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The map label for this gene is tpm

Identifier: 66046846

GI number: 66046846

Start: 4301417

End: 4302079

Strand: Reverse

Name: tpm

Synonym: Psyr_3617

Alternate gene names: 66046846

Gene position: 4302079-4301417 (Counterclockwise)

Preceding gene: 66046848

Following gene: 66046843

Centisome position: 70.6

GC content: 59.58

Gene sequence:

>663_bases
ATGAAGACGGATTTTTGGCTGCAGCGCTGGAGCGCCGGACAGATCGGCTTTCATCAGTCCGAGGTCAATCAGGACCTGCA
GCAATACTGGTCCTCGTTGAGTGTTGCACCAGGGGCGCGGGTTCTGGTGCCGTTATGTGGCAAGAGCCAGGACATGAGCT
GGCTGAGGGGGCAGGGGTATCACGTGGTGGGCGCCGAGCTGTCCGAGGCGGCGGTAGAGAGCTATTTCACCGAGCGTGGT
GAGCAGCCGCAGATTACGTCGCAGGGCGACTTCAAGGTCTACGCAGCGCCCGGTATCGAAATCTGGTGCGGTGATTTCTT
CGCGCTGACTGTGCGCGATATCGGTCATTGCGCGGCGTTTTACGACCGTGCCGCGATGATCGCCTTGCCAGCGGATATGC
GCGAACGCTATGTACGGCAGCTTGAAGCGCTGATGCCGCAAGCGTGTAGCGGTTTACTGATCACCCTGGAATACGATCAG
ACCCTGCTCGAAGGCCCGCCATTCTCCGTGCCGCGCACATGGCTGCAGAGGGTCATGTCGGGAAACTGGGAGGTAACGAA
GGTAGGCGGGCAGGATACGCTGCACAGCAGTCCCAAGGCGTTGAAGGCCGGATTGGAGCGTATGGATGAGCATGTTTATG
TGTTGGAGCGTCAATCGCGCTGA

Upstream 100 bases:

>100_bases
AAAGCTCCAGAATAGAGAGATGACTCATAGTCGGTCATTTTTATGATCTAAATCTAATATAAGTTCTGGCGCTTTTTTAT
CGAATTTTCAGGAGGTTTTC

Downstream 100 bases:

>100_bases
GTTGGTCCTGAATCTCTCTGAATCGCAGAACCGTTTGACGCCCTGCGTCACGAACTGCATTCCCACGCGGAGCGTAAGGA
ACGAGAGGTGTCCGGAAGAA

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKTDFWLQRWSAGQIGFHQSEVNQDLQQYWSSLSVAPGARVLVPLCGKSQDMSWLRGQGYHVVGAELSEAAVESYFTERG
EQPQITSQGDFKVYAAPGIEIWCGDFFALTVRDIGHCAAFYDRAAMIALPADMRERYVRQLEALMPQACSGLLITLEYDQ
TLLEGPPFSVPRTWLQRVMSGNWEVTKVGGQDTLHSSPKALKAGLERMDEHVYVLERQSR

Sequences:

>Translated_220_residues
MKTDFWLQRWSAGQIGFHQSEVNQDLQQYWSSLSVAPGARVLVPLCGKSQDMSWLRGQGYHVVGAELSEAAVESYFTERG
EQPQITSQGDFKVYAAPGIEIWCGDFFALTVRDIGHCAAFYDRAAMIALPADMRERYVRQLEALMPQACSGLLITLEYDQ
TLLEGPPFSVPRTWLQRVMSGNWEVTKVGGQDTLHSSPKALKAGLERMDEHVYVLERQSR
>Mature_220_residues
MKTDFWLQRWSAGQIGFHQSEVNQDLQQYWSSLSVAPGARVLVPLCGKSQDMSWLRGQGYHVVGAELSEAAVESYFTERG
EQPQITSQGDFKVYAAPGIEIWCGDFFALTVRDIGHCAAFYDRAAMIALPADMRERYVRQLEALMPQACSGLLITLEYDQ
TLLEGPPFSVPRTWLQRVMSGNWEVTKVGGQDTLHSSPKALKAGLERMDEHVYVLERQSR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=220, Percent_Identity=30.4545454545455, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_PSEU2 (Q4ZQC3)

Other databases:

- EMBL:   CP000075
- RefSeq:   YP_236687.1
- ProteinModelPortal:   Q4ZQC3
- SMR:   Q4ZQC3
- STRING:   Q4ZQC3
- GeneID:   3369152
- GenomeReviews:   CP000075_GR
- KEGG:   psb:Psyr_3617
- NMPDR:   fig|205918.4.peg.4054
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   PSYR205918:PSYR_3617-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24792; Mature: 24792

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDFWLQRWSAGQIGFHQSEVNQDLQQYWSSLSVAPGARVLVPLCGKSQDMSWLRGQGY
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCCC
HVVGAELSEAAVESYFTERGEQPQITSQGDFKVYAAPGIEIWCGDFFALTVRDIGHCAAF
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHH
YDRAAMIALPADMRERYVRQLEALMPQACSGLLITLEYDQTLLEGPPFSVPRTWLQRVMS
HHCHHEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCHHHHHHHHC
GNWEVTKVGGQDTLHSSPKALKAGLERMDEHVYVLERQSR
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHEEEEEECCC
>Mature Secondary Structure
MKTDFWLQRWSAGQIGFHQSEVNQDLQQYWSSLSVAPGARVLVPLCGKSQDMSWLRGQGY
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCCC
HVVGAELSEAAVESYFTERGEQPQITSQGDFKVYAAPGIEIWCGDFFALTVRDIGHCAAF
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHH
YDRAAMIALPADMRERYVRQLEALMPQACSGLLITLEYDQTLLEGPPFSVPRTWLQRVMS
HHCHHEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCHHHHHHHHC
GNWEVTKVGGQDTLHSSPKALKAGLERMDEHVYVLERQSR
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA