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The map label for this gene is yeaU [C]

Identifier: 66045632

GI number: 66045632

Start: 2778054

End: 2779175

Strand: Reverse

Name: yeaU [C]

Synonym: Psyr_2396

Alternate gene names: 66045632

Gene position: 2779175-2778054 (Counterclockwise)

Preceding gene: 66045634

Following gene: 66045630

Centisome position: 45.61

GC content: 61.5

Gene sequence:

>1122_bases
ATGGATCGATTCAGAGAGAGCGCCGCCATGAACAACAACAAACTGCGTATTGCTGCCATCGCCGGTGACGGCATCGGCCT
GGAGGTGCTGCCCGAAGGAGTGCGCGTGGTGCAGGCCGCTGCCGCACGGCACGGGCTGGAACTGGAGTTCGAATACTTCG
AATGGGCCAGCTGCGATTACTACCTGAAACACGGCAAGATGATGCCGGACGACTGGTTCGAACAGCTCAAAGGCTTTGAC
TCGATCTTCTTCGGCGCCGTCGGCTGGCCGGAAAAGGTCCCGGATCACATCTCGCTGTGGGGCTCGCTGCTCAAGTTTCG
TCGCGAATTCGATCAGTACGCAAATATCCGCCCGGTGCGGCTGTTTCCCGGCGTGCCCTGCCCGCTGGCCAATCGCAAAC
CGGGCGACATCGACTTTGTCGTGGTCCGGGAAAACACCGAAGGTGAATACTCGTCGCTGGGCGGGATCATGTTCGAGAAC
ACCGAAAACGAATTCGTGCTGCAGGAATCGGTGTTCACCCGTCGTGGTGTCGACCGCATTCTCAAGTTCGCCTTCGAGAT
GGCCAGCAAACGCGAGCGCAAGCACGTCACCTCGGCGACCAAATCCAATGGCATGGCCATCAGCATGCCGTACTGGGACA
AGCGCACCGAAGCGATGGCCAGCCAGTACCCCGGCATCAGCTGGGACAAGCAACACATCGACATTCTCTGCGCGCGTTTC
GTGCTGCAACCCGAGCGCTTCGACGTGGTGGTGGCGTCCAACCTGTTCGGCGACATCCTCAGCGACCTCGGCCCGGCGTG
CGCAGGCACCATCGGCATTGCGCCGTCAGCCAACCTCAACCCCGAGCGCCACTTCCCGTCGCTGTTCGAACCGGTCCACG
GCTCGGCCCCGGACATCTTCGGCCAGAACATCGCCAACCCGATCGCAATGATTTGGTCCGGCGCACTGATGCTGGAGTTC
CTCGGCCAGGGCGATCAGCGTTTCACGGCGGCCCATGACGAGATCATCACCGCCATCGAGCAAGTGATCGCCAACGGCGA
CGTCACGCCGGATCTGGGCGGCACGCTTTCGACTCAGCACGTGGGTGCGGCGATTGCCGAGCGGGTTTCTGCAGGCCATT
AA

Upstream 100 bases:

>100_bases
CACGATTCGTGTTTTCTCAGTCCATTAATCAGCTGATTATCTTTATATCGTGCGCTTATAGCATGGATGGCCTGTGCAAC
TCATTCATCGCACACCCGTA

Downstream 100 bases:

>100_bases
ACGTTCGCCGGTTCGCTGCGCTGTTCCAGCAGCTCGACAAAGCGGGTCAGGCTGCGCGACACCGTGCCCCGGCGCCAGAT
CAGCCAGGTGTGCAGGTAGC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MDRFRESAAMNNNKLRIAAIAGDGIGLEVLPEGVRVVQAAAARHGLELEFEYFEWASCDYYLKHGKMMPDDWFEQLKGFD
SIFFGAVGWPEKVPDHISLWGSLLKFRREFDQYANIRPVRLFPGVPCPLANRKPGDIDFVVVRENTEGEYSSLGGIMFEN
TENEFVLQESVFTRRGVDRILKFAFEMASKRERKHVTSATKSNGMAISMPYWDKRTEAMASQYPGISWDKQHIDILCARF
VLQPERFDVVVASNLFGDILSDLGPACAGTIGIAPSANLNPERHFPSLFEPVHGSAPDIFGQNIANPIAMIWSGALMLEF
LGQGDQRFTAAHDEIITAIEQVIANGDVTPDLGGTLSTQHVGAAIAERVSAGH

Sequences:

>Translated_373_residues
MDRFRESAAMNNNKLRIAAIAGDGIGLEVLPEGVRVVQAAAARHGLELEFEYFEWASCDYYLKHGKMMPDDWFEQLKGFD
SIFFGAVGWPEKVPDHISLWGSLLKFRREFDQYANIRPVRLFPGVPCPLANRKPGDIDFVVVRENTEGEYSSLGGIMFEN
TENEFVLQESVFTRRGVDRILKFAFEMASKRERKHVTSATKSNGMAISMPYWDKRTEAMASQYPGISWDKQHIDILCARF
VLQPERFDVVVASNLFGDILSDLGPACAGTIGIAPSANLNPERHFPSLFEPVHGSAPDIFGQNIANPIAMIWSGALMLEF
LGQGDQRFTAAHDEIITAIEQVIANGDVTPDLGGTLSTQHVGAAIAERVSAGH
>Mature_373_residues
MDRFRESAAMNNNKLRIAAIAGDGIGLEVLPEGVRVVQAAAARHGLELEFEYFEWASCDYYLKHGKMMPDDWFEQLKGFD
SIFFGAVGWPEKVPDHISLWGSLLKFRREFDQYANIRPVRLFPGVPCPLANRKPGDIDFVVVRENTEGEYSSLGGIMFEN
TENEFVLQESVFTRRGVDRILKFAFEMASKRERKHVTSATKSNGMAISMPYWDKRTEAMASQYPGISWDKQHIDILCARF
VLQPERFDVVVASNLFGDILSDLGPACAGTIGIAPSANLNPERHFPSLFEPVHGSAPDIFGQNIANPIAMIWSGALMLEF
LGQGDQRFTAAHDEIITAIEQVIANGDVTPDLGGTLSTQHVGAAIAERVSAGH

Specific function: Has multiple catalytic activities. Apart from catalyzing the oxidation of (+)-tartrate to oxaloglycolate, also converts meso-tartrate to D-glycerate and catalyzes the oxidative decarboxylation of D-malate to pyruvate [H]

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=358, Percent_Identity=32.4022346368715, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI28178821, Length=308, Percent_Identity=29.8701298701299, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI28178816, Length=308, Percent_Identity=29.8701298701299, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4758582, Length=259, Percent_Identity=31.6602316602317, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI28178838, Length=221, Percent_Identity=33.0316742081448, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI28178819, Length=153, Percent_Identity=35.9477124183007, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788101, Length=353, Percent_Identity=76.7705382436261, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI87081683, Length=364, Percent_Identity=35.989010989011, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1787381, Length=395, Percent_Identity=28.6075949367089, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=364, Percent_Identity=32.6923076923077, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71986051, Length=359, Percent_Identity=33.1476323119777, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144293, Length=367, Percent_Identity=28.3378746594005, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=364, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322097, Length=359, Percent_Identity=37.6044568245125, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324709, Length=364, Percent_Identity=31.8681318681319, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319830, Length=369, Percent_Identity=32.7913279132791, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324291, Length=367, Percent_Identity=32.9700272479564, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24643270, Length=346, Percent_Identity=33.5260115606936, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24643268, Length=346, Percent_Identity=33.5260115606936, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24661184, Length=347, Percent_Identity=31.4121037463977, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI281362242, Length=367, Percent_Identity=31.0626702997275, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24648872, Length=367, Percent_Identity=31.0626702997275, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI161078639, Length=272, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161078633, Length=272, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24650122, Length=272, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161078635, Length=272, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161078637, Length=272, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20130355, Length=355, Percent_Identity=25.6338028169014, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 41383; Mature: 41383

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRFRESAAMNNNKLRIAAIAGDGIGLEVLPEGVRVVQAAAARHGLELEFEYFEWASCDY
CCHHHHHHHCCCCCEEEEEEECCCCCCEECHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
YLKHGKMMPDDWFEQLKGFDSIFFGAVGWPEKVPDHISLWGSLLKFRREFDQYANIRPVR
HHHCCCCCCHHHHHHHHCCHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEE
LFPGVPCPLANRKPGDIDFVVVRENTEGEYSSLGGIMFENTENEFVLQESVFTRRGVDRI
ECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHCCEEEECCCCCEEEHHHHHHHHHHHHH
LKFAFEMASKRERKHVTSATKSNGMAISMPYWDKRTEAMASQYPGISWDKQHIDILCARF
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
VLQPERFDVVVASNLFGDILSDLGPACAGTIGIAPSANLNPERHFPSLFEPVHGSAPDIF
HCCCCCCEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHCCCHHHHCCCCCCCCHH
GQNIANPIAMIWSGALMLEFLGQGDQRFTAAHDEIITAIEQVIANGDVTPDLGGTLSTQH
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
VGAAIAERVSAGH
HHHHHHHHHHCCC
>Mature Secondary Structure
MDRFRESAAMNNNKLRIAAIAGDGIGLEVLPEGVRVVQAAAARHGLELEFEYFEWASCDY
CCHHHHHHHCCCCCEEEEEEECCCCCCEECHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
YLKHGKMMPDDWFEQLKGFDSIFFGAVGWPEKVPDHISLWGSLLKFRREFDQYANIRPVR
HHHCCCCCCHHHHHHHHCCHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEE
LFPGVPCPLANRKPGDIDFVVVRENTEGEYSSLGGIMFENTENEFVLQESVFTRRGVDRI
ECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHCCEEEECCCCCEEEHHHHHHHHHHHHH
LKFAFEMASKRERKHVTSATKSNGMAISMPYWDKRTEAMASQYPGISWDKQHIDILCARF
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
VLQPERFDVVVASNLFGDILSDLGPACAGTIGIAPSANLNPERHFPSLFEPVHGSAPDIF
HCCCCCCEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHCCCHHHHCCCCCCCCHH
GQNIANPIAMIWSGALMLEFLGQGDQRFTAAHDEIITAIEQVIANGDVTPDLGGTLSTQH
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
VGAAIAERVSAGH
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8053675; 2184888; 8457548 [H]