Click here to switch to the map view.

The map label for this gene is copS [H]

Identifier: 66046357

GI number: 66046357

Start: 3750276

End: 3751673

Strand: Direct

Name: copS [H]

Synonym: Psyr_3128

Alternate gene names: 66046357

Gene position: 3750276-3751673 (Clockwise)

Preceding gene: 66046356

Following gene: 66046358

Centisome position: 61.54

GC content: 61.16

Gene sequence:

>1398_bases
ATGTCATTGCCGAACCCGTCTGACGGCTGGCGATCATCCACGAGTCGATTACTGGCGCTGTACAGCTCGCTGTTCGTAGC
CTGGAGCGTGATTCTGCTTGGCGTCCTGTATTGGGAGGTGACGTCTTATCTGGACACCCTCGCCCGCCAGTCGCTCACCC
ATCGCCAGCAACTGTTTTCGCGCTTCGAGGGCCAGGGTCTGGTGGACGCTCTGGCCACCAGCATGACCTTCGATACCCGT
TCGGTGGATGCCTACGGTCTGTTCGACGAGAACTTCCGCCCGGTTGCCGGGCCTATCACCAGCGTCCCGAAAAACCTGCC
TATCGACGGCCAGATTCATGTACTGAACGATTGCATCGAATCGGATGATCCAGGCATGCCGCAAGGCAGTTGCGATGCGA
TCGTCAATCGCACGTCGGACGGCCGCTGGCTGGTGCTGGTTCGCGAGAACGGCTCGCTGTTTGCGGTGAGCACGCTGATC
CTGCATGCCTTGCTGTGGGGCATCTCGCTGACCATTATTCCCGGTGTTGCCGGCTGGCATTTACTGCGCCGCAGGCCGTT
GCGGCGTATCCGCGCGATTCAGGCCAGCGCCGAATCGATCATCGCCGGCGACATGGCCGGCCGTCTGCCGGTCTCCAACA
GGCGCGATGAACTGGACATGCTGGCGGTGATCGTCAACGCCATGCTCGACCGTATCGAAAAGCTCATGAACGAGGTCAAG
GGCGTTTGCGACAATATCGCCCATGACCTGCGCACACCGCTGACCCGCTTGCGTGCGCAGCTTTACCGTATTCAGCAGCA
GTCAGCACACGATTCGACCCATGCCACGCAGATTGCCCAGGTCATCAGCGAAGCTGACACGCTGATGGCACGCTTCCGCG
GACTGTTGCGCATTTCCGAGCTGGAAGACCGCCAGCGGCGCTCGGCATTCGTTGAACTGGAACTGCGTCCATTGCTGCAG
GAGCTACATGATTTCCACCTGCCGCTGGCTGAAGAAGACCAGATCACCCTGATACTCGACCTGCATGAACCGCTACCCAC
TCTGGTAGGCGACCGCGCTCTGCTGTTCGAAGCACTGACCAACCTGCTGGGCAACGCAATCAAGTTCACCCCGGGCGGCG
GAATCGTCAAAGTCAGCGCCTACCCTGCCCCCGGCGGCACCACGCCGTGCATCGAGGTGCAGGATTCCGGGCCTGGCATC
CCCGTCGCCGAGCGCGCGGCTGTCTTTCAGCGCTTCTATCGCAGTGAGGCCGGCACCGAGCAAAGCGGCTTCGGCCTCGG
CCTCTCCGTAGTGGCCGCAATCGTCAATCTGCACGGTTTTACACTGCAGATAGGCACCAGCGAATACGGCGGCGCAAGTT
TGCTGCTGGAATGCCGCACGGTGAATACGCTGGCCTGA

Upstream 100 bases:

>100_bases
CCGGGCACCAACCTGATCGACGTTCACATCGGCCGTCTGCGCAAGAAGATCGACCAACCCGGTACCGCACAGCTCATTCA
GACCGTGCGAGGATCCGGCT

Downstream 100 bases:

>100_bases
GACTCAGGCACTTTCCAAGCCCTTGATTGCACGATCGTGCCTGCTTTTTGACGAGATTAACGCGTCTGGCTCAAGGGTTT
CGGCGATTTCGATATTAATC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSLPNPSDGWRSSTSRLLALYSSLFVAWSVILLGVLYWEVTSYLDTLARQSLTHRQQLFSRFEGQGLVDALATSMTFDTR
SVDAYGLFDENFRPVAGPITSVPKNLPIDGQIHVLNDCIESDDPGMPQGSCDAIVNRTSDGRWLVLVRENGSLFAVSTLI
LHALLWGISLTIIPGVAGWHLLRRRPLRRIRAIQASAESIIAGDMAGRLPVSNRRDELDMLAVIVNAMLDRIEKLMNEVK
GVCDNIAHDLRTPLTRLRAQLYRIQQQSAHDSTHATQIAQVISEADTLMARFRGLLRISELEDRQRRSAFVELELRPLLQ
ELHDFHLPLAEEDQITLILDLHEPLPTLVGDRALLFEALTNLLGNAIKFTPGGGIVKVSAYPAPGGTTPCIEVQDSGPGI
PVAERAAVFQRFYRSEAGTEQSGFGLGLSVVAAIVNLHGFTLQIGTSEYGGASLLLECRTVNTLA

Sequences:

>Translated_465_residues
MSLPNPSDGWRSSTSRLLALYSSLFVAWSVILLGVLYWEVTSYLDTLARQSLTHRQQLFSRFEGQGLVDALATSMTFDTR
SVDAYGLFDENFRPVAGPITSVPKNLPIDGQIHVLNDCIESDDPGMPQGSCDAIVNRTSDGRWLVLVRENGSLFAVSTLI
LHALLWGISLTIIPGVAGWHLLRRRPLRRIRAIQASAESIIAGDMAGRLPVSNRRDELDMLAVIVNAMLDRIEKLMNEVK
GVCDNIAHDLRTPLTRLRAQLYRIQQQSAHDSTHATQIAQVISEADTLMARFRGLLRISELEDRQRRSAFVELELRPLLQ
ELHDFHLPLAEEDQITLILDLHEPLPTLVGDRALLFEALTNLLGNAIKFTPGGGIVKVSAYPAPGGTTPCIEVQDSGPGI
PVAERAAVFQRFYRSEAGTEQSGFGLGLSVVAAIVNLHGFTLQIGTSEYGGASLLLECRTVNTLA
>Mature_464_residues
SLPNPSDGWRSSTSRLLALYSSLFVAWSVILLGVLYWEVTSYLDTLARQSLTHRQQLFSRFEGQGLVDALATSMTFDTRS
VDAYGLFDENFRPVAGPITSVPKNLPIDGQIHVLNDCIESDDPGMPQGSCDAIVNRTSDGRWLVLVRENGSLFAVSTLIL
HALLWGISLTIIPGVAGWHLLRRRPLRRIRAIQASAESIIAGDMAGRLPVSNRRDELDMLAVIVNAMLDRIEKLMNEVKG
VCDNIAHDLRTPLTRLRAQLYRIQQQSAHDSTHATQIAQVISEADTLMARFRGLLRISELEDRQRRSAFVELELRPLLQE
LHDFHLPLAEEDQITLILDLHEPLPTLVGDRALLFEALTNLLGNAIKFTPGGGIVKVSAYPAPGGTTPCIEVQDSGPGIP
VAERAAVFQRFYRSEAGTEQSGFGLGLSVVAAIVNLHGFTLQIGTSEYGGASLLLECRTVNTLA

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cyto

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=259, Percent_Identity=26.2548262548263, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=28.7822878228782, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=267, Percent_Identity=26.5917602996255, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=241, Percent_Identity=30.2904564315353, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=29.3893129770992, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789403, Length=229, Percent_Identity=29.6943231441048, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=211, Percent_Identity=26.5402843601896, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789149, Length=252, Percent_Identity=28.1746031746032, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=25.4612546125461, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790551, Length=312, Percent_Identity=25.6410256410256, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=29.6943231441048, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790861, Length=340, Percent_Identity=25.8823529411765, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=212, Percent_Identity=30.188679245283, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=196, Percent_Identity=27.5510204081633, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=26.027397260274, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=228, Percent_Identity=27.1929824561404, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51091; Mature: 50960

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPNPSDGWRSSTSRLLALYSSLFVAWSVILLGVLYWEVTSYLDTLARQSLTHRQQLFS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFEGQGLVDALATSMTFDTRSVDAYGLFDENFRPVAGPITSVPKNLPIDGQIHVLNDCIE
HHCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCHHHCCCCCCCCCEEHHHHHHHC
SDDPGMPQGSCDAIVNRTSDGRWLVLVRENGSLFAVSTLILHALLWGISLTIIPGVAGWH
CCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
LLRRRPLRRIRAIQASAESIIAGDMAGRLPVSNRRDELDMLAVIVNAMLDRIEKLMNEVK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVCDNIAHDLRTPLTRLRAQLYRIQQQSAHDSTHATQIAQVISEADTLMARFRGLLRISE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEDRQRRSAFVELELRPLLQELHDFHLPLAEEDQITLILDLHEPLPTLVGDRALLFEALT
HHHHHHHHHEEEEHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHCCHHHHHHHHH
NLLGNAIKFTPGGGIVKVSAYPAPGGTTPCIEVQDSGPGIPVAERAAVFQRFYRSEAGTE
HHHCCCEEECCCCCEEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
QSGFGLGLSVVAAIVNLHGFTLQIGTSEYGGASLLLECRTVNTLA
CCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEHHCCCC
>Mature Secondary Structure 
SLPNPSDGWRSSTSRLLALYSSLFVAWSVILLGVLYWEVTSYLDTLARQSLTHRQQLFS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFEGQGLVDALATSMTFDTRSVDAYGLFDENFRPVAGPITSVPKNLPIDGQIHVLNDCIE
HHCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCHHHCCCCCCCCCEEHHHHHHHC
SDDPGMPQGSCDAIVNRTSDGRWLVLVRENGSLFAVSTLILHALLWGISLTIIPGVAGWH
CCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
LLRRRPLRRIRAIQASAESIIAGDMAGRLPVSNRRDELDMLAVIVNAMLDRIEKLMNEVK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVCDNIAHDLRTPLTRLRAQLYRIQQQSAHDSTHATQIAQVISEADTLMARFRGLLRISE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEDRQRRSAFVELELRPLLQELHDFHLPLAEEDQITLILDLHEPLPTLVGDRALLFEALT
HHHHHHHHHEEEEHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHCCHHHHHHHHH
NLLGNAIKFTPGGGIVKVSAYPAPGGTTPCIEVQDSGPGIPVAERAAVFQRFYRSEAGTE
HHHCCCEEECCCCCEEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
QSGFGLGLSVVAAIVNLHGFTLQIGTSEYGGASLLLECRTVNTLA
CCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8449873 [H]