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The map label for this gene is sdaC [H]

Identifier: 66046862

GI number: 66046862

Start: 4314017

End: 4315294

Strand: Reverse

Name: sdaC [H]

Synonym: Psyr_3633

Alternate gene names: 66046862

Gene position: 4315294-4314017 (Counterclockwise)

Preceding gene: 66046864

Following gene: 66046858

Centisome position: 70.82

GC content: 57.9

Gene sequence:

>1278_bases
ATGAATGATCAGGCTAATGGCGTCGTAGAACGTCTGGATGTAGCTCCCGAGAGCATCGCGTCATGGAATCGTAATGACAC
CACCTGGATGCTCGGATTGTTCGGTACCGCCATCGGTGCGGGTACCCTGTTTTTGCCAATCAACGCGGGTATCGGTGGTT
TCTGGCCATTGATGGCGCTGGCACTGCTGGCGTTTCCCATGACCTTCTACGCCCACCGTGGGTTGACGCGCTTCGTGCTC
TCAGGACGTGAAGGTGCCGACATCACCGATGTGGTCGAAGAGCATTTCGGCAAGAGTGCCGGTGCGATGATCACCTTGCT
GTATTTCTTCGCAATTTTCCCGATCCTGCTGATCTACAGCGTGGCCCTCACCAACACCGTCGGCAGTTTTCTTGAGCACC
AGTTGCACATCACGCCACCGCCGCGCGCCGCACTGGCGTTTGTGCTGATCATGGGGCTGCTGGCCGTGGTGCGTTGTGGC
GAGCGGTTCATCGTCAAGGCCATGAGCCTGATGGTTTATCCGTTCATCGTCGCACTATTGTTTCTGGCAATATTCCTCAT
CCCGCACTGGACCGGCGGCATTCTGAGCACCGCTACCACGTTCCCTGAGCTATCGGCGTTCATACCCACGTTGTGGCTGG
CCATTCCGGTGATGGTGTTCTCTTTCAACCACACACCGATCATCTCGGCCTTTGCCGTCGATCAGAAGCGTCAGTATGGC
GAAAACGCCGAGGTGCGCAGTTCGCAGATTCTGGCCCGCGCCCACGGTCTGATGGTCGTGATGGTGCTGTTCTTCGTGTT
CAGTTGCGTGTTGACCCTGTCGCCTGCCCAACTGGCCGAGGCCAAGGCGCAGAACATCTCGATCCTGTCTTACCTGGCCA
ACCACTTCAACAACCCGACCATCGCCTTTGTCGCGCCACTGATCGCGTTCGTGGCTATTTCCAAGTCGTTTCTTGGCCAC
TACATCGGTGCGAGCGAGGGCTTGAAAGGCCTGGTTCTGAAGGCGGGTCGTCGTCCTGCACCCAAGGCCCTGGACCGCAT
GACCGCGGCGTTCATGCTGGTGGTGTGCTGGCTGGTGGCAACGCTCAACCCGAGCATCCTGGGCATGATCGAAACCCTGG
GCGGGCCGGTGATTTCGGCTTTGCTGTTCCTGATGCCGATGTACGCCATCCACAAAGTACCAGCCATGCGTAAATACGCT
GGCGCGTGGTCCAACTACTTTGTGGTGGCCGCCGGTGTGGTGGCAATTTCAGCATTGATCTTTTCGCTGATCCGCTGA

Upstream 100 bases:

>100_bases
CCCGGAGAATCTCGCCCGCTGTTTTCGAGGGGGGCGCTGAACTGCCGTTTTTTTCGACGCGTTTCCCTTTTTGATAAACC
GGCCACGGAGAGTCGACCGG

Downstream 100 bases:

>100_bases
AGCCGGCAAGCGAAACCTCGCAGTCTGCGCCAATCCAGCGGCGCAGACTGCGAGGAGGTCATGCGATCGTGATCAGTCCA
CTGGCTCGGGATACAACGGC

Product: threonine/serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNDQANGVVERLDVAPESIASWNRNDTTWMLGLFGTAIGAGTLFLPINAGIGGFWPLMALALLAFPMTFYAHRGLTRFVL
SGREGADITDVVEEHFGKSAGAMITLLYFFAIFPILLIYSVALTNTVGSFLEHQLHITPPPRAALAFVLIMGLLAVVRCG
ERFIVKAMSLMVYPFIVALLFLAIFLIPHWTGGILSTATTFPELSAFIPTLWLAIPVMVFSFNHTPIISAFAVDQKRQYG
ENAEVRSSQILARAHGLMVVMVLFFVFSCVLTLSPAQLAEAKAQNISILSYLANHFNNPTIAFVAPLIAFVAISKSFLGH
YIGASEGLKGLVLKAGRRPAPKALDRMTAAFMLVVCWLVATLNPSILGMIETLGGPVISALLFLMPMYAIHKVPAMRKYA
GAWSNYFVVAAGVVAISALIFSLIR

Sequences:

>Translated_425_residues
MNDQANGVVERLDVAPESIASWNRNDTTWMLGLFGTAIGAGTLFLPINAGIGGFWPLMALALLAFPMTFYAHRGLTRFVL
SGREGADITDVVEEHFGKSAGAMITLLYFFAIFPILLIYSVALTNTVGSFLEHQLHITPPPRAALAFVLIMGLLAVVRCG
ERFIVKAMSLMVYPFIVALLFLAIFLIPHWTGGILSTATTFPELSAFIPTLWLAIPVMVFSFNHTPIISAFAVDQKRQYG
ENAEVRSSQILARAHGLMVVMVLFFVFSCVLTLSPAQLAEAKAQNISILSYLANHFNNPTIAFVAPLIAFVAISKSFLGH
YIGASEGLKGLVLKAGRRPAPKALDRMTAAFMLVVCWLVATLNPSILGMIETLGGPVISALLFLMPMYAIHKVPAMRKYA
GAWSNYFVVAAGVVAISALIFSLIR
>Mature_425_residues
MNDQANGVVERLDVAPESIASWNRNDTTWMLGLFGTAIGAGTLFLPINAGIGGFWPLMALALLAFPMTFYAHRGLTRFVL
SGREGADITDVVEEHFGKSAGAMITLLYFFAIFPILLIYSVALTNTVGSFLEHQLHITPPPRAALAFVLIMGLLAVVRCG
ERFIVKAMSLMVYPFIVALLFLAIFLIPHWTGGILSTATTFPELSAFIPTLWLAIPVMVFSFNHTPIISAFAVDQKRQYG
ENAEVRSSQILARAHGLMVVMVLFFVFSCVLTLSPAQLAEAKAQNISILSYLANHFNNPTIAFVAPLIAFVAISKSFLGH
YIGASEGLKGLVLKAGRRPAPKALDRMTAAFMLVVCWLVATLNPSILGMIETLGGPVISALLFLMPMYAIHKVPAMRKYA
GAWSNYFVVAAGVVAISALIFSLIR

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=417, Percent_Identity=64.0287769784173, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1789504, Length=428, Percent_Identity=45.5607476635514, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=36.2530413625304, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1789961, Length=396, Percent_Identity=26.010101010101, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI145693183, Length=406, Percent_Identity=25.1231527093596, Blast_Score=128, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46131; Mature: 46131

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDQANGVVERLDVAPESIASWNRNDTTWMLGLFGTAIGAGTLFLPINAGIGGFWPLMAL
CCCCHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHH
ALLAFPMTFYAHRGLTRFVLSGREGADITDVVEEHFGKSAGAMITLLYFFAIFPILLIYS
HHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VALTNTVGSFLEHQLHITPPPRAALAFVLIMGLLAVVRCGERFIVKAMSLMVYPFIVALL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FLAIFLIPHWTGGILSTATTFPELSAFIPTLWLAIPVMVFSFNHTPIISAFAVDQKRQYG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
ENAEVRSSQILARAHGLMVVMVLFFVFSCVLTLSPAQLAEAKAQNISILSYLANHFNNPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH
IAFVAPLIAFVAISKSFLGHYIGASEGLKGLVLKAGRRPAPKALDRMTAAFMLVVCWLVA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TLNPSILGMIETLGGPVISALLFLMPMYAIHKVPAMRKYAGAWSNYFVVAAGVVAISALI
HCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHH
FSLIR
HHHHC
>Mature Secondary Structure
MNDQANGVVERLDVAPESIASWNRNDTTWMLGLFGTAIGAGTLFLPINAGIGGFWPLMAL
CCCCHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHH
ALLAFPMTFYAHRGLTRFVLSGREGADITDVVEEHFGKSAGAMITLLYFFAIFPILLIYS
HHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VALTNTVGSFLEHQLHITPPPRAALAFVLIMGLLAVVRCGERFIVKAMSLMVYPFIVALL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FLAIFLIPHWTGGILSTATTFPELSAFIPTLWLAIPVMVFSFNHTPIISAFAVDQKRQYG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
ENAEVRSSQILARAHGLMVVMVLFFVFSCVLTLSPAQLAEAKAQNISILSYLANHFNNPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH
IAFVAPLIAFVAISKSFLGHYIGASEGLKGLVLKAGRRPAPKALDRMTAAFMLVVCWLVA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TLNPSILGMIETLGGPVISALLFLMPMYAIHKVPAMRKYAGAWSNYFVVAAGVVAISALI
HCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHH
FSLIR
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]