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The map label for this gene is nuoF [H]

Identifier: 66046430

GI number: 66046430

Start: 3831157

End: 3832515

Strand: Direct

Name: nuoF [H]

Synonym: Psyr_3201

Alternate gene names: 66046430

Gene position: 3831157-3832515 (Clockwise)

Preceding gene: 66046429

Following gene: 66046431

Centisome position: 62.87

GC content: 62.4

Gene sequence:

>1359_bases
ATGACCATCACTTCCTTCGGCCCTGCCAACCGCATTGCGCGCACGGCAGAAACCCATCCGCTGACCTGGCGTCTGCGCGA
CGACGGCGAACCGGTCTGGCTCGACGAGTACCAGACCAAGGACGGCTACGCTGCAGCGCGCAAGGCGCTGACGCAGCAGG
CGCCTGACGATATCGTCCAGTCGGTCAAGGATTCCGGCCTCAAGGGCCGCGGTGGCGCAGGCTTCCCCACGGGGGTGAAG
TGGGGCCTGATGCCCAAAGACGAGTCCATGAACATCCGCTACCTGCTGTGCAACGCGGACGAGATGGAACCCAACACGTG
GAAAGACCGCATGCTGATGGAGCAACTGCCCCATCTGCTGGTCGAGGGCATGCTGATCAGTGCCCGCGCGCTGAAAGCCT
ATCGCGGCTATATCTTCCTGCGCGGCGAATACGTCACCGCAGCCAAGCACCTCAATCGCGCAGTGGCTGAAGCCAAGGCC
GCGGGTTTGCTGGGCAAGAACATTCTCGGCACCGGTTTCGACTTCGAACTGTTCGTGCACACGGGTGCCGGTCGCTACAT
CTGCGGTGAAGAAACCGCACTGATCAACTCGCTGGAAGGCCGCCGCGCCAACCCGCGCTCCAAGCCGCCCTTCCCTGCTG
CGGTGGGCGTGTGGGGCAAGCCGACTTGTGTGAACAACGTCGAGACTTTGTGCAACGTGCCTGCCATCGTCAACAACGGC
AACGACTGGTACAAGTCGCTGGCTCGCGAAGGCAGTGAAGACCACGGCACCAAGCTGATGGGTTTCTCCGGCAAGGTCAA
AAACCCCGGTTTGTGGGAACTGCCCTTCGGCGTACAGGCTCGCGAACTGTTCGAGGACTACGCCGGCGGCATGCGCGATG
GTTTCAAGCTCAAGTGCTGGCAACCCGGAGGCGCCGGTACGGGTTTCCTGCTGCCGGAGCATCTGGACGCGCAGATGTAC
GCAGGCGGTATCGCCAAGGTCGGCACCCGGATGGGTACGGGGCTGGCGATGGCGGTCGACGATTCGGTCAACATGGTCTC
GCTGCTGCGCAACATGGAAGAGTTTTTCGCTCAGGAGTCCTGTGGCTTCTGCACGCCATGCCGCGACGGCTTGCCATGGA
GCGTGAAGATGCTTCGCGCCATCGAGAACGGTCAGGGTCAGCCGGGGGATATCGAAACCCTGCTGGGTCTGGTCAATTTC
CTCGGCCCTGGCAAAACCTTCTGTGCCCATGCACCGGGCGCCGTTGAACCCTTGGGCAGTGCGATCAAGTATTTCCGTTC
CGAGTTCGAAGCCGGTATCGCGCCAGCCAGCGCAGCCACGCTCGTTCCGGGCAAAAGTCCGACAGTGGTCGGCGCATAA

Upstream 100 bases:

>100_bases
GCCTCGGCAACTGTGACAAGGCGCCGGCCGTGATGGTCGACGACGACACTTTCGGCGATGTACAGCCTGCTGGCGTTGCC
AAGATGCTGGAGGGTTACCT

Downstream 100 bases:

>100_bases
CAAGACACAACGGTCGGCGGCTGTTCGGGCTGCCGTCCTCGTACCTGCTGACGCCCTCCGGGCTGAACGATACGGGTACT
ACCGAGATTCCATTAGCCAC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTITSFGPANRIARTAETHPLTWRLRDDGEPVWLDEYQTKDGYAAARKALTQQAPDDIVQSVKDSGLKGRGGAGFPTGVK
WGLMPKDESMNIRYLLCNADEMEPNTWKDRMLMEQLPHLLVEGMLISARALKAYRGYIFLRGEYVTAAKHLNRAVAEAKA
AGLLGKNILGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPAAVGVWGKPTCVNNVETLCNVPAIVNNG
NDWYKSLAREGSEDHGTKLMGFSGKVKNPGLWELPFGVQARELFEDYAGGMRDGFKLKCWQPGGAGTGFLLPEHLDAQMY
AGGIAKVGTRMGTGLAMAVDDSVNMVSLLRNMEEFFAQESCGFCTPCRDGLPWSVKMLRAIENGQGQPGDIETLLGLVNF
LGPGKTFCAHAPGAVEPLGSAIKYFRSEFEAGIAPASAATLVPGKSPTVVGA

Sequences:

>Translated_452_residues
MTITSFGPANRIARTAETHPLTWRLRDDGEPVWLDEYQTKDGYAAARKALTQQAPDDIVQSVKDSGLKGRGGAGFPTGVK
WGLMPKDESMNIRYLLCNADEMEPNTWKDRMLMEQLPHLLVEGMLISARALKAYRGYIFLRGEYVTAAKHLNRAVAEAKA
AGLLGKNILGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPAAVGVWGKPTCVNNVETLCNVPAIVNNG
NDWYKSLAREGSEDHGTKLMGFSGKVKNPGLWELPFGVQARELFEDYAGGMRDGFKLKCWQPGGAGTGFLLPEHLDAQMY
AGGIAKVGTRMGTGLAMAVDDSVNMVSLLRNMEEFFAQESCGFCTPCRDGLPWSVKMLRAIENGQGQPGDIETLLGLVNF
LGPGKTFCAHAPGAVEPLGSAIKYFRSEFEAGIAPASAATLVPGKSPTVVGA
>Mature_451_residues
TITSFGPANRIARTAETHPLTWRLRDDGEPVWLDEYQTKDGYAAARKALTQQAPDDIVQSVKDSGLKGRGGAGFPTGVKW
GLMPKDESMNIRYLLCNADEMEPNTWKDRMLMEQLPHLLVEGMLISARALKAYRGYIFLRGEYVTAAKHLNRAVAEAKAA
GLLGKNILGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPAAVGVWGKPTCVNNVETLCNVPAIVNNGN
DWYKSLAREGSEDHGTKLMGFSGKVKNPGLWELPFGVQARELFEDYAGGMRDGFKLKCWQPGGAGTGFLLPEHLDAQMYA
GGIAKVGTRMGTGLAMAVDDSVNMVSLLRNMEEFFAQESCGFCTPCRDGLPWSVKMLRAIENGQGQPGDIETLLGLVNFL
GPGKTFCAHAPGAVEPLGSAIKYFRSEFEAGIAPASAATLVPGKSPTVVGA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=411, Percent_Identity=42.3357664233577, Blast_Score=308, Evalue=9e-84,
Organism=Homo sapiens, GI260656005, Length=411, Percent_Identity=42.3357664233577, Blast_Score=308, Evalue=9e-84,
Organism=Escherichia coli, GI1788620, Length=440, Percent_Identity=77.0454545454545, Blast_Score=704, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17531727, Length=390, Percent_Identity=42.0512820512821, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI19920794, Length=411, Percent_Identity=42.8223844282238, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI45550452, Length=406, Percent_Identity=42.8571428571429, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24653819, Length=432, Percent_Identity=32.8703703703704, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24653817, Length=354, Percent_Identity=32.2033898305085, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48825; Mature: 48694

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITSFGPANRIARTAETHPLTWRLRDDGEPVWLDEYQTKDGYAAARKALTQQAPDDIVQ
CCCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHH
SVKDSGLKGRGGAGFPTGVKWGLMPKDESMNIRYLLCNADEMEPNTWKDRMLMEQLPHLL
HHHHCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
VEGMLISARALKAYRGYIFLRGEYVTAAKHLNRAVAEAKAAGLLGKNILGTGFDFELFVH
HHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEEE
TGAGRYICGEETALINSLEGRRANPRSKPPFPAAVGVWGKPTCVNNVETLCNVPAIVNNG
CCCCCEEECCHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHCCCCEEECC
NDWYKSLAREGSEDHGTKLMGFSGKVKNPGLWELPFGVQARELFEDYAGGMRDGFKLKCW
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCEEEEE
QPGGAGTGFLLPEHLDAQMYAGGIAKVGTRMGTGLAMAVDDSVNMVSLLRNMEEFFAQES
CCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC
CGFCTPCRDGLPWSVKMLRAIENGQGQPGDIETLLGLVNFLGPGKTFCAHAPGAVEPLGS
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHH
AIKYFRSEFEAGIAPASAATLVPGKSPTVVGA
HHHHHHHHHHCCCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
TITSFGPANRIARTAETHPLTWRLRDDGEPVWLDEYQTKDGYAAARKALTQQAPDDIVQ
CCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHH
SVKDSGLKGRGGAGFPTGVKWGLMPKDESMNIRYLLCNADEMEPNTWKDRMLMEQLPHLL
HHHHCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
VEGMLISARALKAYRGYIFLRGEYVTAAKHLNRAVAEAKAAGLLGKNILGTGFDFELFVH
HHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEEE
TGAGRYICGEETALINSLEGRRANPRSKPPFPAAVGVWGKPTCVNNVETLCNVPAIVNNG
CCCCCEEECCHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHCCCCEEECC
NDWYKSLAREGSEDHGTKLMGFSGKVKNPGLWELPFGVQARELFEDYAGGMRDGFKLKCW
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCEEEEE
QPGGAGTGFLLPEHLDAQMYAGGIAKVGTRMGTGLAMAVDDSVNMVSLLRNMEEFFAQES
CCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC
CGFCTPCRDGLPWSVKMLRAIENGQGQPGDIETLLGLVNFLGPGKTFCAHAPGAVEPLGS
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHH
AIKYFRSEFEAGIAPASAATLVPGKSPTVVGA
HHHHHHHHHHCCCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]