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The map label for this gene is phhA [H]

Identifier: 66046804

GI number: 66046804

Start: 4258293

End: 4259090

Strand: Direct

Name: phhA [H]

Synonym: Psyr_3575

Alternate gene names: 66046804

Gene position: 4258293-4259090 (Clockwise)

Preceding gene: 66046802

Following gene: 66046805

Centisome position: 69.88

GC content: 58.9

Gene sequence:

>798_bases
ATGGCCCAGACGCTTTACGTGGCACGCGAGCCGGACGCTTCGGGTTTCATCGATTACACGGCGGACGAACATGCGGTATG
GAACACCCTGATCACCCGGCAGATGGAGATCGTCGACGGGCGTGCCTGCCAGGAGTATCTGGACGGCATCGAGCAACTGG
GCCTGCCGCTTGATCGCATTCCTCAGTTAGGCGAAATCAACAAGGTTCTGGGCGCGACCACGGGCTGGCAGGTCGAGCGA
GTGCCTGCGCTGATCCCCTTCCAGACGTTTTTTGAACTGCTGGCCAGCAAGCGCTTCCCGGTGGCCACGTTCATCCGTAG
CGCAGAAGAACTGGACTACCTGCAGGAACCGGACATCTTTCATGAAATATTTGGCCACTGCCCGCTGCTGACCAATCCGT
GGTTTGCCGAATTCACCCATACCTACGGCAAACTCGGCCTGAGCGCGAGCAAGGAACAACGCGTGTACCTGGCCCGGCTG
TACTGGATGACCATCGAGTTCGGCCTGGTCGATACACCACAAGGGCGGAAAATCTACGGCGGCGGCATCCTTTCTTCACC
GAAGGAAGCGCTGTACAGCTTGTCGTCAGCCCCCGAACACCAGCCTTTCGATGCGCTTGAAGCGATGCGCACGCCTTATC
GCATCGACATTCTGCAACCGCTGTACTTTGTCCTGCCGGATCTGAAGTGTCTGTTCGACCTGGCGCAGCAGGACATCATG
GCGCTGGTCGGGCAAGGCATGCAGTTGGGCTTGCACGCGCCCAAGTTTCCACCTAAAACCAAAAGCCACGCCGCCTGA

Upstream 100 bases:

>100_bases
CCTGCTCACCGCCGCTGACGCGCCCTCGAAACCGGGTTATTCCTGAACACAGGCTTTTACAAGAACACTTTAAAAACAGC
AGCCTTTCGAGGACATCAGC

Downstream 100 bases:

>100_bases
CACTCGGCCAGCTCTCCGAAAAGGACCCTCTGCTTATGACCACCTTGAATCAAGCTCACTGTGAAGCCTGCCGTGCCGAT
GCGCCGCAGGTCAGCGAAGC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MAQTLYVAREPDASGFIDYTADEHAVWNTLITRQMEIVDGRACQEYLDGIEQLGLPLDRIPQLGEINKVLGATTGWQVER
VPALIPFQTFFELLASKRFPVATFIRSAEELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGKLGLSASKEQRVYLARL
YWMTIEFGLVDTPQGRKIYGGGILSSPKEALYSLSSAPEHQPFDALEAMRTPYRIDILQPLYFVLPDLKCLFDLAQQDIM
ALVGQGMQLGLHAPKFPPKTKSHAA

Sequences:

>Translated_265_residues
MAQTLYVAREPDASGFIDYTADEHAVWNTLITRQMEIVDGRACQEYLDGIEQLGLPLDRIPQLGEINKVLGATTGWQVER
VPALIPFQTFFELLASKRFPVATFIRSAEELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGKLGLSASKEQRVYLARL
YWMTIEFGLVDTPQGRKIYGGGILSSPKEALYSLSSAPEHQPFDALEAMRTPYRIDILQPLYFVLPDLKCLFDLAQQDIM
ALVGQGMQLGLHAPKFPPKTKSHAA
>Mature_264_residues
AQTLYVAREPDASGFIDYTADEHAVWNTLITRQMEIVDGRACQEYLDGIEQLGLPLDRIPQLGEINKVLGATTGWQVERV
PALIPFQTFFELLASKRFPVATFIRSAEELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGKLGLSASKEQRVYLARLY
WMTIEFGLVDTPQGRKIYGGGILSSPKEALYSLSSAPEHQPFDALEAMRTPYRIDILQPLYFVLPDLKCLFDLAQQDIMA
LVGQGMQLGLHAPKFPPKTKSHAA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=228, Percent_Identity=35.9649122807018, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI88900505, Length=228, Percent_Identity=35.9649122807018, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI88900501, Length=228, Percent_Identity=35.9649122807018, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4557819, Length=212, Percent_Identity=33.9622641509434, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI4759248, Length=212, Percent_Identity=32.5471698113208, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI31795563, Length=212, Percent_Identity=33.0188679245283, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71980736, Length=217, Percent_Identity=33.6405529953917, Blast_Score=141, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17531391, Length=213, Percent_Identity=37.0892018779343, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI115532103, Length=245, Percent_Identity=31.0204081632653, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115533973, Length=239, Percent_Identity=31.7991631799163, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=30.9677419354839, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17136774, Length=228, Percent_Identity=32.0175438596491, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17136776, Length=228, Percent_Identity=32.0175438596491, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI62472054, Length=212, Percent_Identity=32.0754716981132, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24660393, Length=212, Percent_Identity=32.0754716981132, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24654994, Length=193, Percent_Identity=33.160621761658, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 29923; Mature: 29792

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTLYVAREPDASGFIDYTADEHAVWNTLITRQMEIVDGRACQEYLDGIEQLGLPLDRI
CCCEEEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHC
PQLGEINKVLGATTGWQVERVPALIPFQTFFELLASKRFPVATFIRSAEELDYLQEPDIF
CCCHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHH
HEIFGHCPLLTNPWFAEFTHTYGKLGLSASKEQRVYLARLYWMTIEFGLVDTPQGRKIYG
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEEC
GGILSSPKEALYSLSSAPEHQPFDALEAMRTPYRIDILQPLYFVLPDLKCLFDLAQQDIM
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHH
ALVGQGMQLGLHAPKFPPKTKSHAA
HHHCCCCEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AQTLYVAREPDASGFIDYTADEHAVWNTLITRQMEIVDGRACQEYLDGIEQLGLPLDRI
CCEEEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHC
PQLGEINKVLGATTGWQVERVPALIPFQTFFELLASKRFPVATFIRSAEELDYLQEPDIF
CCCHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHH
HEIFGHCPLLTNPWFAEFTHTYGKLGLSASKEQRVYLARLYWMTIEFGLVDTPQGRKIYG
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEEC
GGILSSPKEALYSLSSAPEHQPFDALEAMRTPYRIDILQPLYFVLPDLKCLFDLAQQDIM
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHH
ALVGQGMQLGLHAPKFPPKTKSHAA
HHHCCCCEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]