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The map label for this gene is qor [C]

Identifier: 66046769

GI number: 66046769

Start: 4217886

End: 4218887

Strand: Direct

Name: qor [C]

Synonym: Psyr_3540

Alternate gene names: 66046769

Gene position: 4217886-4218887 (Clockwise)

Preceding gene: 66046768

Following gene: 66046770

Centisome position: 69.22

GC content: 58.98

Gene sequence:

>1002_bases
ATGAAAGCACTGACATTCGAGAACTACGGCAAATCGCCGGAGATTGCGATTACCCACGTTCCCATACCGGCCATCAAACC
TGATGAACTGTTGGTGGAAGTTCACGCGGCCGGGTTGAACCCGATCGACAACATGATCACTACGGGTGCTTTCAAGACTG
TGGTGAAGCTGCAACTACCGGCCATCATGGGCAGCGATCTGGCAGGCGTGGTCATTCAGGTGGGCAGCGCAGTCACTCGA
TTCAAGGCAGGCGACGCGGTATTCGCGAGCCTGTTCGAGCTGGGTGGCGGCGCAATCGCCGAGTTCGCCGCCGTGCCGGA
ACACGCTGCCGCCCGGAAGCCCGCCAATCTGGACTTTGTTCAGGCAGCCTCCATTCCGATGGTCGGGCTTACGTCGTGGC
AGGCATTCAAGGAGCGCGCCTCTCTTCAATCGGGCCAGAAAGTGTTCATACCGGCCGGGGCTGGAGGTATCGGCACCTTC
GCCATCCAGCTGGCCAAACACCTGGGCGCCGAAGTGGCCACGACCACCAGCACAGGAAATATGGCGCTGGTTCGCAGCCT
GGGCGCAGATGAAGTCGTGAATTACCAAGAGCAGGCATTCGAACAGTTGCTGCACGACGTTGACCTGGTCCTCGGCACCA
CCCGGGGAGACGACCTTGCAAGAGCTGTCGGCATCCTCAAGCCCGGCGGCAGGATCGTATCACTGGTCGGTCCGCTGGAT
GCGTCATTCGCCAAGGCTCGGCGGATGAATGCGTTCTTCACCTTCGTATTCGGGTTGATGAGCCGCAGGATCACGCGTCT
GGCCAGAAAGAAGAATGTGTCGTACTCGTTTCTGTTTGTTCGCGCGGATGGCGCTCAACTTGGCGAGATTGCCAGGTTGC
TTGAACGTGGCCAGATAACACCGGTGATTGACAGGGTCTTTGCGTTTGAACAGGCCCGCGAAGGGCTTGAATACCCGGGT
CAGGGCCGCGCCAAAGGCAAGGTCGTCGTGAAGATCAAGTAA

Upstream 100 bases:

>100_bases
GACAGGCCCAGGCAGCCGAGCGCTATCGCCCGCAAGCCTGAAGCGGATCAAGCCGTGGCAGGCGTCCATCCTTGTTCGAC
GACACTGGAATCAGAGCGTC

Downstream 100 bases:

>100_bases
GCGCTTATTAAAGCCCCGCCCAGCCACCCTTCAGGCACGCGCCTGTTGAGCATTGGAGTATCGAATGAACACCTCTTCCA
AAAGAACCGCCATCGTCACG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKALTFENYGKSPEIAITHVPIPAIKPDELLVEVHAAGLNPIDNMITTGAFKTVVKLQLPAIMGSDLAGVVIQVGSAVTR
FKAGDAVFASLFELGGGAIAEFAAVPEHAAARKPANLDFVQAASIPMVGLTSWQAFKERASLQSGQKVFIPAGAGGIGTF
AIQLAKHLGAEVATTTSTGNMALVRSLGADEVVNYQEQAFEQLLHDVDLVLGTTRGDDLARAVGILKPGGRIVSLVGPLD
ASFAKARRMNAFFTFVFGLMSRRITRLARKKNVSYSFLFVRADGAQLGEIARLLERGQITPVIDRVFAFEQAREGLEYPG
QGRAKGKVVVKIK

Sequences:

>Translated_333_residues
MKALTFENYGKSPEIAITHVPIPAIKPDELLVEVHAAGLNPIDNMITTGAFKTVVKLQLPAIMGSDLAGVVIQVGSAVTR
FKAGDAVFASLFELGGGAIAEFAAVPEHAAARKPANLDFVQAASIPMVGLTSWQAFKERASLQSGQKVFIPAGAGGIGTF
AIQLAKHLGAEVATTTSTGNMALVRSLGADEVVNYQEQAFEQLLHDVDLVLGTTRGDDLARAVGILKPGGRIVSLVGPLD
ASFAKARRMNAFFTFVFGLMSRRITRLARKKNVSYSFLFVRADGAQLGEIARLLERGQITPVIDRVFAFEQAREGLEYPG
QGRAKGKVVVKIK
>Mature_333_residues
MKALTFENYGKSPEIAITHVPIPAIKPDELLVEVHAAGLNPIDNMITTGAFKTVVKLQLPAIMGSDLAGVVIQVGSAVTR
FKAGDAVFASLFELGGGAIAEFAAVPEHAAARKPANLDFVQAASIPMVGLTSWQAFKERASLQSGQKVFIPAGAGGIGTF
AIQLAKHLGAEVATTTSTGNMALVRSLGADEVVNYQEQAFEQLLHDVDLVLGTTRGDDLARAVGILKPGGRIVSLVGPLD
ASFAKARRMNAFFTFVFGLMSRRITRLARKKNVSYSFLFVRADGAQLGEIARLLERGQITPVIDRVFAFEQAREGLEYPG
QGRAKGKVVVKIK

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=355, Percent_Identity=32.112676056338, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI194239674, Length=221, Percent_Identity=32.579185520362, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI13236495, Length=221, Percent_Identity=32.579185520362, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI194239676, Length=182, Percent_Identity=36.2637362637363, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI22538446, Length=344, Percent_Identity=27.6162790697674, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI22538444, Length=344, Percent_Identity=27.6162790697674, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI24308257, Length=346, Percent_Identity=23.6994219653179, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI18379349, Length=320, Percent_Identity=27.1875, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI28557745, Length=221, Percent_Identity=30.316742081448, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI41872631, Length=238, Percent_Identity=28.1512605042017, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI90669511, Length=182, Percent_Identity=29.6703296703297, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790485, Length=242, Percent_Identity=31.8181818181818, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=368, Percent_Identity=30.7065217391304, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17507255, Length=349, Percent_Identity=26.647564469914, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=219, Percent_Identity=31.5068493150685, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17556000, Length=252, Percent_Identity=26.5873015873016, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17536829, Length=253, Percent_Identity=29.6442687747036, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324486, Length=219, Percent_Identity=28.7671232876712, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=223, Percent_Identity=28.2511210762332, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=225, Percent_Identity=28.8888888888889, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24581341, Length=363, Percent_Identity=26.9972451790634, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24581339, Length=363, Percent_Identity=26.9972451790634, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24581345, Length=241, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920632, Length=241, Percent_Identity=24.896265560166, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35459; Mature: 35459

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTFENYGKSPEIAITHVPIPAIKPDELLVEVHAAGLNPIDNMITTGAFKTVVKLQLP
CCCCCCCCCCCCCCEEEEECCCCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHEEEC
AIMGSDLAGVVIQVGSAVTRFKAGDAVFASLFELGGGAIAEFAAVPEHAAARKPANLDFV
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCCEE
QAASIPMVGLTSWQAFKERASLQSGQKVFIPAGAGGIGTFAIQLAKHLGAEVATTTSTGN
ECCCCCEEECHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCC
MALVRSLGADEVVNYQEQAFEQLLHDVDLVLGTTRGDDLARAVGILKPGGRIVSLVGPLD
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCEEEEEECCCC
ASFAKARRMNAFFTFVFGLMSRRITRLARKKNVSYSFLFVRADGAQLGEIARLLERGQIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCC
PVIDRVFAFEQAREGLEYPGQGRAKGKVVVKIK
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKALTFENYGKSPEIAITHVPIPAIKPDELLVEVHAAGLNPIDNMITTGAFKTVVKLQLP
CCCCCCCCCCCCCCEEEEECCCCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHEEEC
AIMGSDLAGVVIQVGSAVTRFKAGDAVFASLFELGGGAIAEFAAVPEHAAARKPANLDFV
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCCEE
QAASIPMVGLTSWQAFKERASLQSGQKVFIPAGAGGIGTFAIQLAKHLGAEVATTTSTGN
ECCCCCEEECHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCC
MALVRSLGADEVVNYQEQAFEQLLHDVDLVLGTTRGDDLARAVGILKPGGRIVSLVGPLD
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCEEEEEECCCC
ASFAKARRMNAFFTFVFGLMSRRITRLARKKNVSYSFLFVRADGAQLGEIARLLERGQIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCC
PVIDRVFAFEQAREGLEYPGQGRAKGKVVVKIK
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA