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The map label for this gene is nuoH

Identifier: 66046432

GI number: 66046432

Start: 3835366

End: 3836373

Strand: Direct

Name: nuoH

Synonym: Psyr_3203

Alternate gene names: 66046432

Gene position: 3835366-3836373 (Clockwise)

Preceding gene: 66046431

Following gene: 66046433

Centisome position: 62.94

GC content: 57.84

Gene sequence:

>1008_bases
ATGACCTGGTTTACCCCTGATGTGATCGACGCAATCATCGCGGTGGTCAAGGCCATCGTGGTGTTGCTGGCCGTCGTGGT
TTGCGGTGCCCTGCTGAGTTTCATCGAGCGTCGTCTGCTGGGTTGGTGGCAGGATCGTTATGGCCCGAACCGCGTGGGTC
CGTTCGGCATGTTCCAGATCGCAGCCGACATGTTGAAAATGTTCTTCAAGGAAGACTGGACCCCACCGTTCGCCGACAAG
GTGATCTTCACCCTGGCGCCGGTGGTTGCCATGAGCGCCTTGCTGATCGCCTTTGCGGTCATCCCGATCACCCCGACCTG
GGGCGTCGCGGATCTGAACATCGGTCTGTTGTTCTTCTTCGCCATGGCCGGTCTGTCCGTATATGCGGTGCTGTTCGCCG
GCTGGTCGAGCAACAACAAGTTCGCCCTGCTGGGCAGCCTGCGTGCCTCGGCACAAACCGTGTCCTACGAAGTGTTCATG
GGCCTTGCGCTGATGGGCATCGTGGTTCAGGTCGGCTCGTTCAACATGCGCGACATCGTTGAATATCAGGCGCAGAACCT
GTGGTTCATCATTCCGCAGTTCTTCGGCTTCTGTACGTTCTTCATCGCAGGCGTCGCGGTGACTCACCGCCACCCGTTCG
ACCAACCGGAAGCCGAGCAGGAACTGGCTGACGGCTACCACATTGAATATGCCGGCATGAAATGGGGCATGTTCTTCGTG
GGCGAATACATCGGGATCATCTTGATCTCGGCGCTGCTGGTGACGCTGTTCTTCGGTGGCTGGCACGGTCCGTTCGACAT
TCTGCCATCGCTGGCTTTCTTCTGGTTCGCCTTGAAAACCGCGTTTTTCATCATGCTGTTCATTCTGCTGCGCGCCTCCA
TCCCGCGCCCGCGTTATGACCAGGTCATGGATTTCAGCTGGAAGTTCTGTCTGCCGCTGACCCTGATCAATTTGCTGGTG
ACTGCTGCGATTGTGTTGTTGAACACACCGGCAGGCTCGGTTCAGTGA

Upstream 100 bases:

>100_bases
AAGAACTGGGCGCGGGTCTTGTGGCATTGCCGGCAGGACTGCCCGGCATTCCGCCAGCACTCTTCGGCAAATCCGTTGAC
GGTCTGCAGGAGGCAGCGCA

Downstream 100 bases:

>100_bases
GGATTTGACCCATGTTCAAATATATTGGTGACATCGTTAAAGGTACGGGTACCCAGTTGCGCAGTATGGTCATGGTCTTC
GGCCACGGCTTTCGCAAGCG

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTWFTPDVIDAIIAVVKAIVVLLAVVVCGALLSFIERRLLGWWQDRYGPNRVGPFGMFQIAADMLKMFFKEDWTPPFADK
VIFTLAPVVAMSALLIAFAVIPITPTWGVADLNIGLLFFFAMAGLSVYAVLFAGWSSNNKFALLGSLRASAQTVSYEVFM
GLALMGIVVQVGSFNMRDIVEYQAQNLWFIIPQFFGFCTFFIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFV
GEYIGIILISALLVTLFFGGWHGPFDILPSLAFFWFALKTAFFIMLFILLRASIPRPRYDQVMDFSWKFCLPLTLINLLV
TAAIVLLNTPAGSVQ

Sequences:

>Translated_335_residues
MTWFTPDVIDAIIAVVKAIVVLLAVVVCGALLSFIERRLLGWWQDRYGPNRVGPFGMFQIAADMLKMFFKEDWTPPFADK
VIFTLAPVVAMSALLIAFAVIPITPTWGVADLNIGLLFFFAMAGLSVYAVLFAGWSSNNKFALLGSLRASAQTVSYEVFM
GLALMGIVVQVGSFNMRDIVEYQAQNLWFIIPQFFGFCTFFIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFV
GEYIGIILISALLVTLFFGGWHGPFDILPSLAFFWFALKTAFFIMLFILLRASIPRPRYDQVMDFSWKFCLPLTLINLLV
TAAIVLLNTPAGSVQ
>Mature_334_residues
TWFTPDVIDAIIAVVKAIVVLLAVVVCGALLSFIERRLLGWWQDRYGPNRVGPFGMFQIAADMLKMFFKEDWTPPFADKV
IFTLAPVVAMSALLIAFAVIPITPTWGVADLNIGLLFFFAMAGLSVYAVLFAGWSSNNKFALLGSLRASAQTVSYEVFMG
LALMGIVVQVGSFNMRDIVEYQAQNLWFIIPQFFGFCTFFIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVG
EYIGIILISALLVTLFFGGWHGPFDILPSLAFFWFALKTAFFIMLFILLRASIPRPRYDQVMDFSWKFCLPLTLINLLVT
AAIVLLNTPAGSVQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=286, Percent_Identity=39.1608391608392, Blast_Score=206, Evalue=4e-53,
Organism=Escherichia coli, GI1788618, Length=326, Percent_Identity=71.4723926380368, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI1789077, Length=235, Percent_Identity=28.0851063829787, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_PSE14 (Q48H48)

Other databases:

- EMBL:   CP000058
- RefSeq:   YP_275285.1
- STRING:   Q48H48
- GeneID:   3557900
- GenomeReviews:   CP000058_GR
- KEGG:   psp:PSPPH_3115
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   MSWLTPE
- PhylomeDB:   Q48H48
- ProtClustDB:   PRK06076
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 37458; Mature: 37327

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1dbfdcbc)-; HASH(0x1bd88e34)-; HASH(0x1fdc8e70)-; HASH(0x1becfee4)-; HASH(0x1de95234)-; HASH(0x1b82e948)-; HASH(0x19f541b8)-; HASH(0x1dbbb978)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWFTPDVIDAIIAVVKAIVVLLAVVVCGALLSFIERRLLGWWQDRYGPNRVGPFGMFQI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
AADMLKMFFKEDWTPPFADKVIFTLAPVVAMSALLIAFAVIPITPTWGVADLNIGLLFFF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AMAGLSVYAVLFAGWSSNNKFALLGSLRASAQTVSYEVFMGLALMGIVVQVGSFNMRDIV
HHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EYQAQNLWFIIPQFFGFCTFFIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFV
HHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCCHHHHHHH
GEYIGIILISALLVTLFFGGWHGPFDILPSLAFFWFALKTAFFIMLFILLRASIPRPRYD
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QVMDFSWKFCLPLTLINLLVTAAIVLLNTPAGSVQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
TWFTPDVIDAIIAVVKAIVVLLAVVVCGALLSFIERRLLGWWQDRYGPNRVGPFGMFQI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH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HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA