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The map label for this gene is gor [H]

Identifier: 66046210

GI number: 66046210

Start: 3571992

End: 3573350

Strand: Reverse

Name: gor [H]

Synonym: Psyr_2979

Alternate gene names: 66046210

Gene position: 3573350-3571992 (Counterclockwise)

Preceding gene: 66046211

Following gene: 66046209

Centisome position: 58.64

GC content: 58.57

Gene sequence:

>1359_bases
ATGGCCTTCGATTTTGATCTGTTTGTAATTGGCGCCGGTTCGGGCGGTGTCAGGGCAGCACGTTTTGCTGCCGGTTTTGG
TGCGCGGGTAGCCGTGGCCGAAAGCCGTTATCTAGGTGGAACCTGCGTCAACGTCGGGTGCGTTCCCAAGAAGTTGCTGG
TGTACGGAGCGCACTTTTCCGAGGATTTCGATCATGCCAAGGGCTTTGGCTGGTCGCTGGGTGAAGCCGAATTCGATTGG
GCGACGCTGATCGCCAACAAGGATCGTGAGATCAATCGCCTCAATGGCATCTATCGCAAGTTGCTGGTAGACAGCGGCGT
GACGCTGCTCGAAGGGCATGCAAGATTGACCGGTCCGCAACAGGTCGAAATCAACGGTCAGACCTACAGTGCCGAGCGCA
TTCTGGTTGCCACCGGCGGCTGGCCGCAGGTGCCTGATGTGCCGGGACGCGAGCACGCGATCACCTCCAACGAGGCGTTC
TACCTCAAAACCTTGCCCAAGCGTGTCGTCGTTGTGGGTGGCGGCTACATCGCGGTGGAGTTCGCCTCGATTTTCAATGG
GCTCGGCGCCGACACCACGCTGGTCTACCGTCGCGAACTGTTTCTGCGTGGCTTTGATGGCGGTGTTCGTACCCATCTTC
ACGAAGAGCTGCTCAAGCGTGACATGACGATTCGCTTCAACAGCGATATCGAGCGCATCGACAAGCAGGCCGACGGCAGT
CTGCTGTTGTCCATGAAAGGCGGCGGCACTCTCGAAACTGATTGCGTGTTCTACGCAACAGGGCGTCGGCCGATGCTCGA
CAACCTCGGTCTGGACAGTGTTGACGTCAAGCTGGACGAGCACGGTTACATCAAGGTCGATGAGCATTACCAGAGCAGCG
AGCCTTCCATTCTGGCCATCGGCGACGTCATCGGAGGTGTGCAGCTGACCCCGGTCGCGCTGGCTGAAGGCATGGCGGTC
GCGCGTCGACTGTTCAAGCCCGAGCAGTATCGCCCGGTAGACTACAATCACATCCCGACGGCGGTTTTCAGTCTGCCGAA
CATTGGTACGGTCGGTCTGACCGAAGAAGATGCAATCAAGGCCGGTCACGATGTGCAGATTTTCGAGAGCCGTTTCAGGC
CAATGAAGCTGACCCTGACCGATGATCAGGAGCGCACATTGATGAAGCTGGTCGTCGATGCGAAAACCGACCGCGTGCTG
GGCTGCCATATGGTGGGGCCGGATGCTGGCGAAATCGTCCAGAGCCTGGCCATTGCCATCAAGGCTGGCGCGACCAAGCA
GGTATTCGACGATACTATCGGGGTGCACCCGACCGCAGCAGAAGAGTTCGTCACCATGCGCACGCCTGTCAAACGTTAA

Upstream 100 bases:

>100_bases
ACCTGAATGACGATGCTGTGAAAACGCCACCTCCGGGTGGCTTTTTCATTTCTGAATAGCCGCCGTGCGGTTATGCTGTA
ACTCTGCCCAGGAGATAGCA

Downstream 100 bases:

>100_bases
GTCACGCAGCGCCCGGAGTTCAGGAAGAGCTCCGGGGTAAAGGCTTGAAGAGGATGGATCCCGACGTGAATAGAGAACAA
CCACCGGCCAGAATGCCATT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAFDFDLFVIGAGSGGVRAARFAAGFGARVAVAESRYLGGTCVNVGCVPKKLLVYGAHFSEDFDHAKGFGWSLGEAEFDW
ATLIANKDREINRLNGIYRKLLVDSGVTLLEGHARLTGPQQVEINGQTYSAERILVATGGWPQVPDVPGREHAITSNEAF
YLKTLPKRVVVVGGGYIAVEFASIFNGLGADTTLVYRRELFLRGFDGGVRTHLHEELLKRDMTIRFNSDIERIDKQADGS
LLLSMKGGGTLETDCVFYATGRRPMLDNLGLDSVDVKLDEHGYIKVDEHYQSSEPSILAIGDVIGGVQLTPVALAEGMAV
ARRLFKPEQYRPVDYNHIPTAVFSLPNIGTVGLTEEDAIKAGHDVQIFESRFRPMKLTLTDDQERTLMKLVVDAKTDRVL
GCHMVGPDAGEIVQSLAIAIKAGATKQVFDDTIGVHPTAAEEFVTMRTPVKR

Sequences:

>Translated_452_residues
MAFDFDLFVIGAGSGGVRAARFAAGFGARVAVAESRYLGGTCVNVGCVPKKLLVYGAHFSEDFDHAKGFGWSLGEAEFDW
ATLIANKDREINRLNGIYRKLLVDSGVTLLEGHARLTGPQQVEINGQTYSAERILVATGGWPQVPDVPGREHAITSNEAF
YLKTLPKRVVVVGGGYIAVEFASIFNGLGADTTLVYRRELFLRGFDGGVRTHLHEELLKRDMTIRFNSDIERIDKQADGS
LLLSMKGGGTLETDCVFYATGRRPMLDNLGLDSVDVKLDEHGYIKVDEHYQSSEPSILAIGDVIGGVQLTPVALAEGMAV
ARRLFKPEQYRPVDYNHIPTAVFSLPNIGTVGLTEEDAIKAGHDVQIFESRFRPMKLTLTDDQERTLMKLVVDAKTDRVL
GCHMVGPDAGEIVQSLAIAIKAGATKQVFDDTIGVHPTAAEEFVTMRTPVKR
>Mature_451_residues
AFDFDLFVIGAGSGGVRAARFAAGFGARVAVAESRYLGGTCVNVGCVPKKLLVYGAHFSEDFDHAKGFGWSLGEAEFDWA
TLIANKDREINRLNGIYRKLLVDSGVTLLEGHARLTGPQQVEINGQTYSAERILVATGGWPQVPDVPGREHAITSNEAFY
LKTLPKRVVVVGGGYIAVEFASIFNGLGADTTLVYRRELFLRGFDGGVRTHLHEELLKRDMTIRFNSDIERIDKQADGSL
LLSMKGGGTLETDCVFYATGRRPMLDNLGLDSVDVKLDEHGYIKVDEHYQSSEPSILAIGDVIGGVQLTPVALAEGMAVA
RRLFKPEQYRPVDYNHIPTAVFSLPNIGTVGLTEEDAIKAGHDVQIFESRFRPMKLTLTDDQERTLMKLVVDAKTDRVLG
CHMVGPDAGEIVQSLAIAIKAGATKQVFDDTIGVHPTAAEEFVTMRTPVKR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=41.6122004357298, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI33519430, Length=477, Percent_Identity=34.5911949685535, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI33519428, Length=477, Percent_Identity=34.5911949685535, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI33519426, Length=477, Percent_Identity=34.5911949685535, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI148277065, Length=477, Percent_Identity=34.5911949685535, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI148277071, Length=477, Percent_Identity=34.5911949685535, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI291045266, Length=480, Percent_Identity=33.125, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=31.304347826087, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI22035672, Length=476, Percent_Identity=34.453781512605, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI291045268, Length=478, Percent_Identity=30.9623430962343, Blast_Score=198, Evalue=1e-50,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=42.2897196261682, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=27.9735682819383, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=27.7404921700224, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=29.0393013100437, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71983419, Length=454, Percent_Identity=42.511013215859, Blast_Score=313, Evalue=9e-86,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=42.511013215859, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=32.6923076923077, Blast_Score=254, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=33.1941544885177, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=31.8082788671024, Blast_Score=220, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=37.9609544468547, Blast_Score=313, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6321091, Length=462, Percent_Identity=29.2207792207792, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=28.2051282051282, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=33.8983050847458, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=34.3949044585987, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=34.3949044585987, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=34.1825902335456, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=29.5010845986985, Blast_Score=201, Evalue=7e-52,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49344; Mature: 49213

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDFDLFVIGAGSGGVRAARFAAGFGARVAVAESRYLGGTCVNVGCVPKKLLVYGAHFS
CCEEEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCCCCCEEEECCCCCCEEEEEECCCC
EDFDHAKGFGWSLGEAEFDWATLIANKDREINRLNGIYRKLLVDSGVTLLEGHARLTGPQ
CCHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCEECCCCE
QVEINGQTYSAERILVATGGWPQVPDVPGREHAITSNEAFYLKTLPKRVVVVGGGYIAVE
EEEECCCEEECCEEEEEECCCCCCCCCCCCCCEECCCCEEEEEECCCEEEEEECCEEEEE
FASIFNGLGADTTLVYRRELFLRGFDGGVRTHLHEELLKRDMTIRFNSDIERIDKQADGS
HHHHHCCCCCCEEEEEEEEHHEECCCCHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCC
LLLSMKGGGTLETDCVFYATGRRPMLDNLGLDSVDVKLDEHGYIKVDEHYQSSEPSILAI
EEEEECCCCCEECCEEEEECCCCCCHHHCCCCEEEEEECCCCEEEEECCCCCCCCCEEEE
GDVIGGVQLTPVALAEGMAVARRLFKPEQYRPVDYNHIPTAVFSLPNIGTVGLTEEDAIK
CCHHCCCEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCEECCCCHHHHC
AGHDVQIFESRFRPMKLTLTDDQERTLMKLVVDAKTDRVLGCHMVGPDAGEIVQSLAIAI
CCCCCHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHH
KAGATKQVFDDTIGVHPTAAEEFVTMRTPVKR
CCCCCHHHHHHHCCCCCCCHHHHEECCCCCCC
>Mature Secondary Structure 
AFDFDLFVIGAGSGGVRAARFAAGFGARVAVAESRYLGGTCVNVGCVPKKLLVYGAHFS
CEEEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCCCCCEEEECCCCCCEEEEEECCCC
EDFDHAKGFGWSLGEAEFDWATLIANKDREINRLNGIYRKLLVDSGVTLLEGHARLTGPQ
CCHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCEECCCCE
QVEINGQTYSAERILVATGGWPQVPDVPGREHAITSNEAFYLKTLPKRVVVVGGGYIAVE
EEEECCCEEECCEEEEEECCCCCCCCCCCCCCEECCCCEEEEEECCCEEEEEECCEEEEE
FASIFNGLGADTTLVYRRELFLRGFDGGVRTHLHEELLKRDMTIRFNSDIERIDKQADGS
HHHHHCCCCCCEEEEEEEEHHEECCCCHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCC
LLLSMKGGGTLETDCVFYATGRRPMLDNLGLDSVDVKLDEHGYIKVDEHYQSSEPSILAI
EEEEECCCCCEECCEEEEECCCCCCHHHCCCCEEEEEECCCCEEEEECCCCCCCCCEEEE
GDVIGGVQLTPVALAEGMAVARRLFKPEQYRPVDYNHIPTAVFSLPNIGTVGLTEEDAIK
CCHHCCCEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCEECCCCHHHHC
AGHDVQIFESRFRPMKLTLTDDQERTLMKLVVDAKTDRVLGCHMVGPDAGEIVQSLAIAI
CCCCCHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHH
KAGATKQVFDDTIGVHPTAAEEFVTMRTPVKR
CCCCCHHHHHHHCCCCCCCHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1849605; 10984043 [H]