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The map label for this gene is lig [H]

Identifier: 66047100

GI number: 66047100

Start: 4613364

End: 4615067

Strand: Direct

Name: lig [H]

Synonym: Psyr_3873

Alternate gene names: 66047100

Gene position: 4613364-4615067 (Clockwise)

Preceding gene: 66047099

Following gene: 66047101

Centisome position: 75.71

GC content: 63.32

Gene sequence:

>1704_bases
ATGAAAGCCTTTGCTGAACTCTACGCACAGCTGGACGCGACCACTTCCAGCAACGCCAAACTCGCCGCAATGCGCGACTA
CTTCGAAAAGGCGGCAGCAGAGGACGCCGCCTGGGCGGTGTACTTTCTGTCAGGCGGCCGCCCACGGCAACTGGTGCCGA
CCCGTGTACTGCGCGAACAGGCCATGACCCTGGCAAGTCTGCCGGAATGGCTGTTCGAAGAGAGCTATCAGGCGGTCGGC
GACCTGGCGGAAACCCTGTCGCTGTTACTGCCCCAGGCCGACCACAGTAATGACGAAGGTCTGGCCACCTGGATGGAAGA
CAAGCTGTTGCCGTTGCGCGGCCTGCCGCCTGAAGAACTTGCCGAGCGGCTGCCGATGTTCTGGTCGCAGTTGGACCGCA
GCAGTCTGATGGTCTGCATCAAGCTGATCACCGGCAGTTTCCGGGTCGGCGTGTCGAAGCTGCTGGTCACCCGTGCGCTG
GCGGCGCTGGCAGATATCGACAGCAAACGCGTCGCACAACGGCTGGTGGGCTACACCGATCTATCGCACCGGCCCAGCGC
CGAACGCTATTTGAAGCTGATCGCGCCGGAATCCGAGGATGAGCACGCCCAACGCGGCGGCCAGCCCTACCCGTTTTTTC
TCGCCCACTCCCTGCAACAGCCCGCCGATCAGTTTGAGGCGTTGCTCGGTCCGGCGCAGAACTGGCAGGTGGAATGGAAG
TGGGACGGCATTCGCGCGCAACTGGTCAAACGCGACGGGCGCTTGTGGATCTGGTCACGCGGCGAAGAACTGGTGACCGA
CCGTTTTCCGGAGCTGCACAGCCTGGTGCAGTGCCTGCCGGACGGTACGGTGATCGACGGCGAAATCGTGGTCTGGAAAG
CCCCCGATGCGAACCCCGATGCCGATGCGGAGTTTGCCTTGAACAGCGATGCTCCTGCGGCTGCGCCTTCAGTCCAACCG
TTCGCCCTGCTGCAACAGCGCATAGGCCGGAAGACGCTGGGGAAAAAGATTCTTGCCGACGTTCCGGTCGTGGTGCTCGC
CTATGACCTGCTGGAGTGGCAAGGCGATGACTGGCGCAGCCGCCCGCAACATGAACGCCGCTCGCAACTGGAAGCCTTGA
TCGAAACCTGCCAGAGCGAGGTGCTGATGCCCTCCCCGGTGCTCAGCGGCAAGGATTGGCTCGACCTGGCCACCCAGCGC
GAAGCCTCCCGCAGCCTGGGCGTCGAGGGCATGATGCTCAAGGCTCGCGACTCGCTGTATGGCGTCGGTCGCACCAAGGA
CATGGGAGTGTGGTGGAAATGGAAAATCGACCCGTTCAGTGTCGATGCCGTGCTGATTTACGCGCAACGCGGTCACGGAC
GACGCGCCAGCCTGTACAGCGACTACACCTTTGCGGTGTGGGATGGCCCGCCCGAAGCCAGTGAACGCACGCTGGTGCCG
TTCGCCAAGGCCTACTCGGGGCTGACCGATGAAGAAATGCGCAAGGTCGACGCCATCGTTCGCAAGACGACGGTGGAGAA
ATTCGGGCCGGTCAGCAGCGTAACGCCGACGCTGGTGTTCGAGCTGGGCTTTGAAGGCATCGCCCTGTCGAAGCGCCACA
AGAGCGGCATCGCGGTGCGTTTCCCGCGCATGCTGCGCTGGCGCCAGGACAAGCCCGTCGCCGAAGCCGACAGTCTGGCG
ACGCTGCAGGACCTGCTGAACTAG

Upstream 100 bases:

>100_bases
GTCTCGACGCACAGGGCTTCAGCACCGAATACGGCGATGAAGAAGACAGCAACCCGGCAGCCGGCGAACCCGAGGCGGCA
GGCACGGGTGAGGCTCAGTC

Downstream 100 bases:

>100_bases
AGCACCAAAAAGGCGCACACCAAATAGCGTGCACCTTTTTGAAACATCGAAGAACGAATCATCCCGCCTCCCTGCAGGAA
ACCTCCTGATTCGTTACCAA

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MKAFAELYAQLDATTSSNAKLAAMRDYFEKAAAEDAAWAVYFLSGGRPRQLVPTRVLREQAMTLASLPEWLFEESYQAVG
DLAETLSLLLPQADHSNDEGLATWMEDKLLPLRGLPPEELAERLPMFWSQLDRSSLMVCIKLITGSFRVGVSKLLVTRAL
AALADIDSKRVAQRLVGYTDLSHRPSAERYLKLIAPESEDEHAQRGGQPYPFFLAHSLQQPADQFEALLGPAQNWQVEWK
WDGIRAQLVKRDGRLWIWSRGEELVTDRFPELHSLVQCLPDGTVIDGEIVVWKAPDANPDADAEFALNSDAPAAAPSVQP
FALLQQRIGRKTLGKKILADVPVVVLAYDLLEWQGDDWRSRPQHERRSQLEALIETCQSEVLMPSPVLSGKDWLDLATQR
EASRSLGVEGMMLKARDSLYGVGRTKDMGVWWKWKIDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPEASERTLVP
FAKAYSGLTDEEMRKVDAIVRKTTVEKFGPVSSVTPTLVFELGFEGIALSKRHKSGIAVRFPRMLRWRQDKPVAEADSLA
TLQDLLN

Sequences:

>Translated_567_residues
MKAFAELYAQLDATTSSNAKLAAMRDYFEKAAAEDAAWAVYFLSGGRPRQLVPTRVLREQAMTLASLPEWLFEESYQAVG
DLAETLSLLLPQADHSNDEGLATWMEDKLLPLRGLPPEELAERLPMFWSQLDRSSLMVCIKLITGSFRVGVSKLLVTRAL
AALADIDSKRVAQRLVGYTDLSHRPSAERYLKLIAPESEDEHAQRGGQPYPFFLAHSLQQPADQFEALLGPAQNWQVEWK
WDGIRAQLVKRDGRLWIWSRGEELVTDRFPELHSLVQCLPDGTVIDGEIVVWKAPDANPDADAEFALNSDAPAAAPSVQP
FALLQQRIGRKTLGKKILADVPVVVLAYDLLEWQGDDWRSRPQHERRSQLEALIETCQSEVLMPSPVLSGKDWLDLATQR
EASRSLGVEGMMLKARDSLYGVGRTKDMGVWWKWKIDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPEASERTLVP
FAKAYSGLTDEEMRKVDAIVRKTTVEKFGPVSSVTPTLVFELGFEGIALSKRHKSGIAVRFPRMLRWRQDKPVAEADSLA
TLQDLLN
>Mature_567_residues
MKAFAELYAQLDATTSSNAKLAAMRDYFEKAAAEDAAWAVYFLSGGRPRQLVPTRVLREQAMTLASLPEWLFEESYQAVG
DLAETLSLLLPQADHSNDEGLATWMEDKLLPLRGLPPEELAERLPMFWSQLDRSSLMVCIKLITGSFRVGVSKLLVTRAL
AALADIDSKRVAQRLVGYTDLSHRPSAERYLKLIAPESEDEHAQRGGQPYPFFLAHSLQQPADQFEALLGPAQNWQVEWK
WDGIRAQLVKRDGRLWIWSRGEELVTDRFPELHSLVQCLPDGTVIDGEIVVWKAPDANPDADAEFALNSDAPAAAPSVQP
FALLQQRIGRKTLGKKILADVPVVVLAYDLLEWQGDDWRSRPQHERRSQLEALIETCQSEVLMPSPVLSGKDWLDLATQR
EASRSLGVEGMMLKARDSLYGVGRTKDMGVWWKWKIDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPEASERTLVP
FAKAYSGLTDEEMRKVDAIVRKTTVEKFGPVSSVTPTLVFELGFEGIALSKRHKSGIAVRFPRMLRWRQDKPVAEADSLA
TLQDLLN

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=361, Percent_Identity=27.7008310249307, Blast_Score=87, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71985269, Length=478, Percent_Identity=24.4769874476987, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24762424, Length=374, Percent_Identity=26.7379679144385, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 63600; Mature: 63600

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFAELYAQLDATTSSNAKLAAMRDYFEKAAAEDAAWAVYFLSGGRPRQLVPTRVLREQ
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHH
AMTLASLPEWLFEESYQAVGDLAETLSLLLPQADHSNDEGLATWMEDKLLPLRGLPPEEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHH
AERLPMFWSQLDRSSLMVCIKLITGSFRVGVSKLLVTRALAALADIDSKRVAQRLVGYTD
HHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
LSHRPSAERYLKLIAPESEDEHAQRGGQPYPFFLAHSLQQPADQFEALLGPAQNWQVEWK
CCCCCCHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCEEEEE
WDGIRAQLVKRDGRLWIWSRGEELVTDRFPELHSLVQCLPDGTVIDGEIVVWKAPDANPD
ECCHHHHHHHCCCCEEEEECCCHHHHHCCHHHHHHHHHCCCCCEECCEEEEEECCCCCCC
ADAEFALNSDAPAAAPSVQPFALLQQRIGRKTLGKKILADVPVVVLAYDLLEWQGDDWRS
CCCEEEECCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
RPQHERRSQLEALIETCQSEVLMPSPVLSGKDWLDLATQREASRSLGVEGMMLKARDSLY
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHHHC
GVGRTKDMGVWWKWKIDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPEASERTLVP
CCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEECCEEEEEECCCCCCCCCCCCH
FAKAYSGLTDEEMRKVDAIVRKTTVEKFGPVSSVTPTLVFELGFEGIALSKRHKSGIAVR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCEEECCCCCCCCEEE
FPRMLRWRQDKPVAEADSLATLQDLLN
CHHHHHCCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MKAFAELYAQLDATTSSNAKLAAMRDYFEKAAAEDAAWAVYFLSGGRPRQLVPTRVLREQ
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHH
AMTLASLPEWLFEESYQAVGDLAETLSLLLPQADHSNDEGLATWMEDKLLPLRGLPPEEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHH
AERLPMFWSQLDRSSLMVCIKLITGSFRVGVSKLLVTRALAALADIDSKRVAQRLVGYTD
HHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
LSHRPSAERYLKLIAPESEDEHAQRGGQPYPFFLAHSLQQPADQFEALLGPAQNWQVEWK
CCCCCCHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCEEEEE
WDGIRAQLVKRDGRLWIWSRGEELVTDRFPELHSLVQCLPDGTVIDGEIVVWKAPDANPD
ECCHHHHHHHCCCCEEEEECCCHHHHHCCHHHHHHHHHCCCCCEECCEEEEEECCCCCCC
ADAEFALNSDAPAAAPSVQPFALLQQRIGRKTLGKKILADVPVVVLAYDLLEWQGDDWRS
CCCEEEECCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
RPQHERRSQLEALIETCQSEVLMPSPVLSGKDWLDLATQREASRSLGVEGMMLKARDSLY
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHHHC
GVGRTKDMGVWWKWKIDPFSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPEASERTLVP
CCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEECCEEEEEECCCCCCCCCCCCH
FAKAYSGLTDEEMRKVDAIVRKTTVEKFGPVSSVTPTLVFELGFEGIALSKRHKSGIAVR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCEEECCCCCCCCEEE
FPRMLRWRQDKPVAEADSLATLQDLLN
CHHHHHCCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA