGTCGCGACTTGAGTACGCAGCTGTTTACCTGA

Upstream 100 bases:

>100_bases
TGTTCGATAATCGCACAACCGGGGATTGGCTTCGCTCCCCTGCAAAGAGCTGAAACCTGCGGTTTACAGGGCCTGAAAGG
CAGTTACATAAGGTGTGTCA

Downstream 100 bases:

>100_bases
AGTGGCCGTGTTTCGGCATGATGGAATTCGTTCGATTACCGAACGTTTAGTCGATTATCGGATTGTTTGCCCTCTTGCTC
AGGCATAACCTCATTTTCAT

Product: regulatory proteins, IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNDELRKSFASLAPPIVASPAKRIQALTGDPDFMTSLARGLAVIHAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKL
GYATTDGRTYSLLPKVLTLGHAYLSSTPLATSSQPYLDRMSDQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGR
LPAYCTSMGRILLAALDDVSLHEYLDHVDLQPKTSRTIRTPEALLECLQLVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
VLAALNVSTSAGRVARSELEQRFLPIMLDASRDLSTQLFT

Sequences:

>Translated_280_residues
MNDELRKSFASLAPPIVASPAKRIQALTGDPDFMTSLARGLAVIHAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKL
GYATTDGRTYSLLPKVLTLGHAYLSSTPLATSSQPYLDRMSDQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGR
LPAYCTSMGRILLAALDDVSLHEYLDHVDLQPKTSRTIRTPEALLECLQLVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
VLAALNVSTSAGRVARSELEQRFLPIMLDASRDLSTQLFT
>Mature_280_residues
MNDELRKSFASLAPPIVASPAKRIQALTGDPDFMTSLARGLAVIHAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKL
GYATTDGRTYSLLPKVLTLGHAYLSSTPLATSSQPYLDRMSDQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGR
LPAYCTSMGRILLAALDDVSLHEYLDHVDLQPKTSRTIRTPEALLECLQLVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
VLAALNVSTSAGRVARSELEQRFLPIMLDASRDLSTQLFT

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=256, Percent_Identity=33.203125, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786468, Length=230, Percent_Identity=29.1304347826087, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789999, Length=255, Percent_Identity=27.843137254902, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87082359, Length=265, Percent_Identity=23.3962264150943, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786715, Length=248, Percent_Identity=25, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30880; Mature: 30880

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDELRKSFASLAPPIVASPAKRIQALTGDPDFMTSLARGLAVIHAFQERKRHLTIAQIS
CCHHHHHHHHHHCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
HRTEIPRAAVRRCLHTLIKLGYATTDGRTYSLLPKVLTLGHAYLSSTPLATSSQPYLDRM
HHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
SDQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGRLPAYCTSMGRILLAALDDVS
HHHHHHHHCCCEECCCCEEEEECCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCHH
LHEYLDHVDLQPKTSRTIRTPEALLECLQLVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHHCCEEECCCCC
VLAALNVSTSAGRVARSELEQRFLPIMLDASRDLSTQLFT
EEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCHHHCCC
>Mature Secondary Structure
MNDELRKSFASLAPPIVASPAKRIQALTGDPDFMTSLARGLAVIHAFQERKRHLTIAQIS
CCHHHHHHHHHHCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
HRTEIPRAAVRRCLHTLIKLGYATTDGRTYSLLPKVLTLGHAYLSSTPLATSSQPYLDRM
HHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
SDQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGRLPAYCTSMGRILLAALDDVS
HHHHHHHHCCCEECCCCEEEEECCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCHH
LHEYLDHVDLQPKTSRTIRTPEALLECLQLVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHHCCEEECCCCC
VLAALNVSTSAGRVARSELEQRFLPIMLDASRDLSTQLFT
EEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]