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The map label for this gene is mprA [H]

Identifier: 66046320

GI number: 66046320

Start: 3706730

End: 3707404

Strand: Reverse

Name: mprA [H]

Synonym: Psyr_3091

Alternate gene names: 66046320

Gene position: 3707404-3706730 (Counterclockwise)

Preceding gene: 66046321

Following gene: 66046319

Centisome position: 60.84

GC content: 59.41

Gene sequence:

>675_bases
ATGAACATTCTGGTTATTGAAGACCACCGTGATATTCACGATAACCTGCTGGAATTCTTCGAACTCAGGGGGCATGCGGT
AGAAGGGGCGCTGGACGGCCTGAGCGGGCTGCACCTGGCCGCCTCGAAACGCTTCGATGCGATCATTCTCGACATCATGC
TGCCCGGCATCGACGGCAATCAGATCTGCCACAGCCTGCGCCAGTATTCGAAGTCGGAAGTCGCGATTGTGATGCTCAGC
GCGCGCGATGAACTGGATGATCGGCTCACCGGTTTCAAGGTGGGGGCCGACGACTACATCACCAAGCCGTTCGCGATGTC
CGAAGTGCTCGCCAGAGTCGAAGCGATCGTCAGCCGACGGCAGCGCCAGGACAACCGGATGATGGTGGTCGCCGACCTGC
AGTTCGATCTGGACACCCTTGAAATCACCCGCAAAGGCGTGCCCTTGAAGCTCAATCCGACCAACATGAAGCTGTTGGAA
CTGTTGATGCGCAAGAGCCCGCATATCGTCAAGCGCTCCGACCTGGAAGAGGCGCTTTGGGGCCGTGATGCCCCGAACAG
CAGCAGCTTGCGCAGCAACATCCATGTGCTCAGGCGGGTACTGGATGGCGGGCACGACACGCCATTGCTGCACACCGCCC
ATGGCCTGGGTTACAAGCTGTGCGTGCAGCGCTGA

Upstream 100 bases:

>100_bases
CGGTGGCCGTCAACAGACCTGATGCATTCGTCACGCAGCCTGCAGACTCATTGGTAACAGGTTCCCGGTCGGCCGGGTAG
AAAGACAAGAAGGCGCGGCA

Downstream 100 bases:

>100_bases
GGCGCGTTCAGTCGGCGTTGAACAGGCAACTGACTCATTCGATCAGGGTCCGGGGTGAAGAATACCTTTCACTACCGGAT
CAAGCAGGTGGCCGTGTGTG

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNILVIEDHRDIHDNLLEFFELRGHAVEGALDGLSGLHLAASKRFDAIILDIMLPGIDGNQICHSLRQYSKSEVAIVMLS
ARDELDDRLTGFKVGADDYITKPFAMSEVLARVEAIVSRRQRQDNRMMVVADLQFDLDTLEITRKGVPLKLNPTNMKLLE
LLMRKSPHIVKRSDLEEALWGRDAPNSSSLRSNIHVLRRVLDGGHDTPLLHTAHGLGYKLCVQR

Sequences:

>Translated_224_residues
MNILVIEDHRDIHDNLLEFFELRGHAVEGALDGLSGLHLAASKRFDAIILDIMLPGIDGNQICHSLRQYSKSEVAIVMLS
ARDELDDRLTGFKVGADDYITKPFAMSEVLARVEAIVSRRQRQDNRMMVVADLQFDLDTLEITRKGVPLKLNPTNMKLLE
LLMRKSPHIVKRSDLEEALWGRDAPNSSSLRSNIHVLRRVLDGGHDTPLLHTAHGLGYKLCVQR
>Mature_224_residues
MNILVIEDHRDIHDNLLEFFELRGHAVEGALDGLSGLHLAASKRFDAIILDIMLPGIDGNQICHSLRQYSKSEVAIVMLS
ARDELDDRLTGFKVGADDYITKPFAMSEVLARVEAIVSRRQRQDNRMMVVADLQFDLDTLEITRKGVPLKLNPTNMKLLE
LLMRKSPHIVKRSDLEEALWGRDAPNSSSLRSNIHVLRRVLDGGHDTPLLHTAHGLGYKLCVQR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.5565610859729, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=32.8828828828829, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=33.4782608695652, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.4444444444444, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=29.4642857142857, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=31.25, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=30.0884955752212, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=31.5555555555556, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.2608695652174, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.5154185022026, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=27.7272727272727, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=32.7433628318584, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=28.0373831775701, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25264; Mature: 25264

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILVIEDHRDIHDNLLEFFELRGHAVEGALDGLSGLHLAASKRFDAIILDIMLPGIDGN
CEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCCHHEEEEEEEECCCCHH
QICHSLRQYSKSEVAIVMLSARDELDDRLTGFKVGADDYITKPFAMSEVLARVEAIVSRR
HHHHHHHHCCCCCEEEEEEECCHHHHHHHCCEEECCCHHHCCCHHHHHHHHHHHHHHHHH
QRQDNRMMVVADLQFDLDTLEITRKGVPLKLNPTNMKLLELLMRKSPHIVKRSDLEEALW
HCCCCCEEEEEECCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHC
GRDAPNSSSLRSNIHVLRRVLDGGHDTPLLHTAHGLGYKLCVQR
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEECC
>Mature Secondary Structure
MNILVIEDHRDIHDNLLEFFELRGHAVEGALDGLSGLHLAASKRFDAIILDIMLPGIDGN
CEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCCHHEEEEEEEECCCCHH
QICHSLRQYSKSEVAIVMLSARDELDDRLTGFKVGADDYITKPFAMSEVLARVEAIVSRR
HHHHHHHHCCCCCEEEEEEECCHHHHHHHCCEEECCCHHHCCCHHHHHHHHHHHHHHHHH
QRQDNRMMVVADLQFDLDTLEITRKGVPLKLNPTNMKLLELLMRKSPHIVKRSDLEEALW
HCCCCCEEEEEECCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHC
GRDAPNSSSLRSNIHVLRRVLDGGHDTPLLHTAHGLGYKLCVQR
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA