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The map label for this gene is hbd [H]

Identifier: 66046149

GI number: 66046149

Start: 3506769

End: 3507725

Strand: Direct

Name: hbd [H]

Synonym: Psyr_2918

Alternate gene names: 66046149

Gene position: 3506769-3507725 (Clockwise)

Preceding gene: 66046148

Following gene: 66046150

Centisome position: 57.55

GC content: 61.44

Gene sequence:

>957_bases
ATGAGCTTTATCACTGAAATCAAAACTTTCGCCGCTCTCGGCAGCGGCGTCATCGGCAGTGGCTGGGTATCCCGCGCCCT
CGCCCATGGCCTGGATGTGGTTGCCTGGGACCCCGCGCCCGGCGCCGAAGCAGCGCTGCGTAACCGTGTCGCCAAGTGCT
GGGGGGCGCTGGAACAACAGGGCCTGGTACCCGGTGCATCCCAGAACCGCCTGCGTTTTGTGGCCACTGTCGAAGAATGT
GTGAGAGACGCCGACTTCATTCAGGAAAGCGCCCCGGAACGCCTGGAACTGAAACTGGATCTGCACAGCAGGATCAGCGC
GGCGGCCAGGTCGAATGTGTTAATTGGCTCGAGTACGTCGGGCCTGTTGCCAAGTGACGTCTACGAAAGCTCCGCGCACC
CGGAACGCTGCGTGGTCGGTCACCCGTTCAATCCGGTGTACCTGCTGCCGTTGGTCGAAGTGGTGGGCGGCAAAAATACT
GCTCCGGCAGCCATACAGGCGGCAATCAAGGTCTATGAATCCCTCGGTATGCGCCCGCTGCACGTGCGCAAGGAAGTCCC
CGGTTTTATCGCTGACCGCTTGCTCGAAGCGCTATGGCGTGAGGCGCTGCACCTGGTCAATGACGGCGTGGCGACCACCG
GCGAAATCGATGATGCGATTCGCTTCGGCGCAGGGCTGCGCTGGTCGTTCATGGGCACCTTTCTCACCTACACGTTGGCG
GGTGGCGAAGCGGGCATGCGCCACTTCATGACTCAGTTCGGCCCGGCGTTGCAGTTGCCGTGGACCTACCTGCCGGCACC
GGAACTGACCGACAAACTGATCGACGATGTGGTCGACGGCACCACTGACCAGTTGGGTAAACACAGTATCTCTGGGTTGG
AGCGCTACCGTGACGATTGCTTGCTCGCCGTGCTGGAGGCGGTAAAGACTACCAAGGCCAGGCATGGCATGGCATGA

Upstream 100 bases:

>100_bases
CGAGTCATGAGCCCGGCAGAAGGCCGCACCAAGATGGGCCTTACCAAGCGCGGCTAATGCCTCCGAGACATAAATCACCG
CACTCTTCAGGAACGTCGCC

Downstream 100 bases:

>100_bases
GCTTCACGCAATGAACCTCCGCAAGCTGGCTTGCCTTTGATGGGTGGCGGTGATTCTTCCATCGTCCTGCAAAGCACGCC
CGCGCCCTCATTTTGATCAG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSFITEIKTFAALGSGVIGSGWVSRALAHGLDVVAWDPAPGAEAALRNRVAKCWGALEQQGLVPGASQNRLRFVATVEEC
VRDADFIQESAPERLELKLDLHSRISAAARSNVLIGSSTSGLLPSDVYESSAHPERCVVGHPFNPVYLLPLVEVVGGKNT
APAAIQAAIKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLA
GGEAGMRHFMTQFGPALQLPWTYLPAPELTDKLIDDVVDGTTDQLGKHSISGLERYRDDCLLAVLEAVKTTKARHGMA

Sequences:

>Translated_318_residues
MSFITEIKTFAALGSGVIGSGWVSRALAHGLDVVAWDPAPGAEAALRNRVAKCWGALEQQGLVPGASQNRLRFVATVEEC
VRDADFIQESAPERLELKLDLHSRISAAARSNVLIGSSTSGLLPSDVYESSAHPERCVVGHPFNPVYLLPLVEVVGGKNT
APAAIQAAIKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLA
GGEAGMRHFMTQFGPALQLPWTYLPAPELTDKLIDDVVDGTTDQLGKHSISGLERYRDDCLLAVLEAVKTTKARHGMA
>Mature_317_residues
SFITEIKTFAALGSGVIGSGWVSRALAHGLDVVAWDPAPGAEAALRNRVAKCWGALEQQGLVPGASQNRLRFVATVEECV
RDADFIQESAPERLELKLDLHSRISAAARSNVLIGSSTSGLLPSDVYESSAHPERCVVGHPFNPVYLLPLVEVVGGKNTA
PAAIQAAIKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLAG
GEAGMRHFMTQFGPALQLPWTYLPAPELTDKLIDDVVDGTTDQLGKHSISGLERYRDDCLLAVLEAVKTTKARHGMA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=303, Percent_Identity=30.3630363036304, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI296179429, Length=307, Percent_Identity=27.0358306188925, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI296179427, Length=324, Percent_Identity=25.6172839506173, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787661, Length=234, Percent_Identity=29.0598290598291, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788682, Length=140, Percent_Identity=30, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=269, Percent_Identity=29.368029739777, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193203623, Length=268, Percent_Identity=29.4776119402985, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17549919, Length=304, Percent_Identity=27.9605263157895, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17553560, Length=230, Percent_Identity=27.3913043478261, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17563036, Length=230, Percent_Identity=26.5217391304348, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508951, Length=221, Percent_Identity=24.8868778280543, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=221, Percent_Identity=24.8868778280543, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25144276, Length=221, Percent_Identity=24.8868778280543, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=221, Percent_Identity=23.9819004524887, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45549573, Length=295, Percent_Identity=28.8135593220339, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI20129993, Length=247, Percent_Identity=31.1740890688259, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24583077, Length=215, Percent_Identity=26.046511627907, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583079, Length=215, Percent_Identity=26.046511627907, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921000, Length=215, Percent_Identity=26.046511627907, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34340; Mature: 34208

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFITEIKTFAALGSGVIGSGWVSRALAHGLDVVAWDPAPGAEAALRNRVAKCWGALEQQ
CCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHC
GLVPGASQNRLRFVATVEECVRDADFIQESAPERLELKLDLHSRISAAARSNVLIGSSTS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCEEEECCCC
GLLPSDVYESSAHPERCVVGHPFNPVYLLPLVEVVGGKNTAPAAIQAAIKVYESLGMRPL
CCCCHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
HVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLA
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHC
GGEAGMRHFMTQFGPALQLPWTYLPAPELTDKLIDDVVDGTTDQLGKHSISGLERYRDDC
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLAVLEAVKTTKARHGMA
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SFITEIKTFAALGSGVIGSGWVSRALAHGLDVVAWDPAPGAEAALRNRVAKCWGALEQQ
CHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHC
GLVPGASQNRLRFVATVEECVRDADFIQESAPERLELKLDLHSRISAAARSNVLIGSSTS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCEEEECCCC
GLLPSDVYESSAHPERCVVGHPFNPVYLLPLVEVVGGKNTAPAAIQAAIKVYESLGMRPL
CCCCHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
HVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLA
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHC
GGEAGMRHFMTQFGPALQLPWTYLPAPELTDKLIDDVVDGTTDQLGKHSISGLERYRDDC
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLAVLEAVKTTKARHGMA
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA