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The map label for this gene is dctB [H]

Identifier: 66047139

GI number: 66047139

Start: 4654401

End: 4656308

Strand: Direct

Name: dctB [H]

Synonym: Psyr_3912

Alternate gene names: 66047139

Gene position: 4654401-4656308 (Clockwise)

Preceding gene: 66047138

Following gene: 66047140

Centisome position: 76.38

GC content: 62.74

Gene sequence:

>1908_bases
ATGAAATGCGACCCCACTCTTTATCGCGCCGCCCCGCCATCACTCGCCGTGAAACCCCGTCTGATCCGTCAACTGTTTCT
GCCGCCGCTGATCCTCATGCTGATGATCGGGCTGGGCTATATCGCCTATCTGGTCAGTGAACACAGCGGCATCAAGAGCC
TGCGCGAAACCGGCGAACGTCAGCTCGAGCTGCACGCGCGCACGGTCGAGAGCGAAATCAGCAAATACACCTACCTGCCC
AGCGTGCTGGAGCTCGAATCCAGCGTGTCGCAGTTGCTGAACGAACCGGGACCCGAGCTTCAGCAGCAGGTCAACCGCTA
CCTCGAAGGGCTGAATCGACGCAGTCGCAGCCGTGCCATTTATGTAATGGATACCACCGGACGCGTGCTGGCCACCAGCA
ACTGGCGCGACGCCGACAGTTATCAGGGTGAAGACCTGTCTTTCCGTGCCTACTTTCAGGACGCGGTGCGCGGCCTGCCC
GGGCGCTTTTACGGCATCGGCACCACCACCGGGGAGTCGGGCTATTACCTGGCGCACGGGCTGGAAGACAAAGGCCGCAT
TATCGGCGTTGCGGTGATCAAGGTGCGCCTCGAAGCACTCGAAGAACGCTGGCAGCGGGCACGGCTGGAGGCGTTTGTCA
GCGACGAGAATGGCATCATCATCCTCTCCAGCGACCCGGCCCGGCGTCTGAAATCAGTGCGCCCGCTCACGGCTGAGGTC
AAGGAGCGCCTGGCTCGCAGCCTGCAATATTACTGGTGGCCGCTCAACGAATTGGTGCCACTGGAACGGGAAACCTTGTC
CGAGGGCGTCGAGACACTGGTTTTCCCCGCCAACATCAGTGTCGACCGCGAACACAAAAAGGTCAGTTATCTGGCCCAGA
GCCGCCCGCTGAGTGACACCGCCTGGCACCTGACACTGCTTACCCCGCTGGAGAATCTGCGCCGTGAAGCGGCCAATCAG
GGCATGCTGGTCGCCGTGGCTTGCGCGCTGGTGACCTTTCTGCTGATCGCCTGGAACGAGCGGCGCAAGGTCATCTCGAC
CCGGCTTGCGGCCAGGGAAGCGCTGCAGGCTGCCAACAACGAGCTGGAACGCAAGATCGCCGAACGTACCGAACACCTGC
GGGCCAGCAACGAACGCCTCAAGGCGCAGATTCGTGAACGAAGGCAGGCTGAGGACACCTTGCGCAAGGCGCAGGACGAG
CTGGTACAGGCCGGAAAGCTGGCAGCCATCGGCCAGATGTCGACCAGCATCGCGCATGAACTGAACCAGCCTCTGGCTGC
ACTGCGCACCTTGTCCGGCAACACCGTGCGCTTTCTGGAACGAGGTGCGCTGGACACCGCGAGCACCAACCTGCGTACCA
TCAATGATCTGGTCGATCGCATGGGCCGCATCACCGCCAGCCTGCGCGCATTCGCCAGACGCGGCGACGATCAGGGCCAG
GCGCAACTGAGCAAGGCTGTCGATGCGGCGATGCAATTGCTGGGCGTGCGCGTGGAGCAGTCCGGTCTGACGCTGCATCG
AGACTTCGTCGACGCCACCCTGACCATCGACCAGACCCGCCTGGAACAGATTCTGGTCAACCTGATCGGCAACGCACTGG
ACGCCATGTTCGACCTGCAGCAACCGGAGTTATGGCTCACCGGATCGGTTATCGACGGCCGATACCGTCTGCGGGTACGT
GATAACGGGCACGGCGTCGATGCCGACGCGCGCAAGCATCTGTTTGAACCTTTTTTCACCACCAAACCGGGCGAACAAGG
CCTGGGGCTGGGCCTGACACTGTCGGCGAGCCTTGCCGCCGCAGCCGGGGGCAGCCTGAGCGCAGAGCATCCGCAGGACG
GCGGTACGACGTTTGTCCTGAGCCTGCCGTTCATCCCCGATGCCCGCCACCCGGACAGCCCGACATGA

Upstream 100 bases:

>100_bases
ACGCGCTCAGCAATTCCTCGCCAAGATTCTTCAGCACTAGGCAATAGCTTGACGGCTGTCCGCCTATCAGCGGGCAGCTG
TTCGGTCCAGGACGACTGTG

Downstream 100 bases:

>100_bases
GACGACACCCATGAGCATAAACAGCGACCTGACCGTCCTGATCGTCGAAGACGATCCGCATGTATTGCTCGGCTGCCAGC
AGGCCCTCGCGCTGGAAGAC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MKCDPTLYRAAPPSLAVKPRLIRQLFLPPLILMLMIGLGYIAYLVSEHSGIKSLRETGERQLELHARTVESEISKYTYLP
SVLELESSVSQLLNEPGPELQQQVNRYLEGLNRRSRSRAIYVMDTTGRVLATSNWRDADSYQGEDLSFRAYFQDAVRGLP
GRFYGIGTTTGESGYYLAHGLEDKGRIIGVAVIKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVRPLTAEV
KERLARSLQYYWWPLNELVPLERETLSEGVETLVFPANISVDREHKKVSYLAQSRPLSDTAWHLTLLTPLENLRREAANQ
GMLVAVACALVTFLLIAWNERRKVISTRLAAREALQAANNELERKIAERTEHLRASNERLKAQIRERRQAEDTLRKAQDE
LVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLERGALDTASTNLRTINDLVDRMGRITASLRAFARRGDDQGQ
AQLSKAVDAAMQLLGVRVEQSGLTLHRDFVDATLTIDQTRLEQILVNLIGNALDAMFDLQQPELWLTGSVIDGRYRLRVR
DNGHGVDADARKHLFEPFFTTKPGEQGLGLGLTLSASLAAAAGGSLSAEHPQDGGTTFVLSLPFIPDARHPDSPT

Sequences:

>Translated_635_residues
MKCDPTLYRAAPPSLAVKPRLIRQLFLPPLILMLMIGLGYIAYLVSEHSGIKSLRETGERQLELHARTVESEISKYTYLP
SVLELESSVSQLLNEPGPELQQQVNRYLEGLNRRSRSRAIYVMDTTGRVLATSNWRDADSYQGEDLSFRAYFQDAVRGLP
GRFYGIGTTTGESGYYLAHGLEDKGRIIGVAVIKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVRPLTAEV
KERLARSLQYYWWPLNELVPLERETLSEGVETLVFPANISVDREHKKVSYLAQSRPLSDTAWHLTLLTPLENLRREAANQ
GMLVAVACALVTFLLIAWNERRKVISTRLAAREALQAANNELERKIAERTEHLRASNERLKAQIRERRQAEDTLRKAQDE
LVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLERGALDTASTNLRTINDLVDRMGRITASLRAFARRGDDQGQ
AQLSKAVDAAMQLLGVRVEQSGLTLHRDFVDATLTIDQTRLEQILVNLIGNALDAMFDLQQPELWLTGSVIDGRYRLRVR
DNGHGVDADARKHLFEPFFTTKPGEQGLGLGLTLSASLAAAAGGSLSAEHPQDGGTTFVLSLPFIPDARHPDSPT
>Mature_635_residues
MKCDPTLYRAAPPSLAVKPRLIRQLFLPPLILMLMIGLGYIAYLVSEHSGIKSLRETGERQLELHARTVESEISKYTYLP
SVLELESSVSQLLNEPGPELQQQVNRYLEGLNRRSRSRAIYVMDTTGRVLATSNWRDADSYQGEDLSFRAYFQDAVRGLP
GRFYGIGTTTGESGYYLAHGLEDKGRIIGVAVIKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVRPLTAEV
KERLARSLQYYWWPLNELVPLERETLSEGVETLVFPANISVDREHKKVSYLAQSRPLSDTAWHLTLLTPLENLRREAANQ
GMLVAVACALVTFLLIAWNERRKVISTRLAAREALQAANNELERKIAERTEHLRASNERLKAQIRERRQAEDTLRKAQDE
LVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLERGALDTASTNLRTINDLVDRMGRITASLRAFARRGDDQGQ
AQLSKAVDAAMQLLGVRVEQSGLTLHRDFVDATLTIDQTRLEQILVNLIGNALDAMFDLQQPELWLTGSVIDGRYRLRVR
DNGHGVDADARKHLFEPFFTTKPGEQGLGLGLTLSASLAAAAGGSLSAEHPQDGGTTFVLSLPFIPDARHPDSPT

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=28.75, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=29.1304347826087, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=28.5087719298246, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=286, Percent_Identity=26.5734265734266, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=280, Percent_Identity=25.7142857142857, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 70809; Mature: 70809

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCDPTLYRAAPPSLAVKPRLIRQLFLPPLILMLMIGLGYIAYLVSEHSGIKSLRETGER
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHH
QLELHARTVESEISKYTYLPSVLELESSVSQLLNEPGPELQQQVNRYLEGLNRRSRSRAI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEE
YVMDTTGRVLATSNWRDADSYQGEDLSFRAYFQDAVRGLPGRFYGIGTTTGESGYYLAHG
EEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEC
LEDKGRIIGVAVIKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVRPLTAEV
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHHCCCHHHHH
KERLARSLQYYWWPLNELVPLERETLSEGVETLVFPANISVDREHKKVSYLAQSRPLSDT
HHHHHHHHHEEEECHHHCCCCCHHHHHCCHHEEEEECCCCCCCHHHHHHHHHHCCCCCCC
AWHLTLLTPLENLRREAANQGMLVAVACALVTFLLIAWNERRKVISTRLAAREALQAANN
CEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELERKIAERTEHLRASNERLKAQIRERRQAEDTLRKAQDELVQAGKLAAIGQMSTSIAHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LNQPLAALRTLSGNTVRFLERGALDTASTNLRTINDLVDRMGRITASLRAFARRGDDQGQ
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AQLSKAVDAAMQLLGVRVEQSGLTLHRDFVDATLTIDQTRLEQILVNLIGNALDAMFDLQ
HHHHHHHHHHHHHHCCCEECCCCEEEHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHCCC
QPELWLTGSVIDGRYRLRVRDNGHGVDADARKHLFEPFFTTKPGEQGLGLGLTLSASLAA
CCCEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHH
AAGGSLSAEHPQDGGTTFVLSLPFIPDARHPDSPT
HCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKCDPTLYRAAPPSLAVKPRLIRQLFLPPLILMLMIGLGYIAYLVSEHSGIKSLRETGER
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHH
QLELHARTVESEISKYTYLPSVLELESSVSQLLNEPGPELQQQVNRYLEGLNRRSRSRAI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEE
YVMDTTGRVLATSNWRDADSYQGEDLSFRAYFQDAVRGLPGRFYGIGTTTGESGYYLAHG
EEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEC
LEDKGRIIGVAVIKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVRPLTAEV
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHHCCCHHHHH
KERLARSLQYYWWPLNELVPLERETLSEGVETLVFPANISVDREHKKVSYLAQSRPLSDT
HHHHHHHHHEEEECHHHCCCCCHHHHHCCHHEEEEECCCCCCCHHHHHHHHHHCCCCCCC
AWHLTLLTPLENLRREAANQGMLVAVACALVTFLLIAWNERRKVISTRLAAREALQAANN
CEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELERKIAERTEHLRASNERLKAQIRERRQAEDTLRKAQDELVQAGKLAAIGQMSTSIAHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LNQPLAALRTLSGNTVRFLERGALDTASTNLRTINDLVDRMGRITASLRAFARRGDDQGQ
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AQLSKAVDAAMQLLGVRVEQSGLTLHRDFVDATLTIDQTRLEQILVNLIGNALDAMFDLQ
HHHHHHHHHHHHHHCCCEECCCCEEEHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHCCC
QPELWLTGSVIDGRYRLRVRDNGHGVDADARKHLFEPFFTTKPGEQGLGLGLTLSASLAA
CCCEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHH
AAGGSLSAEHPQDGGTTFVLSLPFIPDARHPDSPT
HCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]