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The map label for this gene is mhpE [C]

Identifier: 66046303

GI number: 66046303

Start: 3671466

End: 3672494

Strand: Reverse

Name: mhpE [C]

Synonym: Psyr_3072

Alternate gene names: 66046303

Gene position: 3672494-3671466 (Counterclockwise)

Preceding gene: 66046304

Following gene: 66046302

Centisome position: 60.27

GC content: 57.05

Gene sequence:

>1029_bases
ATGGCCGACGTAAAAATTCTCGACGTTACCTTGCGTGACGGTGGTTATCGGAACAACTTCAATTTCACAGAAGATCAGGC
ACAGGTTATCACCACTGGCCTGGCCAATGCGGGTGTGGACCTCTGCGAAATTGGTTATTGCAAAGGATCCTTCGCGCCGA
AAGGCGAGCACGGTCTGACCAGTGATGTAGGCGCAGTCTTCATTGAAAAGATTGCACAGGCCGCTAAAGGCCGCATCGAA
CTGGCCGTCATGGTTCATCCCAGAAACATCACCACCGATGACTTGGCCATGCTCAAGGAGCAGGGCGTTTCGATGATCCG
TGTCTGTTTGAGGCGCGATCAACTGGATGAGGGGCTTGTGACCTTGTCGCTGGCTCGTGATCACGGCTTTAGCGTCAGCG
CCAATGTGACGCATGTGACCTCGCAGACGCCAGGCTCCGTGCTCGATACGGCCGTGCGCGCAGAGGGGGCCGGCGCGGAT
ATCGTTTGTTGCGCGGATTCCAATGGTCATATGGTGCCGACCGATGTAGATCGGCTGTTCAGTCGTCTCTCAAGCCGATT
GTTGGTGCCGCTGGGCTTTCACGCGCATAACAATCTGTCGTTGGCGCTGGCGAATGCAGCGGCGGCTATAGAAGCCGGCG
CTGAATACATCGACACGTCCATATGTGGCATGGGCAAGGGGGCCGGCAATCTTCACCTGAGTATGCTGGTTGCCTATCTG
GAGCGTACCGGCGTCAGTCATGGTTATGACCTGGTGAAAGTGATTGAACTGTCGGAAGCCACAGCCCGCGCGATCCCGCA
AAATAATATGCCCAGCCCGCTGATGGATATCATTCTGGGCACTTACAACTTCCCCTATGACAGCAGTCAACGCATGCGCG
ACACCCTCGAGCGCTTTCAGTTGACCTCCGAGTACCGAGCGATCGAGGTCATGTATCAGCAGGACAAGGTGGCGCGCCTT
GCGCCGCGAGCGGTGTTGTCGACCATCGCCACCGGCTTGCCGAACGGCGCGAAGGGAGTCGCGCTATGA

Upstream 100 bases:

>100_bases
TTTGTTAGATGGCGCGCTGTTGGATAATTATAAAAACTCATGCAGTGGCAAGATCATCTCAAGCACCCTGGTGACACCCT
AAGGACAGCCGGAGATTCTC

Downstream 100 bases:

>100_bases
CCACTCAAATGCTCCGAAAGCGCATATGTGTCTTGCCCGGTGACGGGATCGGTATTGAAGTCATGGAGGCGGCGCTTCCG
GTGATTGCGGCGCTGAACCT

Product: HMG-CoA lyase-like

Products: NA

Alternate protein names: HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MADVKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPKGEHGLTSDVGAVFIEKIAQAAKGRIE
LAVMVHPRNITTDDLAMLKEQGVSMIRVCLRRDQLDEGLVTLSLARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGAD
IVCCADSNGHMVPTDVDRLFSRLSSRLLVPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGNLHLSMLVAYL
ERTGVSHGYDLVKVIELSEATARAIPQNNMPSPLMDIILGTYNFPYDSSQRMRDTLERFQLTSEYRAIEVMYQQDKVARL
APRAVLSTIATGLPNGAKGVAL

Sequences:

>Translated_342_residues
MADVKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPKGEHGLTSDVGAVFIEKIAQAAKGRIE
LAVMVHPRNITTDDLAMLKEQGVSMIRVCLRRDQLDEGLVTLSLARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGAD
IVCCADSNGHMVPTDVDRLFSRLSSRLLVPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGNLHLSMLVAYL
ERTGVSHGYDLVKVIELSEATARAIPQNNMPSPLMDIILGTYNFPYDSSQRMRDTLERFQLTSEYRAIEVMYQQDKVARL
APRAVLSTIATGLPNGAKGVAL
>Mature_341_residues
ADVKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPKGEHGLTSDVGAVFIEKIAQAAKGRIEL
AVMVHPRNITTDDLAMLKEQGVSMIRVCLRRDQLDEGLVTLSLARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGADI
VCCADSNGHMVPTDVDRLFSRLSSRLLVPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGNLHLSMLVAYLE
RTGVSHGYDLVKVIELSEATARAIPQNNMPSPLMDIILGTYNFPYDSSQRMRDTLERFQLTSEYRAIEVMYQQDKVARLA
PRAVLSTIATGLPNGAKGVAL

Specific function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxy-2-oxovalerate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1786548, Length=268, Percent_Identity=30.2238805970149, Blast_Score=92, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017629
- InterPro:   IPR013785
- InterPro:   IPR012425
- InterPro:   IPR000891
- ProDom:   PD005364 [H]

Pfam domain/function: PF07836 DmpG_comm; PF00682 HMGL-like [H]

EC number: =4.1.3.39 [H]

Molecular weight: Translated: 36652; Mature: 36521

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPKGEHGLT
CCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
SDVGAVFIEKIAQAAKGRIELAVMVHPRNITTDDLAMLKEQGVSMIRVCLRRDQLDEGLV
HHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCEE
TLSLARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGADIVCCADSNGHMVPTDVDRLF
EEEEECCCCCEEECCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHH
SRLSSRLLVPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGNLHLSMLVAYL
HHHHCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ERTGVSHGYDLVKVIELSEATARAIPQNNMPSPLMDIILGTYNFPYDSSQRMRDTLERFQ
HHCCCCCCCCHHHEEEHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LTSEYRAIEVMYQQDKVARLAPRAVLSTIATGLPNGAKGVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ADVKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPKGEHGLT
CCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
SDVGAVFIEKIAQAAKGRIELAVMVHPRNITTDDLAMLKEQGVSMIRVCLRRDQLDEGLV
HHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCEE
TLSLARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGADIVCCADSNGHMVPTDVDRLF
EEEEECCCCCEEECCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHH
SRLSSRLLVPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGNLHLSMLVAYL
HHHHCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ERTGVSHGYDLVKVIELSEATARAIPQNNMPSPLMDIILGTYNFPYDSSQRMRDTLERFQ
HHCCCCCCCCHHHEEEHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LTSEYRAIEVMYQQDKVARLAPRAVLSTIATGLPNGAKGVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA