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The map label for this gene is cusR [H]

Identifier: 66046356

GI number: 66046356

Start: 3749615

End: 3750298

Strand: Direct

Name: cusR [H]

Synonym: Psyr_3127

Alternate gene names: 66046356

Gene position: 3749615-3750298 (Clockwise)

Preceding gene: 66046355

Following gene: 66046357

Centisome position: 61.53

GC content: 59.36

Gene sequence:

>684_bases
ATGACCCGAATTCTGGCAATCGAAGATGATGCCATCACTGCAAAGGAAATCGTGACCGAACTCAGCAGCCACGGACTGGA
AGTGGACTGGGTCGACAATGGCCGTGACGGCCTGGCGCGTGCAGTGAGTGGCGATTATGACCTTATTACCCTGGACCGCA
TGTTGCCGGAGATGGATGGTCTGACCATCGTCACCCACTTGCGTGCCCAGGGCATTTCCACGCCGATCCTGATGATCAGC
GCCCTTTCCGACGTGGACGAGCGCGTTCGCGGCCTGCGTGCCGGAGGGGACGACTATCTGCCCAAGCCCTTCGCGTCGGA
TGAGATGGCTGCGCGCGTCGAGGTGTTATTGCGACGCAGTAACCCGGTCAGTGCCGCCAAGACGGTATTGCAGGTTGCCG
ACCTGGAACTGAACCTGATCACCCGGGAAGCGTGTCGCGGCGGCGAGCCGCTGACCCTGCTGCCCACCGAATTCAAGCTG
CTTGAGTTTCTGATGCGCAACAGCGGACAGATCATCACCCGAATGATGATTTTTCAGGAAGTCTGGGGCTACCACTTCGA
TCCGGGCACCAACCTGATCGACGTTCACATCGGCCGTCTGCGCAAGAAGATCGACCAACCCGGTACCGCACAGCTCATTC
AGACCGTGCGAGGATCCGGCTATGTCATTGCCGAACCCGTCTGA

Upstream 100 bases:

>100_bases
AGCGAGAAATATGATCCCTATCATTAAACTTTCTTTCAGGAAACGCGGCGGGTTTTAAAGGCAGAATGACTCTTTGAACG
CATCTATTCAGGCAGGGACC

Downstream 100 bases:

>100_bases
CGGCTGGCGATCATCCACGAGTCGATTACTGGCGCTGTACAGCTCGCTGTTCGTAGCCTGGAGCGTGATTCTGCTTGGCG
TCCTGTATTGGGAGGTGACG

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTRILAIEDDAITAKEIVTELSSHGLEVDWVDNGRDGLARAVSGDYDLITLDRMLPEMDGLTIVTHLRAQGISTPILMIS
ALSDVDERVRGLRAGGDDYLPKPFASDEMAARVEVLLRRSNPVSAAKTVLQVADLELNLITREACRGGEPLTLLPTEFKL
LEFLMRNSGQIITRMMIFQEVWGYHFDPGTNLIDVHIGRLRKKIDQPGTAQLIQTVRGSGYVIAEPV

Sequences:

>Translated_227_residues
MTRILAIEDDAITAKEIVTELSSHGLEVDWVDNGRDGLARAVSGDYDLITLDRMLPEMDGLTIVTHLRAQGISTPILMIS
ALSDVDERVRGLRAGGDDYLPKPFASDEMAARVEVLLRRSNPVSAAKTVLQVADLELNLITREACRGGEPLTLLPTEFKL
LEFLMRNSGQIITRMMIFQEVWGYHFDPGTNLIDVHIGRLRKKIDQPGTAQLIQTVRGSGYVIAEPV
>Mature_226_residues
TRILAIEDDAITAKEIVTELSSHGLEVDWVDNGRDGLARAVSGDYDLITLDRMLPEMDGLTIVTHLRAQGISTPILMISA
LSDVDERVRGLRAGGDDYLPKPFASDEMAARVEVLLRRSNPVSAAKTVLQVADLELNLITREACRGGEPLTLLPTEFKLL
EFLMRNSGQIITRMMIFQEVWGYHFDPGTNLIDVHIGRLRKKIDQPGTAQLIQTVRGSGYVIAEPV

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=45.5357142857143, Blast_Score=195, Evalue=2e-51,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=42.9223744292237, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=42.6008968609865, Blast_Score=168, Evalue=2e-43,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=34.841628959276, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=35.7466063348416, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=33.7837837837838, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.3612334801762, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=30.316742081448, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI2367329, Length=177, Percent_Identity=37.8531073446328, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=32.2727272727273, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.0357142857143, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=29.1304347826087, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.8761061946903, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=30.5439330543933, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=31.1926605504587, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790437, Length=122, Percent_Identity=29.5081967213115, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=31.5315315315315, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25108; Mature: 24977

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRILAIEDDAITAKEIVTELSSHGLEVDWVDNGRDGLARAVSGDYDLITLDRMLPEMDG
CCEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCEEEHHHHCCCCCC
LTIVTHLRAQGISTPILMISALSDVDERVRGLRAGGDDYLPKPFASDEMAARVEVLLRRS
EEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
NPVSAAKTVLQVADLELNLITREACRGGEPLTLLPTEFKLLEFLMRNSGQIITRMMIFQE
CCHHHHHHHHHHHCCHHHEEEHHHHCCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHH
VWGYHFDPGTNLIDVHIGRLRKKIDQPGTAQLIQTVRGSGYVIAEPV
HHCEECCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCC
>Mature Secondary Structure 
TRILAIEDDAITAKEIVTELSSHGLEVDWVDNGRDGLARAVSGDYDLITLDRMLPEMDG
CEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCEEEHHHHCCCCCC
LTIVTHLRAQGISTPILMISALSDVDERVRGLRAGGDDYLPKPFASDEMAARVEVLLRRS
EEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
NPVSAAKTVLQVADLELNLITREACRGGEPLTLLPTEFKLLEFLMRNSGQIITRMMIFQE
CCHHHHHHHHHHHCCHHHEEEHHHHCCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHH
VWGYHFDPGTNLIDVHIGRLRKKIDQPGTAQLIQTVRGSGYVIAEPV
HHCEECCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]